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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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PAD-S/CSA as a candidate shared representation layer for computational psychotherapy: minimal architecture and a staged validation roadmap
Psychotherapy schools often describe overlapping process phenomena in non-interoperable vocabularies. This pluralism is clinically valuable but computationally costly: datasets become difficult to compare, clinically load-bearing distinctions are collapsed into convenience labels, and artificial intelligence (AI) systems inherit annotation schemes rather…
Stigma in adults with ADHD: a systematic review of types, experiences, and potential implications for quality of life
BackgroundAttention deficit hyperactivity disorder (ADHD) is a disorder characterized by hyperactive, impulsive, and/or inattentive symptoms. Adults with ADHD often report reduced quality of life (QoL) across social, educational, and occupational functioning. Part of these deficits may be attributed to stigma,…
mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression
Nature Biotechnology, Published online: 29 April 2026; doi:10.1038/s41587-026-03099-zmRNA vaccine efficacy is enhanced by silencing cell-type-specific expression.
Tuning the immune response to mRNA vaccines
Nature Biotechnology, Published online: 29 April 2026; doi:10.1038/s41587-026-03125-0A strategy to control translation of mRNA vaccines reveals cell type–specific contributions to immunity that may be harnessed to enhance vaccine efficacy.
Predicting referral need for febrile children in low-resource community settings in South and Southeast Asia
Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04338-1A multicountry cohort study found that prediction models combining clinical parameters with either pulse oximetry or the host biomarker sTREM1 more accurately identified febrile children needing referral than standard WHO criteria.
Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial
Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04366-xPreclinical and phase 1/2 trial data show that anti-CD38 monoclonal antibody treatment restores platelet counts in patients with immune thrombocytopenia by increasing nicotinamide adenine dinucleotide (NAD+) levels, and low-dose oral treatment with the…
An agentic framework for autonomous scientific discovery in cancer pathology
Nature Medicine, Published online: 29 April 2026; doi:10.1038/s41591-026-04357-yEvaluated across 18 multicancer cohorts, the agentic artificial intelligence workflow SPARK uses language as a universal interface to autonomously generate biological ideas.
A septo–entorhinal GABAergic pathway that enables switching between episodic memories
Nature Neuroscience, Published online: 29 April 2026; doi:10.1038/s41593-026-02280-6How the brain organizes the retrieval of old and new memories remains unknown. Kim et al. identify a septo−entorhinal GABAergic pathway that controls flexible switching between episodic memories during memory retrieval to enable…
Food safety experts warn of USDA brain drain
An autism advisory committee finally meets again, antipsychotics and dementia, and more health news from Morning Rounds
Opinion: Why alternative medicine can feel so much better than mainstream health care
Modern medicine is about making people better — not necessarily making them feel good.
Opinion: The medical school nutrition blues
“I don’t think anyone has the answers. But the conversation needs to start”: medical students on bringing a preventive mindset to medical education.
Opinion: STAT+: Did Kennedy just stack the deck on FDA oversight of peptides?
RFK Jr. had long signaled that he was going to do something big on peptides. Now the moment has arrived.
It’s time to make a plan for nuclear waste
Today, nuclear energy enjoys a rare moment of support across the political spectrum in the US. Interest from tech companies that are scrambling to meet demand for massive data centers has sparked a resurgence of money and attention in the…
New report shows some health equity wins. Experts fear they will be short-lived
A report released Wednesday highlights successes in reducing health disparities in U.S. states between 2022 and 2024.
Circulating Oxytocin Changes in Response to MDMA vs. Placebo in Adult Patients With Autism Spectrum Disorder and Matched Healthy Controls
Conditions: Autism Spectrum Disorder Interventions: Diagnostic Test: MDMA; Diagnostic Test: Placebo Sponsors: University Hospital, Basel, Switzerland Not yet recruiting
A Study of Home-use Brain Stimulation to Treat Bipolar Depression
Conditions: Bipolar Disorder (BD) Interventions: Device: Flow FL-100 tDCS headset Sponsors: King's College London; South London and Maudsley NHS Foundation Trust Recruiting
A Study Of Senyo Health With Comorbid Alcohol Use Disorder Treatment In Bipolar Patients
Conditions: Bipolar Disorder; Substance Use (Drugs, Alcohol) Interventions: Other: Senyo Health App Sponsors: Mayo Clinic Not yet recruiting
Efficacy and Safety of Daridorexant in Patients With Major Depressive Disorder and Insomnia
Conditions: Insomnia; Major Depressive Disorder Interventions: Drug: Daridorexant 50 mg; Drug: Placebo Sponsors: Institut d'Investigació Biomèdica de Bellvitge; Idorsia Pharmaceuticals Ltd.; Hospital Universitari de Bellvitge Not yet recruiting
The Impact of Digital Detox Training on Screen Use, Sleep Quality, and Healthy Lifestyle Behaviors in Adolescents
Conditions: Digital Screen Addiction and Sleep Quality in Adolescents Interventions: Behavioral: Digital Detox Intervention Sponsors: Şırnak Üniversitesi Completed