News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
A device that revives eyeballs from dead donors could make eye transplants possible
It’s not easy to transplant a whole human eye. The surgery is difficult. And the eyes themselves start to degenerate as soon as they’ve left the body. When surgeons attempted it a few years ago, the newly-transplanted eye wasn’t able…
High-altitude hypoxic cues and cerebral ischemic tolerance: an evidence-graded translational framework for stroke research
High altitude exposes the brain to heterogeneous hypoxic, hemodynamic, rheological, inflammatory, and healthcare-access conditions. This heterogeneity makes altitude biologically informative for stroke research, but it does not justify treating natural altitude exposure as a single protective or harmful state. In…
Oscillatory dynamics as the coordination layer of the organism: waves, Markov blankets, and the virtual space of cognition
Neural oscillations are not a mechanism that implements cognition. We present a new theoretical framework through a synthesis of relevant literature that has emerged in recent years: metabolic activity in the body, including but not limited to neural tissue, gives…
Synaptic output from suprachiasmatic nucleus cholecystokinin neurons regulates locomotor rhythmicity
BackgroundThe mammalian suprachiasmatic nucleus (SCN) serves as the master circadian pacemaker, which coordinates daily behavioral and physiological rhythms through functionally diverse neuronal subtypes. Cholecystokinin (CCK) is expressed in a subset of SCN neurons; however, its role in locomotor activity rhythms…
Focal volume, steering, and aberration correction in transcranial focused ultrasound: reconsidering the tradeoffs between single-element transducers, phased arrays, and acoustic holograms
Transducer architecture is an increasingly important design consideration in transcranial focused ultrasound, where focal precision, electronic steering, skull-aberration correction, workflow complexity, and cost must be balanced. Under matched aperture, transmit frequency, focal depth, effective source geometry, and equivalent aberration correction,…
From sympathetic storm to systemic inflammation: spatiotemporal dynamics of the brain-lung axis in neurogenic pulmonary edema
Neurogenic pulmonary edema (NPE) is a life-threatening complication of acute central nervous system (CNS) injury, characterized by the rapid onset of hypoxemia and pulmonary fluid accumulation in the absence of underlying cardiopulmonary disease. In recent years, emerging integrative frameworks such…
“Mirror, mirror, on the wall, without you, I will fall”: investigation into body dysmorphic disorder from an attachment perspective
ObjectiveBody dysmorphic disorder (BDD) is a prevalent concern among young adults. However, the underlying mechanisms of BDD development remain elusive. This study aims to investigate the intricate relationship between attachment styles and BDD symptoms, with appearance-based rejection sensitivity (ARS) as…
Intranasal esketamine plus oral antidepressant for treatment-resistant depression: acute induction and maintenance relapse-prevention outcomes in a systematic review and meta-analysis
Treatment-resistant depression (TRD) remains a major clinical challenge. Intranasal esketamine, used adjunctively with an oral antidepressant, has been evaluated in randomized trials, but uncertainty persists regarding the magnitude and consistency of benefit, durability, and key harms. This systematic review and…
Exercise interventions are most consistently supported for depressive disorders: an umbrella review of diagnosed depressive and anxiety disorders
BackgroundExercise is increasingly discussed as part of lifestyle-based and multimodal care for mood and anxiety disorders, but review-level evidence often mixes formally diagnosed clinical populations with symptom-defined or medically mixed samples.MethodsWe conducted an umbrella review of systematic reviews, meta-analyses, and…
Health outcomes across socioeconomic strata B, C, and DE among Brazilian adults living in moderate social vulnerability
ObjectivesThis study examined whether socioeconomic status was associated with anxiety symptoms, depressive symptoms, BMI, waist-to-hip ratio, and quality of life among Brazilian adults living in areas of moderate social vulnerability. In addition, we described anxiety and depressive symptoms, BMI and…
Author Correction: Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates
Nature Biotechnology, Published online: 03 July 2026; doi:10.1038/s41587-026-03246-6Author Correction: Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates
Lassa fever countermeasures gather pace
Nature Medicine, Published online: 03 July 2026; doi:10.1038/s41591-026-04478-4Two early phase clinical trials represent progress in Lassa fever vaccine and therapeutic development, including the first interventional treatment trial in decades.
Generalizable AI predicts immunotherapy outcomes across cancers and treatments
Nature Medicine, Published online: 03 July 2026; doi:10.1038/s41591-026-04502-7COMPASS is a pan-cancer foundation model that predicts immunotherapy response, across cancer types and treatments, from bulk tumor transcriptomes.
Immune aging biomarkers for clinical trials
Nature Medicine, Published online: 03 July 2026; doi:10.1038/s41591-026-04493-5The authors present a framework for the selection of immune aging biomarkers suitable for clinical trials in geroscience, alongside a translational roadmap for biomarker development to support the next generation of clinical studies…
The Download: a smoking “endgame” and a new Elizabeth Bear story
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The UK’s generational tobacco ban might not work. I’m supporting it anyway. —Jessica Hamzelou As the…
The UK’s generational tobacco ban might not work. I’m supporting it anyway.
As the parent of two little girls, I often think about how their childhood is different from mine. The seven-year-old is learning about AI at school. The five-year-old is given internet-based homework every week. And they are both absolutely repulsed…
Unlocking the chemical potential of filamentous fungi using prime editing
Nature Biotechnology, Published online: 02 July 2026; doi:10.1038/s41587-026-03219-9We developed the prime editor fPE7max, which is optimized for filamentous fungi and enables precise genome engineering — from single-base substitutions to kilobase-scale insertions and multi-kilobase deletions, across diverse species. Editing of translation-regulatory…
Why high scores do not mean application readiness for health AI
Nature Medicine, Published online: 02 July 2026; doi:10.1038/s41591-026-04500-9Large language models achieve high scores on health application benchmarks, yet adversarial stress tests now reveal prevalent brittleness — shortcut reliance, fragile visual grounding and fabricated reasoning traces — which exposes substantial gaps…
STAT+: Medicare takes another swing at 340B cuts to hospitals
Reducing Medicare payments for 340B drugs is the latest proposal focused on the hotly debated drug discount program.
News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test
Background: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this…
News
3070 results
A device that revives eyeballs from dead donors could make eye transplants possible
It’s not easy to transplant a whole human eye. The surgery is difficult. And the eyes themselves start to degenerate as soon as they’ve left the body. When surgeons attempted it a few years ago, the newly-transplanted eye wasn’t able…
High-altitude hypoxic cues and cerebral ischemic tolerance: an evidence-graded translational framework for stroke research
High altitude exposes the brain to heterogeneous hypoxic, hemodynamic, rheological, inflammatory, and healthcare-access conditions. This heterogeneity makes altitude biologically informative for stroke research, but it does not justify treating natural altitude exposure as a single protective or harmful state. In…
Oscillatory dynamics as the coordination layer of the organism: waves, Markov blankets, and the virtual space of cognition
Neural oscillations are not a mechanism that implements cognition. We present a new theoretical framework through a synthesis of relevant literature that has emerged in recent years: metabolic activity in the body, including but not limited to neural tissue, gives…
Synaptic output from suprachiasmatic nucleus cholecystokinin neurons regulates locomotor rhythmicity
BackgroundThe mammalian suprachiasmatic nucleus (SCN) serves as the master circadian pacemaker, which coordinates daily behavioral and physiological rhythms through functionally diverse neuronal subtypes. Cholecystokinin (CCK) is expressed in a subset of SCN neurons; however, its role in locomotor activity rhythms…
Focal volume, steering, and aberration correction in transcranial focused ultrasound: reconsidering the tradeoffs between single-element transducers, phased arrays, and acoustic holograms
Transducer architecture is an increasingly important design consideration in transcranial focused ultrasound, where focal precision, electronic steering, skull-aberration correction, workflow complexity, and cost must be balanced. Under matched aperture, transmit frequency, focal depth, effective source geometry, and equivalent aberration correction,…
From sympathetic storm to systemic inflammation: spatiotemporal dynamics of the brain-lung axis in neurogenic pulmonary edema
Neurogenic pulmonary edema (NPE) is a life-threatening complication of acute central nervous system (CNS) injury, characterized by the rapid onset of hypoxemia and pulmonary fluid accumulation in the absence of underlying cardiopulmonary disease. In recent years, emerging integrative frameworks such…
“Mirror, mirror, on the wall, without you, I will fall”: investigation into body dysmorphic disorder from an attachment perspective
ObjectiveBody dysmorphic disorder (BDD) is a prevalent concern among young adults. However, the underlying mechanisms of BDD development remain elusive. This study aims to investigate the intricate relationship between attachment styles and BDD symptoms, with appearance-based rejection sensitivity (ARS) as…
Intranasal esketamine plus oral antidepressant for treatment-resistant depression: acute induction and maintenance relapse-prevention outcomes in a systematic review and meta-analysis
Treatment-resistant depression (TRD) remains a major clinical challenge. Intranasal esketamine, used adjunctively with an oral antidepressant, has been evaluated in randomized trials, but uncertainty persists regarding the magnitude and consistency of benefit, durability, and key harms. This systematic review and…
Exercise interventions are most consistently supported for depressive disorders: an umbrella review of diagnosed depressive and anxiety disorders
BackgroundExercise is increasingly discussed as part of lifestyle-based and multimodal care for mood and anxiety disorders, but review-level evidence often mixes formally diagnosed clinical populations with symptom-defined or medically mixed samples.MethodsWe conducted an umbrella review of systematic reviews, meta-analyses, and…
Health outcomes across socioeconomic strata B, C, and DE among Brazilian adults living in moderate social vulnerability
ObjectivesThis study examined whether socioeconomic status was associated with anxiety symptoms, depressive symptoms, BMI, waist-to-hip ratio, and quality of life among Brazilian adults living in areas of moderate social vulnerability. In addition, we described anxiety and depressive symptoms, BMI and…
Author Correction: Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates
Nature Biotechnology, Published online: 03 July 2026; doi:10.1038/s41587-026-03246-6Author Correction: Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates
Lassa fever countermeasures gather pace
Nature Medicine, Published online: 03 July 2026; doi:10.1038/s41591-026-04478-4Two early phase clinical trials represent progress in Lassa fever vaccine and therapeutic development, including the first interventional treatment trial in decades.
Generalizable AI predicts immunotherapy outcomes across cancers and treatments
Nature Medicine, Published online: 03 July 2026; doi:10.1038/s41591-026-04502-7COMPASS is a pan-cancer foundation model that predicts immunotherapy response, across cancer types and treatments, from bulk tumor transcriptomes.
Immune aging biomarkers for clinical trials
Nature Medicine, Published online: 03 July 2026; doi:10.1038/s41591-026-04493-5The authors present a framework for the selection of immune aging biomarkers suitable for clinical trials in geroscience, alongside a translational roadmap for biomarker development to support the next generation of clinical studies…
The Download: a smoking “endgame” and a new Elizabeth Bear story
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The UK’s generational tobacco ban might not work. I’m supporting it anyway. —Jessica Hamzelou As the…
The UK’s generational tobacco ban might not work. I’m supporting it anyway.
As the parent of two little girls, I often think about how their childhood is different from mine. The seven-year-old is learning about AI at school. The five-year-old is given internet-based homework every week. And they are both absolutely repulsed…
Unlocking the chemical potential of filamentous fungi using prime editing
Nature Biotechnology, Published online: 02 July 2026; doi:10.1038/s41587-026-03219-9We developed the prime editor fPE7max, which is optimized for filamentous fungi and enables precise genome engineering — from single-base substitutions to kilobase-scale insertions and multi-kilobase deletions, across diverse species. Editing of translation-regulatory…
Why high scores do not mean application readiness for health AI
Nature Medicine, Published online: 02 July 2026; doi:10.1038/s41591-026-04500-9Large language models achieve high scores on health application benchmarks, yet adversarial stress tests now reveal prevalent brittleness — shortcut reliance, fragile visual grounding and fabricated reasoning traces — which exposes substantial gaps…
STAT+: Medicare takes another swing at 340B cuts to hospitals
Reducing Medicare payments for 340B drugs is the latest proposal focused on the hotly debated drug discount program.