News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
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3069 results
Psychological function in the context of protracted stress during war: a multi-sample, multivariate longitudinal study
Continuous traumatic stress has wide-ranging implications for important life outcomes across multiple domains. We present the design protocol from the first waves of one of the most comprehensive studies of the impact of one pervasive continuous traumatic stress context—war—on individuals.…
Cyclothymic and anxious affective temperament in perinatal depression: findings from an exploratory cross-sectional study
IntroductionThe perinatal period represents a vulnerable period in which women may experience high psychic distress due to psychological, biological and social changes. The prevalence of perinatal depression (PND) is estimated around 15%-20% during pregnancy and 16%-18% after childbirth. Although several…
Auditory processing and communication in autism: exploring verbal abilities and vocal affective cues
This study examined the role of auditory processing in autism spectrum disorder, focusing on its association with verbal and non-verbal vocal communication skills in children and adolescents. A total of 97 English-speaking autistic participants (ages 7.9–17.4 years, mean = 12.3)…
Association between the geriatric nutritional risk index and postoperative delirium: a meta-analysis
BackgroundMalnutrition has been suggested as an important contributor to postoperative delirium (POD). The geriatric nutritional risk index (GNRI), a simple indicator based on serum albumin and body weight, has been increasingly evaluated in surgical patients. This meta-analysis aimed to clarify…
High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics
Nature Biotechnology, Published online: 23 April 2026; doi:10.1038/s41587-026-03107-2Intravital imaging is improved by applying deep learning to wave-optics modeling.
Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering
Nature Biotechnology, Published online: 23 April 2026; doi:10.1038/s41587-026-03076-6Retron-based systems for genome editing are functional across bacterial species.
How to meaningfully evaluate AI in clinical medicine
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04350-5How to meaningfully evaluate AI in clinical medicine
Africa’s moment for health security
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04330-9Advancing pandemic readiness to secure Africa’s health sovereignty.
Intestinal metaplasia is the only precursor to esophageal adenocarcinoma
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04332-7We integrated large-scale epidemiological and genomic data from patients with esophageal adenocarcinoma to compare cancers with and without Barrett’s esophagus (BE). We found shared risk factors, molecular features, evolutionary trajectories and BE lineage…
BOLD fMRI reflects both vascular and metabolic signals
Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02288-yA recent study by Epp et al. uses advanced, quantitative functional MRI measures to demonstrate that the ‘canonical’ interpretation of blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) — that increases and decreases in brain activation…
Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer’s disease
Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02260-wThe authors reveal entorhinal cortex dopaminergic and behavioral dysfunction in Alzheimer’s model mice, suggesting the possibility that entorhinal dopamine loss may contribute to aspects of Alzheimer’s disease.
Trump reclassifies state-licensed medical marijuana as a less-dangerous drug in a historic shift
President Trump is reclassifying state-licensed medical marijuana as a less-dangerous drug, a major policy shift long sought by advocates.
STAT+: Pharmalittle: We’re reading about cheap telehealth visits, pharma withholding meds in Europe, and more
Drugmakers have begun using coupons to discount the cost of telehealth visits with clinicians who can prescribe their drugs
The Download: introducing the Nature issue
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Introducing: the Nature issue When we talk about “nature,” we usually mean something untouched by humans.…
Across 7 hearings, RFK Jr. talks a new, more moderate MAHA
Discount telehealth visits, maternal mortality data, and more health news from Morning Rounds
STAT+: Can Erasca be biotech’s next big thing? We’ll see
Can Erasca be biotech's next big thing?
Will fusion power get cheap? Don’t count on it.
Fusion power could provide a steady, zero-emissions source of electricity in the future—if companies can get plants built and running. But a new study suggests that even if that future arrives, it might not come cheap. Technologies tend to get…
Opinion: Kennedy’s new silence on vaccines is political — and it won’t last
Kennedy’s public messaging on vaccines has shifted ahead of the midterms. It won’t last.
Steady-state Bioequivalence Study of Aripiprazole for Injection in Patients With Schizophrenia.
Conditions: Schizophrenia Interventions: Drug: Aripiprazole for Injection; Drug: Aripiprazole for Injection Sponsors: CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. Not yet recruiting
Growth, Empowerment, and Mindfulness (GEM): A Mindfulness-based Intervention to Address Mental Health in Young Adults With Early Life Adversity
Conditions: Anxiety; Depression Interventions: Behavioral: Growth, Empowerment, and Mindfulness (GEM) Sponsors: Brown University Recruiting
News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
Psychological function in the context of protracted stress during war: a multi-sample, multivariate longitudinal study
Continuous traumatic stress has wide-ranging implications for important life outcomes across multiple domains. We present the design protocol from the first waves of one of the most comprehensive studies of the impact of one pervasive continuous traumatic stress context—war—on individuals.…
Cyclothymic and anxious affective temperament in perinatal depression: findings from an exploratory cross-sectional study
IntroductionThe perinatal period represents a vulnerable period in which women may experience high psychic distress due to psychological, biological and social changes. The prevalence of perinatal depression (PND) is estimated around 15%-20% during pregnancy and 16%-18% after childbirth. Although several…
Auditory processing and communication in autism: exploring verbal abilities and vocal affective cues
This study examined the role of auditory processing in autism spectrum disorder, focusing on its association with verbal and non-verbal vocal communication skills in children and adolescents. A total of 97 English-speaking autistic participants (ages 7.9–17.4 years, mean = 12.3)…
Association between the geriatric nutritional risk index and postoperative delirium: a meta-analysis
BackgroundMalnutrition has been suggested as an important contributor to postoperative delirium (POD). The geriatric nutritional risk index (GNRI), a simple indicator based on serum albumin and body weight, has been increasingly evaluated in surgical patients. This meta-analysis aimed to clarify…
High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics
Nature Biotechnology, Published online: 23 April 2026; doi:10.1038/s41587-026-03107-2Intravital imaging is improved by applying deep learning to wave-optics modeling.
Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering
Nature Biotechnology, Published online: 23 April 2026; doi:10.1038/s41587-026-03076-6Retron-based systems for genome editing are functional across bacterial species.
How to meaningfully evaluate AI in clinical medicine
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04350-5How to meaningfully evaluate AI in clinical medicine
Africa’s moment for health security
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04330-9Advancing pandemic readiness to secure Africa’s health sovereignty.
Intestinal metaplasia is the only precursor to esophageal adenocarcinoma
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04332-7We integrated large-scale epidemiological and genomic data from patients with esophageal adenocarcinoma to compare cancers with and without Barrett’s esophagus (BE). We found shared risk factors, molecular features, evolutionary trajectories and BE lineage…
BOLD fMRI reflects both vascular and metabolic signals
Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02288-yA recent study by Epp et al. uses advanced, quantitative functional MRI measures to demonstrate that the ‘canonical’ interpretation of blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) — that increases and decreases in brain activation…
Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer’s disease
Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02260-wThe authors reveal entorhinal cortex dopaminergic and behavioral dysfunction in Alzheimer’s model mice, suggesting the possibility that entorhinal dopamine loss may contribute to aspects of Alzheimer’s disease.
Trump reclassifies state-licensed medical marijuana as a less-dangerous drug in a historic shift
President Trump is reclassifying state-licensed medical marijuana as a less-dangerous drug, a major policy shift long sought by advocates.
STAT+: Pharmalittle: We’re reading about cheap telehealth visits, pharma withholding meds in Europe, and more
Drugmakers have begun using coupons to discount the cost of telehealth visits with clinicians who can prescribe their drugs
The Download: introducing the Nature issue
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Introducing: the Nature issue When we talk about “nature,” we usually mean something untouched by humans.…
Across 7 hearings, RFK Jr. talks a new, more moderate MAHA
Discount telehealth visits, maternal mortality data, and more health news from Morning Rounds
STAT+: Can Erasca be biotech’s next big thing? We’ll see
Can Erasca be biotech's next big thing?
Will fusion power get cheap? Don’t count on it.
Fusion power could provide a steady, zero-emissions source of electricity in the future—if companies can get plants built and running. But a new study suggests that even if that future arrives, it might not come cheap. Technologies tend to get…
Opinion: Kennedy’s new silence on vaccines is political — and it won’t last
Kennedy’s public messaging on vaccines has shifted ahead of the midterms. It won’t last.
Steady-state Bioequivalence Study of Aripiprazole for Injection in Patients With Schizophrenia.
Conditions: Schizophrenia Interventions: Drug: Aripiprazole for Injection; Drug: Aripiprazole for Injection Sponsors: CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. Not yet recruiting
Growth, Empowerment, and Mindfulness (GEM): A Mindfulness-based Intervention to Address Mental Health in Young Adults With Early Life Adversity
Conditions: Anxiety; Depression Interventions: Behavioral: Growth, Empowerment, and Mindfulness (GEM) Sponsors: Brown University Recruiting