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Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
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3069 results
Computerized Cognitive Behavioral Therapy-Depression (cCBT-D) for Caregivers of Veterans
Conditions: Depression Interventions: Behavioral: cCBT-D for Caregivers Sponsors: VA Eastern Colorado Health Care System; Face the Fight; Denver Research Institute Not yet recruiting
The Download: introducing the 10 Things That Matter in AI Right Now
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Introducing: 10 Things That Matter in AI Right Now What actually matters in AI right now?…
STAT+: Publicly, Kennedy embraces a more moderate MAHA
Kennedy continues to make waves across health care, but he's pulled back on a number of core MAHA issues.
STAT+: Federal test of AI prior authorization is delaying care for seniors, report says
A new Medicare prior authorization test is delaying care at Washington state hospitals – and should be scrapped, senator says.
Former tobacco executive joins CDC senior leadership, raising concerns over industry influence
Naming a former Imperial Brands executive for a CDC job is the latest example, advocates say, of tobacco industry influence in Trump administration.
Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial
Background: Given the increasing prevalence of depression and anxiety disorders and enduring barriers to care, there is a critical need for alternative treatment options. Generative artificial intelligence (AI) chatbots show promise for increasing access to mental health care, though more…
STAT+: At AACR, talk of Chinese biotech, oncology’s comms issue, and more
At AACR, there was talk of Chinese biotech's place in cancer research, oncology’s comms issue, and more.
Video: Robert F. Kennedy Jr. testifies before Senate HELP committee
Watch RFK Jr. testify before the Senate's health care panel.
Fifth Annual SoFi Child Mind Institute Golf Invitational Raises $630,000 to Support Youth Mental Health
On April 20, the Child Mind Institute and SoFi held its fifth annual Golf Invitational at the Olympic Club in San Francisco. The event raised $630,000 to support the organization’s mission to transform the lives of children and families struggling…
Tideglusib improves novel object recognition memory in the preclinical DBA/2J mdx mouse model of Duchenne muscular dystrophy
IntroductionDuchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder characterized by progressive muscle wasting. Approximately 1 in 3 DMD patients experience cognitive dysfunction, with research suggesting an Alzheimer’s disease (AD)-like pathology. We have previously shown that treatment with the…
Exploring neural mechanisms of Mandarin tone sandhi perception via fNIRS: the role of gesture in multimodal integration
IntroductionThe use of pitch gestures in teaching Mandarin tone (i.e., gesture-augmented instruction) has been reported to facilitate lexical tone acquisition. However, the neural mechanisms underlying how gestures aid the learning of complex phonological rules, such as tone sandhi, remain unclear.…
Oral administration of kratom leaf extract alleviates anxiety-like behavior, urinary bladder pain, voiding dysfunction, and bladder hypercontractility via attenuating muscarinic receptor response in male mice exposed to chronic water avoidance stress
Psychological stress causes and deteriorates interstitial cystitis/painful bladder syndrome with urinary frequency, incontinence, bladder pain and urgency. The major alkaloid of kratom (Mitragyna speciosa), mitragynine, shows analgesic, anxiolytic, and smooth muscle relaxant effects. However, the effects of kratom leaf extract…
Chronic stress and cognitive dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: HPA axis dysregulation and hippocampal plasticity
Cognitive dysfunction is a common and disabling clinical feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), often described by patients as “brain fog.” These symptoms typically manifest as difficulties in attention, memory, and concentration. Chronic stress has been proposed as an…
Psychometric properties of Lithuanian translation of the self-report version of the Liebowitz social anxiety scale in young adult sample
BackgroundSocial anxiety disorder starts in adolescence or young adulthood and may have damaging effects on psychosocial development of the individual. Any intervention starts from assessment and the Liebowitz social anxiety scale with later developed self-report version is a valuable tool…
From stigma to support: the mediating role of sympathy between nurses’ perceived stigma and helping behavior tendency for alcohol use disorder
BackgroundThe detrimental effect of stigma on healthcare for individuals with alcohol use disorders (AUDs) is well-established, often resulting in social distance and diminished helping behavior tendencies. However, contemporary neuroscience reconceptualizes addiction as a brain disease, potentially altering emotional responses to…
The temporal stability of core symptoms of social media addiction and their comorbidity with anxiety and depression in adolescents: a longitudinal network analysis
IntroductionSocial media addiction (SMA) is often comorbid with anxiety and depression. This study examined the temporal stability of core SMA symptoms and the bridging symptoms with anxiety and depression.MethodsA total of 1,240 adolescents (179 males, 1,061 females; mean age =…
Group CBT targeting hostile attribution bias in adolescents and young adults with ASD traits
BackgroundAdolescence is characterized by heightened self-consciousness and sensitivity to social evaluations. During this period, hostile attribution bias—interpreting ambiguous social cues as hostile—can lower quality of life (QOL) and contribute to future mental health problems. Adolescents with autism spectrum disorder (ASD)…
News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
Computerized Cognitive Behavioral Therapy-Depression (cCBT-D) for Caregivers of Veterans
Conditions: Depression Interventions: Behavioral: cCBT-D for Caregivers Sponsors: VA Eastern Colorado Health Care System; Face the Fight; Denver Research Institute Not yet recruiting
The Download: introducing the 10 Things That Matter in AI Right Now
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Introducing: 10 Things That Matter in AI Right Now What actually matters in AI right now?…
STAT+: Publicly, Kennedy embraces a more moderate MAHA
Kennedy continues to make waves across health care, but he's pulled back on a number of core MAHA issues.
STAT+: Federal test of AI prior authorization is delaying care for seniors, report says
A new Medicare prior authorization test is delaying care at Washington state hospitals – and should be scrapped, senator says.
Former tobacco executive joins CDC senior leadership, raising concerns over industry influence
Naming a former Imperial Brands executive for a CDC job is the latest example, advocates say, of tobacco industry influence in Trump administration.
Effectiveness of a Fully Automated Mobile Therapeutic Versus a General Chatbot in Reducing Depression and Anxiety and Improving Well-Being: Feasibility Randomized Controlled Trial
Background: Given the increasing prevalence of depression and anxiety disorders and enduring barriers to care, there is a critical need for alternative treatment options. Generative artificial intelligence (AI) chatbots show promise for increasing access to mental health care, though more…
STAT+: At AACR, talk of Chinese biotech, oncology’s comms issue, and more
At AACR, there was talk of Chinese biotech's place in cancer research, oncology’s comms issue, and more.
Video: Robert F. Kennedy Jr. testifies before Senate HELP committee
Watch RFK Jr. testify before the Senate's health care panel.
Fifth Annual SoFi Child Mind Institute Golf Invitational Raises $630,000 to Support Youth Mental Health
On April 20, the Child Mind Institute and SoFi held its fifth annual Golf Invitational at the Olympic Club in San Francisco. The event raised $630,000 to support the organization’s mission to transform the lives of children and families struggling…
Tideglusib improves novel object recognition memory in the preclinical DBA/2J mdx mouse model of Duchenne muscular dystrophy
IntroductionDuchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder characterized by progressive muscle wasting. Approximately 1 in 3 DMD patients experience cognitive dysfunction, with research suggesting an Alzheimer’s disease (AD)-like pathology. We have previously shown that treatment with the…
Exploring neural mechanisms of Mandarin tone sandhi perception via fNIRS: the role of gesture in multimodal integration
IntroductionThe use of pitch gestures in teaching Mandarin tone (i.e., gesture-augmented instruction) has been reported to facilitate lexical tone acquisition. However, the neural mechanisms underlying how gestures aid the learning of complex phonological rules, such as tone sandhi, remain unclear.…
Oral administration of kratom leaf extract alleviates anxiety-like behavior, urinary bladder pain, voiding dysfunction, and bladder hypercontractility via attenuating muscarinic receptor response in male mice exposed to chronic water avoidance stress
Psychological stress causes and deteriorates interstitial cystitis/painful bladder syndrome with urinary frequency, incontinence, bladder pain and urgency. The major alkaloid of kratom (Mitragyna speciosa), mitragynine, shows analgesic, anxiolytic, and smooth muscle relaxant effects. However, the effects of kratom leaf extract…
Chronic stress and cognitive dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: HPA axis dysregulation and hippocampal plasticity
Cognitive dysfunction is a common and disabling clinical feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), often described by patients as “brain fog.” These symptoms typically manifest as difficulties in attention, memory, and concentration. Chronic stress has been proposed as an…
Psychometric properties of Lithuanian translation of the self-report version of the Liebowitz social anxiety scale in young adult sample
BackgroundSocial anxiety disorder starts in adolescence or young adulthood and may have damaging effects on psychosocial development of the individual. Any intervention starts from assessment and the Liebowitz social anxiety scale with later developed self-report version is a valuable tool…
From stigma to support: the mediating role of sympathy between nurses’ perceived stigma and helping behavior tendency for alcohol use disorder
BackgroundThe detrimental effect of stigma on healthcare for individuals with alcohol use disorders (AUDs) is well-established, often resulting in social distance and diminished helping behavior tendencies. However, contemporary neuroscience reconceptualizes addiction as a brain disease, potentially altering emotional responses to…
The temporal stability of core symptoms of social media addiction and their comorbidity with anxiety and depression in adolescents: a longitudinal network analysis
IntroductionSocial media addiction (SMA) is often comorbid with anxiety and depression. This study examined the temporal stability of core SMA symptoms and the bridging symptoms with anxiety and depression.MethodsA total of 1,240 adolescents (179 males, 1,061 females; mean age =…
Group CBT targeting hostile attribution bias in adolescents and young adults with ASD traits
BackgroundAdolescence is characterized by heightened self-consciousness and sensitivity to social evaluations. During this period, hostile attribution bias—interpreting ambiguous social cues as hostile—can lower quality of life (QOL) and contribute to future mental health problems. Adolescents with autism spectrum disorder (ASD)…