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Organ Aging Linked to Breakdown in Immune Cell Interaction and Senescent Neutrophil Clearance
A study in mice and in human cells found that blocking a single receptor on tissue-resident macrophages promoted clearance of accumulating senescent neutrophils, preserved the youthfulness of multiple organs in mice, and substantially slowed…
Opinion: STAT readers on the value of primary care, obesity as a disease, and more
“The real opportunity is to move beyond policies and narratives that pit specialties against one another,” presidents of the AAFP, ACP, and AAP write.
Circuit logic of oxytocin and vasopressin complementary actions
Oxytocin (OT) and vasopressin (VP) are evolutionarily conserved neuropeptides that regulate social behavior, emotional processing and physiological homeostasis. Although traditionally studied as individual modulators of affiliation, stress and autonomic function, emerging evidence indicates that…
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Job titles of the future: Wildlife first responder
Grizzly bears have made such a comeback across eastern Montana that in 2017, the state hired its first-ever prairie-based grizzly manager: wildlife biologist Wesley Sarmento. For some seven years, Sarmento worked to keep both the bears, which are still listed…
Opinion: Sports betting is creating a twofold public health crisis for some young men
“Even if not everybody is losing a ton of money right now, you're creating this culture of large numbers of gamblers,” Isaac Rose-Berman says on the First Opinion Podcast.
Opinion: What STAT readers think about nutrition education in med school
“Is ‘lack of education’ really what we think the problem is in prevention care?” a STAT reader asks.
Epigenetics at Birth Links Microbiome to Neurodevelopment, Potentially ASD and ADHD
Researchers have found that the human gut microbiome and epigenetics are intertwined, and that both contribute to early life neurodevelopment, and potentially to the development of ASD and ADHD. The post Epigenetics at Birth Links Microbiome to Neurodevelopment, Potentially ASD…
GAO report shows gap between scale of illegal vapes and enforcement
The Justice Department's actions on illegal vapes pales next to the scale of the problem, anti-smoking advocates say.
STAT+: Replimune skin cancer drug that became FDA flashpoint is rejected again
A cancer drug candidate that, rightly or wrongly, became a flashpoint at FDA, fails on a second try at approval.
What’s in a name? Moderna’s “vaccine” vs. “therapy” dilemma
Is it the Department of Defense or the Department of War? The Gulf of Mexico or the Gulf of America? A vaccine—or an “individualized neoantigen treatment”? That’s the Trump-era vocabulary paradox facing Moderna, the covid-19 shot maker whose plans for…
The Download: an exclusive Jeff VanderMeer story and AI models too scary to release
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Constellations —Constellations is a short story by Jeff VanderMeer, the author of the critically acclaimed, bestselling…
How blindness shapes personality: a neuro-ecological account
IntroductionThe established link between personality and psychological well-being underscores the need to understand how major life changes, such as vision loss, reshape an individual’s disposition. While previous research has produced inconsistent findings, the roles of concurrent environmental factors and underlying…
Zingerone alleviates acute seizures by reducing intrinsic hippocampal neuronal excitability in a rat model of temporal lobe epilepsy
BackgroundEpilepsy is a complex neurological disorder characterized by recurrent seizures. Neuroinflammation and excessive neuronal excitation are key pathogenic factors, but current therapies fail to target these mechanisms effectively, highlighting the need for novel therapeutic agents. Zingerone, a bioactive compound derived…
Exploratory assessment of cerebrospinal fluid-related microdynamics after mild traumatic brain injury using intravoxel incoherent motion magnetic resonance imaging
AimThis study aimed to characterize regional alterations in cerebrospinal fluid (CSF) microdynamics following mild traumatic brain injury (TBI) using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and compare f-value–based CSF motion between patients with TBI and healthy controls.MethodsIn this…
A novel phase-difference transcranial alternating current stimulation system enables precise dual-site neuromodulation
Precise modulation of large-scale brain networks requires neuromodulation technologies capable of delivering frequency-locked stimulation with accurate and stable inter-regional phase control. However, conventional transcranial alternating current stimulation (tACS) systems generally lack robust dual-channel phase regulation and are rarely validated under…
A survey on data augmentation for EEG-based emotion recognition and cognitive workload decoding
Electroencephalography (EEG) is extensively employed in emotion recognition and cognitive workload decoding. However, signal characteristics and inter-subject variability pose significant challenges for deep learning models, particularly due to data scarcity and limited generalization. Although data augmentation (DA) is a critical…
Effect of transcranial magnetic stimulation on prognosis in patients with postherpetic neuralgia and comorbid depression undergoing interventional neuromodulation therapy: protocol for a randomized double-blind placebo-controlled trial
BackgroundPostherpetic neuralgia (PHN) is often accompanied by depression, creating a vicious cycle that exacerbates symptoms and contributes to suboptimal treatment outcomes, even with interventional therapies. Repetitive transcranial magnetic stimulation (rTMS) has demonstrated potential in alleviating both pain and mood disturbances.…
The efficacy and safety of transcranial direct current stimulation in patients with ADHD: a systematic review and meta-analysis
ObjectiveThis meta-analysis evaluated the efficacy and safety of transcranial direct current stimulation (tDCS) for treating Attention-Deficit/Hyperactivity Disorder (ADHD).MethodsFollowing PRISMA guidelines, we analyzed 28 randomized controlled trials (RCTs) involving 1,864 participants. Outcomes encompassed core ADHD symptoms, hot and cold executive functions…
From work-related trauma to suicidal ideation: a serial mediation model of posttraumatic stress and depression in rescue workers
ObjectivesRescue workers face frequent occupational trauma, increasing their risk for posttraumatic stress symptoms (PTSS), depression, and suicidal ideation. However, pathways linking trauma to suicidality remain poorly understood. This study investigated these mechanisms by testing a serial mediation model.MethodsFrom a larger…
The mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest in students with learning disabilities
IntroductionThe present work is investigating the mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest among students with learning disabilities.MethodsThis descriptive-analytical study employed a correlational design within a structural equation modelling framework. The…
Nonlinear relationships between fatigue, fear of COVID-19, and PTSD among mental health professionals: the findings of a multi-site survey in China
BackgroundMental health professionals (MHPs) are susceptible to fatigue, particularly during public health crises like the COVID-19 pandemic. This study examined nonlinear relationships between fatigue, post-traumatic stress disorder (PTSD), and fear of COVID-19 (FOC) among MHPs.MethodsA multi-site survey was conducted from…
Therapeutic Potential of GLP-1 Receptor Agonists for Smoking Cessation
Glucagon-like peptide-1 (GLP-1) therapies are under investigation for a growing number of neuropsychiatric conditions, including substance use disorders. Cigarette smoking accounts for the largest proportion of substance use-related morbidity and mortality, in part reflecting increased risk for cardiometabolic disease among…
Neural sequences underlying directed turning in Caenorhabditis elegans
Nature Neuroscience, Published online: 10 April 2026; doi:10.1038/s41593-026-02257-5During olfactory navigation, Caenorhabditis elegans can execute error-correcting turns. Whole-brain imaging and perturbation experiments identify an ensemble of neurons that control reorientation and turning behaviors.