News Feed
News
1478 results
Markers of neuroinflammation in the CSF of patients with difficult to treat psychiatric disease
IntroductionThe immune system is recognized as participating in the pathophysiology of psychiatric disease and there is renewed interest in identifying biomarkers of this immune activation. MethodsWe measured serum and cerebral spinal fluid (CSF) autoantibodies with other routine and novel markers…
Excessive Internet use and depressive symptom levels in adolescents with depressive disorders: chain mediation of social anxiety and sleep quality
BackgroundAdolescents with depressive disorders are at elevated risk for adverse mental health outcomes, and excessive Internet use has been increasingly linked to greater symptom severity. Therefore, this study aimed to examine the chain mediating roles of social anxiety and sleep…
When the market asks no price: AI chatbot interaction as psychic market disruption
The rapid adoption of AI chatbots for emotional support and quasi-therapeutic interaction raises questions that existing clinical and regulatory frameworks are not equipped to address. This Perspective applies the psychic arbitrage framework—which reconceptualizes defense mechanisms as energy-conversion operations on internal…
Adverse childhood experiences and non-suicidal self-injury in adolescents: the roles of depressive symptoms and teacher care
BackgroundNon-suicidal self-injury (NSSI) has become an increasingly prominent mental health problem during adolescence and often co-occurs with depressive symptoms, anxiety, personality-related difficulties, and experiences of childhood trauma, forming a complex psychosocial risk structure. From a risk and protective factor perspective,…
Distinct sleep-disordered breathing phenotypes in elderly patients with depressive disorder: links to hypoxemia severity and inflammatory burden
ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.MethodsElderly patients with depressive disorder and OSAHS were consecutively enrolled from January to December 2025. A Gower…
Digital twins of ex vivo human lungs enable accurate and personalized evaluation of therapeutic efficacy
Nature Biotechnology, Published online: 04 May 2026; doi:10.1038/s41587-026-03121-4A comprehensive ‘digital twin’ of a human organ has been built.
An international and independent scientific foundation for AI governance
Nature Medicine, Published online: 04 May 2026; doi:10.1038/s41591-026-04375-wAn international and independent scientific foundation for AI governance
Depressive Symptoms Are Associated with Altered Development of Amygdala-Ventrolateral Prefrontal Connectivity During Implicit Emotion Regulation Across Adolescence
Adolescence is characterized by extensive development in neural circuits that support emotion processing and regulation, and by increased risk for depression. While altered frontolimbic functioning during emotion processing has been implicated in youth with depression relative to healthy controls, the…
Phasing out animal research prematurely will maintain gender inequities in medicine
Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02309-wDecades of male bias in animal research have left female biology critically understudied. Prematurely phasing out animal research would lock this inequity into future biomedicine, disproportionately harming women.
Microglia-dependent regulation of fear memory extinction
Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02286-0Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories by temporarily silencing and…
Stochastic growth and ligand–receptor interaction-mediated stabilization generate stereotyped dendritic arbors
Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02278-0Stereotyped dendritic arbors arise from stochastic growth and selective stabilization of dendritic branches. Two pools of guidance receptor are required. Ligand-free receptors drive stochastic growth while ligand-bound receptors stabilize branches.
STAT+: Biotech raises $42 million to run Huntington’s disease trial
Latus Bio raised $42 million as it prepares to seek FDA approval to start a clinical trial for its gene therapy for Huntington's disease.
Immigration changes are driving foreign researchers to leave the U.S. — or not come to begin with
Labs are seeing fewer applications from international students and researchers, and some doctoral students are considering leaving early.
Opinion: Are blue zones real? Answering that question is harder than ever
"Blue zones" as a concept have strayed far and wide from their humble roots, write Shelley Wood and Eric Topol.
Opinion: STAT+: China’s strict new supply chain regulations could create massive problems for Western biopharma companies
China is now a peer competitor in drug innovation — and it intends to stay that way on its own terms, writes Dennis Kwok.
Effects and Mechanisms of Transcranial Direct Current Stimulation Combined With Dialectical Behavior Therapy Skills Training in Adults With Attention-Deficit/Hyperactivity Disorder
Conditions: Adult Attention Deficit Hyperactivity Disorder Interventions: Device: Transcranial Direct Current Stimulation (tDCS) Sponsors: Nanjing Medical University Recruiting
Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications
Conditions: Negative Symptoms of Schizophrenia Interventions: Drug: Roluperidone; Drug: risperidone; Drug: aripiprazole; Drug: olanzapine; Drug: Placebo Sponsors: Minerva Neurosciences Recruiting
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression
Conditions: Depression; Anxiety Interventions: Drug: Psilocybin Sponsors: University of Washington Not yet recruiting
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Conditions: Treatment Resistant Depression (TRD) Interventions: Behavioral: Psychedelic Integration Coaching Sponsors: Massachusetts General Hospital; Fireside Project Recruiting
Group PACBT for Depression
Conditions: Depression - Major Depressive Disorder; Psilocybin; Cognitive Behavioral Therapy Interventions: Drug: Psilocybin (drug); Behavioral: Group Cognitive Behavioral Therapy Sponsors: University of California, Los Angeles Not yet recruiting