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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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A Scalable Trans Diagnostic Intervention Targeting Adolescent Agency Supported by Conversational AI (AGENCIA)
Conditions: Irritability; Neurodevelopmental Disorders; Impulsivity; Emotional Dysregulation; Distress, Emotional; Distress, Psychological Interventions: Behavioral: AGENCIA Digital Self-Guided; Behavioral: AGENCIA In-person With Digital Assistant Sponsors: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla; Hospital Universitario Virgen del Rocio; Instituto…
Many Trauma-affected Youth Face Long Waits for Therapy, Worsening Stress, and Avoidance. CISS, a 90-minute Session Based on Stanford’s Cue-Centered Therapy, Offers Coping Tools and Psychoeducation During This Gap. This Pilot Tests CISS’s Feasibility, Acceptability, and Impact on 30-40 Adolescents.
Conditions: Wellbeing; Mental Health; Psychological; Stress; Trauma Exposure Interventions: Other: Cue-Centered Therapy (CCT)-Informed Single Session Intervention (CISS) Sponsors: Stanford University; University of Auckland, New Zealand; Health New Zealand Not yet recruiting
STAT+: Supreme Court justices appear to signal ‘skinny labeling’ can survive
At Wednesday's argument, the justices did not appear to question whether skinny labeling is valid.
The Comprehensive Assessment of Social Media Use: Development and Validation Study
Background: Nearly all youth use the internet daily, with many maintaining several social media accounts. As increasing numbers of young people engage online and the ways we communicate fundamentally change, it is increasingly important to ask: how do these shifts…
Designing and Evaluating Digital Mental Health Interventions: Scoping Review
Background: The ongoing adoption and use of digital interventions offer promising opportunities to meet the growing demand for mental health support. The effectiveness, implementation, and usage of these interventions depend on how well they are designed and evaluated. However, given…
Errors in AI-Transformed Patient-Centered Mental Health Documentation Written by Psychiatrists: Qualitative Pre-Post Study
Background: Patients’ digital access to their personal health data is becoming increasingly common worldwide. However, medical documentation often contains technical language and sensitive information, which can lead to potential misunderstandings and distress among patients. These issues may be particularly impactful…
STAT+: Why conversations around health AI may be evolving beyond hype
In this edition of AI Prognosis, Brittany Trang argues that the tide may be turning when it comes to how the health care industry talks about AI.
Infant formula largely safe from heavy metals, FDA finds
FDA sampled 312 major infant formula brands and found low or undetectable levels of pesticide residue, PFAS, heavy metals and phthalates.
STAT+: A patent win for Pfizer and BridgeBio
A change to FDA clinical trial data review, Rocket sells its priority review voucher, and more biotech news from The Readout
STAT+: Pharmalittle: We’re reading about the FDA speeding up trials, a Supreme Court hearing on ‘skinny labels,’ and more
The FDA announced efforts to make clinical trials more efficient, starting by reviewing data in real time from trials conducted by AstraZeneca and Amgen
The Download: storing nuclear waste and orchestrating agents
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. It’s time to make a plan for nuclear waste Today, nuclear energy enjoys rare support across…
Mechanistic insights from experimental autoimmune encephalomyelitis into immune regulation, autophagy, gut microbiota, blood-brain barrier integrity, and NLRP3 inflammasome-mediated pyroptosis in multiple sclerosis: potential clinical implications
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammatory demyelination in the central nervous system, predominantly presenting in young adults, with a steadily increasing global incidence. In China, MS is classified as a rare disease and imposes a…
Bibliometric analysis of neurite orientation dispersion and density imaging: research patterns, evolution, and frontier
BackgroundNeurite orientation dispersion and density imaging (NODDI), an emerging diffusion MRI technique for estimating the microstructural pathology of brain tissue in vivo, has attracted significant research interest. However, a systematic bibliometric analysis of this field remains unexamined. This study aims…
Serum cystatin C levels are independently correlated with cognitive impairment in individuals with cerebral small vessel disease
Background and purposePrevious studies have shown that serum cystatin C (CysC) is associated with cerebral small vessel disease (CSVD) and that elevated CysC levels are linked to an increased risk of cognitive impairment in the elderly. However, whether CysC is…
Autonomic-vascular dysregulation in CKD-associated hypertension: a narrative review with evidence hierarchy
Hypertension and chronic kidney disease frequently coexist and mutually accelerate cardiovascular and renal injury. This narrative review prioritizes direct human autonomic phenotyping (Level 1: microneurography, HRV/BRS), human vascular correlates (Level 2: PWV, FMD), and complementary preclinical evidence (Level 3) to…
Effects of bifrontal-transcranial direct current stimulation combined with music listening on sleep quality, cortical activation and functional connectivity in patients with insomnia: a randomised controlled trial by fNIRS
BackgroundAlthough music listening and transcranial direct current stimulation (tDCS) alone have certain effects in the treatment of insomnia, the sleep regulatory effects and neural mechanisms of the combined treatment in patients with insomnia disorder (ID) are unclear. This study aimed…
The long-term psychological processing of an autism spectrum disorder diagnosis in parents
IntroductionA child’s ASD diagnosis represents a critical event for parents, often requiring them to face the loss of their child’s ideal image and reevaluate the family life projects. The aim of this study is to explore how parents retrospectively reconstruct…
Acupoint temperature as a biomarker: infrared thermography in the diagnosis of adolescents with major depressive disorder
BackgroundThe prevalence of adolescent major depressive disorder (MDD) is rising; however, diagnosis relies on subjective measures due to a lack of objective biomarkers. This study explored infrared thermography (IRT) as a non-invasive tool to quantify thermal radiation characteristics of acupoints…