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From autophagy–lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders
Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder caused by loss-of-function mutations in the NPC1 gene. NPC1 deficit primarily disrupts lipid homeostasis and subsequently drives cellular degeneration through mechanisms involving impaired autophagy and mitophagy, mitochondrial dysfunction, and,…
Effects of motor imagery brain-computer interface task on quantitative EEG features in patients with prolonged disorders of consciousness
ObjectiveTo analyze quantitative electroencephalographic (EEG) characteristics during Motor Imagery Brain-Computer Interface (MI-BCI) task in patients with prolonged disorders of consciousness (pDoC).MethodsForty-three patients with pDoC due to various brain injuries were enrolled. Based on modified Coma Recovery Scale-Revised (CRS-R) assessments, the…
Multivariate age-related variations in quantitative MRI maps: widespread age-related differences revisited
This study applied multivariate ANOVA to investigate age-related microstructural changes in the brain tissues driven primarily by myelin, iron, and water content, as observed in MRI (semi-)quantitative R1, R2*, MTsat and PD maps. This is effectively a re-analysis of the…
Neurocognitive function among individuals with problematic social media use
BackgroundWith the development of technology and the internet, social networks gained momentum quickly and play a central role in daily activities. Despite this, there is a public health concern over excessive or problematic social media use. There is also a…
Psychological inflexibility and resilience in anxiety: insights from machine-learning and robust mediation-based models
IntroductionPsychological inflexibility (PI) has been associated with anxiety symptoms, while resilience serves as a protective factor; however, their roles and interrelationship remain poorly understood. We investigated the role of PI on anxiety-related symptoms while assessing the mediating role of resilience…
Heatwave-related variations in psychiatric consultations and admissions: a time-series analysis
BackgroundHeatwaves are becoming increasingly frequent and intense across Europe, posing significant risks to physical and mental health. Emerging evidence suggests that prolonged exposure to high temperatures may exacerbate psychiatric symptoms and increase the demand for acute mental health services.ObjectivesThis study…
The trajectories of Demoralization Syndrome and its related factors among elderly patients with end-stage kidney disease: a longitudinal study
ObjectiveElderly ESKD patients frequently experience a range of psychosocial difficulties, with Demoralization Syndrome (DS) being especially prevalent. This study sought to delineate distinct longitudinal trajectories of DS and to examine factors associated with trajectory membership.MethodsA prospective longitudinal cohort of 363…
Microstructural abnormalities in the ATR and VOF underlie tone awareness deficits in Chinese children with developmental dyslexia: a DTI study
ObjectiveTone awareness is crucial for reading in Chinese children, significantly affecting those with developmental dyslexia (DD). This paper identifies microstructural abnormalities in the inferior fronto-occipital fasciculus (IFOF), uncinate fasciculus (UF), anterior thalamic radiation (ATR), and vertical occipital fasciculus (VOF) in…
Author Correction: RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators
Nature Biotechnology, Published online: 18 May 2026; doi:10.1038/s41587-026-03167-4Author Correction: RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators
When cure exists but access does not
Nature Medicine, Published online: 18 May 2026; doi:10.1038/s41591-026-04396-5In this World View, Ali T. Taher explains why thalassemia is a stress test for fragile health systems.
Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states
Nature Neuroscience, Published online: 18 May 2026; doi:10.1038/s41593-026-02267-3Myeloid cells show marked heterogeneity in Alzheimer’s disease. This study introduces CODEX-CNS, a single-cell spatial proteomics pipeline, and identifies a human microglial subpopulation enriched in Alzheimer’s disease brains that associates with dense amyloid-β…
Texas is opening up a detransition clinic
Americans exposed to Ebola outbreak, Bill Cassidy's primary defeat, and more health news from Morning Rounds
Opinion: ‘Patient autonomy’ has nothing to do with childhood vaccine policies
Opinion: Vaccine policy it is not a matter of autonomy at all, because infants do not decline vaccination — their parents do.
STAT+: The China question is tearing biotech apart
China's ascent is forcing U.S. biotech companies and investors to pick a side: Is it an ally or an existential threat?
Opinion: How to restore credibility to the CDC’s vaccine advisory committee
Jesse Goodman, former director of CBER and former FDA chief scientist, calls for five critical changes to restore trust in the Advisory Committee on Immunization Practices.
Deep Brain Stimulation for Treatment-Resistant Schizophrenia
Conditions: Treatment Resistant Disorders Interventions: Device: Medtronic Percept with SensSight Deep Brain Stimulation System Sponsors: Johns Hopkins University Not yet recruiting
NST-SPARK Open-Label Phase 1 STTR (IGNITE)
Conditions: Schizophrenia / Schizoaffective Disorder Interventions: Device: NST-SPARK Sponsors: North Shore Therapeutics, Inc.; Northwell Health; University of Pennsylvania Not yet recruiting
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
Conditions: Major Depressive Disorder Interventions: Other: Placebo; Drug: DT120 Sponsors: Definium Therapeutics US, Inc. Recruiting
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Conditions: Major Depressive Disorder Interventions: Device: Motif XCS System Sponsors: Motif Neurotech, Inc.; Bright Research Partners Not yet recruiting
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji
Conditions: Resting Heart Rate; Blood Glucose Control; Depression; Heat-related Symptoms; Physician Diagnosed Heat-related Illnesses; Food Insecurity; Diet Quality; Health-Related Quality-of-Life; Indoor Thermal Comfort; Coping Ability; Life Satisfaction; Healthcare Provider Utilization; Hospitalization; Systolic Blood Pressure; Diastolic Blood Pressure; Inner Ear Canal…