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Diagnostic Discrimination of BOKE STARS, a Bimodal Continuous Performance Test, for Attention-Deficit/Hyperactivity Disorder Assessment in Chinese Children: Single-Center Case-Control Study
Background: Attention-deficit/hyperactivity disorder (ADHD) affects 6.3% of Chinese children, but only 10% are diagnosed, as diagnosis is hindered by low awareness and lack of culturally adapted, objective tools. Existing continuous performance tests are unimodal…
Clinical Decision Support for Digital Dietary Counseling Under GLP-1 Receptor Agonist Therapy: Convergent Mixed Methods Usability and Treatment Satisfaction Pilot Study of the Personalized Nutrition Advisor
Background: Dietary counseling is an essential complement to the growing use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to achieve sustainable weight loss. Diverse patient needs, the demand for ongoing support, and limited resources…
Medtech CDMO Aptyx names new CEO
Aptyx has promoted CFO David Price to the role of CEO effective immediately, succeeding former Aptyx CEO Gregg Tobin. Price joined the Tempe, Arizona-based medical device contract development and manufacturing organization as CFO in…
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Examining circadian rhythm dysregulation using actigraphy among treatment-seeking individuals with alcohol use disorder
BackgroundIdentifying factors predictive of relapse in patients with alcohol use disorder (AUD) following a period of abstinence and/or treatment is essential to discover effective treatment plans for this disease. Previous evidence found that individuals with AUD who relapsed had lower…
Timing of exercise differentially modulates fear memory and hippocampal neurotransmitters in male rats
Exercise promotes neurogenesis and enhances memory consolidation while reducing the retention of aversive memories and anxiety-like behaviors. While our previous work found that acute exercise alters neurotransmitter concentrations, including dopamine and serotonin, in a time-of-day-dependent manner, the long-term effects of…
A game-theoretic framework for multimodal information utilization under heterogeneous processing environments in neuroscience and perception science
Multimodal data integration is increasingly central to neuroscience and perception science, where heterogeneous signals such as behavioral responses, sensory inputs, electrophysiological recordings, neuroimaging measurements, and computational representations must be jointly interpreted. Based on the realistic background, there is a core…
Context-tuned strategies for marker selection precision in neuronal studies
Marker selection precision in neuronal studies is critical for reliable neuron identification. However, it largely depends on the experimental context. Variations in neuronal marker specificity across experimental models, neuronal maturation stages, and neurotransmitter phenotypes have highlighted the vitality of implementing…
Meta-analysis of the effects of exercise intervention on physical health in individuals undergoing compulsory isolation
BackgroundPhysical health is the basic indicator to evaluate the health of drug addicts after the process of drug rehabilitation. In order to better improve the deficiency degree of physical health of drug addicts, it is necessary to carry out a…
RecoveryWorks: vocational support services for recovery capital growth
This paper introduces RecoveryWorks, a multi-system recovery and vocational support program designed to expand the therapeutic landscape of recovery by increasing access to career development resources that support meaningful employment. In contrast to vocational approaches that prioritize rapid job placement,…
Research trends and knowledge mapping of transcranial direct current stimulation in depression: a bibliometric study based on web of science, Scopus, and PubMed (2000-2025)
BackgroundDepressive disorders are clinically heterogeneous and mechanistically complex psychiatric conditions. Transcranial direct current stimulation (tDCS), a key non-invasive neuromodulation technique, has expanded rapidly in both therapeutic application and mechanistic research. However, the field is marked by rapid publication growth, thematic…
Case Report: Prism for PTSD in severe traumatic brain injury with psychiatric comorbidities: two cases
BackgroundTraumatic brain injury (TBI) with post-traumatic stress disorder (PTSD) is treatment-resistant, with conventional psychotherapy showing limited efficacy due to neurocognitive impairments.Case SummaryWe report two patients with severe TBI and psychiatric comorbidities treated with Prism neurofeedback.Case 144-year-old female, 35 years post-childhood…
Tryptophan modulates the impact of prolactin on insomnia in perimenopausal women: a cross-sectional study
BackgroundInsomnia is highly prevalent among perimenopausal women and exerts detrimental effects on physical health, psychological well-being, and overall quality of life. However, its underlying mechanisms remain incompletely understood. This cross-sectional study aimed to identify factors associated with insomnia in perimenopausal…
TxPert: using multiple knowledge graphs for prediction of transcriptomic perturbation effects
Nature Biotechnology, Published online: 01 May 2026; doi:10.1038/s41587-026-03113-4TxPert predicts unseen single transcriptomic perturbations with accuracy approaching split-half experimental reproducibility.
DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage
Nature Biotechnology, Published online: 01 May 2026; doi:10.1038/s41587-026-03120-5Synthetic DNA guides (crDNA) reprogram Cas12a nucleases for RNA targeting.
Rethinking triage for febrile children in low-resource settings
Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04387-6Integrating clinical data with simple physiological measures or biomarkers improves triage of febrile children and could reshape frontline care in resource-limited settings.
Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
Nature Medicine, Published online: 01 May 2026; doi:10.1038/s41591-026-04373-yBrazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
A communication subspace relays context-dependent actions from human prefrontal to motor cortex
Nature Neuroscience, Published online: 01 May 2026; doi:10.1038/s41593-026-02290-4Context-dependent behavior selects actions according to task demands. Using direct brain recordings in humans, Binish et al. uncover how coordinated population activity efficiently channels information from prefrontal to motor cortex.
Inexpensive seafloor-hopping submersibles could stoke deep-sea science—and mining
Smack dab between Australia and South America, the US National Oceanic and Atmospheric Administration (NOAA) research vessel Rainier is currently on a mission to map more than 8,000 square nautical miles of the Pacific seafloor in search of critical mineral…
A new US phone network for Christians aims to block porn and gender-related content
A new US-wide cell phone network marketed to Christians is set to launch next week. It blocks porn, which experts in network security say marks the first time a US cell plan has used network-level blocking for such content that…
Trump’s mass firing just dealt another blow to American science
This past week delivered another gut punch for science in the US. This time, the target was the National Science Foundation—a federal agency that funds major research projects to the tune of around $9 billion. The foundation’s efforts were overseen…
Opinion: America is worrying about fertility again. But it’s not really about families
Where the state once worried about too many births, it now worries about too few.
STAT+: Her daughter Mila got a bespoke medicine. Now she’s starting a new biotech to make more
Efforts to make customized medicines at scale have hit commercial and regulatory roadblocks. Julia Vintarello is trying again.
‘Forever chemicals’ in baby formula? Scientists unpack FDA results
FDA review confirmed overall safety of 16 brands of baby formula. In a STAT Q&A, experts unpack what low-level PFAS findings mean to worried moms.