News Feed
New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
News
1477 results
Artificial intelligence-based analysis of visual electrophysiological signals for clinical interpretation support
IntroductionVisual electrophysiology, including electroretinograms (ERG) and visual evoked potentials (VEP), provides a real-time functional assessment of retinal and post-retinal pathways, complementing structural imaging. Subtypes such as transient, periodic, multifocal, and code-modulated signals probe distinct physiological mechanisms and reveal pathological signatures…
Acceptance of mental illness and attitude towards pharmacotherapy among patients hospitalized in forensic psychiatry departments
Aim of the studyThe aim of the study was to assess the level of acceptance of the disease and attitudes towards pharmacological treatment in patients hospitalized in forensic psychiatry departments and to analyze the relationship between these variables and the…
Harsh discipline mediates the association between parenting stress and internalizing problems in children and adolescents: survey-based and online intervention evidence
BackgroundParenting stress evokes harsh discipline and induces internalizing problems in children and adolescents. To test this hypothesis, this study examined the potential mediating role of harsh discipline in the association between parenting stress and internalizing problems in children and adolescents…
A novel music-based real-time fMRI neurofeedback interface modulates interhemispheric connectivity and enhances mood
IntroductionMusic is a universal language that transcends cultures and is deeply rooted in human evolutionary history. Its creation and appreciation recruit the limbic and reward systems, leading to the evocation of emotions ranging from happiness and sadness to tenderness and…
Combinatorial effects of multi-site stimulation on depression-related brain regions: clinical data analysis and predictive modeling
BackgroundDespite growing evidence supporting deep brain stimulation (DBS) for treatment- resistant depression (TRD), how stimulation delivered across hemispheres or across multiple targets interact to shape large-scale network activity remains poorly characterized.ObjectiveUsing a unique opportunity to simultaneously stimulate the subcallosal cingulate…
A phenomenological study on psychological resilience among medical vocational college freshmen
BackgroundMedical vocational college freshmen face severe challenges to their psychological resilience from various stressful events upon their enrollment. This qualitative study aimed to explore the authentic experiences and intrinsic characteristics of psychological resilience among medical vocational college freshmen.MethodsThe study employed…
Tracing the rise of biomedical foundation models
Nature Biotechnology, Published online: 30 April 2026; doi:10.1038/s41587-026-03135-yA survey of biological foundation models reveals current trends and provides an outlook for future developments in this rapidly evolving field
A data-driven risk stratification framework for clinical obesity
Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04370-1To inform precision management of obesity, this study developed and externally validated a parsimonious model (OBSCORE) that accurately predicts the risk of 18 obesity-related complications. This was achieved by integrating thousands of clinical,…
Uncovering risk factors in the exposome for early-onset colorectal cancer
Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04369-8The alarming rise in the incidence of colorectal cancer among younger individuals is probably due to environmental factors; epigenetic signatures of exposures may help uncover drivers of this trend, but questions remain.
Data-driven prioritization of high-risk individuals for weight loss interventions
Nature Medicine, Published online: 30 April 2026; doi:10.1038/s41591-026-04353-2OBSCORE is a machine learning-based risk prediction tool that uses a set of clinical features to stratify individuals with a body mass index (BMI) of ≥ 27 kg m−2 by their 10-year risk of obesity-related complications, outperforming…
Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation
Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02263-7The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-CoA from other sources being used for myelination.
Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges
Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02258-4High-density single-neuron recordings in patients with epilepsy revealed interictal discharges are generated by structured laminar circuits. These circuits overlapped with cognitive circuits and could predict discharges up to 1 s in advance.
Smog from wildfires increasingly harmful, data show
American baby formula testing, Medicaid work requirements, and more Morning Rounds health news
STAT+: What does Akeso’s primo plenary spot say about its survival data?
Mystery cloaks an ASCO plenary lung cancer survival result.
STAT+: New obesity tool aims to predict risk of 18 serious complications
A new tool, OBSCORE, is meant to better define who's at risk for obesity complications, going beyond BMI to include family history, diet, and more.
Securing NIH awards is getting more competitive — and confusing
The likelihood of snagging NIH grants has plunged to historic lows, forcing academic researchers to resort to a variety of tactics to try to obtain funding
Opinion: Congress must hold RFK Jr. accountable after hearings
Michael Burgess and Larry Bucshon, former Republican congressmen and doctors, weigh in on RFK Jr.’s recent congressional hearings.
OCD LIFU Target Engagement
Conditions: Obsessive Compulsive Disorder (OCD) Interventions: Device: Low Intensity Focused Ultrasound Sponsors: University of Pennsylvania; Attune Neurosciences Inc Recruiting
Multi-target TMS for Schizophrenia Negative Symptoms
Conditions: SCHIZOPHRENIA 1 (Disorder) Interventions: Device: repetitive transcranial magnetic stimulation (rTMS) Sponsors: Shanghai Mental Health Center Recruiting
Temporal Interference in Psychiatry (TIP): Neuromodulation Using Temporal Interference
Conditions: Anxiety; PTSD Interventions: Device: Electrical stimulation device; Device: TI stimulation device Sponsors: Emory University Not yet recruiting