News Feed
Opinion: Beware the unintended consequences of testosterone screening for military servicemembers
“I fear that the widespread rollout of testosterone screening may lead to some surprising and unintended consequences,” writes a urologist who studies testosterone.
Organ Aging Linked to Breakdown in Immune Cell Interaction and Senescent Neutrophil Clearance
A study in mice and in human cells found that blocking a single receptor on tissue-resident macrophages promoted clearance of accumulating senescent neutrophils, preserved the youthfulness of multiple organs in mice, and substantially slowed…
Opinion: STAT readers on the value of primary care, obesity as a disease, and more
“The real opportunity is to move beyond policies and narratives that pit specialties against one another,” presidents of the AAFP, ACP, and AAP write.
News
2646 results
A calibration-aware hierarchical CNN-SWIN fusion framework for robust Cross-Dataset brain MRI analysis
IntroductionDeep learning approaches have become central to brain MRI analysis; however, their reliability under dataset shift remains a critical barrier to safe and scalable deployment in neuroscience and clinical research. While convolutional neural networks (CNNs) provide strong locality-driven inductive biases…
Immersive virtual reality as a novel approach to improve social cognition in multiple sclerosis: an EEG-based pilot study
IntroductionMultiple sclerosis (MS) affects different cognitive domains, including social cognition. Immersive Virtual Reality (VR) may provide a novel rehabilitative approach to treat motor and cognitive symptoms of MS. This exploratory pilot study evaluated the effects of immersive VR rehabilitation on…
Retrospective longitudinal analysis of blood microRNA-7-5p as a possible progression biomarker in people with Parkinson’s disease
BackgroundMicroRNA-7-5p (miR-7-5p) may play a neuroprotective role in people with Parkinson’s disease (PwP), as it has been found to regulate α-synuclein (α-syn) and the NLRP3 inflammasome in animal models of Parkinson’s disease (PD).ObjectiveThe study aimed to investigate the use of…
Self images: an empirical enquiry into Rembrandt’s self-portraits
Many have speculated that events of personal and financial loss in the life of Rembrandt van Rijn (Rembrandt) caused depression and that this is revealed by examination of his work particularly self-portraits painted in old age. Some report detecting various…
Medical evaluation of first presentation of psychotic symptoms in children and adolescents
IntroductionPsychotic symptoms in children and adolescents may represent either normative developmental phenomena or severe psychiatric and medical conditions, requiring careful differential diagnosis.MethodsThis retrospective study aimed to evaluate the medical workup of children and adolescents admitted for a first presentation of…
A longitudinal analysis of the prevalence of restrictive interventions involving women with mental health conditions, learning disabilities or autism in mental health services in England
IntroductionRestrictive interventions, including physical restraint, seclusion, chemical restraint, and segregation, continue to be used within mental health services, despite sustained policy efforts to promote least-restrictive and trauma-informed care. However, little is known about national trends affecting women, for whom restrictive…
How stressful life events are associated with depression: the mediating pathway of security in a clinical adolescent sample
BackgroundStressful life events are well-established risk factors for adolescent depression; however, the psychological mechanisms underlying this association remain insufficiently understood, particularly regarding which types of stress and which dimensions of security are most closely linked to depression. This study aimed…
Unmasking deep-rooted trauma: long-term effects of childhood adversities on posttraumatic stress disorder in healthcare workers facing acute multi-trauma
PurposeIn recent years, healthcare workers (HCWs) in Lebanon have encountered compounded traumatic exposures, including the Beirut Port blast, COVID-19, and an ongoing economic crisis, often preceded by early-life adversities such as adverse childhood experiences (ACEs). Understanding how these acute stressors…
Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2
Nature Biotechnology, Published online: 14 April 2026; doi:10.1038/s41587-026-03095-3FAMSA2 accurately aligns millions of protein sequences at high speed.
The gut microbiome as a fingerprint of antibiotic use history
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04360-3Antibiotic use over the past 8 years was associated with alterations in the gut microbiome composition in 14,979 individuals. These analyses integrated data from the Swedish National Prescribed Drug Register and stool metagenomic…
Editorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04390-xEditorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
KRAS-targeting PROTAC drug passes first clinical test
Nature Medicine, Published online: 14 April 2026; doi:10.1038/d41591-026-00020-8A phase 1 study evaluating setidegrasib shows promising safety and clinical activity, establishing targeted protein degradation as a viable new approach for treating KRAS G12D-driven solid tumors.
Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04314-9Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus.
Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04317-6A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness following treatment.
White matter pathways mediating dorsolateral prefrontal TMS therapy for depression
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02248-6Seguin et al. show that the efficacy of transcranial magnetic stimulation for depression depends on how stimulation spreads through the brain’s wiring. Patients with shorter communication pathways between stimulated sites and mood-related regions…
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02254-8By assembling into ‘virion vesicles’, the H129 strain of herpes simplex virus-1 hijacks synaptic machinery for its anterograde spread, co-opting voltage-gated Ca2+ channels, Syt7 and SNAREs for presynaptic exit, then nectin-1/CME for postsynaptic…
Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02250-yThis study shows that the brain’s smell center uses precise timing and inhibition to read out early odor signals, enabling reliable odor identity across concentrations while rapidly separating (decorrelating) similar smell patterns for…
Prediction of Relapse Using Digital Technology in People in Recovery From Substance Use Disorders: Early Economic Evaluation With a Case Study of the Subreal App
Background: Many people relapse after achieving abstinence in substance use disorders. Health care providers may scan the horizon for new technologies to predict response that allow interventions to be targeted rather than routine. Currently, no such predictive technologies are available…
STAT+: FDA pressures drugmakers to report trial results
Ben Sasse on enrolling in Rev Med's drug trial, more ADC investment, and other biotech news from The Readout
STAT+: Hospitals offer chatbots to fight off ChatGPT
In this edition of STAT Health Tech: Hospitals offer their own chatbots, Medicare's ACCESS pilot, and an update Utah's 'AI doctor' experiment.