News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
The relationship between intracranial artery hemodynamics and subjective cognitive decline in patients with cerebral small vessel disease: a 4D flow study
BackgroundRecent studies link disrupted intracranial artery hemodynamics, including pulsatility index (PI), resistance index (RI), and wall shear stress (WSS), to neuroimaging features of cerebral small vessel disease (CSVD). Cognitive dysfunction is a key clinical manifestation of CSVD. Subjective cognitive decline…
The relationship between mobile phone addiction and depression, anxiety among Chinese college students: the mediating role of friendship quality and the moderating effect of preference for solitude
BackgroundThe university stage represents a critical period for the development of individual mental health. Mobile phone addiction is closely linked to depression and anxiety among college students, and both friendship quality and preference for solitude are tightly associated with college…
Smoking as a correlate of suicidal behavior and self-harm in adolescents with depressive disorders
Suicidal behavior and self-harm are major public health concerns among adolescents, particularly those with depressive disorders. While smoking has been linked to suicidality in general populations, its independent role in both suicidal behavior and self-harm within well-characterized clinical samples of…
Burned aggression: the relationship between burnout and aggressive behaviour among young adults in Czechia
IntroductionDespite stress being a critical component of burnout, few studies have investigated the relationship between burnout and aggressive behaviour. Therefore, the current study aims to verify whether states of exhaustion are associated with aggression.MethodsStructural equation models were constructed using data…
Collaborative care treatment for major depressive disorder
IntroductionMajor Depressive Disorder (MDD) is a burdensome behavioral health condition that is costly and difficult to treat, particularly for patients with severe cases. The Collaborative Care Model (CoCM) has been shown to be effective for moderate depression treatment but less…
Association of oxidative stress, metacognition, and psychopathology in patients with schizophrenia: a case-control study
BackgroundMetacognitive deficits are common in schizophrenia (SZ) and may worsen symptoms and impair insight. Oxidative stress (OS) abnormalities have also been reported, but findings are inconsistent, and no study has examined their associations with metacognition and psychopathology.MethodsThis case-control study included…
A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells
Nature Biotechnology, Published online: 01 July 2026; doi:10.1038/s41587-026-03199-wA transcriptional regulatory map of pluripotent stem cells is generated by CRISPR screening.
A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04514-3Results from an individual participant data meta-analysis across 51 randomized trials challenge the assumption that the cardiovascular benefits from antihypertensive treatment compound over a prolonged duration of treatment.
Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04483-7Local and systemic immune profiling after a controlled human influenza infection challenge in humans found that the participants with increased innate cell responsiveness were more likely to become symptomatically infected.
Blood-based circular RNAs for early diagnosis of Alzheimer’s disease
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04485-5Tested in large cohorts, a predictive model including 34 blood circular RNAs predicts progression to symptomatic AD, outperforming pTau217 and amyloid-PET.
Just how goal-directed are hippocampal theta sweeps, anyway?
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02366-1Planning is a cognitive process that is thought to be grounded in hippocampal sequences, but recent studies have suggested that a simpler mechanism, fundamentally incompatible with those planning hypotheses, underlies these sequences. Two…
Goal-directed hippocampal theta sweeps during memory-guided navigation
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02364-3Hippocampal neural activity sweeps toward remembered goals on internal maps during navigation. These goal-directed sweeps coordinate with prefrontal cortex activity and are preferentially replayed offline, supporting flexible memory-guided planning.
Hippocampal theta sweeps indicate goal direction during navigation
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02365-2Yu et al. show that hippocampal theta sweeps encode goal direction during memory-guided navigation, independent of movement or head direction and correlating with performance, providing a neural substrate for online spatial planning.
A Phase 3 Bridging Study of Viloxazine ER Capsules in Korean Children and Adolescents With ADHD
Conditions: Attention Deficit Hyperactivity Disorder; Attention-Deficit / Hyperactivity Disorder; ADHD Interventions: Drug: AK-D101; Drug: Placebo Sponsors: Alvogen Korea Not yet recruiting
Type D Personality and Life Satisfaction in Bipolar Disorder Type 2 and Major Depressive Disorder
Conditions: Bipolar Disorder II; Major Depressive Disorder (MDD) Sponsors: Elazığ Mental Health and Diseases Hospital Recruiting
Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students
Conditions: Eveningness; Insomnia; Circadian Rhythm; Depressed Mood Interventions: Behavioral: digital cognitive behavioral therapy for insomnia and digital circadian intervention; Behavioral: digital cognitive behavioral therapy for insomnia; Other: digital health education Sponsors: Chinese University of Hong Kong Not yet recruiting
Agriculture is ready for AI, but its data isn’t
Artificial intelligence is transforming what is possible in agriculture, but industry leaders should be wary of investing in AI without first laying the groundwork. The use cases are promising, especially for an industry navigating volatile fertilizer costs, unpredictable weather, and…
Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation
IntroductionCannabis use during pregnancy and the postpartum period has increased in recent years, raising clinical concerns regarding maternal and infant health, particularly during lactation. However, evidence regarding Δ9-THC concentrations in breast milk during the early postpartum period and their relationship…
The burden of care, parenting stress, and navigating welfare services: parents’ everyday experiences of young children with autism spectrum disorder
BackgroundParenting a child with autism spectrum disorder (ASD) is demanding and affects all aspects of life, yet parents’ experiences during the child’s early years remain underexplored, especially from Scandinavian countries. This study examined parents’ experiences in a Scandinavian context characterized…
Dose–response relationship of exercise interventions on sleep quality in patients with depression: a systematic review and meta-analysis
BackgroundThis meta-analysis aimed to systematically evaluate the effects of exercise interventions on sleep quality in patients with depression and to explore the dose–response relationships of key intervention parameters.MethodsA comprehensive search was conducted in PubMed, Web of Science, Embase, Scopus, and…
News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
The relationship between intracranial artery hemodynamics and subjective cognitive decline in patients with cerebral small vessel disease: a 4D flow study
BackgroundRecent studies link disrupted intracranial artery hemodynamics, including pulsatility index (PI), resistance index (RI), and wall shear stress (WSS), to neuroimaging features of cerebral small vessel disease (CSVD). Cognitive dysfunction is a key clinical manifestation of CSVD. Subjective cognitive decline…
The relationship between mobile phone addiction and depression, anxiety among Chinese college students: the mediating role of friendship quality and the moderating effect of preference for solitude
BackgroundThe university stage represents a critical period for the development of individual mental health. Mobile phone addiction is closely linked to depression and anxiety among college students, and both friendship quality and preference for solitude are tightly associated with college…
Smoking as a correlate of suicidal behavior and self-harm in adolescents with depressive disorders
Suicidal behavior and self-harm are major public health concerns among adolescents, particularly those with depressive disorders. While smoking has been linked to suicidality in general populations, its independent role in both suicidal behavior and self-harm within well-characterized clinical samples of…
Burned aggression: the relationship between burnout and aggressive behaviour among young adults in Czechia
IntroductionDespite stress being a critical component of burnout, few studies have investigated the relationship between burnout and aggressive behaviour. Therefore, the current study aims to verify whether states of exhaustion are associated with aggression.MethodsStructural equation models were constructed using data…
Collaborative care treatment for major depressive disorder
IntroductionMajor Depressive Disorder (MDD) is a burdensome behavioral health condition that is costly and difficult to treat, particularly for patients with severe cases. The Collaborative Care Model (CoCM) has been shown to be effective for moderate depression treatment but less…
Association of oxidative stress, metacognition, and psychopathology in patients with schizophrenia: a case-control study
BackgroundMetacognitive deficits are common in schizophrenia (SZ) and may worsen symptoms and impair insight. Oxidative stress (OS) abnormalities have also been reported, but findings are inconsistent, and no study has examined their associations with metacognition and psychopathology.MethodsThis case-control study included…
A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells
Nature Biotechnology, Published online: 01 July 2026; doi:10.1038/s41587-026-03199-wA transcriptional regulatory map of pluripotent stem cells is generated by CRISPR screening.
A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04514-3Results from an individual participant data meta-analysis across 51 randomized trials challenge the assumption that the cardiovascular benefits from antihypertensive treatment compound over a prolonged duration of treatment.
Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04483-7Local and systemic immune profiling after a controlled human influenza infection challenge in humans found that the participants with increased innate cell responsiveness were more likely to become symptomatically infected.
Blood-based circular RNAs for early diagnosis of Alzheimer’s disease
Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04485-5Tested in large cohorts, a predictive model including 34 blood circular RNAs predicts progression to symptomatic AD, outperforming pTau217 and amyloid-PET.
Just how goal-directed are hippocampal theta sweeps, anyway?
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02366-1Planning is a cognitive process that is thought to be grounded in hippocampal sequences, but recent studies have suggested that a simpler mechanism, fundamentally incompatible with those planning hypotheses, underlies these sequences. Two…
Goal-directed hippocampal theta sweeps during memory-guided navigation
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02364-3Hippocampal neural activity sweeps toward remembered goals on internal maps during navigation. These goal-directed sweeps coordinate with prefrontal cortex activity and are preferentially replayed offline, supporting flexible memory-guided planning.
Hippocampal theta sweeps indicate goal direction during navigation
Nature Neuroscience, Published online: 01 July 2026; doi:10.1038/s41593-026-02365-2Yu et al. show that hippocampal theta sweeps encode goal direction during memory-guided navigation, independent of movement or head direction and correlating with performance, providing a neural substrate for online spatial planning.
A Phase 3 Bridging Study of Viloxazine ER Capsules in Korean Children and Adolescents With ADHD
Conditions: Attention Deficit Hyperactivity Disorder; Attention-Deficit / Hyperactivity Disorder; ADHD Interventions: Drug: AK-D101; Drug: Placebo Sponsors: Alvogen Korea Not yet recruiting
Type D Personality and Life Satisfaction in Bipolar Disorder Type 2 and Major Depressive Disorder
Conditions: Bipolar Disorder II; Major Depressive Disorder (MDD) Sponsors: Elazığ Mental Health and Diseases Hospital Recruiting
Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students
Conditions: Eveningness; Insomnia; Circadian Rhythm; Depressed Mood Interventions: Behavioral: digital cognitive behavioral therapy for insomnia and digital circadian intervention; Behavioral: digital cognitive behavioral therapy for insomnia; Other: digital health education Sponsors: Chinese University of Hong Kong Not yet recruiting
Agriculture is ready for AI, but its data isn’t
Artificial intelligence is transforming what is possible in agriculture, but industry leaders should be wary of investing in AI without first laying the groundwork. The use cases are promising, especially for an industry navigating volatile fertilizer costs, unpredictable weather, and…
Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation
IntroductionCannabis use during pregnancy and the postpartum period has increased in recent years, raising clinical concerns regarding maternal and infant health, particularly during lactation. However, evidence regarding Δ9-THC concentrations in breast milk during the early postpartum period and their relationship…
The burden of care, parenting stress, and navigating welfare services: parents’ everyday experiences of young children with autism spectrum disorder
BackgroundParenting a child with autism spectrum disorder (ASD) is demanding and affects all aspects of life, yet parents’ experiences during the child’s early years remain underexplored, especially from Scandinavian countries. This study examined parents’ experiences in a Scandinavian context characterized…
Dose–response relationship of exercise interventions on sleep quality in patients with depression: a systematic review and meta-analysis
BackgroundThis meta-analysis aimed to systematically evaluate the effects of exercise interventions on sleep quality in patients with depression and to explore the dose–response relationships of key intervention parameters.MethodsA comprehensive search was conducted in PubMed, Web of Science, Embase, Scopus, and…