News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
Vagus nerve stimulation as an anti-inflammatory therapy for maternal immune activation-induced alterations in offspring microglia and neurodevelopment
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by a combination of genetic and environmental factors. With the increasing prevalence of ASD diagnosis, it is crucial to understand the mechanisms behind preventable causes, such as prenatal infections, and…
Toward an NGF-based therapy for Rett syndrome
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Although recent therapeutic advances, such as the approval of Trofinetide, offer partial relief, no comprehensive curative treatment is currently available. Among the emerging strategies,…
Impact of extremely low frequency electromagnetic fields exposure on sleep quality and mental health in a Tunisian power plant: a cross-sectional study
IntroductionExtremely low-frequency electromagnetic fields (ELF-EMFs) are ubiquitous in our daily life. They may have an impact not only on physical health but also on mental health.ObjectivesTo assess the impact of occupational exposure to the ELF-EMFs on sleep quality, depression, anxiety…
Associations of psychological distress, gaming motives and internet gaming disorder in adolescents: a network analysis
Background and objectiveThe rapid popularization of the Internet among Chinese adolescents has resulted in the emergence of a public major concern known as Internet Gaming Disorder (IGD). As demonstrated by previous studies, an association has been demonstrated among emotional distress,…
Sex-specific impact of vitamin D and B9 concentrations on neuroticism: a polygenic score-based study
IntroductionNeuroticism is a personality domain with prognostic value for physical and mental health. To properly inform public health policy, it is crucial to uncover the mechanisms underlying high neuroticism. Many internal and external factors that affect brain development and functioning…
Mental health in the time of polycrisis: geopolitical determinants and modern psychiatry
Psychiatry is increasingly being practised in environments affected by geopolitical instabilities, including economic fragmentation, democratic backsliding, and widening inequities. The confluence of these phenomena contributes to what has been described as a contemporary polycrisis, encompassing synchronous disruptions that reinforce one…
Adult attachment and intimate relationship satisfaction among university students: the chain mediating roles of appreciation and sense of giving
BackgroundSatisfying intimate relationships are fundamental to young adults’ psychological well-being. Although adult attachment theory provides a robust framework for understanding relationship quality, the mechanisms linking higher attachment anxiety and avoidance to lower relationship satisfaction remain underexplored. This study tested a…
The value of patient-focused drug development
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04364-zThe value of patient-focused drug development
Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04354-1In a biomarker-driven trial evaluating radiotherapy with erlotinib, everolimus or dasatinib in patients with newly diagnosed diffuse intrinsic pontine glioma, the primary endpoint of overall survival was not met, but features associated with…
Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04301-0A 22-year-old patient with cystic fibrosis and chronic, drug-resistant Bordetella bronchialis infection received compassionate-use phage therapy. Serum samples revealed that pre-existing antiphage immunity existed before treatment, indicating that future studies must evaluate antiphage…
From the discovery of GLP-1 to today’s diabetes/obesity therapy and beyond
Glucagon-like peptide-1 was discovered as an insulinotropic peptide from the gut during a search for candidates for the incretin effect. It turned out to also inhibit glucagon secretion and is now considered an important regulator of glucose metabolism. In further…
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo
Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02247-7By studying 23 neurodevelopmental disorder genes across model systems and brain cell types, the authors uncovered shared downstream effects that converge on synaptic biology, epigenetic regulation and mitochondrial function.
The Download: supercharged scams and studying AI healthcare
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. We’re in a new era of AI-driven scams When ChatGPT was released in late 2022, it…
Health-care AI is here. We don’t know if it actually helps patients.
I don’t need to tell you that AI is everywhere. Or that it is being used, increasingly, in hospitals. Doctors are using AI to help them with notetaking. AI-based tools are trawling through patient records, flagging people who may require certain…
Opinion: I started medical school at 69 and will begin residency at 72. Here’s what I learned
Starting residency at 72 isn’t for the faint of heart. But that’s what Dawn Zuidegeest-Craft is doing.
Psychedelics get a boost from the White House
In this week’s STATus Report, host Alex Hogan chats with STAT Washington correspondent Daniel Payne about Trump's psychedelics EO.
Opinion: The local news crisis is also a public health crisis
Health and science reporting is often treated as optional coverage. It is anything but.
Growing use of guest editors has turned some journals into a ‘playground of bad science’
The problematic use of guest editors was spotlighted last week when a genetics journal retracted nearly an entire special issue.
Rational causal induction from events in time.
A longstanding focus in the causal learning literature has been on inferring causal relations from contingencies, where these abstract away from time by collating independent instances or by aggregating over regularly demarcated trials. In contrast, individual causal learners encounter events…
Mechanical load inhibits cancer growth in mouse and human hearts
Science, Volume 392, Issue 6796, April 2026.
News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
Vagus nerve stimulation as an anti-inflammatory therapy for maternal immune activation-induced alterations in offspring microglia and neurodevelopment
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by a combination of genetic and environmental factors. With the increasing prevalence of ASD diagnosis, it is crucial to understand the mechanisms behind preventable causes, such as prenatal infections, and…
Toward an NGF-based therapy for Rett syndrome
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Although recent therapeutic advances, such as the approval of Trofinetide, offer partial relief, no comprehensive curative treatment is currently available. Among the emerging strategies,…
Impact of extremely low frequency electromagnetic fields exposure on sleep quality and mental health in a Tunisian power plant: a cross-sectional study
IntroductionExtremely low-frequency electromagnetic fields (ELF-EMFs) are ubiquitous in our daily life. They may have an impact not only on physical health but also on mental health.ObjectivesTo assess the impact of occupational exposure to the ELF-EMFs on sleep quality, depression, anxiety…
Associations of psychological distress, gaming motives and internet gaming disorder in adolescents: a network analysis
Background and objectiveThe rapid popularization of the Internet among Chinese adolescents has resulted in the emergence of a public major concern known as Internet Gaming Disorder (IGD). As demonstrated by previous studies, an association has been demonstrated among emotional distress,…
Sex-specific impact of vitamin D and B9 concentrations on neuroticism: a polygenic score-based study
IntroductionNeuroticism is a personality domain with prognostic value for physical and mental health. To properly inform public health policy, it is crucial to uncover the mechanisms underlying high neuroticism. Many internal and external factors that affect brain development and functioning…
Mental health in the time of polycrisis: geopolitical determinants and modern psychiatry
Psychiatry is increasingly being practised in environments affected by geopolitical instabilities, including economic fragmentation, democratic backsliding, and widening inequities. The confluence of these phenomena contributes to what has been described as a contemporary polycrisis, encompassing synchronous disruptions that reinforce one…
Adult attachment and intimate relationship satisfaction among university students: the chain mediating roles of appreciation and sense of giving
BackgroundSatisfying intimate relationships are fundamental to young adults’ psychological well-being. Although adult attachment theory provides a robust framework for understanding relationship quality, the mechanisms linking higher attachment anxiety and avoidance to lower relationship satisfaction remain underexplored. This study tested a…
The value of patient-focused drug development
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04364-zThe value of patient-focused drug development
Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04354-1In a biomarker-driven trial evaluating radiotherapy with erlotinib, everolimus or dasatinib in patients with newly diagnosed diffuse intrinsic pontine glioma, the primary endpoint of overall survival was not met, but features associated with…
Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04301-0A 22-year-old patient with cystic fibrosis and chronic, drug-resistant Bordetella bronchialis infection received compassionate-use phage therapy. Serum samples revealed that pre-existing antiphage immunity existed before treatment, indicating that future studies must evaluate antiphage…
From the discovery of GLP-1 to today’s diabetes/obesity therapy and beyond
Glucagon-like peptide-1 was discovered as an insulinotropic peptide from the gut during a search for candidates for the incretin effect. It turned out to also inhibit glucagon secretion and is now considered an important regulator of glucose metabolism. In further…
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo
Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02247-7By studying 23 neurodevelopmental disorder genes across model systems and brain cell types, the authors uncovered shared downstream effects that converge on synaptic biology, epigenetic regulation and mitochondrial function.
The Download: supercharged scams and studying AI healthcare
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. We’re in a new era of AI-driven scams When ChatGPT was released in late 2022, it…
Health-care AI is here. We don’t know if it actually helps patients.
I don’t need to tell you that AI is everywhere. Or that it is being used, increasingly, in hospitals. Doctors are using AI to help them with notetaking. AI-based tools are trawling through patient records, flagging people who may require certain…
Opinion: I started medical school at 69 and will begin residency at 72. Here’s what I learned
Starting residency at 72 isn’t for the faint of heart. But that’s what Dawn Zuidegeest-Craft is doing.
Psychedelics get a boost from the White House
In this week’s STATus Report, host Alex Hogan chats with STAT Washington correspondent Daniel Payne about Trump's psychedelics EO.
Opinion: The local news crisis is also a public health crisis
Health and science reporting is often treated as optional coverage. It is anything but.
Growing use of guest editors has turned some journals into a ‘playground of bad science’
The problematic use of guest editors was spotlighted last week when a genetics journal retracted nearly an entire special issue.
Rational causal induction from events in time.
A longstanding focus in the causal learning literature has been on inferring causal relations from contingencies, where these abstract away from time by collating independent instances or by aggregating over regularly demarcated trials. In contrast, individual causal learners encounter events…
Mechanical load inhibits cancer growth in mouse and human hearts
Science, Volume 392, Issue 6796, April 2026.