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New Center for Therapeutic Genetics to Develop Rare Disease Genetic Medicines
The new Center for Therapeutic Genetics will focus on developing precision genetic medicines for treating rare disease through collaboration between the Broad Institute, Boston Children’s Hospital, and The Jackson Laboratory. The post New Center…
Curcumin attenuates α-synuclein pathology in Parkinson’s disease model mice through modulation of UBC9-associated SUMOylation signaling
BackgroundPost-translational modifications, particularly SUMOylation, plays a crucial role in α-synuclein (α-syn) aggregation, a key pathological feature of Parkinson’s disease (PD). Curcumin, a natural polyphenol, has shown neuroprotective potential, but its effects on SUMOylation-related signaling…
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Across 7 hearings, RFK Jr. talks a new, more moderate MAHA
Discount telehealth visits, maternal mortality data, and more health news from Morning Rounds
STAT+: Can Erasca be biotech’s next big thing? We’ll see
Can Erasca be biotech's next big thing?
Will fusion power get cheap? Don’t count on it.
Fusion power could provide a steady, zero-emissions source of electricity in the future—if companies can get plants built and running. But a new study suggests that even if that future arrives, it might not come cheap. Technologies tend to get…
Opinion: Kennedy’s new silence on vaccines is political — and it won’t last
Kennedy’s public messaging on vaccines has shifted ahead of the midterms. It won’t last.
Steady-state Bioequivalence Study of Aripiprazole for Injection in Patients With Schizophrenia.
Conditions: Schizophrenia Interventions: Drug: Aripiprazole for Injection; Drug: Aripiprazole for Injection Sponsors: CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. Not yet recruiting
Growth, Empowerment, and Mindfulness (GEM): A Mindfulness-based Intervention to Address Mental Health in Young Adults With Early Life Adversity
Conditions: Anxiety; Depression Interventions: Behavioral: Growth, Empowerment, and Mindfulness (GEM) Sponsors: Brown University Recruiting
Computerized Cognitive Behavioral Therapy-Depression (cCBT-D) for Caregivers of Veterans
Conditions: Depression Interventions: Behavioral: cCBT-D for Caregivers Sponsors: VA Eastern Colorado Health Care System; Face the Fight; Denver Research Institute Not yet recruiting
The Download: introducing the 10 Things That Matter in AI Right Now
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Introducing: 10 Things That Matter in AI Right Now What actually matters in AI right now?…
STAT+: Publicly, Kennedy embraces a more moderate MAHA
Kennedy continues to make waves across health care, but he's pulled back on a number of core MAHA issues.
STAT+: Federal test of AI prior authorization is delaying care for seniors, report says
A new Medicare prior authorization test is delaying care at Washington state hospitals – and should be scrapped, senator says.
Former tobacco executive joins CDC senior leadership, raising concerns over industry influence
Naming a former Imperial Brands executive for a CDC job is the latest example, advocates say, of tobacco industry influence in Trump administration.
Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial
Background: Given the increasing prevalence of depression and anxiety disorders and enduring barriers to care, there is a critical need for alternative treatment options. Generative artificial intelligence (AI) chatbots show promise for increasing access to mental health care, though more…
STAT+: At AACR, talk of Chinese biotech, oncology’s comms issue, and more
At AACR, there was talk of Chinese biotech's place in cancer research, oncology’s comms issue, and more.
Video: Robert F. Kennedy Jr. testifies before Senate HELP committee
Watch RFK Jr. testify before the Senate's health care panel.
Fifth Annual SoFi Child Mind Institute Golf Invitational Raises $630,000 to Support Youth Mental Health
On April 20, the Child Mind Institute and SoFi held its fifth annual Golf Invitational at the Olympic Club in San Francisco. The event raised $630,000 to support the organization’s mission to transform the lives of children and families struggling…
Tideglusib improves novel object recognition memory in the preclinical DBA/2J mdx mouse model of Duchenne muscular dystrophy
IntroductionDuchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder characterized by progressive muscle wasting. Approximately 1 in 3 DMD patients experience cognitive dysfunction, with research suggesting an Alzheimer’s disease (AD)-like pathology. We have previously shown that treatment with the…
Exploring neural mechanisms of Mandarin tone sandhi perception via fNIRS: the role of gesture in multimodal integration
IntroductionThe use of pitch gestures in teaching Mandarin tone (i.e., gesture-augmented instruction) has been reported to facilitate lexical tone acquisition. However, the neural mechanisms underlying how gestures aid the learning of complex phonological rules, such as tone sandhi, remain unclear.…
Oral administration of kratom leaf extract alleviates anxiety-like behavior, urinary bladder pain, voiding dysfunction, and bladder hypercontractility via attenuating muscarinic receptor response in male mice exposed to chronic water avoidance stress
Psychological stress causes and deteriorates interstitial cystitis/painful bladder syndrome with urinary frequency, incontinence, bladder pain and urgency. The major alkaloid of kratom (Mitragyna speciosa), mitragynine, shows analgesic, anxiolytic, and smooth muscle relaxant effects. However, the effects of kratom leaf extract…