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Medtech CDMO Aptyx names new CEO
Aptyx has promoted CFO David Price to the role of CEO effective immediately, succeeding former Aptyx CEO Gregg Tobin. Price joined the Tempe, Arizona-based medical device contract development and manufacturing organization as CFO in…
AI is moving inside the device. Who owns the clinical risk?
Tips to mitigate the risk that medtech teams keep leaving unowned as artificial intelligence moves into Class II and III medical devices. By Dr. Sarah Matt, Vital Werks By the time a clinician trusts…
Medline to open new distribution facility in California
Medline (Nasdaq:MDLN) announced today that it plans to open a new distribution facility in Perris, California. The approximately 1-million-square-foot facility marks the latest expansion to the company’s distribution network, following a buildout in Texas…
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AI framework for multidisease detection via retinal imaging
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04359-wReti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.
Human Ventral Tegmental Local Field Potentials in Treatment-Resistant Depression and Obsessive-Compulsive Disorder
The ventral tegmental area (VTA) is a key node within the limbic circuitry. Through dense dopaminergic, glutamatergic, and GABAergic projections, the VTA forms reciprocal loops with prefrontal and limbic cortices that are consistently implicated in major depressive disorder (MDD) and…
The Biological Psychiatry Family of Journals Is Rewarding Its Reviewers
The Biological Psychiatry family of Journals (Biological Psychiatry (BPS); Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (BP:CNNI); Biological Psychiatry: Global Open Science (BP:GOS) is pleased to announce a new program that, beginning this year, will both recognize and reward our most…
The prefrontal cortex controls memory organization in the hippocampus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02231-1Related memories are sometimes encoded in overlapping neurons. The authors show that the prefrontal cortex controls this type of memory organization in the hippocampus through direct projections to the medial entorhinal cortex.
Genoarchitecture and input–output organization of the mouse basal ganglia and thalamic parafascicular nucleus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02253-9The authors investigate the transcriptomic and connectivity organization of the basal ganglia and parafascicular nucleus. The analyses suggest that combinatorial gene expression underlies the modular and cell-type-specific basal ganglia input–output networks.
Predicting consequences of new hepatitis B vaccine recs
New data on public trust in science, AI and mental health, and other news from Morning Rounds
STAT+: Eli Lilly enlists AI startup for next-generation gene editors
Eli Lilly's deal with Profluent aims to go beyond CRISPR by using AI-designed enzymes to insert entire genes. It could reshape genetic medicine.
Opinion: Why do discussions about ‘brain health’ ignore mental illness?
“Failing to adopt a more inclusive concept of brain health represents a massive loss of human potential,” write Husseini K. Manji, Eric J. Nestler, and Patrick J. Kennedy.
STAT+: A giant question looms over GOP’s new Medicaid work requirements
Coverage losses tied to Medicaid work requirements may not be tracked in every states.
STAT+: Google clinical director says AI can be a ‘bridge’ for people having a mental health crisis
Google's clinical director Megan Bell Jones on how the company is addressing concerns over mental health impacts of its AI products.
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
Conditions: Depressive Symptoms; Allostatic Load; Metabolic Syndrome Interventions: Behavioral: Rise Together: Community Engagement Intervention; Behavioral: Adulting 101: Life Skills Sponsors: Ann & Robert H Lurie Children's Hospital of Chicago; National Institute on Minority Health and Health Disparities (NIMHD); Policy Research…
TIS for NSSI in Adolescent Depression
Conditions: Temporal Interference Stimulation; Non Suicidal Self Injury; Major Depressive Disorder Interventions: Device: Active Temporal Interference Stimulation (TIS); Device: Sham Temporal Interference Stimulation (TIS) Sponsors: The Second Hospital of Anhui Medical University Recruiting
Auditory Stimulation for Insomnia and Depression
Conditions: Depression - Major Depressive Disorder; Insomnia Interventions: Device: Alpha phase-locked auditory stimulation; Device: Sham Stimulation Sponsors: Wake Forest University Health Sciences Not yet recruiting
Symptom-based approach treats opioid withdrawal in newborns with minimal drug exposure
NIH-funded clinical trial shows that the new approach could also decrease time in the hospital.
Adapted RPM-08 for Substance Use Disorder in Pakistan
Conditions: Substance Use Disorder (SUD); Drug Abuse; Relapse Interventions: Behavioral: Adapted Relapse Prevention Module (RPM-08); Other: Treatment as Usual (TAU) Sponsors: Universiti Sains Malaysia Completed
Oxytocin Plus Self-compassion Training in Borderline Personality Disorder
Conditions: Self-compassion Training (SCT) Plus Intranasal Oxytocin; Self-compassion Training (SCT) Plus Intranasal Placebo Interventions: Drug: Intranasal Oxytocin (IN-OXT); Drug: Intranasal Placebo; Behavioral: Self-Compassion Training (SCT) Sponsors: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau Recruiting
Comparing Acupuncture With Medication to Reduce Anxiety and Depression in China
Conditions: Anxiety Depression Interventions: Drug: Selective serotonin reuptake inhibitor (SSRI); Other: Acupuncture Sponsors: Duke Kunshan University; Kunshan Hospital of Traditional Chinese Medicine; Kunshan Mental Health Center; National Natural Science Foundation of China Not yet recruiting
Women’s Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine
Conditions: Perinatal Mental Health; Reproductive Behavior; Women; Cohort Studies Interventions: Diagnostic Test: Psychological Assessment; Diagnostic Test: Routine Clinical Data Collection Sponsors: Taras Shevchenko National University of Kyiv Not yet recruiting
A Random Controlled Trial of Home-based Digital Therapy for Treating ADHD in Children
Conditions: Attention Deficit Hyperactivity Disorder (ADHD) Interventions: Device: Home-based digital therapy with brain-controlled games Sponsors: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Recruiting
Elon Musk and Sam Altman are going to court over OpenAI’s future
After a yearslong legal feud, Elon Musk and OpenAI CEO Sam Altman are heading to trial this week in Northern California in a case that could have sweeping consequences. Ahead of OpenAI’s highly anticipated IPO, the court could rule on…