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Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
Efficacy and Safety of Transcranial Temporal Interference Stimulation for Depression
Conditions: Major Depressive Disorder (MDD) Interventions: Device: Active Transcranial Temporal Interference Stimulation Targeting Left ALIC; Device: Active Transcranial Temporal Interference Stimulation Targeting Left sgACC; Device: Sham Transcranial Temporal Interference Stimulation Sponsors: Yonggui Yuan Not yet recruiting
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Conditions: Depression / Major Depressive Disorder; Mental Health (Depression) Interventions: Behavioral: Stress Management and Resiliency Training with Qigong/Tai Chi; Behavioral: Healthy Living Program Sponsors: Massachusetts General Hospital; National Center for Complementary and Integrative Health (NCCIH) Not yet recruiting
The Efficacy of Psilocybin Therapy for Depression in Parkinson’s Disease
Conditions: Depression; Parkinson's Disease (PD) Interventions: Drug: Psilocybin (drug); Drug: Psilocybin (drug) Sponsors: Yale University; Michael J. Fox Foundation for Parkinson's Research Not yet recruiting
EEG Prediction and Clinical Efficacy of tDCS in Major Depression
Conditions: Depression - Major Depressive Disorder Interventions: Device: High-dose home-tDCS; Device: Conventional home-tDCS Sponsors: Ionclinics & Deionic SL; Hospital Universitario Doctor Peset; Universidad Europea de Valencia Not yet recruiting
Centering People, Centering Stories: Folklore as an Unlikely Ally in the OCD Misdiagnosis Crisis
By: Rebecca Bernstein, MA Folklore The International OCD Foundation’s (IOCDF) recent landmark white paper reveals more than 80% of OCD cases in America remain undiagnosed (International OCD Foundation, 2025). Considering... Read more » The post Centering People, Centering Stories: Folklore…
STAT+: Heart patch engineered from stem cells revved up weakened hearts
A stem cell-based heart patch improved pumping in a small trial for advanced heart failure. "Very good first step," researcher says.
Real-World Implementation of EndoConnect in Brazilian Primary Care: Formative Study of Usability, Engagement, and Equity in Digital Endometriosis Care
Background: Endometriosis is a chronic gynecological condition affecting approximately 10% of women of reproductive age worldwide and is associated with chronic pelvic pain, infertility, and reduced quality of life. In Brazil’s Unified Health System (Sistema Único de Saúde [SUS]), diagnostic…
Opinion: MIT president: Why so many optimistic scientists are losing heart
“This erosion of our strength is a loss for the nation,” writes MIT President Sally Kornbluth.
STAT+: Kailera’s own ‘triple-G’ drug also looks very powerful
The business of living forever, Chan Zuckerberg Biohub's AI protein model, and other biotech news from The Readout
STAT+: Pharmalittle: We’re reading about an AstraZeneca breast cancer pill, an ADAP deal in Florida, and more
The FDA extended the decision deadline for an experimental breast cancer pill from AstraZeneca after an advisory panel voted against the drug
STAT+: Where patients and hospitals disagree about AI
In this edition of AI Prognosis, Brittany Trang takes a look at patients' role in how Stanford Health Care adopts AI tools, and more health AI news.
Scoring gene importance by interpreting single-cell foundation models
Nature Biotechnology, Published online: 27 May 2026; doi:10.1038/s41587-026-03112-5SIGnature enables scalable cross-dataset analyses by combining explainable artificial intelligence with RNA foundation models.
Accurate quantification in proteomics with QuantUMS
Nature Biotechnology, Published online: 27 May 2026; doi:10.1038/s41587-026-03131-2QuantUMS implements uncertainty estimation for protein quantification in mass spectrometry.
What Utah’s clinical AI sandbox reveals about independent oversight
Nature Medicine, Published online: 27 May 2026; doi:10.1038/s41591-026-04418-2What Utah’s clinical AI sandbox reveals about independent oversight
Marmoset models for the study of autism spectrum disorders
Neurological and psychiatric disorders are a highly prevalent source of global disability. For the majority of these conditions, including autism spectrum disorder (ASD), disease-modifying treatments remain unavailable, and existing pharmacological interventions are largely palliative.
The multiple scales of astrocytic functional units
Nature Neuroscience, Published online: 27 May 2026; doi:10.1038/s41593-026-02308-xAstrocytes modulate complex brain functions. These ubiquitous glial cells constitute a multilayered system of functional units that operate across multiple spatial scales, thereby increasing the degrees of freedom in brain information processing.
News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
Efficacy and Safety of Transcranial Temporal Interference Stimulation for Depression
Conditions: Major Depressive Disorder (MDD) Interventions: Device: Active Transcranial Temporal Interference Stimulation Targeting Left ALIC; Device: Active Transcranial Temporal Interference Stimulation Targeting Left sgACC; Device: Sham Transcranial Temporal Interference Stimulation Sponsors: Yonggui Yuan Not yet recruiting
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Conditions: Depression / Major Depressive Disorder; Mental Health (Depression) Interventions: Behavioral: Stress Management and Resiliency Training with Qigong/Tai Chi; Behavioral: Healthy Living Program Sponsors: Massachusetts General Hospital; National Center for Complementary and Integrative Health (NCCIH) Not yet recruiting
The Efficacy of Psilocybin Therapy for Depression in Parkinson’s Disease
Conditions: Depression; Parkinson's Disease (PD) Interventions: Drug: Psilocybin (drug); Drug: Psilocybin (drug) Sponsors: Yale University; Michael J. Fox Foundation for Parkinson's Research Not yet recruiting
EEG Prediction and Clinical Efficacy of tDCS in Major Depression
Conditions: Depression - Major Depressive Disorder Interventions: Device: High-dose home-tDCS; Device: Conventional home-tDCS Sponsors: Ionclinics & Deionic SL; Hospital Universitario Doctor Peset; Universidad Europea de Valencia Not yet recruiting
Centering People, Centering Stories: Folklore as an Unlikely Ally in the OCD Misdiagnosis Crisis
By: Rebecca Bernstein, MA Folklore The International OCD Foundation’s (IOCDF) recent landmark white paper reveals more than 80% of OCD cases in America remain undiagnosed (International OCD Foundation, 2025). Considering... Read more » The post Centering People, Centering Stories: Folklore…
STAT+: Heart patch engineered from stem cells revved up weakened hearts
A stem cell-based heart patch improved pumping in a small trial for advanced heart failure. "Very good first step," researcher says.
Real-World Implementation of EndoConnect in Brazilian Primary Care: Formative Study of Usability, Engagement, and Equity in Digital Endometriosis Care
Background: Endometriosis is a chronic gynecological condition affecting approximately 10% of women of reproductive age worldwide and is associated with chronic pelvic pain, infertility, and reduced quality of life. In Brazil’s Unified Health System (Sistema Único de Saúde [SUS]), diagnostic…
Opinion: MIT president: Why so many optimistic scientists are losing heart
“This erosion of our strength is a loss for the nation,” writes MIT President Sally Kornbluth.
STAT+: Kailera’s own ‘triple-G’ drug also looks very powerful
The business of living forever, Chan Zuckerberg Biohub's AI protein model, and other biotech news from The Readout
STAT+: Pharmalittle: We’re reading about an AstraZeneca breast cancer pill, an ADAP deal in Florida, and more
The FDA extended the decision deadline for an experimental breast cancer pill from AstraZeneca after an advisory panel voted against the drug
STAT+: Where patients and hospitals disagree about AI
In this edition of AI Prognosis, Brittany Trang takes a look at patients' role in how Stanford Health Care adopts AI tools, and more health AI news.
Scoring gene importance by interpreting single-cell foundation models
Nature Biotechnology, Published online: 27 May 2026; doi:10.1038/s41587-026-03112-5SIGnature enables scalable cross-dataset analyses by combining explainable artificial intelligence with RNA foundation models.
Accurate quantification in proteomics with QuantUMS
Nature Biotechnology, Published online: 27 May 2026; doi:10.1038/s41587-026-03131-2QuantUMS implements uncertainty estimation for protein quantification in mass spectrometry.
What Utah’s clinical AI sandbox reveals about independent oversight
Nature Medicine, Published online: 27 May 2026; doi:10.1038/s41591-026-04418-2What Utah’s clinical AI sandbox reveals about independent oversight
Marmoset models for the study of autism spectrum disorders
Neurological and psychiatric disorders are a highly prevalent source of global disability. For the majority of these conditions, including autism spectrum disorder (ASD), disease-modifying treatments remain unavailable, and existing pharmacological interventions are largely palliative.
The multiple scales of astrocytic functional units
Nature Neuroscience, Published online: 27 May 2026; doi:10.1038/s41593-026-02308-xAstrocytes modulate complex brain functions. These ubiquitous glial cells constitute a multilayered system of functional units that operate across multiple spatial scales, thereby increasing the degrees of freedom in brain information processing.