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Early Genomic Indicators of Praziquantel Resistance in Schistosoma mansoni
Schistosomiasis affects more than 250 million people worldwide, with 90% of infections occurring in sub‑Saharan Africa. The post Early Genomic Indicators of Praziquantel Resistance in Schistosoma mansoni appeared first on GEN - Genetic Engineering…
Publisher Correction: Artificial allosteric protein switches with machine-learning-designed receptors
Nature Biotechnology, Published online: 20 July 2026; doi:10.1038/s41587-026-03263-5Publisher Correction: Artificial allosteric protein switches with machine-learning-designed receptors
Flu Virus Interaction with Host Cell Machinery Mapped Inside Infected Cells
Researchers developed a customized experimental workflow combining cross-linking mass spectrometry with AlphaFold-based structural modeling and functional assays to directly map protein-protein interactions in influenza-infected human cells. The post Flu Virus Interaction with Host Cell…
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Opinion: Behind every miracle drug is a story
“In every drug, there is a much larger story to tell about health and medicine and society and business and economics,” says Thomas Goetz.
Carea adds miscarriage support feature to maternal health app
Carea has launched a digital support tool within its app to provide guidance and mental health support for women following pregnancy loss.
Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients
Conditions: Palliative Care; Refractory Pain; Anxiety; Depression Disorders; Fatigue, Mental; Psychological Distress Interventions: Device: ZenctuaryVR+ Interactive Virtual Reality Sponsors: University Hospital, Strasbourg, France; MOME, University of Arts and Design Not yet recruiting
A Mindfulness-Based Stress Reduction Training Program Model
Conditions: Depression; Anxiety; Stress; Well-Being, Psychological Interventions: Behavioral: The mindfulness group-"Mindfulness-Based Stress Reduction Program"; Behavioral: The life skills workshop group-"Lifestyle Management and Well-being Workshop" Sponsors: Istanbul Medeniyet University Not yet recruiting
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Conditions: Depression - Major Depressive Disorder; Irritability Interventions: Drug: Kurvelo; Drug: Placebo COC Sponsors: University of North Carolina, Chapel Hill; Foundation of Hope for the Research and Treatment of Mental Illness Not yet recruiting
THE EFFECTS OF AN ONLINE FAMILY PSYCHOEDUCATION PROGRAM ON EXPRESSED EMOTION OF FAMILY MEMBERS AND MEDICATION ADHERENCE OF PATIENTS WITH FIRST-EPISODE SCHIZOPHRENIA
Conditions: First- Episode Schizophrenia Interventions: Behavioral: Mobile based family psychoeducation program Sponsors: Mahidol University Completed
Dr. Jonathan M. Green selected as CEO of the NIH Clinical Center
The NIH Clinical Center is the largest research hospital in the world.
NIH-funded AI model predicts cancer survival from single-cell tumor data
Study links specific cell populations to patient risk in melanoma and liver cancer.
Adapting Behavioral Interventions for Dementia to Address NCDs and Mental Health
Conditions: Mental Health; Non Communicable Diseases; Dementia Interventions: Behavioral: BECOME-D Intervention Sponsors: Possible; University of California, San Francisco; National Institute of Mental Health (NIMH); Ministry of Health and Population, Nepal Completed
MDMA Assisted Therapy for BN
Conditions: Bulimia Nervosa Interventions: Drug: MDMA-AT; Drug: MDMA-AT-BN; Behavioral: Standard Treatment (ST) Sponsors: Icahn School of Medicine at Mount Sinai Not yet recruiting
Pilot Randomized Trial of BA-GSH in VA PC-MHI
Conditions: Depression Interventions: Behavioral: Behavioral Activation-Guided Self-Help Sponsors: VA Office of Research and Development Not yet recruiting
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression : A Multicenter Randomized Controlled Trial
Conditions: Major Depressive Disorder (MDD); Probiotic Intervention Interventions: Combination Product: Sertraline combined with Lactobacillus crispatus; Combination Product: Sertraline combined with placebo Sponsors: First Affiliated Hospital of Chongqing Medical University Not yet recruiting
Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression
Conditions: Treatment-resistant Depression (TRD); Major Depression Disorder Interventions: Device: transcranial photobiomodulation Sponsors: Taipei Veterans General Hospital, Taiwan Recruiting
Photobiomodulation on Core Symptoms of Autism
Conditions: Autism Interventions: Device: Photobiomodulation Sponsors: Suez University Not yet recruiting
Internet addiction among nursing students: application of latent profile analysis and network analysis
BackgroundInternet addiction is widely reported and heterogeneous among nursing students. However, variable-centered approaches may not fully capture profile differences and core symptom patterns, potentially limiting precise interventions. Therefore, identifying distinct profiles and key symptoms is important for informing effective prevention.ObjectiveThis…
Shinya Yamanaka
Dr. Shinya Yamanaka is recognized for the generation of induced pluripotent stem cells (iPSCs) from fibroblasts by a combination of multiple transcription factors, and he won the Nobel Prize in Physiology or Medicine in 2012 jointly with Sir John B.…
The healthy human global project – Hong Kong: A community-based cross-sectional study of a healthy Asian population
A deeply phenotyped healthy Hong Kong cohort reveals age- and sex-dependent immune, clinical, and lifestyle variation, highlighting population-specific differences and the need to extend systems immunology frameworks beyond European ancestry.
Identifying the role of NLRP3 inflammasome in stroke progression and outcome before recanalization
Bellut et al. show that the NLRP3 inflammasome drives hyperacute inflammation and infarct progression during large vessel occlusion in stroke. Pharmacological inhibition reduces infarct growth in mice. NLRP3-positive cells in human pial blood before thrombectomy correlate with clinical outcome and…
Out-of-frame CBX3::ALK fusion drives ALK activation and therapy response
Hang et al. identify an out-of-frame CBX3::ALK fusion in metastatic melanoma that generates functional ALK isoforms through alternative translation start sites. This study demonstrates that rare noncanonical out-of-frame fusions can be oncogenic and therapeutically actionable, highlighting an analytic blind spot…
Combination immunotherapy for colorectal cancer: Clinical applications, rationale, challenges, and future perspectives
Fei et al. review combination immunotherapy strategies for colorectal cancer, focusing on overcoming resistance in pMMR/MSS/MSI-L tumors. They highlight integrating ICIs with chemotherapy, targeted therapy, and radiotherapy and discuss insights into the tumor microenvironment and biomarkers to improve outcomes.