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Medtech CDMO Aptyx names new CEO
Aptyx has promoted CFO David Price to the role of CEO effective immediately, succeeding former Aptyx CEO Gregg Tobin. Price joined the Tempe, Arizona-based medical device contract development and manufacturing organization as CFO in…
AI is moving inside the device. Who owns the clinical risk?
Tips to mitigate the risk that medtech teams keep leaving unowned as artificial intelligence moves into Class II and III medical devices. By Dr. Sarah Matt, Vital Werks By the time a clinician trusts…
Medline to open new distribution facility in California
Medline (Nasdaq:MDLN) announced today that it plans to open a new distribution facility in Perris, California. The approximately 1-million-square-foot facility marks the latest expansion to the company’s distribution network, following a buildout in Texas…
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STAT+: FDA launches effort to speed up clinical trials, using AI
Monitoring trials in real time may help shorten the time interval between trial phases.
Opinion: Healthcare or health care? Help STAT decide
Should STAT use “healthcare” or “health care”? We want to hear from you.
Opinion: FDA commissioner: ‘Smarter,’ real-time clinical trials could transform drug development
“For the first time, FDA regulators will be able to see what’s happening in a clinical trial, looking at endpoints in the cloud as they occur,” writes FDA commissioner.
The Download: Musk and Altman’s legal showdown, and AI’s profit problem
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Elon Musk and Sam Altman are going to court over OpenAI’s future Elon Musk and OpenAI…
A structured narrative review on VNS-treated drug-resistant epilepsy: EEG markers, neurochemical mechanisms, and future biomarker-driven computational directions
Vagus nerve stimulation (VNS) is an established adjunctive therapy for drug-resistant epilepsy. Experimental and clinical evidence indicates that its therapeutic effects involve distributed brain networks and multiple neurochemical pathways. Electroencephalography (EEG) has been widely used to characterize VNS-related neurophysiological changes,…
Functional connectivity changes in the thalamocortical network due to neck pain and the multiscale regulatory effects of acupuncture: a cross-scale multi-omics neuroimaging study
BackgroundNeck pain correlates with multiscale brain abnormalities, but cross-scale mechanisms of acupuncture analgesia are unclear. This study aimed to: (1) Explore differential modulation of thalamic functional networks by verum vs. sham acupuncture; (2) Examine associations between functional connectivity changes and…
Experimental investigation of sharp-tip microwire-based brain electrode buckling during implantation through dura and pia mater
IntroductionWide use of miniaturized and flexible microwire electrodes faces challenges of wire buckling against the brain membrane layers. The field lacks quantitative understanding of such buckling phenomena, especially on the effective length factor, which is required to determine the wire’s…
Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer’s disease and non-Alzheimer’s dementias
IntroductionWe aimed to understand the pathophysiological differences between 16 Alzheimer’s disease (AD) and 15 non-AD dementia patients by quantifying oxygen extraction fraction (OEF) in cortical (CGM) and deep gray matter (DGM) regions.MethodsTo achieve this, we used a novel MRI-based OEF…
Quality, reliability, and transparency of late-life depression videos on Chinese social media: a cross-sectional study of Douyin, Rednotes, and BiliBili
BackgroundLate-life depression is common in older adults and is often under-recognized. Short-video platforms have become a major source of mental health information. However, content quality and transparency remain uncertain.MethodsWe conducted a cross-sectional assessment of highly viewed videos on late-life depression…
Scoping review of therapeutic approaches among individuals with secondary exercise addiction
Secondary exercise addiction shows high comorbidity with eating and body image disorders. Despite its substantial impact on physical and mental health and daily functioning, evidence on effective therapeutic interventions remains limited. The aim of this scoping review was to identify…
Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico
Background/objectiveAnxiety and depressive disorders are leading causes of disability worldwide, and access to evidence-based psychological treatment remains limited in many middle-income countries. Digital cognitive–behavioral therapy (CBT) interventions have emerged as scalable tools to address this treatment gap, yet few have…
Real-world effectiveness of medication-assisted treatment and psychotherapy for opioid use disorder: a national multi–health care organization analysis
BackgroundHarm reduction strategies for opioid use disorder (OUD) emphasize pragmatic, evidence-based approaches that reduce overdose risk, relapse, and other adverse outcomes without requiring abstinence. Medication for opioid use disorder (MOUD) and structured psychotherapy represent core harm-reduction modalities, yet their real-world…
A prospective cohort study on the incidence and influencing factors of subsyndromal delirium in ICU patients
BackgroundThis study aims to develop and validate a machine learning-based risk prediction model for subsyndromal delirium (SSD) in ICU patients, while identifying key risk factors.MethodThis study was a prospective study, selecting patients who were hospitalized in the ICU from October…
A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03109-0AI targets lipid nanoparticles to specific tissues while avoiding off-target delivery to the liver.
Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03097-1Pooled production of recombinant AAV vectors leads to frequent genetic recombination.
Australia legislates against genetic discrimination in life insurance
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04372-zGenomic screening is increasing rapidly, but insurance protections globally are outdated. Australia’s new law offers the clearest model yet for safeguarding public trust while supporting population genomics.
A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04267-zA reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Clinical trials for continuously monitored and updated AI systems
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04368-9As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.