BackgroundThe high turnover of young nurses poses a significant challenge to the stability of healthcare systems worldwide. While the relationships between perceived organizational climate, work engagement, and turnover intention are established, there is a lack of research integrating a humanistic care management perspective to elucidate the specific psychological mechanisms among young nurses at their uniquely vulnerable career stage. Drawing upon this contextual lens, this study aims to evaluate the status of perceived organizational climate, work engagement, and turnover intention among young nurses, and to further explore the potential mediating role of work engagement in the relationship between perceived organizational climate and turnover intention.MethodsA cross-sectional study was conducted from July to September 2025, surveying 366 young nurses from a tertiary Grade-A hospital in Shaanxi Province, China, using convenience sampling. Data were collected using a general information questionnaire, the Utrecht Work Engagement Scale, the Organizational Climate Questionnaire, and the Turnover Intention Questionnaire. A Structural Equation Model was employed to analyze the mediating effect.ResultsThe findings revealed significant interrelationships among perceived organizational climate, work engagement, and turnover intention. Work engagement was found to partially mediate the relationship between perceived organizational climate and turnover intention during young nurses, explaining 34.78% of the variance.ConclusionThese findings suggest that organizational climate functions as a critical job resource that may buffer turnover intention by fostering higher levels of work engagement. To maintain workforce stability, nursing managers should integrate humanistic care into organizational policies to cultivate a supportive environment. However, due to the cross-sectional design and convenience sampling from a single institution, causal inferences should be made with caution, and the generalizability of the findings may be limited.
Correction: Effectiveness of digital self-care device for at risk drinking problems: focus on individuals at risk for alcohol-related issues
Correction: Bridging reward and resilience: the endocannabinoid system as a unifying mechanism in exercise-induced protection against major depressive disorder
Cultural adaptation and feasibility of action over inertia in Japan: a multi-site pilot intervention study
IntroductionAction Over Inertia (AOI) is a recovery-oriented intervention designed to promote occupational engagement and support personal recovery through changes in everyday activity patterns. While AOI has been examined in Western contexts, its applicability and clinical adaptation in East Asian settings remain underexplored. This study used a mixed-methods approach to examine the feasibility and cultural adaptation of a group-based AOI program in Japan.MethodsA mixed-methods pilot feasibility design was used. The quantitative component was a single-arm repeated-measures pilot study conducted across four psychiatric daycare facilities in Japan. Outcomes were assessed at baseline, post-intervention, and 1-month follow-up in 12 participants with serious mental illness using the Recovery Assessment Scale (RAS), Temple University Community Participation Measure-Japanese version (TUCP-J), and Social Functioning Scale (SFS), alongside symptom severity assessed with the Brief Psychiatric Rating Scale (BPRS). These measures were used as exploratory clinical outcomes to describe preliminary patterns of change and to inform future controlled studies, rather than to determine intervention effectiveness. The qualitative component involved semi-structured interviews with occupational therapists who delivered the intervention, to contextualize the quantitative findings and identify implementation barriers and adaptations. The quantitative intervention study was approved by the Research Ethics Committee of the Graduate School of Medicine, Nagoya University, Japan (2023-0209), and registered with the UMIN Clinical Trials Registry (UMIN000045392). The qualitative interview study was approved by the Ethics Review Committee for Research Involving Human Participants, Nihon Fukushi University, Japan (23-041-03).ResultsNo significant improvements were observed in the exploratory outcomes of recovery, participation, or social functioning. Although BPRS showed a significant overall time effect, post-hoc comparisons between time points were not significant, and this change cannot be causally attributed to AOI because of the single-arm design. In an exploratory observation, participants with higher symptom severity appeared to show lower community participation. Qualitative findings suggested that the intervention dose, participant–program fit, readiness for activity change, and group-based delivery conditions may need further optimization within Japanese psychiatric daycare settings.DiscussionThe findings suggest that group-based AOI may be feasible to implement in Japanese psychiatric daycare settings, but further cultural and clinical adaptation is needed before effectiveness can be evaluated in controlled trials. Adaptation may require preserving AOI’s theoretical foundations while making the intervention less exposing, less abstract, and more accessible in group-based settings. Future studies should use controlled designs, longer follow-up periods, and broader outcome indicators to examine the effectiveness and implementation of culturally adapted AOI.Clinical trial registrationUMIN Clinical Trials Registry https://www.umin.ac.jp/ctr/, identifier UMIN000045392.
Social anxiety but not callous-unemotional traits predicts shame coping in conduct disorder
IntroductionConduct disorders are characterized by emotional dysregulation. Both callous-unemotional traits and social anxiety are heightened in conduct disorder patients and are associated with different mechanisms of emotion regulation. Previous evidence has proposed that secondary emotions, such as shame, might also be affected in conduct disorder and that callous-unemotional traits and social anxiety might be related to shame as well as to shame coping. Therefore, the current study investigated links between callous-unemotional traits, social anxiety, shame proneness, and shame coping in adolescent inpatients with conduct disorder.MethodsForty adolescent inpatients with conduct disorders (M = 12.4, SD = 1.4) filled in questionnaires on callous-unemotional traits, social anxiety, shame proneness, and shame coping. Correlational and regression analyses, as well as mediation analyses were performed.ResultsCallous-unemotional traits were not associated with any other construct. Social anxiety showed positive correlations with shame proneness and internalizing as well as externalizing shame coping. Social anxiety was also a significant predictor of internalizing shame coping while controlling for shame proneness and callous-unemotional traits. No predictors emerged for externalizing shame coping. Mediation analyses confirmed that neither shame proneness nor social anxiety mediated the relationship between CU traits and shame coping, as CU traits were not significantly associated with either variable.DiscussionThe findings suggest that social anxiety plays a key role in internalizing shame coping in conduct disorder patients. CU traits appear to be unrelated to shame proneness and shame coping, either directly or indirectly, in conduct disorder.
Spatial CRISPR screens map total RNA in tissue
Nature Biotechnology, Published online: 11 June 2026; doi:10.1038/s41587-026-03126-z
A method for spatial CRISPR perturbation screening reveals how genetic changes alter coding and non-coding RNA in a native tissue context, including the tumor microenvironment.
Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT
Nature Biotechnology, Published online: 11 June 2026; doi:10.1038/s41587-026-03127-y
In vivo CRISPR genetic perturbations are spatially mapped at scale.
Clinical Profile and Genomic Characterization of the 2026 Bundibugyo Virus Index Case in Uganda
Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04510-7
Clinical Profile and Genomic Characterization of the 2026 Bundibugyo Virus Index Case in Uganda
STAT+: Enliven Therapeutics’ leukemia drug shows promise in new study
A targeted drug from Enliven Therapeutics induced molecular responses in nearly half of patients with advanced leukemia, including higher response rates in patients treated at an earlier stage of their disease.
The updated early-stage study results reported Thursday for the Enliven drug, ELVN-001, compare favorably to a current blockbuster medicine sold by Novartis and an upstart experimental drug recently bought by Merck.
At 24 weeks, an 80 mg, once-daily dose of ELVN-001 achieved a major molecular response in 48% of patients with chronic myeloid leukemia, or CML, a slow-growing cancer that starts in myeloid cells.
STAT+: ‘Synthetic lethality’ could trigger another round of biotech M&A
This story first appeared in Adam’s Biotech Scorecard, a subscriber-only newsletter. STAT+ subscribers can sign up here to get it delivered to their inbox.
Never before have I covered so much positive news about pancreatic cancer in such a short period of time. What happens next? Could Revolution Medicines buy Tango Therapeutics? Or, perhaps Bristol Myers Squibb goes all out and acquires Revolution Medicines?
To be clear, neither of these deals has been announced, or even rumored. I’m just playing the biotech M&A speculation game. But a strong case for something to happen can be made in the wake of Monday’s exciting report from Tango. In an early-stage clinical trial, patients with advanced pancreatic cancer benefited more from a combination of two targeted drugs — a PRMT5 inhibitor from Tango and Revolution’s pan-RAS inhibitor — than they might from each drug on its own.