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Open Letter to the European Council: Protecting ESF and ERDF
Open Letter to the European Council: Protecting ESF and ERDF: building on what works for people and regions Brussels, Belgium – 19 June 2026 Dear President Costa, dear Presidents, dear […] The post Open…
Joint statement: Council of Europe takes a positive step on autonomy in mental health care
We applaud the adoption of the Recommendation on respect of autonomy in mental healthcare by the Council of Europe on the 17th of June. The post Joint statement: Council of Europe takes a positive…
West Midlands NHS imaging programme enters procurement
An NHS imaging transformation programme serving 6.6 million people across the West Midlands has entered procurement.
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Medtech OEMs face a rare but closing window of opportunity
This is a manufacturing decision you can’t defer in 2026. Mark Freitas, Alvarez & Marsal Private-equity-backed CDMO platforms are aging into exits. OEMs who know what they want will move first. The 2022-2024 structural reset is over and the financing…
A Gamified Pain Management Intervention for Adults With Chronic Pain in Mainland China: Single-Arm Pre-Post Pilot Study With Machine Learning Predictive Modeling
Background: The widespread prevalence of chronic pain (CP) significantly impacts daily functioning worldwide. In mainland China, maintaining engagement in biopsychosocial interventions remains challenging. Gamification, designed based on self-determination theory, can enhance motivation, while machine learning (ML) algorithms can assist clinicians…
Synaptic remodeling and the female depression exposome: a mini-review of neuroendocrine, epigenetic, and social determinants
Depression is a multifactorial, chronic disorder and represents a leading cause of disability, with women exhibiting nearly twice the lifetime prevalence compared to men. Growing evidence indicates that this disparity cannot be explained by hormonal or psychosocial factors, but rather…
Stage-specific ERP correlates of audiovisual facial emotion processing across depressive tendencies
Emotional dysregulation can emerge as early as the initial stages of depression. This study aimed to examine event-related potential characteristics during the perception of negative, positive, and neutral facial expressions in healthy individuals across depressive tendencies. Twenty-six healthy participants underwent…
Analysis of the prevalence of dyslipidemia in early-onset schizophrenia patients and its correlation with clinical characteristics
ObjectiveTo analyze the prevalence of dyslipidemia and related influencing factors in patients with early-onset schizophrenia (EOS).MethodsWe recruited 289 pediatric and adolescent EOS patients from October 2021 to June 2024 in the Third People’s Hospital of Fuyang. Researchers gathered comprehensive demographic…
Esketamine ameliorates depression-like behavior in mice via modulation of the NRG1–ErbB4 pathway
BackgroundEsketamine has a significant and rapid antidepressant effect. Although studies have shown that Neuregulin 1 (NRG1) and it’s signaling pathway are associated with depression, the possible regulatory relationship of esketamine on the NRG1-ErbB4 pathway is not yet clear.MethodsTo induce depressive-like…
Vitamin A status is associated with sleep, clock genes, and symptoms in children with autism spectrum disorder
BackgroundVitamin A signals through retinoic acid receptors and may influence neurodevelopment and the expression of clock genes. However, the biological pathway linking vitamin A status to sleep disturbance in ASD remains insufficiently defined. This study aimed to examine associations between…
Methylome-Wide Association Study of Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition influenced by both genetic and environmental risk factors. Epigenetic modifications, such as DNA methylation, may offer insights into biologically meaningful differences associated with the disorder.
Digital Health Coffee Time Briefing ☕
Today's briefing features a saliva-based pregnancy test called the Lollipop and a healthcare-focused AI interpreter app.
Efficacy of Yoga-Based Intervention in Improving Mother-Child Bonding in Maternal Depression
Conditions: Perinatal Depression; Postpartum Depression; Mother-Infant Bonding Disorder Interventions: Behavioral: Add-on Yoga Intervention; Drug: Treatment as Usual(Medication Based) Sponsors: All India Institute of Medical Sciences Not yet recruiting
The Most Effective OCD Treatment Reaches Almost No One: Here’s What We Can Do About It
– Rebecca Deusser, MS, MBA and Sanjaya Saxena, MD “It took me years to find out that what I was dealing with was OCD!” This is a phrase all too... Read more » The post The Most Effective OCD Treatment…
It Is the Journey, Not the Destination: Moving From End Points to Trajectories When Assessing Chatbot Mental Health Safety
Large language models are rapidly becoming embedded in everyday life through artificial intelligence (AI) chatbots that people use for practical assistance and companionship, as well as for support with mental health and emotional wellbeing. Alongside clear benefits, clinicians and public…
Opinion: When my child is in psychosis, the pediatric health care system can’t help us
“There is no off switch when the crisis is your child,” writes Liz Koch.
Home tDCS for the Treatment of Major Depression.
Conditions: Major Depression Disorder Interventions: Device: Accelerated protocol of home Transcranial direct current stimulation; Device: Conventional protocol of home Transcranial direct current stimulation; Device: Conventional protocol of in person Transcranial direct current stimulation Sponsors: Ionclinics & Deionic SL; Hospital Universitari…
Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech
Conditions: Cognitive Function Assessment; Mild Cognitive Impairment; Subjective Cognitive Decline Interventions: Behavioral: AI-Based Storytelling Speech Assessment Sponsors: Chang Gung Memorial Hospital Recruiting
Effectiveness of Hatha Yoga and From Feeling to Seeing the Body (FSB) in Female Adolescents and Young Adults With Eating Disorders.
Conditions: Body Image; Eating Disorders; Anorexia Nervosa; Bulimia Nervosa Interventions: Behavioral: Hatha Yoga Group (Y); Behavioral: From Feeling to Seeing the Body Group (FSB); Behavioral: Control Group (C) Sponsors: Azienda Ulss 2 Marca Trevigiana Completed
Social cognitive deficits and altered multi-brain dynamics during problem-solving in heroin abstainers: An fNIRS hyperscanning study
Despite extensive research on the neurobiology of addiction, little is known about how repeated drug use and withdrawal are related to social functioning impairments in humans, a highly social species. This obscures the broader societal impact of drug addiction and…
Long Term Follow-up of Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences 10+ Year After Receiving MBT Day Hospital or MBT Intensive Outpatient
Conditions: Borderline Personality Disorder Sponsors: De Viersprong; Arkin Not yet recruiting