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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03109-0AI targets lipid nanoparticles to specific tissues while avoiding off-target delivery to the liver.
A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04267-zA reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Clinical trials for continuously monitored and updated AI systems
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04368-9As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.
Australia legislates against genetic discrimination in life insurance
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04372-zGenomic screening is increasing rapidly, but insurance protections globally are outdated. Australia’s new law offers the clearest model yet for safeguarding public trust while supporting population genomics.
AI framework for multidisease detection via retinal imaging
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04359-wReti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.
The prefrontal cortex controls memory organization in the hippocampus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02231-1Related memories are sometimes encoded in overlapping neurons. The authors show that the prefrontal cortex controls this type of memory organization in the hippocampus through direct projections to the medial entorhinal cortex.
Genoarchitecture and input–output organization of the mouse basal ganglia and thalamic parafascicular nucleus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02253-9The authors investigate the transcriptomic and connectivity organization of the basal ganglia and parafascicular nucleus. The analyses suggest that combinatorial gene expression underlies the modular and cell-type-specific basal ganglia input–output networks.
Predicting consequences of new hepatitis B vaccine recs
New data on public trust in science, AI and mental health, and other news from Morning Rounds
STAT+: Eli Lilly enlists AI startup for next-generation gene editors
Eli Lilly's deal with Profluent aims to go beyond CRISPR by using AI-designed enzymes to insert entire genes. It could reshape genetic medicine.
Opinion: Why do discussions about ‘brain health’ ignore mental illness?
“Failing to adopt a more inclusive concept of brain health represents a massive loss of human potential,” write Husseini K. Manji, Eric J. Nestler, and Patrick J. Kennedy.
STAT+: A giant question looms over GOP’s new Medicaid work requirements
Coverage losses tied to Medicaid work requirements may not be tracked in every states.
STAT+: Google clinical director says AI can be a ‘bridge’ for people having a mental health crisis
Google's clinical director Megan Bell Jones on how the company is addressing concerns over mental health impacts of its AI products.
TIS for NSSI in Adolescent Depression
Conditions: Temporal Interference Stimulation; Non Suicidal Self Injury; Major Depressive Disorder Interventions: Device: Active Temporal Interference Stimulation (TIS); Device: Sham Temporal Interference Stimulation (TIS) Sponsors: The Second Hospital of Anhui Medical University Recruiting
Auditory Stimulation for Insomnia and Depression
Conditions: Depression - Major Depressive Disorder; Insomnia Interventions: Device: Alpha phase-locked auditory stimulation; Device: Sham Stimulation Sponsors: Wake Forest University Health Sciences Not yet recruiting
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
Conditions: Depressive Symptoms; Allostatic Load; Metabolic Syndrome Interventions: Behavioral: Rise Together: Community Engagement Intervention; Behavioral: Adulting 101: Life Skills Sponsors: Ann & Robert H Lurie Children's Hospital of Chicago; National Institute on Minority Health and Health Disparities (NIMHD); Policy Research…
Symptom-based approach treats opioid withdrawal in newborns with minimal drug exposure
NIH-funded clinical trial shows that the new approach could also decrease time in the hospital.
Human Ventral Tegmental Local Field Potentials in Treatment-Resistant Depression and Obsessive-Compulsive Disorder
The ventral tegmental area (VTA) is a key node within the limbic circuitry. Through dense dopaminergic, glutamatergic, and GABAergic projections, the VTA forms reciprocal loops with prefrontal and limbic cortices that are consistently implicated in major depressive disorder (MDD) and…
Elon Musk and Sam Altman are going to court over OpenAI’s future
After a yearslong legal feud, Elon Musk and OpenAI CEO Sam Altman are heading to trial this week in Northern California in a case that could have sweeping consequences. Ahead of OpenAI’s highly anticipated IPO, the court could rule on…
Multimodal Depression Detection Through Conversational Interactions with an Emotion-Aware Social Robot: Pilot Study
Background: Depression affects more than 300 million people worldwide and is a leading contributor to the global disease burden. Traditional diagnostic methods, such as structured clinical interviews, are reliable but impractical for frequent or large-scale screening. Self-report tools like the…
New U.S. recommendation on hepatitis B vaccine will have dire consequences, studies project
Policy that recommends offering hep B vaccine at birth only to babies perceived to be at risk will lead to increased numbers of infected infants, new studies project.