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Large Language Models and Their Applications in Mental Health: Scoping Review
Background: Large language models (LLMs) are poised to transform mental health care, offering advanced capabilities in diagnosis, prognosis, and decision support. Since their inception, numerous mental health-focused LLMs have emerged in the scientific literature, reflecting the growing interest in leveraging…
STAT+: Takeda will pay $13.6 million to settle allegations it paid kickbacks to doctors
Takeda Pharmaceuticals agreed to pay $13.6 million to settle allegations that it paid kickbacks to doctors to prescribe an antidepressant.
Applications Open for the SNF Global Center Communicator Fellowship
The fellowship is designed to support a new generation of communicators working to shape child and adolescent mental health care in low- and middle-income countries, in addition to the SNF Global Center’s core country offices in Brazil, Greece, and South…
The Download: China’s AI drama factory and the WHO’s missing health targets
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. How Chinese short dramas became AI content machines China’s short drama industry is fueled by bite-sized,…
Molecular mechanisms of autophagy-lysosomal pathway dysfunction in neurodegenerative diseases and therapeutic strategies for lysosomal repair: a review
The autophagy-lysosomal pathway (ALP) is a critical intracellular protein degradation system responsible for maintaining proteostasis and metabolic balance within cells. Dysfunction of this pathway has been increasingly recognized as a key pathological basis underlying various neurodegenerative diseases (NDs). This review…
RNA editing in Parkinson’s disease: emerging mechanisms, translational potential, and current challenges
Parkinson’s disease (PD) is a major neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and accumulation of α-synuclein. Current treatments primarily focus on symptom alleviation, highlighting the necessity for identifying novel molecular therapeutic targets. RNA editing, as a post-transcriptional…
Exosome-based therapy for epilepsy: a systematic review and meta-analysis of preclinical studies
ObjectiveThis study aims to quantitatively assess the efficacy of exosome therapy for epilepsy through a systematic review and meta-analysis of preclinical animal experiments. We seek to clarify its overall effects on seizure reduction, cognitive function preservation, and neuroinflammation suppression.MethodsA systematic…
Autonomic dysreflexia: the concealed killer behind recurrent cerebral hemorrhage in spinal cord injury—a case report with management insights
Autonomic dysreflexia (AD) is a potentially life-threatening complication of high-level spinal cord injury (SCI), marked by paroxysmal hypertension. Although cerebrovascular events can be triggered by severe hypertension, the direct association between AD and intracerebral hemorrhage (ICH) necessitates increased clinical awareness.…
Context-dependent interaction between oxytocin gene polymorphisms and alcohol dependence in modulating negative emotions during acute alcohol withdrawal in adult males
ObjectiveThe importance of multiple gene-environment interaction (G × E) has been highlighted in understanding the etiology of negative emotions. This study examines the impact of oxytocin (OXT) polymorphisms (rs2740210, rs6133010, and rs2740209) in combination with alcohol dependence on anxiety and…
Protracted encephalopathy and subacute combined degeneration associated with chronic nitrous oxide use: a case report
Nitrous oxide is a dissociative hallucinogen that is increasingly used recreationally, in part due to its widespread availability. Its use is known to cause subacute combined degeneration via inactivation of vitamin B12; it may also result in acute delirium and…
A hierarchical machine learning model for predicting self-harm and suicidal behaviour in hospitalised patients with schizophrenia using clinical history and nursing observations
ObjectiveThis study aimed to develop and evaluate a two-layered machine learning framework that combines admission clinical information with longitudinal nursing observations to identify schizophrenia inpatients at high risk of self-harm or suicidal acts.MethodsWe retrospectively reviewed the records of 477 patients…
Shifting the Overton Window: enhancing therapeutic outcomes for Māori experiencing Ngā Māuiui kai (eating disorders) through the integration of traditional Māori and Western healing systems in Aotearoa New Zealand
Ngā māuiui kai (eating disorders) are understood within a Māori worldview as a manifestation of imbalance across hinengaro (mind), tinana (body), wairua (spirit) and whānau (family or support system). Prevailing Western treatment, which prioritise biopsychosocial interventions, do not address the…
Validation of a criterion-based screening and triage pathway for adult ADHD: a prospective observational study of safety and operational efficiency
BackgroundThe increasing demand for adult attention-deficit hyperactivity disorder (ADHD) assessments has required the development of efficient triage pathways. This study provides a formal assessment of a criterion-based screening model designed to prioritise patient safety and operational efficiency within a National…
Guide DNA — not RNA — expands the CRISPR toolkit
Nature Biotechnology, Published online: 15 May 2026; doi:10.1038/s41587-026-03138-9Cas12 nucleases can use guide DNA instead of guide RNA, which switches their targets from DNA to RNA.
DNA-guided CRISPR–Cas12 for cellular RNA targeting
Nature Biotechnology, Published online: 15 May 2026; doi:10.1038/s41587-026-03129-wΨDNA guides are used with Cas12 for precise, programmable targeting of cellular RNA.
Widespread DNA off-targeting confounds RNA chromatin occupancy studies
Nature Biotechnology, Published online: 15 May 2026; doi:10.1038/s41587-026-03130-3Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.
What Galen’s dissections reveal about tacit learning in modern medical education
Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04412-8What Galen’s dissections reveal about tacit learning in modern medical education
Favipiravir for Lassa fever: an open-label, randomized controlled phase 2 trial
Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04402-wAn open-label, randomized controlled phase 2 trial comparing favipiravir with ribavirin for the treatment of mild-to-moderate Lassa fever in Nigeria found that favipiravir was safe and well tolerated and supports its further optimization…