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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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Historic FDA approval brings first gene therapy for genetic deafness
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03145-wThe first-of-its-kind genetic medicine treats a rare and profound otoferlin-related hearing loss, and will be made available by Regeneron for free in the United States.
STAT+: Health system CEOs get off easy at Congressional hearing on affordability
Committee members largely blamed the other party’s health care policies for driving U.S. health care prices to levels inaccessible to many Americans.
Prevalence of Cognitive Distortion Markers in a Suicide Prevention Chat Service: Mixed Methods Study
Background: Suicide helplines increasingly employ chat services to aid those in urgent need, but the wording and structure of text-driven exchanges may affect their effectiveness. Objective: Given the association of cognitive distortions with depression and anxiety, this study investigated their…
STAT+: AIDS group sues Trump administration over undisclosed agreement with Gilead
The AIDS advocacy group PrEP4All has sued the Trump administration over an undisclosed agreement with Gilead.
STAT+: FDA launches effort to speed up clinical trials, using AI
Monitoring trials in real time may help shorten the time interval between trial phases.
Opinion: Healthcare or health care? Help STAT decide
Should STAT use “healthcare” or “health care”? We want to hear from you.
Opinion: FDA commissioner: ‘Smarter,’ real-time clinical trials could transform drug development
“For the first time, FDA regulators will be able to see what’s happening in a clinical trial, looking at endpoints in the cloud as they occur,” writes FDA commissioner.
The Download: Musk and Altman’s legal showdown, and AI’s profit problem
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Elon Musk and Sam Altman are going to court over OpenAI’s future Elon Musk and OpenAI…
A structured narrative review on VNS-treated drug-resistant epilepsy: EEG markers, neurochemical mechanisms, and future biomarker-driven computational directions
Vagus nerve stimulation (VNS) is an established adjunctive therapy for drug-resistant epilepsy. Experimental and clinical evidence indicates that its therapeutic effects involve distributed brain networks and multiple neurochemical pathways. Electroencephalography (EEG) has been widely used to characterize VNS-related neurophysiological changes,…
Experimental investigation of sharp-tip microwire-based brain electrode buckling during implantation through dura and pia mater
IntroductionWide use of miniaturized and flexible microwire electrodes faces challenges of wire buckling against the brain membrane layers. The field lacks quantitative understanding of such buckling phenomena, especially on the effective length factor, which is required to determine the wire’s…
Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer’s disease and non-Alzheimer’s dementias
IntroductionWe aimed to understand the pathophysiological differences between 16 Alzheimer’s disease (AD) and 15 non-AD dementia patients by quantifying oxygen extraction fraction (OEF) in cortical (CGM) and deep gray matter (DGM) regions.MethodsTo achieve this, we used a novel MRI-based OEF…
Functional connectivity changes in the thalamocortical network due to neck pain and the multiscale regulatory effects of acupuncture: a cross-scale multi-omics neuroimaging study
BackgroundNeck pain correlates with multiscale brain abnormalities, but cross-scale mechanisms of acupuncture analgesia are unclear. This study aimed to: (1) Explore differential modulation of thalamic functional networks by verum vs. sham acupuncture; (2) Examine associations between functional connectivity changes and…
Safety and preliminary efficacy of Aurora: a pilot, non-randomized clinical trial of a culturally adapted digital cognitive behavioral therapy intervention for anxiety and depression in Mexico
Background/objectiveAnxiety and depressive disorders are leading causes of disability worldwide, and access to evidence-based psychological treatment remains limited in many middle-income countries. Digital cognitive–behavioral therapy (CBT) interventions have emerged as scalable tools to address this treatment gap, yet few have…
Quality, reliability, and transparency of late-life depression videos on Chinese social media: a cross-sectional study of Douyin, Rednotes, and BiliBili
BackgroundLate-life depression is common in older adults and is often under-recognized. Short-video platforms have become a major source of mental health information. However, content quality and transparency remain uncertain.MethodsWe conducted a cross-sectional assessment of highly viewed videos on late-life depression…
Real-world effectiveness of medication-assisted treatment and psychotherapy for opioid use disorder: a national multi–health care organization analysis
BackgroundHarm reduction strategies for opioid use disorder (OUD) emphasize pragmatic, evidence-based approaches that reduce overdose risk, relapse, and other adverse outcomes without requiring abstinence. Medication for opioid use disorder (MOUD) and structured psychotherapy represent core harm-reduction modalities, yet their real-world…
Scoping review of therapeutic approaches among individuals with secondary exercise addiction
Secondary exercise addiction shows high comorbidity with eating and body image disorders. Despite its substantial impact on physical and mental health and daily functioning, evidence on effective therapeutic interventions remains limited. The aim of this scoping review was to identify…
A prospective cohort study on the incidence and influencing factors of subsyndromal delirium in ICU patients
BackgroundThis study aims to develop and validate a machine learning-based risk prediction model for subsyndromal delirium (SSD) in ICU patients, while identifying key risk factors.MethodThis study was a prospective study, selecting patients who were hospitalized in the ICU from October…
Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03097-1Pooled production of recombinant AAV vectors leads to frequent genetic recombination.