News Feed
Most Accurate Non-Invasive Tests for Liver Disease Identified in Landmark Studies
Two major studies have identified the most accurate non-invasive tests for diagnosing and assessing the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), potentially reducing the need for liver biopsies. The post Most Accurate…
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
The impact of amblyopia, reduced viewing conditions and binocular vision on reading ability: a narrative review
Amblyopia is a neurodevelopmental disorder of the visual cortex which leads to issues in visual acuity, contrast sensitivity and eye movement patterns, all characteristics which, along with other deficits may negatively influence reading skills. Individuals with reduced reading capabilities due…
Prediction of cardiac cycle duration for cardiac-gated closed-loop auricular vagus nerve stimulation
Auricular vagus nerve stimulation (aVNS) is a neuromodulation technology that establishes balance in the autonomic nervous system and, in turn, provides therapy for numerous chronic ailments. Personalized aVNS adapts the stimulation parameters in accordance with the time-varying physiological state of…
DyAMNet: dynamic adversarial and contrastive network for EEG biometrics
IntroductionElectroencephalogram (EEG)-based biometric recognition for brain–computer interfaces faces challenges from domain shifts, temporal nonstationarity, and limited scalability.MethodsTo address these issues, we present DyAMNet, a framework that combines EEG microstate analysis with a hybrid attention mechanism. DyAMNet employs dynamic loss balancing…
Module-specific diagnostic accuracy of ADOS-2 in real-world clinical referral populations: an updated systematic review and HSROC meta-analysis
BackgroundThe Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), is widely used in the diagnostic evaluation of autism spectrum disorder (ASD); however, its diagnostic performance in real-world clinical referral populations remains heterogeneous, particularly across modules and clinical contexts. This systematic review…
Elevated NHHR at admission is independently associated with elevated post-stroke depressive symptoms
BackgroundElevated post-stroke depressive symptoms are common among acute ischemic stroke (AIS) survivors and are associated with poor functional recovery. However, readily available biomarkers reflecting lipid–inflammation status remain limited. The ratio of non–high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) may…
Suicide and suicidal behavior in the gulf cooperation council countries: a Systematic Review of behavioral patterns, sociocultural determinants, and structural vulnerabilities
Suicide and suicidal behavior in the Gulf Cooperation Council (GCC) countries remain underrepresented in empirical research, largely due to cultural stigma, legal prohibitions, and systematic underreporting. The behavioral and sociocultural determinants of suicidal behavior in these contexts—where rapid modernization intersects…
Efficacy and predictors of cognitive stimulation therapy combined with pharmacotherapy for mild-to-moderate Alzheimer’s disease: a randomized controlled trial
IntroductionAlzheimer’s disease (AD) is associated with progressive cognitive decline, functional impairment, and reduced quality of life. Although pharmacological treatments such as cholinesterase inhibitors and memantine are commonly used, their clinical benefits remain limited and heterogeneous. Cognitive stimulation therapy (CST) may…
Mapping the spatial landscape of extracellular vesicles in tissues with Spatial-EV-seq
Nature Biotechnology, Published online: 26 June 2026; doi:10.1038/s41587-026-03206-0Spatial-EV-seq is a method for spatially resolved profiling of extracellular vesicles (EVs) in tissues while preserving EVs’ native distribution. By integrating EV mapping with spatial transcriptomics, Spatial-EV-seq enables location-specific analysis of EVs and…
Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq
Nature Biotechnology, Published online: 26 June 2026; doi:10.1038/s41587-026-03192-3Spatial-EV-seq reveals spatial patterns of extracellular vesicles in tissues.
Adaptive brain stimulation 2.0 for Parkinsonian gait
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04489-1Two studies show that adaptive neuromodulation can improve Parkinsonian gait by matching stimulation to the right circuit at the right moment, pointing toward strategies that decompose complex symptoms into targetable spatial and temporal…
Immersive virtual reality with synchronous neurostimulation for upper-limb recovery after stroke: a randomized feasibility trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04486-4A multimodal platform combining immersive virtual reality with a synchronous sensory neurostimulation protocol outperformed conventional rehabilitation in individuals with chronic stroke, driving upper-limb motor gains, restored body representation and improved tactile acuity while…
Re-administration of AAV-mediated gene therapy for OTOF-related deafness: a single-arm trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04505-4As part of a clinical trial, re-administration of AAV gene therapy in four patients with congenital deafness, who had previously received a first gene therapy dose and developed neutralizing antibodies, was safe and…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04503-6A pragmatic cluster-randomized trial found that ChatGPT-4o-assisted decision support in Kenyan primary care facilities did not significantly reduce 14-day treatment failure over usual care.
Cliramitug for depletion of cardiac amyloid transthyretin: long-term follow-up of the NI006-101 trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04487-3In an open-label extension study of the NI006-101 trial, in which patients with transthyretin amyloidosis cardiomyopathy were treated with the monoclonal antibody cliramitug, which targets misfolded transthyretin, long-term follow-up for a median of…
Mitochondrial stress response drives microglial senescence
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02264-6The mitochondrial unfolded protein response (UPRmt) drives microglial senescence and disrupts essential glia–neuron communication. By triggering lipid droplet accumulation and dysregulating the S-adenosylmethionine–polyamine axis, UPRmt fuels the senescence-associated secretory pathway, impairs synaptic pruning…
Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02342-9D’Ambrogio et al. combine deep learning and symbolic regression to report an interpretable equation of how humans value information. The equation predicts choices and neural activity in anterior insula, cingulate cortex and midbrain…
The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02320-1Mitochondrial proteotoxic stress rewires methionine and lipid metabolism in human microglia, driving cellular senescence and disrupting neuronal–glial communication, revealing a mechanism linking mitochondrial dysfunction to brain aging and neurodegeneration.
Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02331-yPascoli et al. show that nucleus accumbens dopamine transients evoked by reward-predictive cues encode subjective reward value in mice, predicting individual preference for drugs over natural rewards and forecasting vulnerability to compulsive drug-seeking…
Striatal control of amygdalar acetylcholine release during salience-associated processing
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02353-6Amygdalar acetylcholine signals dynamically represent salience. Chen et al. show that striatal D1 and D2 neurons oppositely control these signals via basal forebrain cholinergic pathways to shape salience-associated learning.
News Feed
Most Accurate Non-Invasive Tests for Liver Disease Identified in Landmark Studies
Two major studies have identified the most accurate non-invasive tests for diagnosing and assessing the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), potentially reducing the need for liver biopsies. The post Most Accurate…
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
The impact of amblyopia, reduced viewing conditions and binocular vision on reading ability: a narrative review
Amblyopia is a neurodevelopmental disorder of the visual cortex which leads to issues in visual acuity, contrast sensitivity and eye movement patterns, all characteristics which, along with other deficits may negatively influence reading skills. Individuals with reduced reading capabilities due…
Prediction of cardiac cycle duration for cardiac-gated closed-loop auricular vagus nerve stimulation
Auricular vagus nerve stimulation (aVNS) is a neuromodulation technology that establishes balance in the autonomic nervous system and, in turn, provides therapy for numerous chronic ailments. Personalized aVNS adapts the stimulation parameters in accordance with the time-varying physiological state of…
DyAMNet: dynamic adversarial and contrastive network for EEG biometrics
IntroductionElectroencephalogram (EEG)-based biometric recognition for brain–computer interfaces faces challenges from domain shifts, temporal nonstationarity, and limited scalability.MethodsTo address these issues, we present DyAMNet, a framework that combines EEG microstate analysis with a hybrid attention mechanism. DyAMNet employs dynamic loss balancing…
Module-specific diagnostic accuracy of ADOS-2 in real-world clinical referral populations: an updated systematic review and HSROC meta-analysis
BackgroundThe Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), is widely used in the diagnostic evaluation of autism spectrum disorder (ASD); however, its diagnostic performance in real-world clinical referral populations remains heterogeneous, particularly across modules and clinical contexts. This systematic review…
Elevated NHHR at admission is independently associated with elevated post-stroke depressive symptoms
BackgroundElevated post-stroke depressive symptoms are common among acute ischemic stroke (AIS) survivors and are associated with poor functional recovery. However, readily available biomarkers reflecting lipid–inflammation status remain limited. The ratio of non–high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) may…
Suicide and suicidal behavior in the gulf cooperation council countries: a Systematic Review of behavioral patterns, sociocultural determinants, and structural vulnerabilities
Suicide and suicidal behavior in the Gulf Cooperation Council (GCC) countries remain underrepresented in empirical research, largely due to cultural stigma, legal prohibitions, and systematic underreporting. The behavioral and sociocultural determinants of suicidal behavior in these contexts—where rapid modernization intersects…
Efficacy and predictors of cognitive stimulation therapy combined with pharmacotherapy for mild-to-moderate Alzheimer’s disease: a randomized controlled trial
IntroductionAlzheimer’s disease (AD) is associated with progressive cognitive decline, functional impairment, and reduced quality of life. Although pharmacological treatments such as cholinesterase inhibitors and memantine are commonly used, their clinical benefits remain limited and heterogeneous. Cognitive stimulation therapy (CST) may…
Mapping the spatial landscape of extracellular vesicles in tissues with Spatial-EV-seq
Nature Biotechnology, Published online: 26 June 2026; doi:10.1038/s41587-026-03206-0Spatial-EV-seq is a method for spatially resolved profiling of extracellular vesicles (EVs) in tissues while preserving EVs’ native distribution. By integrating EV mapping with spatial transcriptomics, Spatial-EV-seq enables location-specific analysis of EVs and…
Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq
Nature Biotechnology, Published online: 26 June 2026; doi:10.1038/s41587-026-03192-3Spatial-EV-seq reveals spatial patterns of extracellular vesicles in tissues.
Adaptive brain stimulation 2.0 for Parkinsonian gait
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04489-1Two studies show that adaptive neuromodulation can improve Parkinsonian gait by matching stimulation to the right circuit at the right moment, pointing toward strategies that decompose complex symptoms into targetable spatial and temporal…
Immersive virtual reality with synchronous neurostimulation for upper-limb recovery after stroke: a randomized feasibility trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04486-4A multimodal platform combining immersive virtual reality with a synchronous sensory neurostimulation protocol outperformed conventional rehabilitation in individuals with chronic stroke, driving upper-limb motor gains, restored body representation and improved tactile acuity while…
Re-administration of AAV-mediated gene therapy for OTOF-related deafness: a single-arm trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04505-4As part of a clinical trial, re-administration of AAV gene therapy in four patients with congenital deafness, who had previously received a first gene therapy dose and developed neutralizing antibodies, was safe and…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04503-6A pragmatic cluster-randomized trial found that ChatGPT-4o-assisted decision support in Kenyan primary care facilities did not significantly reduce 14-day treatment failure over usual care.
Cliramitug for depletion of cardiac amyloid transthyretin: long-term follow-up of the NI006-101 trial
Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04487-3In an open-label extension study of the NI006-101 trial, in which patients with transthyretin amyloidosis cardiomyopathy were treated with the monoclonal antibody cliramitug, which targets misfolded transthyretin, long-term follow-up for a median of…
Mitochondrial stress response drives microglial senescence
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02264-6The mitochondrial unfolded protein response (UPRmt) drives microglial senescence and disrupts essential glia–neuron communication. By triggering lipid droplet accumulation and dysregulating the S-adenosylmethionine–polyamine axis, UPRmt fuels the senescence-associated secretory pathway, impairs synaptic pruning…
Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02342-9D’Ambrogio et al. combine deep learning and symbolic regression to report an interpretable equation of how humans value information. The equation predicts choices and neural activity in anterior insula, cingulate cortex and midbrain…
The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02320-1Mitochondrial proteotoxic stress rewires methionine and lipid metabolism in human microglia, driving cellular senescence and disrupting neuronal–glial communication, revealing a mechanism linking mitochondrial dysfunction to brain aging and neurodegeneration.
Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02331-yPascoli et al. show that nucleus accumbens dopamine transients evoked by reward-predictive cues encode subjective reward value in mice, predicting individual preference for drugs over natural rewards and forecasting vulnerability to compulsive drug-seeking…
Striatal control of amygdalar acetylcholine release during salience-associated processing
Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02353-6Amygdalar acetylcholine signals dynamically represent salience. Chen et al. show that striatal D1 and D2 neurons oppositely control these signals via basal forebrain cholinergic pathways to shape salience-associated learning.