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Diagnostic Discrimination of BOKE STARS, a Bimodal Continuous Performance Test, for Attention-Deficit/Hyperactivity Disorder Assessment in Chinese Children: Single-Center Case-Control Study
Background: Attention-deficit/hyperactivity disorder (ADHD) affects 6.3% of Chinese children, but only 10% are diagnosed, as diagnosis is hindered by low awareness and lack of culturally adapted, objective tools. Existing continuous performance tests are unimodal…
Clinical Decision Support for Digital Dietary Counseling Under GLP-1 Receptor Agonist Therapy: Convergent Mixed Methods Usability and Treatment Satisfaction Pilot Study of the Personalized Nutrition Advisor
Background: Dietary counseling is an essential complement to the growing use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to achieve sustainable weight loss. Diverse patient needs, the demand for ongoing support, and limited resources…
Medtech CDMO Aptyx names new CEO
Aptyx has promoted CFO David Price to the role of CEO effective immediately, succeeding former Aptyx CEO Gregg Tobin. Price joined the Tempe, Arizona-based medical device contract development and manufacturing organization as CFO in…
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Dissociation: Signs and Causes in Children
When people use the word dissociation, it can sound alarming. You may have seen it on social media, heard your child mention it, or noticed your child seeming “checked out” and wondered if that’s what’s happening. Dissociation can be confusing…
Artificial intelligence-based analysis of visual electrophysiological signals for clinical interpretation support
IntroductionVisual electrophysiology, including electroretinograms (ERG) and visual evoked potentials (VEP), provides a real-time functional assessment of retinal and post-retinal pathways, complementing structural imaging. Subtypes such as transient, periodic, multifocal, and code-modulated signals probe distinct physiological mechanisms and reveal pathological signatures…
Clinical application of 1H MRS in the human brain at 7T
Proton magnetic resonance spectroscopy (1H MRS) enables non-invasive biochemical sampling of tissues, potentially aiding diagnosis, prognosis and monitoring of various pathologies, while providing novel imaging biomarkers. Ultra-high-field (UHF) imaging at 7 tesla (7T) benefits from improved spectral dispersion due to…
Acceptance of mental illness and attitude towards pharmacotherapy among patients hospitalized in forensic psychiatry departments
Aim of the studyThe aim of the study was to assess the level of acceptance of the disease and attitudes towards pharmacological treatment in patients hospitalized in forensic psychiatry departments and to analyze the relationship between these variables and the…
Machiavellianism, level of personality functioning, and maladaptive personality traits: mediation analyses in a clinical sample
IntroductionMachiavellianism was repeatedly found to be associated with personality dysfunction. The Alternative Model for Personality Disorders offers a dimensional approach to personality disorders including level of personality functioning and maladaptive personality traits. The aim of this study was to test…
A phenomenological study on psychological resilience among medical vocational college freshmen
BackgroundMedical vocational college freshmen face severe challenges to their psychological resilience from various stressful events upon their enrollment. This qualitative study aimed to explore the authentic experiences and intrinsic characteristics of psychological resilience among medical vocational college freshmen.MethodsThe study employed…
Harsh discipline mediates the association between parenting stress and internalizing problems in children and adolescents: survey-based and online intervention evidence
BackgroundParenting stress evokes harsh discipline and induces internalizing problems in children and adolescents. To test this hypothesis, this study examined the potential mediating role of harsh discipline in the association between parenting stress and internalizing problems in children and adolescents…
Momentary predictors of dissociation in functional neurological disorder: an ecological momentary assessment-based pilot study
IntroductionEvidence suggests that dissociation may play a role in the manifestation of functional neurological disorder (FND). Dissociative experiences are frequently reported in FND, yet their dynamic associations with affective and physiological states remain underexplored. This pilot study aimed to examine…
Tracing the rise of biomedical foundation models
Nature Biotechnology, Published online: 30 April 2026; doi:10.1038/s41587-026-03135-yA survey of biological foundation models reveals current trends and provides an outlook for future developments in this rapidly evolving field
A data-driven risk stratification framework for clinical obesity
Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04370-1To inform precision management of obesity, this study developed and externally validated a parsimonious model (OBSCORE) that accurately predicts the risk of 18 obesity-related complications. This was achieved by integrating thousands of clinical,…
Uncovering risk factors in the exposome for early-onset colorectal cancer
Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04369-8The alarming rise in the incidence of colorectal cancer among younger individuals is probably due to environmental factors; epigenetic signatures of exposures may help uncover drivers of this trend, but questions remain.
Data-driven prioritization of high-risk individuals for weight loss interventions
Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04353-2OBSCORE is a machine learning-based risk prediction tool that uses a set of clinical features to stratify individuals with a body mass index (BMI) of ≥ 27 kg m−2 by their 10-year risk of obesity-related complications, outperforming…
Facilitating Thought Progression: A Neurocognitive Framework Linking Thought Dynamics and Mood Disorders
Mood and thought are tightly coupled, but the mechanisms linking them are not understood. This link is particularly important when considering mood disorders such as depression. We propose the Facilitating Thought Progression (FTP) framework, which characterizes depression as a disorder…
Implications of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) for Mood Disorders and Suicide Risk
A strategic imperative in mood disorders is to identify innovative mechanisms that translate into improved therapeutics when compared to the extant options. More specifically, there is a need for treatments with greater efficacy, shorter time-to-peak efficacy, greater durability of effect…
Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation
Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02263-7The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-CoA from other sources being used for myelination.
Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges
Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02258-4High-density single-neuron recordings in patients with epilepsy revealed interictal discharges are generated by structured laminar circuits. These circuits overlapped with cognitive circuits and could predict discharges up to 1 s in advance.
The Download: the North Pole’s future and humanoid data
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Digging for clues about the North Pole’s past In the past, getting to the North Pole…
Smog from wildfires increasingly harmful, data show
American baby formula testing, Medicaid work requirements, and more Morning Rounds health news
STAT+: What does Akeso’s primo plenary spot say about its survival data?
Mystery cloaks an ASCO plenary lung cancer survival result.
STAT+: New obesity tool aims to predict risk of 18 serious complications
A new tool, OBSCORE, is meant to better define who's at risk for obesity complications, going beyond BMI to include family history, diet, and more.