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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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Redefining the future of software engineering
Software engineering has experienced two seismic shifts this century. First was the rise of the open source movement, which gradually made code accessible to developers and engineers everywhere. Second, the adoption of development operations (DevOps) and agile methodologies took software…
Prediction of Relapse Using Digital Technology in People in Recovery From Substance Use Disorders: Early Economic Evaluation With a Case Study of the Subreal App
Background: Many people relapse after achieving abstinence in substance use disorders. Health care providers may scan the horizon for new technologies to predict response that allow interventions to be targeted rather than routine. Currently, no such predictive technologies are available…
STAT+: Congress returns to a packed health care agenda
The key health care issues we're watching as Congress returns from recess.
STAT+: FDA pressures drugmakers to report trial results
Ben Sasse on enrolling in Rev Med's drug trial, more ADC investment, and other biotech news from The Readout
STAT+: Hospitals offer chatbots to fight off ChatGPT
In this edition of STAT Health Tech: Hospitals offer their own chatbots, Medicare's ACCESS pilot, and an update Utah's 'AI doctor' experiment.
STAT+: Pharmalittle: We’re reading about an FDA push for trial transparency, a Novo-OpenAI deal, and more
The FDA told more than 2,200 companies and researchers that they are required to report clinical trial results, or they may face fines
The Download: the state of AI, and protecting bears with drones
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Want to understand the current state of AI? Check out these charts. If you’re following AI news, you’re probably getting whiplash.…
A calibration-aware hierarchical CNN-SWIN fusion framework for robust Cross-Dataset brain MRI analysis
IntroductionDeep learning approaches have become central to brain MRI analysis; however, their reliability under dataset shift remains a critical barrier to safe and scalable deployment in neuroscience and clinical research. While convolutional neural networks (CNNs) provide strong locality-driven inductive biases…
Mitochondrial dysfunction, neuroinflammation, and associated mechanisms in sepsis-associated encephalopathy: from pathogenesis to emerging therapeutics
Sepsis-associated encephalopathy (SAE) is a devastating neurological complication of sepsis, leading to diffuse brain dysfunction, long-term cognitive deficits, and increased mortality. Its pathogenesis is complex, with mitochondrial dysfunction and neuroinflammation emerging as central, interconnected drivers. This review systematically elucidates the…
Immersive virtual reality as a novel approach to improve social cognition in multiple sclerosis: an EEG-based pilot study
IntroductionMultiple sclerosis (MS) affects different cognitive domains, including social cognition. Immersive Virtual Reality (VR) may provide a novel rehabilitative approach to treat motor and cognitive symptoms of MS. This exploratory pilot study evaluated the effects of immersive VR rehabilitation on…
How stressful life events are associated with depression: the mediating pathway of security in a clinical adolescent sample
BackgroundStressful life events are well-established risk factors for adolescent depression; however, the psychological mechanisms underlying this association remain insufficiently understood, particularly regarding which types of stress and which dimensions of security are most closely linked to depression. This study aimed…
A longitudinal analysis of the prevalence of restrictive interventions involving women with mental health conditions, learning disabilities or autism in mental health services in England
IntroductionRestrictive interventions, including physical restraint, seclusion, chemical restraint, and segregation, continue to be used within mental health services, despite sustained policy efforts to promote least-restrictive and trauma-informed care. However, little is known about national trends affecting women, for whom restrictive…
Self images: an empirical enquiry into Rembrandt’s self-portraits
Many have speculated that events of personal and financial loss in the life of Rembrandt van Rijn (Rembrandt) caused depression and that this is revealed by examination of his work particularly self-portraits painted in old age. Some report detecting various…
Unmasking deep-rooted trauma: long-term effects of childhood adversities on posttraumatic stress disorder in healthcare workers facing acute multi-trauma
PurposeIn recent years, healthcare workers (HCWs) in Lebanon have encountered compounded traumatic exposures, including the Beirut Port blast, COVID-19, and an ongoing economic crisis, often preceded by early-life adversities such as adverse childhood experiences (ACEs). Understanding how these acute stressors…
Medical evaluation of first presentation of psychotic symptoms in children and adolescents
IntroductionPsychotic symptoms in children and adolescents may represent either normative developmental phenomena or severe psychiatric and medical conditions, requiring careful differential diagnosis.MethodsThis retrospective study aimed to evaluate the medical workup of children and adolescents admitted for a first presentation of…
Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2
Nature Biotechnology, Published online: 14 April 2026; doi:10.1038/s41587-026-03095-3FAMSA2 accurately aligns millions of protein sequences at high speed.
Editorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04390-xEditorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
The gut microbiome as a fingerprint of antibiotic use history
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04360-3Antibiotic use over the past 8 years was associated with alterations in the gut microbiome composition in 14,979 individuals. These analyses integrated data from the Swedish National Prescribed Drug Register and stool metagenomic…