News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
Prime editing for precise genome engineering and modulation of fungal metabolism
Nature Biotechnology, Published online: 30 June 2026; doi:10.1038/s41587-026-03202-4fPE7max efficiently installs base substitutions, insertions and deletions to modulate filamentous fungal metabolism.
Author Correction: Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial
Nature Medicine, Published online: 30 June 2026; doi:10.1038/s41591-026-04540-1Author Correction: Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial
Multi-antigen-targeting T cells in pediatric central nervous system tumors: a phase 1 trial
Nature Medicine, Published online: 30 June 2026; doi:10.1038/s41591-026-04449-9In the phase 1 ReMIND trial of tumor-associated antigen-specific T cells in patients with pediatric central nervous system tumors, treatment was generally well tolerated with one complete response and three long-term responders.
Clinical decision support in hematological malignancies using a case-grounded AI agent
Nature Medicine, Published online: 30 June 2026; doi:10.1038/s41591-026-04494-4A locally deployable, case-grounded large language model agent achieved high concordance with hematology tumor board decisions across retrospective, external and prospective evaluations.
Connectomic evidence that ordered activity drives neuromuscular network formation
Nature Neuroscience, Published online: 30 June 2026; doi:10.1038/s41593-026-02344-7Complete neuromuscular connectomes across development show that motor neuron recruitment order shapes both local and long-distance synapse elimination, leaving adult wiring as a structural record of the activity patterns that formed it.
Building tech in the world’s secret R&D hub
Apple. Anthropic. Disney Research. Google. Meta. Microsoft. NVIDIA. OpenAI. Few places outside Silicon Valley can claim R&D hubs from all of these companies. Fewer still are concentrated in a city of just over 400,000 people—roughly half the size of San…
This Study Aims to Compare the Efficacy and Safety of Lumateperone and Cariprazine in Patients With Bipolar I Depression Using Montgomery-Åsberg Depression Rating Scale (MADRS) and Clinical Global Impression Bipolar Severity Scale (CGI-BP-S) and Recording Treatment Emergent Adverse Effects.
Conditions: Bipolar 1 Depression Interventions: Drug: Lumateperone; Drug: Cariprazine Sponsors: Watim Medical & Dental College Not yet recruiting
Clinical Risk Score Prediction for Risk of Dementia Among Late-life Population With Depression
Conditions: Alzheimer Dementia (AD); Dementia; Late Life Depression (LLD); Risk Scores; Prediction; Chinese Population; Obs e r; Observational Cohort Study; External Validation Interventions: Other: No Intervention: Observational Cohort Sponsors: Second Affiliated Hospital of Nanchang University Recruiting
Anorexia Prevention in Female College Students
Conditions: Eating Disorder Risk; Body Shape Concern Interventions: Behavioral: Acceptance-Based Embodied Movement; Behavioral: Functional Fitness Control; Behavioral: Psychoeducation Sponsors: Jinan University Guangzhou Completed
The effect of weather on unscheduled healthcare utilisation for mental health conditions in England, 2014–2022
BackgroundWeather conditions have been linked to adverse mental health outcomes, and rising concern about climate change has increased interest in these associations. However, most existing research focuses on extreme weather events, such as heatwaves, or on acute clinical outcomes, such…
Delivering the benefits of genomic data reanalysis for diagnosis equitably and at scale
Nature Medicine, Published online: 29 June 2026; doi:10.1038/s41591-026-04516-1We developed a tool, Talos, for automated reanalysis of genomic data from patients with a rare disease and show that frequent reanalysis can be delivered at scale and low cost. Talos is open…
Author Correction: SEZ6-targeting antibody−drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial
Nature Medicine, Published online: 29 June 2026; doi:10.1038/s41591-026-04544-xAuthor Correction: SEZ6-targeting antibody−drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial
Treating ADHD With Methylphenidate (Ritalin, Concerta)
Methylphenidate is a stimulant medication used to treat symptoms of ADHD. It helps the brain regulate attention, focus, and impulsive behaviors. It’s one of the two stimulants widely used in ADHD medications. Methylphenidate is the active ingredient in Ritalin and…
AI agents are not your “coworkers”
This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here. Imagine coming in to work to learn that a new underling will report to you. The worker…
Agent confidence on the technical frontier
Enterprise investment in AI is booming. Gartner is calling 2026 an “inflection year” for organizations to align their AI projects with strategic business objectives. As the pressure to prove ROI mounts, executives and technology leaders are looking to agentic AI…
The Download: metric weaknesses and AI elephant warnings
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The inevitable weakness of metrics There are plenty of useful things a metric can reveal. There…
Association of MAP2 gene polymorphisms and altered expression with schizophrenia risk in a Chinese Han population
BackgroundSchizophrenia (SCZ) is a highly heritable primary psychotic disorder. The microtubule-associated protein 2 (MAP2) gene is essential for dendritic integrity and synaptic plasticity, positioning it as a key candidate for bridging genetic risk and neuropathology. Nevertheless, the role of common…
Association between objective sleep structure and suicidal ideation in patients with depression: a study based on polysomnographic regression and cluster analysis
BackgroundDepression is a common mental disorder, and current suicidal ideation (SI) is a clinically important symptom. Sleep disturbance is common in depression, but the relationship between objective sleep architecture and current SI remains unclear. This study examined associations between objective…
Subjective sleepiness and objective sleep propensity in adults with attention-deficit/hyperactivity disorder referred for multiple sleep latency testing
IntroductionAdults with attention-deficit/hyperactivity disorder (ADHD) often report excessive daytime sleepiness, but the relationship between subjective sleepiness and objective sleep propensity remains unclear. We examined this relationship in adults referred for Multiple Sleep Latency Test (MSLT) evaluation, using a clinical comparison…
Associations of TNF-α, MIF, and cortisol with cognitive function in patients with bipolar disorder during acute manic episodes: a short-term follow-up study
BackgroundBipolar disorder (BD) is frequently accompanied by cognitive impairment, and growing evidence suggests that immune-inflammatory activation and hypothalamic-pituitary-adrenal axis dysregulation may contribute to its pathophysiology. This study aimed to examine the associations of tumor necrosis factor-α (TNF-α), macrophage migration inhibitory…
News Feed
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
Prime editing for precise genome engineering and modulation of fungal metabolism
Nature Biotechnology, Published online: 30 June 2026; doi:10.1038/s41587-026-03202-4fPE7max efficiently installs base substitutions, insertions and deletions to modulate filamentous fungal metabolism.
Author Correction: Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial
Nature Medicine, Published online: 30 June 2026; doi:10.1038/s41591-026-04540-1Author Correction: Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial
Multi-antigen-targeting T cells in pediatric central nervous system tumors: a phase 1 trial
Nature Medicine, Published online: 30 June 2026; doi:10.1038/s41591-026-04449-9In the phase 1 ReMIND trial of tumor-associated antigen-specific T cells in patients with pediatric central nervous system tumors, treatment was generally well tolerated with one complete response and three long-term responders.
Clinical decision support in hematological malignancies using a case-grounded AI agent
Nature Medicine, Published online: 30 June 2026; doi:10.1038/s41591-026-04494-4A locally deployable, case-grounded large language model agent achieved high concordance with hematology tumor board decisions across retrospective, external and prospective evaluations.
Connectomic evidence that ordered activity drives neuromuscular network formation
Nature Neuroscience, Published online: 30 June 2026; doi:10.1038/s41593-026-02344-7Complete neuromuscular connectomes across development show that motor neuron recruitment order shapes both local and long-distance synapse elimination, leaving adult wiring as a structural record of the activity patterns that formed it.
Building tech in the world’s secret R&D hub
Apple. Anthropic. Disney Research. Google. Meta. Microsoft. NVIDIA. OpenAI. Few places outside Silicon Valley can claim R&D hubs from all of these companies. Fewer still are concentrated in a city of just over 400,000 people—roughly half the size of San…
This Study Aims to Compare the Efficacy and Safety of Lumateperone and Cariprazine in Patients With Bipolar I Depression Using Montgomery-Åsberg Depression Rating Scale (MADRS) and Clinical Global Impression Bipolar Severity Scale (CGI-BP-S) and Recording Treatment Emergent Adverse Effects.
Conditions: Bipolar 1 Depression Interventions: Drug: Lumateperone; Drug: Cariprazine Sponsors: Watim Medical & Dental College Not yet recruiting
Clinical Risk Score Prediction for Risk of Dementia Among Late-life Population With Depression
Conditions: Alzheimer Dementia (AD); Dementia; Late Life Depression (LLD); Risk Scores; Prediction; Chinese Population; Obs e r; Observational Cohort Study; External Validation Interventions: Other: No Intervention: Observational Cohort Sponsors: Second Affiliated Hospital of Nanchang University Recruiting
Anorexia Prevention in Female College Students
Conditions: Eating Disorder Risk; Body Shape Concern Interventions: Behavioral: Acceptance-Based Embodied Movement; Behavioral: Functional Fitness Control; Behavioral: Psychoeducation Sponsors: Jinan University Guangzhou Completed
The effect of weather on unscheduled healthcare utilisation for mental health conditions in England, 2014–2022
BackgroundWeather conditions have been linked to adverse mental health outcomes, and rising concern about climate change has increased interest in these associations. However, most existing research focuses on extreme weather events, such as heatwaves, or on acute clinical outcomes, such…
Delivering the benefits of genomic data reanalysis for diagnosis equitably and at scale
Nature Medicine, Published online: 29 June 2026; doi:10.1038/s41591-026-04516-1We developed a tool, Talos, for automated reanalysis of genomic data from patients with a rare disease and show that frequent reanalysis can be delivered at scale and low cost. Talos is open…
Author Correction: SEZ6-targeting antibody−drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial
Nature Medicine, Published online: 29 June 2026; doi:10.1038/s41591-026-04544-xAuthor Correction: SEZ6-targeting antibody−drug conjugate ABBV-706 in advanced small cell lung cancer and solid tumors: a phase 1 trial
Treating ADHD With Methylphenidate (Ritalin, Concerta)
Methylphenidate is a stimulant medication used to treat symptoms of ADHD. It helps the brain regulate attention, focus, and impulsive behaviors. It’s one of the two stimulants widely used in ADHD medications. Methylphenidate is the active ingredient in Ritalin and…
AI agents are not your “coworkers”
This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here. Imagine coming in to work to learn that a new underling will report to you. The worker…
Agent confidence on the technical frontier
Enterprise investment in AI is booming. Gartner is calling 2026 an “inflection year” for organizations to align their AI projects with strategic business objectives. As the pressure to prove ROI mounts, executives and technology leaders are looking to agentic AI…
The Download: metric weaknesses and AI elephant warnings
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The inevitable weakness of metrics There are plenty of useful things a metric can reveal. There…
Association of MAP2 gene polymorphisms and altered expression with schizophrenia risk in a Chinese Han population
BackgroundSchizophrenia (SCZ) is a highly heritable primary psychotic disorder. The microtubule-associated protein 2 (MAP2) gene is essential for dendritic integrity and synaptic plasticity, positioning it as a key candidate for bridging genetic risk and neuropathology. Nevertheless, the role of common…
Association between objective sleep structure and suicidal ideation in patients with depression: a study based on polysomnographic regression and cluster analysis
BackgroundDepression is a common mental disorder, and current suicidal ideation (SI) is a clinically important symptom. Sleep disturbance is common in depression, but the relationship between objective sleep architecture and current SI remains unclear. This study examined associations between objective…
Subjective sleepiness and objective sleep propensity in adults with attention-deficit/hyperactivity disorder referred for multiple sleep latency testing
IntroductionAdults with attention-deficit/hyperactivity disorder (ADHD) often report excessive daytime sleepiness, but the relationship between subjective sleepiness and objective sleep propensity remains unclear. We examined this relationship in adults referred for Multiple Sleep Latency Test (MSLT) evaluation, using a clinical comparison…
Associations of TNF-α, MIF, and cortisol with cognitive function in patients with bipolar disorder during acute manic episodes: a short-term follow-up study
BackgroundBipolar disorder (BD) is frequently accompanied by cognitive impairment, and growing evidence suggests that immune-inflammatory activation and hypothalamic-pituitary-adrenal axis dysregulation may contribute to its pathophysiology. This study aimed to examine the associations of tumor necrosis factor-α (TNF-α), macrophage migration inhibitory…