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Long-Read DNA Test Could Replace 15 Existing Tests for Rare Diseases
A DNA test for rare diseases using long-read sequencing can provide much more comprehensive results than standard diagnostics in a shorter amount of time. The post Long-Read DNA Test Could Replace 15 Existing Tests…
Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study
Background: University students experience elevated psychological distress, with limited access to mental health services. While cognitive behavioral therapy (CBT) demonstrates efficacy for anxiety and depression, treatment gaps persist due to access barriers and insufficient…
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From work-related trauma to suicidal ideation: a serial mediation model of posttraumatic stress and depression in rescue workers
ObjectivesRescue workers face frequent occupational trauma, increasing their risk for posttraumatic stress symptoms (PTSS), depression, and suicidal ideation. However, pathways linking trauma to suicidality remain poorly understood. This study investigated these mechanisms by testing a serial mediation model.MethodsFrom a larger…
The efficacy and safety of transcranial direct current stimulation in patients with ADHD: a systematic review and meta-analysis
ObjectiveThis meta-analysis evaluated the efficacy and safety of transcranial direct current stimulation (tDCS) for treating Attention-Deficit/Hyperactivity Disorder (ADHD).MethodsFollowing PRISMA guidelines, we analyzed 28 randomized controlled trials (RCTs) involving 1,864 participants. Outcomes encompassed core ADHD symptoms, hot and cold executive functions…
The mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest in students with learning disabilities
IntroductionThe present work is investigating the mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest among students with learning disabilities.MethodsThis descriptive-analytical study employed a correlational design within a structural equation modelling framework. The…
Nonlinear relationships between fatigue, fear of COVID-19, and PTSD among mental health professionals: the findings of a multi-site survey in China
BackgroundMental health professionals (MHPs) are susceptible to fatigue, particularly during public health crises like the COVID-19 pandemic. This study examined nonlinear relationships between fatigue, post-traumatic stress disorder (PTSD), and fear of COVID-19 (FOC) among MHPs.MethodsA multi-site survey was conducted from…
Therapeutic Potential of GLP-1 Receptor Agonists for Smoking Cessation
Glucagon-like peptide-1 (GLP-1) therapies are under investigation for a growing number of neuropsychiatric conditions, including substance use disorders. Cigarette smoking accounts for the largest proportion of substance use-related morbidity and mortality, in part reflecting increased risk for cardiometabolic disease among…
Neural sequences underlying directed turning in Caenorhabditis elegans
Nature Neuroscience, Published online: 10 April 2026; doi:10.1038/s41593-026-02257-5During olfactory navigation, Caenorhabditis elegans can execute error-correcting turns. Whole-brain imaging and perturbation experiments identify an ensemble of neurons that control reorientation and turning behaviors.
Constellations
I. We had crash-landed on the planet. We were far from home. The spaceship could not be repaired, and the rescue beacon had failed. Besides me, only the astrogator, part of the captain, and the ship’s AI mind were left. …
Opinion: I’m a MAHA activist. I went into the public health lion’s den — and it changed how I think
“In my most honest of moments, what I want from the medical community is the chance to trust it again,” a MAHA advocate writes.
Opinion: What public health can learn from the MAHA movement
“What MAHA has built, in a relatively short time, is social capital,” writes Monica L. Wang.
How sports betting apps hook users
In this week's STATus Report, host Alex Hogan dives into how sports betting apps hook users — and how he himself fell for some too-good-to-be-true promotions.
Peer Mentor Training and Supervision for a Digital Adolescent Depression Treatment in South Africa and Uganda: Mixed Methods Evaluation
Background: Blended digital mental health interventions combining technology with human support are more effective than stand-alone treatments. However, limited research has examined how to train and supervise personnel delivering human support components. The Kuamsha app, a gamified digital intervention for…
In Memoriam: Edna B. Foa, PhD
Dr. Edna Foa served for decades as a professor of clinical psychology in psychiatry at the University of Pennsylvania, where she also directed the Center for the Treatment and Study... Read more » The post In Memoriam: Edna B. Foa,…
In Memoriam: Judith L. Rapoport, MD
Dr. Judith L. Rapoport has left an indelible mark on the field of obsessive compulsive disorder (OCD) — not only through her extraordinary scientific contributions, but through the compassion, curiosity,... Read more » The post In Memoriam: Judith L. Rapoport,…
The Mental Health Commission of Canada is pleased to welcome Shauna Cronin
The Mental Health Commission of Canada is pleased to welcome Shauna Cronin (she/her) as our new Vice President, Programs, effective April 27, 2026. Shauna brings nearly two decades of national leadership in mental health system transformation, program design, and policy…
Speech in noise prediction by use of cortical auditory evoked potentials in normal hearing and sensorineural hearing loss: a systematic review
IntroductionSpeech perception in noise (SPiN) is a critical challenge for individuals with sensorineural hearing loss (SNHL), and current behavioral assessments can be unreliable in populations with language barriers or cognitive impairment. Cortical auditory evoked potentials (CAEPs) can serve as a…
Monitoring Daily Mobility in Children With Autism
Conditions: Autism Spectrum Disorder (ASD Interventions: Device: placement of a wearable wrist sensor Sponsors: IRCCS San Raffaele Roma Recruiting
Mindfulness-based Stress Reduction for PTSD in Road Traffic Accident Victims: A Randomized Controlled Trial
Conditions: Posttraumatic Stress Disorder (PTSD) Interventions: Behavioral: mindfulness-based stress reduction Sponsors: Universiti Sains Malaysia; Xinjiang Medical University; Jinzhou Medical University; Universiti Sultan Zainal Abidin Recruiting
MTCL2 Is Essential for the Bipolar-to-Multipolar Transition in the Dendrite Extension of Cerebellar Granule Neurons
The dynamic regulation of neuronal polarity is essential for the formation of neural networks during brain development. Primary cultures of rodent neurons recapitulate several aspects of this polarity regulation, providing valuable insights into the molecular mechanisms underlying axon specification, dendrite…
Prefrontal and hippocampal microstructural gray matter following cognitive training under moderate hypoxia in mood disorders: a randomized controlled trial
BackgroundCognitive impairment persists during partial or full remission in 50–70% of individuals with mood disorders and impacts daily functioning and clinical prognosis. Preclinical evidence suggests that extended exposure to moderate hypoxia, combined with motor-cognitive learning, may elevate neuroplasticity and improve…