News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
Experimental investigation of sharp-tip microwire-based brain electrode buckling during implantation through dura and pia mater
IntroductionWide use of miniaturized and flexible microwire electrodes faces challenges of wire buckling against the brain membrane layers. The field lacks quantitative understanding of such buckling phenomena, especially on the effective length factor, which is required to determine the wire’s…
Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer’s disease and non-Alzheimer’s dementias
IntroductionWe aimed to understand the pathophysiological differences between 16 Alzheimer’s disease (AD) and 15 non-AD dementia patients by quantifying oxygen extraction fraction (OEF) in cortical (CGM) and deep gray matter (DGM) regions.MethodsTo achieve this, we used a novel MRI-based OEF…
Quality, reliability, and transparency of late-life depression videos on Chinese social media: a cross-sectional study of Douyin, Rednotes, and BiliBili
BackgroundLate-life depression is common in older adults and is often under-recognized. Short-video platforms have become a major source of mental health information. However, content quality and transparency remain uncertain.MethodsWe conducted a cross-sectional assessment of highly viewed videos on late-life depression…
Scoping review of therapeutic approaches among individuals with secondary exercise addiction
Secondary exercise addiction shows high comorbidity with eating and body image disorders. Despite its substantial impact on physical and mental health and daily functioning, evidence on effective therapeutic interventions remains limited. The aim of this scoping review was to identify…
Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico
Background/objectiveAnxiety and depressive disorders are leading causes of disability worldwide, and access to evidence-based psychological treatment remains limited in many middle-income countries. Digital cognitive–behavioral therapy (CBT) interventions have emerged as scalable tools to address this treatment gap, yet few have…
Real-world effectiveness of medication-assisted treatment and psychotherapy for opioid use disorder: a national multi–health care organization analysis
BackgroundHarm reduction strategies for opioid use disorder (OUD) emphasize pragmatic, evidence-based approaches that reduce overdose risk, relapse, and other adverse outcomes without requiring abstinence. Medication for opioid use disorder (MOUD) and structured psychotherapy represent core harm-reduction modalities, yet their real-world…
A prospective cohort study on the incidence and influencing factors of subsyndromal delirium in ICU patients
BackgroundThis study aims to develop and validate a machine learning-based risk prediction model for subsyndromal delirium (SSD) in ICU patients, while identifying key risk factors.MethodThis study was a prospective study, selecting patients who were hospitalized in the ICU from October…
A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03109-0AI targets lipid nanoparticles to specific tissues while avoiding off-target delivery to the liver.
Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03097-1Pooled production of recombinant AAV vectors leads to frequent genetic recombination.
Australia legislates against genetic discrimination in life insurance
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04372-zGenomic screening is increasing rapidly, but insurance protections globally are outdated. Australia’s new law offers the clearest model yet for safeguarding public trust while supporting population genomics.
A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04267-zA reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Clinical trials for continuously monitored and updated AI systems
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04368-9As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.
AI framework for multidisease detection via retinal imaging
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04359-wReti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.
Human Ventral Tegmental Local Field Potentials in Treatment-Resistant Depression and Obsessive-Compulsive Disorder
The ventral tegmental area (VTA) is a key node within the limbic circuitry. Through dense dopaminergic, glutamatergic, and GABAergic projections, the VTA forms reciprocal loops with prefrontal and limbic cortices that are consistently implicated in major depressive disorder (MDD) and…
The Biological Psychiatry Family of Journals Is Rewarding Its Reviewers
The Biological Psychiatry family of Journals (Biological Psychiatry (BPS); Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (BP:CNNI); Biological Psychiatry: Global Open Science (BP:GOS) is pleased to announce a new program that, beginning this year, will both recognize and reward our most…
The prefrontal cortex controls memory organization in the hippocampus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02231-1Related memories are sometimes encoded in overlapping neurons. The authors show that the prefrontal cortex controls this type of memory organization in the hippocampus through direct projections to the medial entorhinal cortex.
Genoarchitecture and input–output organization of the mouse basal ganglia and thalamic parafascicular nucleus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02253-9The authors investigate the transcriptomic and connectivity organization of the basal ganglia and parafascicular nucleus. The analyses suggest that combinatorial gene expression underlies the modular and cell-type-specific basal ganglia input–output networks.
Predicting consequences of new hepatitis B vaccine recs
New data on public trust in science, AI and mental health, and other news from Morning Rounds
STAT+: Eli Lilly enlists AI startup for next-generation gene editors
Eli Lilly's deal with Profluent aims to go beyond CRISPR by using AI-designed enzymes to insert entire genes. It could reshape genetic medicine.
Opinion: Why do discussions about ‘brain health’ ignore mental illness?
“Failing to adopt a more inclusive concept of brain health represents a massive loss of human potential,” write Husseini K. Manji, Eric J. Nestler, and Patrick J. Kennedy.
News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
Experimental investigation of sharp-tip microwire-based brain electrode buckling during implantation through dura and pia mater
IntroductionWide use of miniaturized and flexible microwire electrodes faces challenges of wire buckling against the brain membrane layers. The field lacks quantitative understanding of such buckling phenomena, especially on the effective length factor, which is required to determine the wire’s…
Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer’s disease and non-Alzheimer’s dementias
IntroductionWe aimed to understand the pathophysiological differences between 16 Alzheimer’s disease (AD) and 15 non-AD dementia patients by quantifying oxygen extraction fraction (OEF) in cortical (CGM) and deep gray matter (DGM) regions.MethodsTo achieve this, we used a novel MRI-based OEF…
Quality, reliability, and transparency of late-life depression videos on Chinese social media: a cross-sectional study of Douyin, Rednotes, and BiliBili
BackgroundLate-life depression is common in older adults and is often under-recognized. Short-video platforms have become a major source of mental health information. However, content quality and transparency remain uncertain.MethodsWe conducted a cross-sectional assessment of highly viewed videos on late-life depression…
Scoping review of therapeutic approaches among individuals with secondary exercise addiction
Secondary exercise addiction shows high comorbidity with eating and body image disorders. Despite its substantial impact on physical and mental health and daily functioning, evidence on effective therapeutic interventions remains limited. The aim of this scoping review was to identify…
Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico
Background/objectiveAnxiety and depressive disorders are leading causes of disability worldwide, and access to evidence-based psychological treatment remains limited in many middle-income countries. Digital cognitive–behavioral therapy (CBT) interventions have emerged as scalable tools to address this treatment gap, yet few have…
Real-world effectiveness of medication-assisted treatment and psychotherapy for opioid use disorder: a national multi–health care organization analysis
BackgroundHarm reduction strategies for opioid use disorder (OUD) emphasize pragmatic, evidence-based approaches that reduce overdose risk, relapse, and other adverse outcomes without requiring abstinence. Medication for opioid use disorder (MOUD) and structured psychotherapy represent core harm-reduction modalities, yet their real-world…
A prospective cohort study on the incidence and influencing factors of subsyndromal delirium in ICU patients
BackgroundThis study aims to develop and validate a machine learning-based risk prediction model for subsyndromal delirium (SSD) in ICU patients, while identifying key risk factors.MethodThis study was a prospective study, selecting patients who were hospitalized in the ICU from October…
A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03109-0AI targets lipid nanoparticles to specific tissues while avoiding off-target delivery to the liver.
Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03097-1Pooled production of recombinant AAV vectors leads to frequent genetic recombination.
Australia legislates against genetic discrimination in life insurance
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04372-zGenomic screening is increasing rapidly, but insurance protections globally are outdated. Australia’s new law offers the clearest model yet for safeguarding public trust while supporting population genomics.
A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04267-zA reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Clinical trials for continuously monitored and updated AI systems
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04368-9As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.
AI framework for multidisease detection via retinal imaging
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04359-wReti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.
Human Ventral Tegmental Local Field Potentials in Treatment-Resistant Depression and Obsessive-Compulsive Disorder
The ventral tegmental area (VTA) is a key node within the limbic circuitry. Through dense dopaminergic, glutamatergic, and GABAergic projections, the VTA forms reciprocal loops with prefrontal and limbic cortices that are consistently implicated in major depressive disorder (MDD) and…
The Biological Psychiatry Family of Journals Is Rewarding Its Reviewers
The Biological Psychiatry family of Journals (Biological Psychiatry (BPS); Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (BP:CNNI); Biological Psychiatry: Global Open Science (BP:GOS) is pleased to announce a new program that, beginning this year, will both recognize and reward our most…
The prefrontal cortex controls memory organization in the hippocampus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02231-1Related memories are sometimes encoded in overlapping neurons. The authors show that the prefrontal cortex controls this type of memory organization in the hippocampus through direct projections to the medial entorhinal cortex.
Genoarchitecture and input–output organization of the mouse basal ganglia and thalamic parafascicular nucleus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02253-9The authors investigate the transcriptomic and connectivity organization of the basal ganglia and parafascicular nucleus. The analyses suggest that combinatorial gene expression underlies the modular and cell-type-specific basal ganglia input–output networks.
Predicting consequences of new hepatitis B vaccine recs
New data on public trust in science, AI and mental health, and other news from Morning Rounds
STAT+: Eli Lilly enlists AI startup for next-generation gene editors
Eli Lilly's deal with Profluent aims to go beyond CRISPR by using AI-designed enzymes to insert entire genes. It could reshape genetic medicine.
Opinion: Why do discussions about ‘brain health’ ignore mental illness?
“Failing to adopt a more inclusive concept of brain health represents a massive loss of human potential,” write Husseini K. Manji, Eric J. Nestler, and Patrick J. Kennedy.