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Long-Read DNA Test Could Replace 15 Existing Tests for Rare Diseases
A DNA test for rare diseases using long-read sequencing can provide much more comprehensive results than standard diagnostics in a shorter amount of time. The post Long-Read DNA Test Could Replace 15 Existing Tests…
Opinion: ‘I’m pretty much all in’: An interview with a woman starting medical residency at almost 73
"There are some physicians that work to 100”: Dawn Zuidgeest-Craft on becoming a medical doctor in her 70s.
Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
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Opinion: The U.S. health care system is built around looking backward
A reconstruction layer has fallen on medicine. It asks: Was the original decision justified?
Opinion: What happens when a chief executive loses executive functions?
When a CEO develops acquired executive dysfunction yet remains in their role, the challenges are significant.
Pilot Randomized Trial of BA-GSH in VA PC-MHI
Conditions: Depression Interventions: Behavioral: Behavioral Activation-Guided Self-Help Sponsors: VA Office of Research and Development Not yet recruiting
MDMA Assisted Therapy for BN
Conditions: Bulimia Nervosa Interventions: Drug: MDMA-AT; Drug: MDMA-AT-BN; Behavioral: Standard Treatment (ST) Sponsors: Icahn School of Medicine at Mount Sinai Not yet recruiting
Adapting Behavioral Interventions for Dementia to Address NCDs and Mental Health
Conditions: Mental Health; Non Communicable Diseases; Dementia Interventions: Behavioral: BECOME-D Intervention Sponsors: Possible; University of California, San Francisco; National Institute of Mental Health (NIMH); Ministry of Health and Population, Nepal Completed
Photobiomodulation on Core Symptoms of Autism
Conditions: Autism Interventions: Device: Photobiomodulation Sponsors: Suez University Not yet recruiting
Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression
Conditions: Treatment-resistant Depression (TRD); Major Depression Disorder Interventions: Device: transcranial photobiomodulation Sponsors: Taipei Veterans General Hospital, Taiwan Recruiting
Policy implications for halting human trafficking and sexual exploitation at U.S. colleges and universities: results from a 12-campus survey
Human trafficking is a priority concern in the U.S, but few research studies have investigated the nature and extent of its occurrence on U.S. college campuses nor strategies to stop it. The objective of this research was to identify its…
Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04380-zAs presented at the 2026 AACR Annual Meeting: in a phase 1b trial, patients with microsatellite-stable colorectal cancer received a FAP-4-1BB ligand together with the CEA-directed T cell engager cibisatamab; the treatment was…
Ciltacabtagene autoleucel in high-risk smoldering multiple myeloma: the CAR-PRISM phase 2 trial
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04365-yAs presented at the 2026 AACR Annual Meeting, in a phase 2 trial, treatment of patients with high-risk smoldering multiple myeloma with BCMA-targeting CAR T cell therapy ciltacabtagene autoleucel was safe and led…
Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04318-5Microbiome analysis suggests that gut microbial changes in Parkinson’s disease evolve progressively from healthy individuals to genetically at-risk individuals to clinically affected patients, with the degree of dysbiosis correlating with disease progression.
STAT+: At AACR, a provocative use of CAR-T, Merck’s new thing and cancer’s geography problem
At AACR, a bold use of CAR-T raises hopes and provocative questions about its use in smoldering multiple myeloma.
STAT+: Former banker brought on to revitalize Pfizer’s strategy departs his post
Andrew Baum, a former Citi analyst, has left his role as Pfizer's executive vice president and chief strategy and innovation officer.
Access to Technology-Mediated Community Mental Health Care Among Low-Socioeconomic Status Consumers With Serious Mental Illness: Qualitative Study
Background: Access to mental health care is critical for the effective management of serious mental illness (SMI), but consumers with low socioeconomic status (SES) have lower rates of service usage and worse retention in care. Digital technologies are often lauded…
STAT+: In early trial, CAR-T results raise hope of preventing multiple myeloma in high-risk patients
A CAR-T trial shows promise in preventing smoldering multiple myeloma from becoming the real thing.
Opportunities for Digital Health to Support Early Psychosis Care in Ghana: Qualitative Study Among Patients, Caregivers, and Clinicians
Background: Youth experiencing early psychosis in West Africa often face delays in accessing evidence-based treatment. Digital mental health interventions may offer an acceptable and scalable approach to improve access to early psychosis care in West Africa; however, few data exist…
Popular Online Content as a Treatment-as-Usual Control in Digital Mental Health Intervention Trials: Secondary Analysis of Two Online Randomized Controlled Trials With Repeated Measures
Background: Treatment-as-usual (TAU) conditions are intended to reflect the support typically received in routine treatment settings. For digital mental health interventions (DMHIs) delivered online, TAU conditions should reflect the usual patterns of online help-seeking. The lack of ecologically valid TAU…
STAT+: Trump order to advance psychedelic treatments generates excitement — and worries
President Trump’s executive order on was largely applauded by advocates. But some also quietly worried the White House’s role risks politicizing their field and undermining its credibility.
Opinion: The contradiction at the heart of Republicans’ embrace of psychedelics
“The research is clear about one thing: Recovery is not primarily a pharmacological event,” write Dimitri Mugianis and Ross Ellenhorn.