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Opinion: STAT readers on the value of primary care, obesity as a disease, and more
“The real opportunity is to move beyond policies and narratives that pit specialties against one another,” presidents of the AAFP, ACP, and AAP write.
Circuit logic of oxytocin and vasopressin complementary actions
Oxytocin (OT) and vasopressin (VP) are evolutionarily conserved neuropeptides that regulate social behavior, emotional processing and physiological homeostasis. Although traditionally studied as individual modulators of affiliation, stress and autonomic function, emerging evidence indicates that…
Development and validation of the digital well-being scale using university students
IntroductionDigital technologies are central to university students' academic, social, and personal lives, offering opportunities for learning and connection while also introducing challenges such as distraction, emotional strain, and difficulties with self-regulation. Despite increasing interest…
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Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder
Conditions: Williams Syndrome; Autism Disorder Sponsors: Qilu Hospital of Shandong University Not yet recruiting
The Unspoken Toll: Why Exam Pressure Must Be Part of the Youth Mental Health Discussion
A Conversation with Tatum Redmond and Amanda van der Vyver-Anderson from Community Keepers, South Africa By Mai El Shoush, Partnerships Campaign Manager, Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute Community…
Beyond dopamine blockade: mechanistic humility and the rise of muscarinic, TAAR1, and glutamatergic pathways in schizophrenia
The approval of the first non–dopamine-blocking therapy for schizophrenia marks a defining moment in psychiatry. Muscarinic M1/M4 modulation, alongside emerging TAAR1 and glutamatergic pathways, signals a shift beyond dopamine dominance toward circuit-level integration. These advances embody mechanistic humility: the scientific…
Associations between adult ADHD core symptoms, cognitive flexibility, and emotional eating: a case-control study
IntroductionAttention-deficit/hyperactivity disorder (ADHD) in adults often co-occurs with eating disorders (EDs), potentially through shared difficulties in emotional regulation, and executive functions. This study explored the associations between cognitive flexibility as a component of executive functions, core adult ADHD symptom dimensions…
Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications for precision sleep medicine
Narcolepsy can no longer be adequately conceptualized by excessive sleepiness and cataplexy. It is increasingly recognized as a multisystem hypothalamic encephalopathy, rooted in the selective loss or dysfunction of orexin neurons, yet extending across motor, psychiatric, metabolic, and autonomic domains.…
CABG-AI-Supported Discharge Education
Conditions: Coronary Artery Disease; Postoperative Care; Patient Discharge; Recovery of Function; Anxiety; Pain; Stress, Physiological; Surgical Nursing; Nursing; Discharge Education Interventions: Behavioral: AI-Supported Individualized Discharge Education; Behavioral: Standard Discharge Education Sponsors: Hasan Kalyoncu University Not yet recruiting
Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk…
CARED : A Novel Rapid Treatment Paradigm for Depression
Conditions: Major Depressive Disorder Interventions: Device: Intermittent Theta Burst Stimulation (iTBS); Device: Transcranial Alternating Current Stimulation (tACS); Behavioral: Psychotherapy; Device: Sham (Placebo) Transcranial Alternating Current Stimulation (tACS) Sponsors: University of North Carolina, Chapel Hill; Foundation of Hope for the Research…
Efficacy of Spectrally Optimized Light on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms
Conditions: Major Depressive Disorder (MDD); Neuroimaging; Bright Light Treatment; Cognitive Impairment Interventions: Device: bright light; Device: dim red light(placebo) Sponsors: Peking University Sixth Hospital Not yet recruiting
The exposome of brain aging across 34 countries
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-zExposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.
Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion
Conditions: Concussion; Depression Interventions: Device: ONE-D TMS protocol and d-cycloserine (125 mg) Sponsors: University of Florida Not yet recruiting
Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-wTo accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.
Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD
Conditions: Obessive-Compulsive Disorder Interventions: Behavioral: mindfulness based exposure therapy; Other: Treatment as Usual (TAU) Sponsors: Shanghai Mental Health Center Recruiting
Improving Caregiver Engagement in Early Interventions
Conditions: Autism Interventions: Behavioral: FANS-EI; Behavioral: Early Intervention Sponsors: University of California, Davis; National Institute of Mental Health (NIMH) Not yet recruiting
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Conditions: Psychiatric Disorders; Depression - Major Depressive Disorder; Schizophrenia and Other Psychotic Disorders; Anxiety and Mood Disorders; Bipolar and Related Disorders; PTSD - Post Traumatic Stress Disorder; Autism Spectrum Disorder Interventions: Behavioral: Action-Based Cognitive Remediation Sponsors: The Royal Ottawa Mental…
Safety Planning Intervention for Autistic Youth: A Randomized Controlled Trial With Providers in Developmental-Behavioral Pediatric Clinics
Conditions: Autism; Suicide Prevention Interventions: Behavioral: Safety Planning Intervention; Behavioral: Crisis Interventions for Pediatric Providers - Autism version (CIPP-A) Sponsors: Children's Hospital Los Angeles; Children's Hospital of Philadelphia Not yet recruiting
CFT Guided Self-help Intervention: Parents of Autistic Children
Conditions: Autism Disorders and Maternal Stress; Autism; Autism Disorder; Autism Spectrum Disorder; Autism in Children; Parent; Parent Mental Health; Parent Stress; Parent Support Interventions: Other: Guided, self-help compassion-focused intervention for parents of autistic children Sponsors: University of Nottingham; University Hospitals…
Telehealth Mindfulness-based Intervention for Adolescents With Autism Spectrum Disorder and Their Caregivers
Conditions: Autism Spectrum Disorder Interventions: Behavioral: MINDful TIME; Behavioral: Mindfulness Mobile App Sponsors: Nicole Matthews, Ph.D.; Southwest Autism Research & Resource Center; Arizona State University Recruiting
ADHD&me: Targeting Self-esteem in Youth With ADHD
Conditions: ADHD Interventions: Behavioral: ADHD&me Sponsors: Universiteit Leiden; Leids Universiteits Fonds Not yet recruiting
Unified Junction of Care, Integrated Treatments and Team Coordination for ADHD in Prison Settings With Substance Use Disorder
Conditions: Attention Deficit Disorder With Hyperactivity (ADHD); Substance Use Disorder (SUD) Interventions: Other: Workshop Sponsors: University Hospital, Brest Not yet recruiting