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Organ Aging Linked to Breakdown in Immune Cell Interaction and Senescent Neutrophil Clearance
A study in mice and in human cells found that blocking a single receptor on tissue-resident macrophages promoted clearance of accumulating senescent neutrophils, preserved the youthfulness of multiple organs in mice, and substantially slowed…
Opinion: STAT readers on the value of primary care, obesity as a disease, and more
“The real opportunity is to move beyond policies and narratives that pit specialties against one another,” presidents of the AAFP, ACP, and AAP write.
Circuit logic of oxytocin and vasopressin complementary actions
Oxytocin (OT) and vasopressin (VP) are evolutionarily conserved neuropeptides that regulate social behavior, emotional processing and physiological homeostasis. Although traditionally studied as individual modulators of affiliation, stress and autonomic function, emerging evidence indicates that…
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Constellations
I. We had crash-landed on the planet. We were far from home. The spaceship could not be repaired, and the rescue beacon had failed. Besides me, only the astrogator, part of the captain, and the ship’s AI mind were left. …
Opinion: I’m a MAHA activist. I went into the public health lion’s den — and it changed how I think
“In my most honest of moments, what I want from the medical community is the chance to trust it again,” a MAHA advocate writes.
Opinion: What public health can learn from the MAHA movement
“What MAHA has built, in a relatively short time, is social capital,” writes Monica L. Wang.
How sports betting apps hook users
In this week's STATus Report, host Alex Hogan dives into how sports betting apps hook users — and how he himself fell for some too-good-to-be-true promotions.
Peer Mentor Training and Supervision for a Digital Adolescent Depression Treatment in South Africa and Uganda: Mixed Methods Evaluation
Background: Blended digital mental health interventions combining technology with human support are more effective than stand-alone treatments. However, limited research has examined how to train and supervise personnel delivering human support components. The Kuamsha app, a gamified digital intervention for…
In Memoriam: Edna B. Foa, PhD
Dr. Edna Foa served for decades as a professor of clinical psychology in psychiatry at the University of Pennsylvania, where she also directed the Center for the Treatment and Study... Read more » The post In Memoriam: Edna B. Foa,…
In Memoriam: Judith L. Rapoport, MD
Dr. Judith L. Rapoport has left an indelible mark on the field of obsessive compulsive disorder (OCD) — not only through her extraordinary scientific contributions, but through the compassion, curiosity,... Read more » The post In Memoriam: Judith L. Rapoport,…
The Mental Health Commission of Canada is pleased to welcome Shauna Cronin
The Mental Health Commission of Canada is pleased to welcome Shauna Cronin (she/her) as our new Vice President, Programs, effective April 27, 2026. Shauna brings nearly two decades of national leadership in mental health system transformation, program design, and policy…
Speech in noise prediction by use of cortical auditory evoked potentials in normal hearing and sensorineural hearing loss: a systematic review
IntroductionSpeech perception in noise (SPiN) is a critical challenge for individuals with sensorineural hearing loss (SNHL), and current behavioral assessments can be unreliable in populations with language barriers or cognitive impairment. Cortical auditory evoked potentials (CAEPs) can serve as a…
Monitoring Daily Mobility in Children With Autism
Conditions: Autism Spectrum Disorder (ASD Interventions: Device: placement of a wearable wrist sensor Sponsors: IRCCS San Raffaele Roma Recruiting
Mindfulness-based Stress Reduction for PTSD in Road Traffic Accident Victims: A Randomized Controlled Trial
Conditions: Posttraumatic Stress Disorder (PTSD) Interventions: Behavioral: mindfulness-based stress reduction Sponsors: Universiti Sains Malaysia; Xinjiang Medical University; Jinzhou Medical University; Universiti Sultan Zainal Abidin Recruiting
MTCL2 Is Essential for the Bipolar-to-Multipolar Transition in the Dendrite Extension of Cerebellar Granule Neurons
The dynamic regulation of neuronal polarity is essential for the formation of neural networks during brain development. Primary cultures of rodent neurons recapitulate several aspects of this polarity regulation, providing valuable insights into the molecular mechanisms underlying axon specification, dendrite…
Prefrontal and hippocampal microstructural gray matter following cognitive training under moderate hypoxia in mood disorders: a randomized controlled trial
BackgroundCognitive impairment persists during partial or full remission in 50–70% of individuals with mood disorders and impacts daily functioning and clinical prognosis. Preclinical evidence suggests that extended exposure to moderate hypoxia, combined with motor-cognitive learning, may elevate neuroplasticity and improve…
Efficacy and Underlying Mechanisms of Group-Based Natural Psychotherapy for Anxiety Disorder
Conditions: Obsessive - Compulsive Disorder Interventions: Behavioral: Group-based Natural Psychotherapy Sponsors: Beijing HuiLongGuan Hospital; Institute of Psychology, Chinese Academy of Sciences; Fourth People's Hospital in Hefei Active, not recruiting
Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder
Conditions: PTSD Interventions: Drug: Psilocybin Sponsors: University of New Mexico Not yet recruiting
Telephone-Based Mental Health Promotion for Rural Women in Brazilian Agrarian Reform Communities: Pre-Post Pilot Study
Background: Women living in rural agrarian reform communities face intersecting challenges related to social, economic, racial, and gender vulnerabilities, which significantly increase their likelihood of developing physical and mental health problems. Despite the potential of telephone-based interventions to promote mental…
Willingness of Patients With Mental Disorders to Engage in Online Psychotherapy: Multicenter Cross-Sectional Survey
Background: China faces a high prevalence of mental disorders but low treatment uptake, a gap driven by limited awareness and unevenly distributed mental health resources. While online psychotherapy has the potential to expand access, patient willingness remains insufficiently explored. Objective:…
Strength of Evidence to Support Decision-Making on the Use of Digital Mental Health Technologies in NICE Evaluations: Cross-Sectional Analysis of Studies
Background: Digital mental health technologies (DMHTs) are playing an increasing role in mental health services. The quality of evidence for DMHTs is variable, and there are concerns that evidence is not sufficient to support decision-making. Objective: This study used a…
Medtech OEMs face a rare but closing window of opportunity
This is a manufacturing decision you can’t defer in 2026. Mark Freitas, Alvarez & Marsal Private-equity-backed CDMO platforms are aging into exits. OEMs who know what they want will move first. The 2022-2024 structural reset is over and the financing…