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Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Conditions: Major Depression; Healthy Participants Interventions: Device: Sham iTBS; Device: TMS; Drug: D-cycloserine; Drug: Dextromethophan; Drug: Placebo Sponsors: Mclean Hospital; National Institute of Mental Health (NIMH) Not yet recruiting
Feasibility, acceptability, and user perspective of a next-generation wrist-worn receiver and digital pills for HIV pre-exposure prophylaxis: a pilot study
ObjectiveThe objective of this study was to assess the feasibility and acceptability of the next-generation wrist-worn receiver (“Reader”) coupled with the ID-Cap digital pill system (DPS) to measure adherence to oral HIV PrEP (pre-exposure prophylaxis) via an ingestible radiofrequency sensor.MethodsThis…
STAT+: U.K. advocacy groups threaten court action over a key provision in the pharma trade deal with the U.S.
A pair of advocacy groups is threatening legal action unless the U.K. government revokes regulations at the heart of a new pharma trade agreement with the U.S.
In Ebola outbreak, a number of Americans in the Congo believed to have had exposure to suspected cases
A number of Americans who are in the Congo are believed to have had exposure to suspected cases in the country’s latest Ebola outbreak, sources have told STAT.
When should you get a mammogram? Conflicting advice makes it hard to know
When should you get a mammogram? Conflicting advice makes it hard to know.
STAT+: The hantavirus outbreak is prompting Covid flashbacks — including the conspiracies
The deadly outbreak of a rare strain of hantavirus on a cruise has generated echoes of the pandemic era, including conspiracy theories.
STAT+: Sen. Bill Cassidy loses primary as race heads to run-off in win for Trump
Key health lawmaker Sen. Bill Cassidy will lose his seat, as Louisiana’s Senate primary heads for a runoff between state treasurer John Fleming and Trump-backed Rep. Julia Letlow.
WHO declares Ebola outbreak an international public health emergency
The WHO said an Ebola outbreak first seen in the Democratic Republic of the Congo was an international public health emergency, underscoring the world's concerns.
Trump blasts ‘disloyal’ Sen. Cassidy while pushing challenger in Louisiana Republican primary
Bill Cassidy, leader of the Senate committee that oversees health policy, is fighting for his political life in Louisiana's Republican primary on Saturday.
Opinion: Marty Makary misunderstood something fundamental about the FDA
“The norm-shattering masks a more fundamental misunderstanding of how administrative power can bring about lasting change,” writes Joshua Sharfstein.
Opinion: The cloudy truth about ‘blue zones’
“There's been interest in longevity, promoting it, for millennia. But this 25-year campaign really brought it to the forefront,” Eric Topol says of blue zones.
NIH-supported project expands access to care for children with amblyopia
Open-access tool guides eye doctors without specific pediatric eye care training in amblyopia diagnosis and management.
Preclinical and Emerging Clinical Evidence Supporting the Translational Potential of GLP-1 Receptor Agonists for Treating Psychostimulant and Nicotine Use Disorders
Psychostimulant use disorder (PSUD) and nicotine use disorder (NUD) affect tens of millions of people worldwide, yet no clinically-approved medications exist for PSUD and existing NUD treatments have limited long-term efficacy. Recent preclinical evidence suggests that glucagon-like peptide-1 receptor (GLP-1R)…
Psychiatric risk implications from behavioral and neural effects of adolescent exposure to environmental insecticides: a systematic review of rodent studies
Adolescence is a sensitive neurodevelopmental period marked by remodeling of brain circuits that support cognitive development and emotion and behavior regulation. These maturation processes heighten psychiatric vulnerability to environmental exposures, including to toxicants such as insecticides. Epidemiological studies show widespread…
Continuous Theta-Burst Stimulation Improves Long-Term Outcomes in Alcohol Use Disorder by Modulating a Craving-Related Dynamic Network
Alcohol use disorder (AUD) is a chronic, relapsing disorder characterized by craving. While continuous theta-burst stimulation (cTBS) shows promise for AUD, its long-term effects on drinking reduction and underlying mechanisms remain unclear. We evaluated the 12-month efficacy of right dorsolateral…
Musk v. Altman week 3: Musk and Altman traded blows over each other’s credibility. Now the jury will pick a side.
In the final week of the Musk v. Altman trial, lawyers traded blows over Elon Musk’s and OpenAI CEO Sam Altman’s credibility. Altman was grilled on his alleged history of lying and self-dealing involving companies that do business with OpenAI.…
Factors Influencing the Initiation and Continued Engagement of Digital Mental Health Tools Among Adults: Theory of Planned Behavior–Informed Systematic Review
Background: Digital mental health tools (DMHTs) offer scalable support, but engagement varies. Understanding the shapes of initiation and ongoing use is essential for effective design and implementation. Objective: This study aims to synthesize determinants of adults’ initiation and engagement with…
STAT+: FDA drug center head Tracy Beth Høeg leaves as agency faces leadership vacuum
The acting director of the FDA’s drug center, Tracy Beth Høeg, is leaving the agency. The news come days after Commissioner Marty Makary handed in his resignation.
Reducing Intrusive Trauma Memories Using a Brief Mental Imagery Competing Task Intervention: Case Series of Trauma-Exposed Women in Iceland
Background: There is a need for scalable and simple interventions for trauma-exposed people. In this case series, we built on our previous case study and case series findings and further explored the use and potential effectiveness of a brief novel…