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Long-Read DNA Test Could Replace 15 Existing Tests for Rare Diseases
A DNA test for rare diseases using long-read sequencing can provide much more comprehensive results than standard diagnostics in a shorter amount of time. The post Long-Read DNA Test Could Replace 15 Existing Tests…
Opinion: ‘I’m pretty much all in’: An interview with a woman starting medical residency at almost 73
"There are some physicians that work to 100”: Dawn Zuidgeest-Craft on becoming a medical doctor in her 70s.
Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
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The Download: murderous ‘mirror’ bacteria, and Chinese workers fighting AI doubles
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. No one’s sure if synthetic mirror life will kill us all In February 2019, a group…
Short-term intrinsic connectivity changes induced by cognitive exertion in healthy participants
IntroductionChanges in brain intrinsic connectivity on the timescale of minutes, as provoked by a cognitive task, have not been well documented.MethodsA total of two 7.5-min 7 Tesla functional MRI (fMRI) scans (Run 1 and Run 2), separated by 90 s, were…
Altered static and dynamic regional homogeneity in basal ganglia–thalamocortical circuits and their association with neuropsychiatric manifestations in Wilson’s disease
PurposeWilson’s disease (WD) is an autosomal recessive disorder caused by ATP7B mutations, resulting in impaired copper metabolism and progressive neuropsychiatric manifestations. This study investigated spatiotemporal alterations in regional brain activity using static and dynamic resting-state fMRI with regional homogeneity (ReHo),…
Neurobiological effects of microbial treatments within psychiatry: a systematic review
ObjectiveThough microbial interventions such as probiotics and fecal microbiota transplantation have had a growing body of evidence suggesting their efficacy in alleviating the symptoms of psychiatric illnesses, their exact mechanisms of action and impacts on the brain are still not…
Electrocardiographic findings in children and adolescents treated with antipsychotics: a cohort study
Background/objectivesAntipsychotic drugs are increasingly prescribed in children and adolescents across a wide range of psychiatric conditions. Although cardiovascular adverse effects are generally considered uncommon, concerns about electrocardiographic abnormalities, particularly QTc interval prolongation, have led to ongoing debate regarding appropriate monitoring…
Postmarketing surveillance of elobixibat for patients with chronic constipation and concomitant schizophrenia or depression in Japan
BackgroundLittle is known about the optimal treatment for constipation in patients with schizophrenia or depression. Elobixibat is a laxative with a novel mechanism of action that inhibits the ileal bile acid transporter, acting as both an osmotic and a stimulant…
Twelve-month outcomes and comparative costs of internet-delivered psychodynamic therapy versus cognitive-behavioral therapy for adolescent depression: a randomized controlled trial
IntroductionAdolescent depression poses a major public health concern with substantial clinical and societal implications. Both internet-delivered cognitive behavioural therapy (ICBT) and internet-delivered psychodynamic therapy (IPDT) have shown efficacy, but questions remain regarding long-term efficacy and cost-effectiveness. The present study presents…
Machine learning for oral frailty factors in hospitalized schizophrenia patients: two-stage feature selection and SHAP analysis
BackgroundLong-term hospitalized patients with schizophrenia (SZ) often experience significant oral health problems, and oral frailty (OF) can further exacerbate the decline in their quality of life. However, the status and key influencing factors contributing to OF in this population remain…
Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing
Nature Biotechnology, Published online: 20 April 2026; doi:10.1038/s41587-026-03090-8A large screen of approved kinase inhibitors expands the druggable kinome.
How weed affects adolescent brains
The latest CDC director nominee, the ongoing measles outbreak, and other health news from Morning Rounds
STAT+: Extended use of Nektar Therapeutics drug shows promise in alopecia
Extended use of a drug from Nektar Therapeutics promoted hair growth in people with alopecia.
Colossal Biosciences said it cloned red wolves. Is it for real?
If you want to capture something wolflike, it’s best to embark before dawn. So on a morning this January, with the eastern horizon still pink-hued, I drove with two young scientists into a blanket of fog. Forty miles to the…
Chinese tech workers are starting to train their AI doubles–and pushing back
Tech workers in China are being instructed by their bosses to train AI agents to replace them—and it’s prompting a wave of soul-searching among otherwise enthusiastic early adopters. Earlier this month a GitHub project called Colleague Skill, which claimed workers…
STAT+: PBMs warn Trump’s proposal to disclose drug prices is illegal
Pharma industry middlemen are pushing back on a major drug price transparency proposal.
Opinion: Politicians are using low teen birth rates to further restrict access to birth control, abortion
“Both narratives — that teen birth rates are too high or too low — problematize teen pregnancy and childbearing,” writes Riley J. Steiner.
STAT+: A controversy over research monkeys highlights ambiguity over health standards
A leading animal rights group is accusing Pfizer of running afoul of its own standards in the handling of research monkeys.
ADOLESCENTS IMAGING USING fMRI: Feasibility Study
Conditions: Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group; Diagnosis of ADHD Using the KSADS-PL for the ADHD Group; Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group; All Participants Were…
A Toolkit to Improve Mental Health Treatment for Autistic Individuals
Conditions: Autism; Mental Health Conditions Interventions: Behavioral: Enhanced Psychotherapy; Behavioral: Treatment as Usual (TAU) Sponsors: Florida International University; Organization for Autism Research Not yet recruiting