News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial
Nature Medicine, Published online: 02 July 2026; doi:10.1038/s41591-026-04504-5In an open-label randomized trial, a polypill containing three types of heart failure medication (metoprolol, spironolactone and empagliflozin) improved left ventricular ejection fraction and resulted in a smaller number of heart failure hospitalizations…
Neural timescales from a computational perspective
Nature Neuroscience, Published online: 02 July 2026; doi:10.1038/s41593-026-02343-8This review integrates computational approaches to provide a unified view on how data analysis methods, biophysical mechanistic models and machine learning approaches can help to uncover the origins and functions of neural timescales.
Why California’s carbon manure math doesn’t add up
Something stinks in California’s climate policies. Years ago, the state set up a system that pays cattle farmers across the country to turn the methane emitted from cattle manure into natural gas, encouraging the dairy sector to produce a gas…
Study to Evaluate the Safety and Efficacy of Ublituximab in Participants With Schizophrenia
Conditions: Schizophrenia Interventions: Drug: Ublituximab Sponsors: TG Therapeutics, Inc. Not yet recruiting
Overnight Thalamic TES-TI to Modulate Sleep Spindles in Individuals With Schizophrenia Spectrum Disorders and Matched Healthy Controls
Conditions: Schizophrenia Interventions: Device: TES-TI; Device: Sham TES-TI Sponsors: University of Wisconsin, Madison; Alkermes, Inc. Not yet recruiting
Neuromodulation of Mood Switch Circuitry in Bipolar Disorder
Conditions: Bipolar Disorder (BD); Bipolar 1 Depression; rTMS; fMRI Interventions: Device: MagVenture MagPro TMS system; Device: Sham Stimulation Sponsors: Weill Medical College of Cornell University; BD2 LLC Not yet recruiting
Accelerated iTBS for PTSD and Depression
Conditions: Post Traumatic Stress Disorder PTSD; Major Depressive Disorder (MDD) Interventions: Device: Accelerated intermittent theta burst stimulation Sponsors: Lawson Research Institute of St. Joseph's Not yet recruiting
CBITS-RTM Pilot Study
Conditions: PTSD - Post Traumatic Stress Disorder; Substance Use Interventions: Behavioral: Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM) Sponsors: University of California, San Francisco Not yet recruiting
Examining the Efficacy of Short-Term Intensive PTSD Treatment on Psychological and Cognitive Impairment Symptoms
Conditions: PTSD; Cognitive Performance Interventions: Behavioral: Cognitive Processing Therapy; Behavioral: Eye-Movement Desensitization and Reprocessing Sponsors: Ohio State University; Congressionally Directed Medical Research Programs Recruiting
Biological aging might help to explain the rising risk of early-onset cancer
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04517-0Cancers have risen rapidly in younger adults in recent generations. Analyzing large population-based cohorts, we found that recent generations exhibited signs of faster biological aging than older ones, and that systemic and organ-specific…
Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02356-3Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons
A Recap of the Inaugural Youth Mental Health Hub at SXSW London
As part of this year’s festival, the Child Mind Institute, in partnership with Wellcome, proudly presented the inaugural Youth Mental Health Hub – a week of programming dedicated to advancing solutions to one of the defining challenges of our time:…
Boys, Masculinity, and the Looksmaxxing Trend
By now, you’ve probably heard of the term looksmaxxing. Think pieces about the trend have popped up all over the internet. And in a recent episode of Saturday Night Live, comedians poked fun at lookmaxxing influencers obsessed with having the…
LLMs are stuck in a groupthink groove. This startup is trying to get them out.
Let’s start with a game. Open up your chatbot of choice—Claude, ChatGPT, Gemini—and type “Give me a random number between 1 and 10.” You’re going to get 7. Almost always. Now type “Another” and you’ll get 3 or 4. Type…
The Download: Anthropic launches Claude Science, and California’s carbon manure math
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Claude Science is Anthropic’s newest flagship product At an event for pharmaceutical executives, biotech founders, and…
Microbiota-gut-brain axis imbalance: a promising therapeutic target for preserving brain health in high-altitude environment
High-altitude hypobaric hypoxia poses a significant threat to brain function, yet effective neuroprotective strategies remain limited. Emerging evidence highlights the microbiota-gut-brain axis (MGBA) as a key mediator in high-altitude-induced cognitive impairment, positioning it as a potential therapeutic target. This review…
Integrating anatomical priors and clinical semantics for MRI-based diagnosis and care support in Alzheimer’s disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and magnetic resonance imaging (MRI) has become an important tool for its auxiliary diagnosis because it can reveal key structural abnormalities, including hippocampal and parahippocampal atrophy, ventricular enlargement, temporal cortical degeneration, and…
Inhibiting the uPAR/FPR1 interactions reduces blood-retinal barrier breakdown and improves retinal function in a rat model of diabetes
Diabetic retinopathy (DR) is a leading cause of blindness characterized by early neurovascular damage driven by hyperglycemia-induced mechanisms, including inflammation. The system composed of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR) has previously emerged as a potential regulator…
Endocannabinoid system modulation in bruxism: a neurobiological hypothesis and translational model of ECS-targeted intervention
Bruxism is a multifactorial motor behavior of predominantly central origin, characterized by repetitive masticatory muscle activity and associated with dysregulation of dopaminergic, serotonergic, GABAergic, and glutamatergic pathways involved in motor control, emotional regulation, and stress responsivity. The endocannabinoid system (ECS)…
News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial
Nature Medicine, Published online: 02 July 2026; doi:10.1038/s41591-026-04504-5In an open-label randomized trial, a polypill containing three types of heart failure medication (metoprolol, spironolactone and empagliflozin) improved left ventricular ejection fraction and resulted in a smaller number of heart failure hospitalizations…
Neural timescales from a computational perspective
Nature Neuroscience, Published online: 02 July 2026; doi:10.1038/s41593-026-02343-8This review integrates computational approaches to provide a unified view on how data analysis methods, biophysical mechanistic models and machine learning approaches can help to uncover the origins and functions of neural timescales.
Why California’s carbon manure math doesn’t add up
Something stinks in California’s climate policies. Years ago, the state set up a system that pays cattle farmers across the country to turn the methane emitted from cattle manure into natural gas, encouraging the dairy sector to produce a gas…
Study to Evaluate the Safety and Efficacy of Ublituximab in Participants With Schizophrenia
Conditions: Schizophrenia Interventions: Drug: Ublituximab Sponsors: TG Therapeutics, Inc. Not yet recruiting
Overnight Thalamic TES-TI to Modulate Sleep Spindles in Individuals With Schizophrenia Spectrum Disorders and Matched Healthy Controls
Conditions: Schizophrenia Interventions: Device: TES-TI; Device: Sham TES-TI Sponsors: University of Wisconsin, Madison; Alkermes, Inc. Not yet recruiting
Neuromodulation of Mood Switch Circuitry in Bipolar Disorder
Conditions: Bipolar Disorder (BD); Bipolar 1 Depression; rTMS; fMRI Interventions: Device: MagVenture MagPro TMS system; Device: Sham Stimulation Sponsors: Weill Medical College of Cornell University; BD2 LLC Not yet recruiting
Accelerated iTBS for PTSD and Depression
Conditions: Post Traumatic Stress Disorder PTSD; Major Depressive Disorder (MDD) Interventions: Device: Accelerated intermittent theta burst stimulation Sponsors: Lawson Research Institute of St. Joseph's Not yet recruiting
CBITS-RTM Pilot Study
Conditions: PTSD - Post Traumatic Stress Disorder; Substance Use Interventions: Behavioral: Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM) Sponsors: University of California, San Francisco Not yet recruiting
Examining the Efficacy of Short-Term Intensive PTSD Treatment on Psychological and Cognitive Impairment Symptoms
Conditions: PTSD; Cognitive Performance Interventions: Behavioral: Cognitive Processing Therapy; Behavioral: Eye-Movement Desensitization and Reprocessing Sponsors: Ohio State University; Congressionally Directed Medical Research Programs Recruiting
Biological aging might help to explain the rising risk of early-onset cancer
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04517-0Cancers have risen rapidly in younger adults in recent generations. Analyzing large population-based cohorts, we found that recent generations exhibited signs of faster biological aging than older ones, and that systemic and organ-specific…
Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02356-3Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons
A Recap of the Inaugural Youth Mental Health Hub at SXSW London
As part of this year’s festival, the Child Mind Institute, in partnership with Wellcome, proudly presented the inaugural Youth Mental Health Hub – a week of programming dedicated to advancing solutions to one of the defining challenges of our time:…
Boys, Masculinity, and the Looksmaxxing Trend
By now, you’ve probably heard of the term looksmaxxing. Think pieces about the trend have popped up all over the internet. And in a recent episode of Saturday Night Live, comedians poked fun at lookmaxxing influencers obsessed with having the…
LLMs are stuck in a groupthink groove. This startup is trying to get them out.
Let’s start with a game. Open up your chatbot of choice—Claude, ChatGPT, Gemini—and type “Give me a random number between 1 and 10.” You’re going to get 7. Almost always. Now type “Another” and you’ll get 3 or 4. Type…
The Download: Anthropic launches Claude Science, and California’s carbon manure math
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Claude Science is Anthropic’s newest flagship product At an event for pharmaceutical executives, biotech founders, and…
Microbiota-gut-brain axis imbalance: a promising therapeutic target for preserving brain health in high-altitude environment
High-altitude hypobaric hypoxia poses a significant threat to brain function, yet effective neuroprotective strategies remain limited. Emerging evidence highlights the microbiota-gut-brain axis (MGBA) as a key mediator in high-altitude-induced cognitive impairment, positioning it as a potential therapeutic target. This review…
Integrating anatomical priors and clinical semantics for MRI-based diagnosis and care support in Alzheimer’s disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and magnetic resonance imaging (MRI) has become an important tool for its auxiliary diagnosis because it can reveal key structural abnormalities, including hippocampal and parahippocampal atrophy, ventricular enlargement, temporal cortical degeneration, and…
Inhibiting the uPAR/FPR1 interactions reduces blood-retinal barrier breakdown and improves retinal function in a rat model of diabetes
Diabetic retinopathy (DR) is a leading cause of blindness characterized by early neurovascular damage driven by hyperglycemia-induced mechanisms, including inflammation. The system composed of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR) has previously emerged as a potential regulator…
Endocannabinoid system modulation in bruxism: a neurobiological hypothesis and translational model of ECS-targeted intervention
Bruxism is a multifactorial motor behavior of predominantly central origin, characterized by repetitive masticatory muscle activity and associated with dysregulation of dopaminergic, serotonergic, GABAergic, and glutamatergic pathways involved in motor control, emotional regulation, and stress responsivity. The endocannabinoid system (ECS)…