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Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study
Background: University students experience elevated psychological distress, with limited access to mental health services. While cognitive behavioral therapy (CBT) demonstrates efficacy for anxiety and depression, treatment gaps persist due to access barriers and insufficient…
Using a Virtual Reality CAVE–Based Mindfulness Intervention to Promote Mental Well-Being in Adolescents With Anxiety Symptoms: Pre-Post Mixed Methods Pilot Study
Background: Adolescent anxiety is a growing public health concern associated with significant social and emotional impairment. Mindfulness-based interventions (MBIs) have shown promise in reducing anxiety and improving well-being; however, engagement remains challenging. Virtual reality…
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Home tDCS for the Treatment of Major Depression.
Conditions: Major Depression Disorder Interventions: Device: Accelerated protocol of home Transcranial direct current stimulation; Device: Conventional protocol of home Transcranial direct current stimulation; Device: Conventional protocol of in person Transcranial direct current stimulation Sponsors: Ionclinics & Deionic SL; Hospital Universitari…
Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech
Conditions: Cognitive Function Assessment; Mild Cognitive Impairment; Subjective Cognitive Decline Interventions: Behavioral: AI-Based Storytelling Speech Assessment Sponsors: Chang Gung Memorial Hospital Recruiting
Effectiveness of Hatha Yoga and From Feeling to Seeing the Body (FSB) in Female Adolescents and Young Adults With Eating Disorders.
Conditions: Body Image; Eating Disorders; Anorexia Nervosa; Bulimia Nervosa Interventions: Behavioral: Hatha Yoga Group (Y); Behavioral: From Feeling to Seeing the Body Group (FSB); Behavioral: Control Group (C) Sponsors: Azienda Ulss 2 Marca Trevigiana Completed
Social cognitive deficits and altered multi-brain dynamics during problem-solving in heroin abstainers: An fNIRS hyperscanning study
Despite extensive research on the neurobiology of addiction, little is known about how repeated drug use and withdrawal are related to social functioning impairments in humans, a highly social species. This obscures the broader societal impact of drug addiction and…
Long Term Follow-up of Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences 10+ Year After Receiving MBT Day Hospital or MBT Intensive Outpatient
Conditions: Borderline Personality Disorder Sponsors: De Viersprong; Arkin Not yet recruiting
Transcranial Photobiomodulation for Bipolar Depression
Conditions: Bipolar; Bipolar Disorder (BD); Bipolar Disorder Depression Interventions: Device: Vielight Neuro Rx Gamma; Device: Sham Device Sponsors: Vielight Inc. Not yet recruiting
Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder
Conditions: Williams Syndrome; Autism Disorder Sponsors: Qilu Hospital of Shandong University Not yet recruiting
The Unspoken Toll: Why Exam Pressure Must Be Part of the Youth Mental Health Discussion
A Conversation with Tatum Redmond and Amanda van der Vyver-Anderson from Community Keepers, South Africa By Mai El Shoush, Partnerships Campaign Manager, Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute Community…
Beyond dopamine blockade: mechanistic humility and the rise of muscarinic, TAAR1, and glutamatergic pathways in schizophrenia
The approval of the first non–dopamine-blocking therapy for schizophrenia marks a defining moment in psychiatry. Muscarinic M1/M4 modulation, alongside emerging TAAR1 and glutamatergic pathways, signals a shift beyond dopamine dominance toward circuit-level integration. These advances embody mechanistic humility: the scientific…
Associations between adult ADHD core symptoms, cognitive flexibility, and emotional eating: a case-control study
IntroductionAttention-deficit/hyperactivity disorder (ADHD) in adults often co-occurs with eating disorders (EDs), potentially through shared difficulties in emotional regulation, and executive functions. This study explored the associations between cognitive flexibility as a component of executive functions, core adult ADHD symptom dimensions…
Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications for precision sleep medicine
Narcolepsy can no longer be adequately conceptualized by excessive sleepiness and cataplexy. It is increasingly recognized as a multisystem hypothalamic encephalopathy, rooted in the selective loss or dysfunction of orexin neurons, yet extending across motor, psychiatric, metabolic, and autonomic domains.…
CABG-AI-Supported Discharge Education
Conditions: Coronary Artery Disease; Postoperative Care; Patient Discharge; Recovery of Function; Anxiety; Pain; Stress, Physiological; Surgical Nursing; Nursing; Discharge Education Interventions: Behavioral: AI-Supported Individualized Discharge Education; Behavioral: Standard Discharge Education Sponsors: Hasan Kalyoncu University Not yet recruiting
Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk…
CARED : A Novel Rapid Treatment Paradigm for Depression
Conditions: Major Depressive Disorder Interventions: Device: Intermittent Theta Burst Stimulation (iTBS); Device: Transcranial Alternating Current Stimulation (tACS); Behavioral: Psychotherapy; Device: Sham (Placebo) Transcranial Alternating Current Stimulation (tACS) Sponsors: University of North Carolina, Chapel Hill; Foundation of Hope for the Research…
Efficacy of Spectrally Optimized Light on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms
Conditions: Major Depressive Disorder (MDD); Neuroimaging; Bright Light Treatment; Cognitive Impairment Interventions: Device: bright light; Device: dim red light(placebo) Sponsors: Peking University Sixth Hospital Not yet recruiting
The exposome of brain aging across 34 countries
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-zExposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.
Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion
Conditions: Concussion; Depression Interventions: Device: ONE-D TMS protocol and d-cycloserine (125 mg) Sponsors: University of Florida Not yet recruiting
Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-wTo accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.
Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD
Conditions: Obessive-Compulsive Disorder Interventions: Behavioral: mindfulness based exposure therapy; Other: Treatment as Usual (TAU) Sponsors: Shanghai Mental Health Center Recruiting
Improving Caregiver Engagement in Early Interventions
Conditions: Autism Interventions: Behavioral: FANS-EI; Behavioral: Early Intervention Sponsors: University of California, Davis; National Institute of Mental Health (NIMH) Not yet recruiting