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Diagnostic Discrimination of BOKE STARS, a Bimodal Continuous Performance Test, for Attention-Deficit/Hyperactivity Disorder Assessment in Chinese Children: Single-Center Case-Control Study
Background: Attention-deficit/hyperactivity disorder (ADHD) affects 6.3% of Chinese children, but only 10% are diagnosed, as diagnosis is hindered by low awareness and lack of culturally adapted, objective tools. Existing continuous performance tests are unimodal…
Clinical Decision Support for Digital Dietary Counseling Under GLP-1 Receptor Agonist Therapy: Convergent Mixed Methods Usability and Treatment Satisfaction Pilot Study of the Personalized Nutrition Advisor
Background: Dietary counseling is an essential complement to the growing use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to achieve sustainable weight loss. Diverse patient needs, the demand for ongoing support, and limited resources…
AI is moving inside the device. Who owns the clinical risk?
Tips to mitigate the risk that medtech teams keep leaving unowned as artificial intelligence moves into Class II and III medical devices. By Dr. Sarah Matt, Vital Werks By the time a clinician trusts…
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Tuning the immune response to mRNA vaccines
Nature Biotechnology, Published online: 29 April 2026; doi:10.1038/s41587-026-03125-0A strategy to control translation of mRNA vaccines reveals cell type–specific contributions to immunity that may be harnessed to enhance vaccine efficacy.
mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression
Nature Biotechnology, Published online: 29 April 2026; doi:10.1038/s41587-026-03099-zmRNA vaccine efficacy is enhanced by silencing cell-type-specific expression.
Predicting referral need for febrile children in low-resource community settings in South and Southeast Asia
Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04338-1A multicountry cohort study found that prediction models combining clinical parameters with either pulse oximetry or the host biomarker sTREM1 more accurately identified febrile children needing referral than standard WHO criteria.
Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial
Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04366-xPreclinical and phase 1/2 trial data show that anti-CD38 monoclonal antibody treatment restores platelet counts in patients with immune thrombocytopenia by increasing nicotinamide adenine dinucleotide (NAD+) levels, and low-dose oral treatment with the…
An agentic framework for autonomous scientific discovery in cancer pathology
Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04357-yEvaluated across 18 multicancer cohorts, the agentic artificial intelligence workflow SPARK uses language as a universal interface to autonomously generate biological ideas.
A septo–entorhinal GABAergic pathway that enables switching between episodic memories
Nature Neuroscience, Published online: 29 April 2026; doi:10.1038/s41593-026-02280-6How the brain organizes the retrieval of old and new memories remains unknown. Kim et al. identify a septo−entorhinal GABAergic pathway that controls flexible switching between episodic memories during memory retrieval to enable…
Food safety experts warn of USDA brain drain
An autism advisory committee finally meets again, antipsychotics and dementia, and more health news from Morning Rounds
Opinion: Why alternative medicine can feel so much better than mainstream health care
Modern medicine is about making people better — not necessarily making them feel good.
Opinion: The medical school nutrition blues
“I don’t think anyone has the answers. But the conversation needs to start”: medical students on bringing a preventive mindset to medical education.
Opinion: STAT+: Did Kennedy just stack the deck on FDA oversight of peptides?
RFK Jr. had long signaled that he was going to do something big on peptides. Now the moment has arrived.
It’s time to make a plan for nuclear waste
Today, nuclear energy enjoys a rare moment of support across the political spectrum in the US. Interest from tech companies that are scrambling to meet demand for massive data centers has sparked a resurgence of money and attention in the…
New report shows some health equity wins. Experts fear they will be short-lived
A report released Wednesday highlights successes in reducing health disparities in U.S. states between 2022 and 2024.
The Impact of Digital Detox Training on Screen Use, Sleep Quality, and Healthy Lifestyle Behaviors in Adolescents
Conditions: Digital Screen Addiction and Sleep Quality in Adolescents Interventions: Behavioral: Digital Detox Intervention Sponsors: Şırnak Üniversitesi Completed
Circulating Oxytocin Changes in Response to MDMA vs. Placebo in Adult Patients With Autism Spectrum Disorder and Matched Healthy Controls
Conditions: Autism Spectrum Disorder Interventions: Diagnostic Test: MDMA; Diagnostic Test: Placebo Sponsors: University Hospital, Basel, Switzerland Not yet recruiting
A Study of Home-use Brain Stimulation to Treat Bipolar Depression
Conditions: Bipolar Disorder (BD) Interventions: Device: Flow FL-100 tDCS headset Sponsors: King's College London; South London and Maudsley NHS Foundation Trust Recruiting
A Study Of Senyo Health With Comorbid Alcohol Use Disorder Treatment In Bipolar Patients
Conditions: Bipolar Disorder; Substance Use (Drugs, Alcohol) Interventions: Other: Senyo Health App Sponsors: Mayo Clinic Not yet recruiting
Efficacy and Safety of Daridorexant in Patients With Major Depressive Disorder and Insomnia
Conditions: Insomnia; Major Depressive Disorder Interventions: Drug: Daridorexant 50 mg; Drug: Placebo Sponsors: Institut d'Investigació Biomèdica de Bellvitge; Idorsia Pharmaceuticals Ltd.; Hospital Universitari de Bellvitge Not yet recruiting
Historic FDA approval brings first gene therapy for genetic deafness
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03145-wThe first-of-its-kind genetic medicine treats a rare and profound otoferlin-related hearing loss, and will be made available by Regeneron for free in the United States.
STAT+: Health system CEOs get off easy at Congressional hearing on affordability
Committee members largely blamed the other party’s health care policies for driving U.S. health care prices to levels inaccessible to many Americans.
Prevalence of Cognitive Distortion Markers in a Suicide Prevention Chat Service: Mixed Methods Study
Background: Suicide helplines increasingly employ chat services to aid those in urgent need, but the wording and structure of text-driven exchanges may affect their effectiveness. Objective: Given the association of cognitive distortions with depression and anxiety, this study investigated their…