News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
Opinion: Ebola at the World Cup? Here’s what we should actually worry about
“Infectious disease threats during the World Cup will almost certainly look much more familiar than frightening headlines suggest,” writes Krutika Kuppalli.
Mechanisms of action and advances in application of music therapy in improving cognitive impairment based on the theory of neuroplasticity
As global population aging accelerates, preventing and treating cognitive impairment has become a major public health priority. Music therapy is a safe, well-tolerated non-pharmacological intervention with substantial potential to improve cognitive function. This review synthesizes the neurologic music therapy (NMT)…
Microglial regulation of synaptic plasticity in transsynaptic degeneration of glaucoma
Glaucoma is a heterogeneous group of irreversible and blinding optic neuropathies caused by multiple factors. It is clinically characterized by progressive loss of visual field and decline in visual acuity, ultimately culminating in complete blindness. Hallmark pathological features include progressive…
Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report
BackgroundAdvanced Alzheimer’s disease (AD) is generally regarded as a stage of irreversible functional decline. Psilocybin is known to transiently alter large-scale brain network dynamics and to induce plasticity-related mechanisms in preclinical models, yet clinical data in advanced dementia remain lacking.Case…
Genetic interaction of DISC1 and Neuroligin in regulation of glutamatergic synaptogenesis
Synaptic development and functionality have been considered as fundamental mechanisms underlying a range of neuropsychiatric disorders, including schizophrenia. Emerging evidence from biological and clinical studies implicates mutations in the Disrupted-in-Schizophrenia-1 (DISC1) gene in the pathogenesis of schizophrenia. In this study,…
Plant-derived bioactives, the gut–brain axis, and neurodegenerative diseases: mechanistic roles of diet–microbiota interactions
Diet is increasingly recognized as a potential upstream modulator of the gut-brain axis (GBA) through its effects on the microbiome, microbial metabolites, and host immune and endocrine responses. The GBA is a complex, bidirectional network connecting the gastrointestinal tract and…
Perceived stress and depression among Chinese nurses: a cross-sectional mediation analysis of psychological flexibility and its components
BackgroundPerceived stress is a significant risk factor for depression among healthcare professionals. While this fundamental relationship is well-documented, the potential mediating mechanisms—specifically the role of psychological flexibility and its distinct components—in buffering the impact of perceived stress on depression within…
Beyond empirically supported treatments: a new contextualized evidence framework for evidence based psychology
Over the past three decades, criteria for Empirically Supported Treatments (ESTs) have strengthened methodological rigor in psychotherapy research by prioritizing randomized controlled trials and systematic evidence synthesis. However, prevailing frameworks remain largely centered on efficacy under controlled conditions, offering limited…
Non-invasive electrical stimulation for sleep disturbances in adults: protocol for an evidence−mapping umbrella review of systematic reviews and meta−analyses with subgroup analysis by intervention type and population
BackgroundSleep disturbances affect 10%–30% of adults worldwide. Non−invasive electrical stimulation (e.g., transcranial electrical stimulation) has emerged as a promising non−pharmacological intervention. Although numerous systematic reviews and meta−analyses have been published, they vary considerably in methodological quality, populations, intervention types, and…
A bidirectional relationship between atrial fibrillation and depression: epidemiology, mechanisms, and clinical implications
Atrial fibrillation (AF) represents a common cardiac arrhythmia that carries substantial morbidity and mortality risks, whereas depression serves as a significant psychological factor affecting cardiovascular health. Recent findings underscore a reciprocal relationship between AF and depression, suggesting that depression may…
Plasma microRNA signatures in drug-naïve Romanian adolescents with first-episode psychosis
Psychotic disorders are a group of severe psychiatric conditions with onset typically occurring in adolescence or early adulthood. Despite significant efforts to identify clinically useful candidates, no validated biomarkers for psychiatric disorders currently exist. The diagnosis of psychotic disorders is…
Genetic–exposome interactions and aging clocks in dementia: the ReDLat2 initiative
Nature Medicine, Published online: 28 May 2026; doi:10.1038/s41591-026-04433-3Genetic–exposome interactions and aging clocks in dementia: the ReDLat2 initiative
STAT+: Blood pressure tech floods the market after FDA relaxes wearables oversight
Wearables with unvalidated blood pressure measuring tech are flooding the market after the FDA relaxed oversight of wellness devices.
STAT+: An ASCO preview: What to watch for at cancer research’s big meeting
Here's what to watch for at ASCO, cancer research's big meeting, in Chicago.
Climate tech companies are going public. What’s next?
This year, there’s been a wave of notable energy companies going public via IPO in the US. The solar and battery company Solv Energy went public in February, to the tune of $6 billion. X-energy, which is building small modular…
The AI Hype Index: AI gets booed in graduation season
It is one thing to say AI will change the world. It is another to expect the class of 2026 to applaud it. In fact, when former Google CEO Eric Schmidt told University of Arizona graduates that their task is…
STAT+: Experimental hepatitis B treatment was a ‘functional cure’ for nearly 1 in 5, new data show
An experimental GSK drug helped 1 in 5 patients with chronic hepatitis B achieve what's known as a functional cure, vastly outpacing current treatments.
STAT+: Trump’s drug-pricing deals set to be tested by new product launches
The public is about to get its first look at the prices of drugs launched since President Trump struck his most-favored-nation deals with 17 drugmakers.
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Conditions: Depression / Major Depressive Disorder; Mental Health (Depression) Interventions: Behavioral: Stress Management and Resiliency Training with Qigong/Tai Chi; Behavioral: Healthy Living Program Sponsors: Massachusetts General Hospital; National Center for Complementary and Integrative Health (NCCIH) Not yet recruiting
News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
Opinion: Ebola at the World Cup? Here’s what we should actually worry about
“Infectious disease threats during the World Cup will almost certainly look much more familiar than frightening headlines suggest,” writes Krutika Kuppalli.
Mechanisms of action and advances in application of music therapy in improving cognitive impairment based on the theory of neuroplasticity
As global population aging accelerates, preventing and treating cognitive impairment has become a major public health priority. Music therapy is a safe, well-tolerated non-pharmacological intervention with substantial potential to improve cognitive function. This review synthesizes the neurologic music therapy (NMT)…
Microglial regulation of synaptic plasticity in transsynaptic degeneration of glaucoma
Glaucoma is a heterogeneous group of irreversible and blinding optic neuropathies caused by multiple factors. It is clinically characterized by progressive loss of visual field and decline in visual acuity, ultimately culminating in complete blindness. Hallmark pathological features include progressive…
Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report
BackgroundAdvanced Alzheimer’s disease (AD) is generally regarded as a stage of irreversible functional decline. Psilocybin is known to transiently alter large-scale brain network dynamics and to induce plasticity-related mechanisms in preclinical models, yet clinical data in advanced dementia remain lacking.Case…
Genetic interaction of DISC1 and Neuroligin in regulation of glutamatergic synaptogenesis
Synaptic development and functionality have been considered as fundamental mechanisms underlying a range of neuropsychiatric disorders, including schizophrenia. Emerging evidence from biological and clinical studies implicates mutations in the Disrupted-in-Schizophrenia-1 (DISC1) gene in the pathogenesis of schizophrenia. In this study,…
Plant-derived bioactives, the gut–brain axis, and neurodegenerative diseases: mechanistic roles of diet–microbiota interactions
Diet is increasingly recognized as a potential upstream modulator of the gut-brain axis (GBA) through its effects on the microbiome, microbial metabolites, and host immune and endocrine responses. The GBA is a complex, bidirectional network connecting the gastrointestinal tract and…
Perceived stress and depression among Chinese nurses: a cross-sectional mediation analysis of psychological flexibility and its components
BackgroundPerceived stress is a significant risk factor for depression among healthcare professionals. While this fundamental relationship is well-documented, the potential mediating mechanisms—specifically the role of psychological flexibility and its distinct components—in buffering the impact of perceived stress on depression within…
Beyond empirically supported treatments: a new contextualized evidence framework for evidence based psychology
Over the past three decades, criteria for Empirically Supported Treatments (ESTs) have strengthened methodological rigor in psychotherapy research by prioritizing randomized controlled trials and systematic evidence synthesis. However, prevailing frameworks remain largely centered on efficacy under controlled conditions, offering limited…
Non-invasive electrical stimulation for sleep disturbances in adults: protocol for an evidence−mapping umbrella review of systematic reviews and meta−analyses with subgroup analysis by intervention type and population
BackgroundSleep disturbances affect 10%–30% of adults worldwide. Non−invasive electrical stimulation (e.g., transcranial electrical stimulation) has emerged as a promising non−pharmacological intervention. Although numerous systematic reviews and meta−analyses have been published, they vary considerably in methodological quality, populations, intervention types, and…
A bidirectional relationship between atrial fibrillation and depression: epidemiology, mechanisms, and clinical implications
Atrial fibrillation (AF) represents a common cardiac arrhythmia that carries substantial morbidity and mortality risks, whereas depression serves as a significant psychological factor affecting cardiovascular health. Recent findings underscore a reciprocal relationship between AF and depression, suggesting that depression may…
Plasma microRNA signatures in drug-naïve Romanian adolescents with first-episode psychosis
Psychotic disorders are a group of severe psychiatric conditions with onset typically occurring in adolescence or early adulthood. Despite significant efforts to identify clinically useful candidates, no validated biomarkers for psychiatric disorders currently exist. The diagnosis of psychotic disorders is…
Genetic–exposome interactions and aging clocks in dementia: the ReDLat2 initiative
Nature Medicine, Published online: 28 May 2026; doi:10.1038/s41591-026-04433-3Genetic–exposome interactions and aging clocks in dementia: the ReDLat2 initiative
STAT+: Blood pressure tech floods the market after FDA relaxes wearables oversight
Wearables with unvalidated blood pressure measuring tech are flooding the market after the FDA relaxed oversight of wellness devices.
STAT+: An ASCO preview: What to watch for at cancer research’s big meeting
Here's what to watch for at ASCO, cancer research's big meeting, in Chicago.
Climate tech companies are going public. What’s next?
This year, there’s been a wave of notable energy companies going public via IPO in the US. The solar and battery company Solv Energy went public in February, to the tune of $6 billion. X-energy, which is building small modular…
The AI Hype Index: AI gets booed in graduation season
It is one thing to say AI will change the world. It is another to expect the class of 2026 to applaud it. In fact, when former Google CEO Eric Schmidt told University of Arizona graduates that their task is…
STAT+: Experimental hepatitis B treatment was a ‘functional cure’ for nearly 1 in 5, new data show
An experimental GSK drug helped 1 in 5 patients with chronic hepatitis B achieve what's known as a functional cure, vastly outpacing current treatments.
STAT+: Trump’s drug-pricing deals set to be tested by new product launches
The public is about to get its first look at the prices of drugs launched since President Trump struck his most-favored-nation deals with 17 drugmakers.
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Conditions: Depression / Major Depressive Disorder; Mental Health (Depression) Interventions: Behavioral: Stress Management and Resiliency Training with Qigong/Tai Chi; Behavioral: Healthy Living Program Sponsors: Massachusetts General Hospital; National Center for Complementary and Integrative Health (NCCIH) Not yet recruiting