News Feed
The Download: GLP-1s and eating disorders, self-aware cities, and forever chemicals
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Eating disorders are on the rise. GLP-1s could make things…
Sex Chromosome Aneuploidies and the Brain: from Neurodevelopmental Risk to Fundamental Biology
Sex chromosome aneuploidies (SCAs) are collectively common (∼1/400 individuals) conditions that involve loss or gain of one or more X- or Y- chromosomes. A recent surge in SCA research has highlighted their underappreciated penetrance…
Trends in Autism Spectrum Disorder Cumulative Incidence and Incidence Density: A Systematic Review
Claims of an “autism epidemic” imply a true increase in ASD occurrence and changing underlying risk yet largely rely on rising prevalence estimates rather than incidence. Both measures are influenced by diagnostic practices, service…
News
3117 results
STAT+: Novo underwhelmed by drug it once fought Pfizer for
Revolution and Tango yield promising cancer results, Incyte buys bleeding disorder drug, and more biotech news
STAT+: Pharmalittle: We’re reading about Lilly and Pfizer obesity drug data, Roche and J&J deals, and more
Lilly disclosed new data that provide more details on the safety and tolerability of its next-generation obesity drug retatrutide
Divergent dFC stability of DMN and SMN in narcolepsy
Narcolepsy type 1 (NT1) is characterized by profound sleep-wake state instability, pointing to a fundamental dysregulation of large-scale brain network dynamics. To elucidate this, we assessed whole-brain dynamic functional connectivity (dFC) stability using resting-state fMRI in 27 patients with NT1…
Gut microbiome dynamics in autism: a prospective nested case–control study demonstrates microbial-clinical associations following rehabilitation interventions
BackgroundChildren with autism spectrum disorder (ASD) commonly exhibit gut microbiota dysbiosis and metabolic abnormalities, yet the mechanisms linking these changes to clinical symptoms remain unclear.ObjectiveThis study employed a nested case–control design and multi-omics approaches to evaluate the effects of rehabilitation…
Postnatal maternal mental health-related hospitalisation and its association with adverse child health and maltreatment outcomes: narrative review
BackgroundMaternal mental health conditions within the postnatal period can have long-lasting consequences on a child’s well-being. This study synthesises current evidence on the association between postnatal maternal mental health-related hospitalisation (MHrH) and adverse child health and maltreatment outcomes.MethodsWe conducted an…
Integrative mechanisms and intervention targets of the microbiota–gut–brain axis in depressive disorders: advances across immune, endocrine, and central nervous system pathways
Depressive disorders are highly heterogeneous syndromes characterized not only by depressed mood but also by cognitive impairment, sleep–circadian rhythm disturbances, altered appetite, somatic discomfort, and metabolic or gastrointestinal comorbidities. In recent years, the microbiota–gut–brain axis (MGBA) has been increasingly recognized…
Disruption of a GalR2–mitochondrial axis in the ventral hippocampus contributes to depression-like phenotypes after prenatal stress
BackgroundPrenatal stress (PS) is a major risk factor for depression later in life, yet the cellular mechanisms linking early-life adversity to long-term affective vulnerability remain incompletely understood. Neuropeptide receptors have emerged as important modulators of stress-related psychopathology, but their roles…
Feasibility study examining the short-term effects of Sonic Augmentation Technology™
BackgroundThe current study evaluated Sonic Augmentation Technology™ (SAT), a novel, Polyvagal-informed probe that incorporates continuously varying and acoustic features modeled on patterns of autonomic regulation into musical soundscapes. Specifically, the study examined whether SAT led to improvements in self-reported biobehavioral…
Social connectedness in mobile gaming: how family dynamics shape children’s virtual interactions
BackgroundMobile gaming is important for children’s social interaction, but its impact on real-life social connectedness depends heavily on family dynamics. How family patterns shape children’s emotional and social experiences around gaming remains underexplored, particularly qualitatively. This study examined how family…
Major readouts from the annual diabetes conference
Why "Schedule F" matters, the Ebola outbreak response, and more health news from Morning Rounds
Global extent and drivers of tree cover loss quantified with high-resolution satellite data
Science, Volume 392, Issue 6802, June 2026.
Severe obesity in human HFpEF alters contractile protein function and organization
Science, Volume 392, Issue 6802, June 2026.
Competition enables rapid adaptation to a warming range edge in a model plant community
Science, Volume 392, Issue 6802, June 2026.
A provocative view of evolution turns 50
Science, Volume 392, Issue 6802, Page 1027-1027, June 2026.
Single-cell spatial pharmacobiology for imaging antibody-based therapies in solid tumors
Nature Biotechnology, Published online: 08 June 2026; doi:10.1038/s41587-026-03171-8We have developed single-cell spatial pharmacobiology (SSP), which combines in situ imaging of a systemically infused fluorescent therapeutic antibody with high-plex spatial proteomics. Applied to head and neck and pancreatic tumors from patients…
Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04439-xIn a whole-exome sequencing analysis, the beneficial effects of the SGLT2 inhibitor dapagliflozin in reducing the risk of future heart failure hospitalization in individuals with type 2 diabetes were markedly greater in individuals…
Post-adjuvant chemotherapy in ctDNA-positive patients with resected colorectal cancer: a randomized phase 3 trial
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04428-0In the randomized, double-blind phase 3 ALTAIR trial, patients with resected colorectal cancer who became positive for circulating tumor DNA during post-adjuvant surveillance received trifluridine/tipiracil hydrochloride therapy, which did not significantly prolong disease-free…
Electronic cigarette use after smoking cessation and lung cancer risk
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04469-5A nationwide retrospective analysis of 4.5 million Korean adults found that electronic cigarette use after smoking cessation was associated with higher lung cancer incidence and mortality compared with complete smoking cessation.
Induction of cortical on/off periods in awake mice fulfills sleep functions
Nature Neuroscience, Published online: 08 June 2026; doi:10.1038/s41593-026-02318-9Driessen et al. show that core benefits of sleep—reduced local sleep pressure, renormalized synaptic strength and memory consolidation—can be reproduced in awake, behaving mice by inducing sleep-like on/off activity patterns in cortex.
News Feed
The Download: GLP-1s and eating disorders, self-aware cities, and forever chemicals
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Eating disorders are on the rise. GLP-1s could make things…
Sex Chromosome Aneuploidies and the Brain: from Neurodevelopmental Risk to Fundamental Biology
Sex chromosome aneuploidies (SCAs) are collectively common (∼1/400 individuals) conditions that involve loss or gain of one or more X- or Y- chromosomes. A recent surge in SCA research has highlighted their underappreciated penetrance…
Trends in Autism Spectrum Disorder Cumulative Incidence and Incidence Density: A Systematic Review
Claims of an “autism epidemic” imply a true increase in ASD occurrence and changing underlying risk yet largely rely on rising prevalence estimates rather than incidence. Both measures are influenced by diagnostic practices, service…
News
3117 results
STAT+: Novo underwhelmed by drug it once fought Pfizer for
Revolution and Tango yield promising cancer results, Incyte buys bleeding disorder drug, and more biotech news
STAT+: Pharmalittle: We’re reading about Lilly and Pfizer obesity drug data, Roche and J&J deals, and more
Lilly disclosed new data that provide more details on the safety and tolerability of its next-generation obesity drug retatrutide
Divergent dFC stability of DMN and SMN in narcolepsy
Narcolepsy type 1 (NT1) is characterized by profound sleep-wake state instability, pointing to a fundamental dysregulation of large-scale brain network dynamics. To elucidate this, we assessed whole-brain dynamic functional connectivity (dFC) stability using resting-state fMRI in 27 patients with NT1…
Gut microbiome dynamics in autism: a prospective nested case–control study demonstrates microbial-clinical associations following rehabilitation interventions
BackgroundChildren with autism spectrum disorder (ASD) commonly exhibit gut microbiota dysbiosis and metabolic abnormalities, yet the mechanisms linking these changes to clinical symptoms remain unclear.ObjectiveThis study employed a nested case–control design and multi-omics approaches to evaluate the effects of rehabilitation…
Postnatal maternal mental health-related hospitalisation and its association with adverse child health and maltreatment outcomes: narrative review
BackgroundMaternal mental health conditions within the postnatal period can have long-lasting consequences on a child’s well-being. This study synthesises current evidence on the association between postnatal maternal mental health-related hospitalisation (MHrH) and adverse child health and maltreatment outcomes.MethodsWe conducted an…
Integrative mechanisms and intervention targets of the microbiota–gut–brain axis in depressive disorders: advances across immune, endocrine, and central nervous system pathways
Depressive disorders are highly heterogeneous syndromes characterized not only by depressed mood but also by cognitive impairment, sleep–circadian rhythm disturbances, altered appetite, somatic discomfort, and metabolic or gastrointestinal comorbidities. In recent years, the microbiota–gut–brain axis (MGBA) has been increasingly recognized…
Disruption of a GalR2–mitochondrial axis in the ventral hippocampus contributes to depression-like phenotypes after prenatal stress
BackgroundPrenatal stress (PS) is a major risk factor for depression later in life, yet the cellular mechanisms linking early-life adversity to long-term affective vulnerability remain incompletely understood. Neuropeptide receptors have emerged as important modulators of stress-related psychopathology, but their roles…
Feasibility study examining the short-term effects of Sonic Augmentation Technology™
BackgroundThe current study evaluated Sonic Augmentation Technology™ (SAT), a novel, Polyvagal-informed probe that incorporates continuously varying and acoustic features modeled on patterns of autonomic regulation into musical soundscapes. Specifically, the study examined whether SAT led to improvements in self-reported biobehavioral…
Social connectedness in mobile gaming: how family dynamics shape children’s virtual interactions
BackgroundMobile gaming is important for children’s social interaction, but its impact on real-life social connectedness depends heavily on family dynamics. How family patterns shape children’s emotional and social experiences around gaming remains underexplored, particularly qualitatively. This study examined how family…
Major readouts from the annual diabetes conference
Why "Schedule F" matters, the Ebola outbreak response, and more health news from Morning Rounds
Global extent and drivers of tree cover loss quantified with high-resolution satellite data
Science, Volume 392, Issue 6802, June 2026.
Severe obesity in human HFpEF alters contractile protein function and organization
Science, Volume 392, Issue 6802, June 2026.
Competition enables rapid adaptation to a warming range edge in a model plant community
Science, Volume 392, Issue 6802, June 2026.
A provocative view of evolution turns 50
Science, Volume 392, Issue 6802, Page 1027-1027, June 2026.
Single-cell spatial pharmacobiology for imaging antibody-based therapies in solid tumors
Nature Biotechnology, Published online: 08 June 2026; doi:10.1038/s41587-026-03171-8We have developed single-cell spatial pharmacobiology (SSP), which combines in situ imaging of a systemically infused fluorescent therapeutic antibody with high-plex spatial proteomics. Applied to head and neck and pancreatic tumors from patients…
Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04439-xIn a whole-exome sequencing analysis, the beneficial effects of the SGLT2 inhibitor dapagliflozin in reducing the risk of future heart failure hospitalization in individuals with type 2 diabetes were markedly greater in individuals…
Post-adjuvant chemotherapy in ctDNA-positive patients with resected colorectal cancer: a randomized phase 3 trial
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04428-0In the randomized, double-blind phase 3 ALTAIR trial, patients with resected colorectal cancer who became positive for circulating tumor DNA during post-adjuvant surveillance received trifluridine/tipiracil hydrochloride therapy, which did not significantly prolong disease-free…
Electronic cigarette use after smoking cessation and lung cancer risk
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04469-5A nationwide retrospective analysis of 4.5 million Korean adults found that electronic cigarette use after smoking cessation was associated with higher lung cancer incidence and mortality compared with complete smoking cessation.
Induction of cortical on/off periods in awake mice fulfills sleep functions
Nature Neuroscience, Published online: 08 June 2026; doi:10.1038/s41593-026-02318-9Driessen et al. show that core benefits of sleep—reduced local sleep pressure, renormalized synaptic strength and memory consolidation—can be reproduced in awake, behaving mice by inducing sleep-like on/off activity patterns in cortex.