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Long-Read DNA Test Could Replace 15 Existing Tests for Rare Diseases
A DNA test for rare diseases using long-read sequencing can provide much more comprehensive results than standard diagnostics in a shorter amount of time. The post Long-Read DNA Test Could Replace 15 Existing Tests…
Opinion: ‘I’m pretty much all in’: An interview with a woman starting medical residency at almost 73
"There are some physicians that work to 100”: Dawn Zuidgeest-Craft on becoming a medical doctor in her 70s.
Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
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Making AI operational in constrained public sector environments
The AI boom has hit across industries, and public sector organizations are facing pressure to accelerate adoption. At the same time, government institutions face distinct constraints around security, governance, and operations that set them apart from their business counterparts. For…
The Download: cyberscammers’ banking bypasses, and carbon removal troubles
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Cyberscammers are bypassing banks’ security with illicit tools sold on Telegram Inside a money-laundering center in Cambodia, an employee…
Spatial evolution in temporal dynamics of hemodynamic response function in human superior colliculi with ultra-high-resolution MRI at 9.4T
The superior colliculus (SC) plays a crucial role in multisensory integration, visual information processing, saccadic target selection, visual selective attention, and decision making. In particular, the SC has a key role in oculomotor coordination, following a rostro-caudal organization. The rostral…
MambaSSM: efficient segmentation of brain structures in anisotropic 3D EM images via state-space models
Accurate segmentation of brain structures from anisotropic 3D electron microscopy (EM) images remains challenging due to the trade-off between global context modeling and computational efficiency. While state-space models (SSMs) like Mamba have shown promise in capturing long-range dependencies, their direct…
Role of TRPC1 in the pathogenesis of depression induced by traumatic brain injury
BackgroundTraumatic brain injury (TBI) is one of the leading causes of mortality and disability, with many patients developing long-term sequelae. Depression is among the most common psychiatric complications following TBI, yet its underlying mechanisms remain unclear. Transient receptor potential canonical…
Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure–function coupling in HIV-associated asymptomatic neurocognitive impairment
ObjectiveConventionally, blood oxygen level-dependent (BOLD) signals derived from resting-state functional magnetic resonance imaging (rs-fMRI) are attributed to gray matter, but recent evidence confirms stable low-frequency oscillations within white matter. While structure–function coupling is pivotal in neuropsychiatry, it remains underexplored in…
The relationship between impulsivity and non-suicidal self-injury in adolescents: the chain-mediated effects of parenting style and distress tolerance
ObjectiveThe purpose of this study is to explore the related risk factors and protective factors of adolescent non suicidal self injury (NSSI).MethodsUtilizing the experience sampling method, we recruited 311 adolescents engaging in NSSI, all without other mental disorders, from five…
Research progress on social participation of young and middle-aged stroke survivors: a narrative review
Stroke is characterized by high morbidity, disability, and mortality, and has become the third leading cause of death worldwide. In China, stroke accounts for 39.9% of all cerebrovascular diseases, with young and middle-aged survivors (aged 40–60 years) comprising 33% of…
A qualitative study on the participation experience in a mental health recovery program based on WHO QualityRights in South Korea
IntroductionThe World Health Organization’s QualityRights initiative offers a practical framework for developing rights-based, person-centered, and recovery-oriented mental health systems. In Korea, the face-to-face WHO QualityRights specialized training module, Recovery practices for mental health and well-being, was culturally and clinically adapted…
Protocol for a randomized trial to predict the efficacy of cognitive and behavioral interventions for symptoms of depression
IntroductionCognitive behavioral therapy (CBT) is one of the most common interventions for depression and has two key components: Cognitive Restructuring (CR) and Behavioral Activation (BA). However, no evidence-based guidelines exist to help clients and clinicians decide whether CBT would be…
Empathy and alexithymia in essential tremor
BackgroundSocial cognition is increasingly recognized as part of the non-motor phenotype of essential tremor (ET). Available ET evidence suggests selective alterations in some socio-cognitive domains, whereas findings on self-reported empathy and alexithymia remain limited and inconsistent.ObjectivesThis cross-sectional study aimed to…
Sequencing peptides by reversing translation
Nature Biotechnology, Published online: 16 April 2026; doi:10.1038/s41587-026-03108-1A new peptide sequencing approach converts amino acids into DNA sequences, which are easily read.
Diversity-generating retroelements for programmable targeted hypermutagenesis
Nature Biotechnology, Published online: 16 April 2026; doi:10.1038/s41587-026-03078-4Diversity-generating retroelements are engineered for directed evolution in E.coli.
Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial
Nature Medicine, Published online: 16 April 2026; doi:10.1038/s41591-026-04340-7In this phase 1/2 trial, patients with Ewing sarcoma received trabectedin and low-dose irinotecan at concentrations known to inhibit the activity of the transcription factor EWS::FLI1, leading to encouraging clinical response rates.
Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma
Nature Medicine, Published online: 16 April 2026; doi:10.1038/s41591-026-04331-8Analyses of epidemiological, clinical and molecular data from a prospective cohort of 3,100 patients with esophageal carcinoma suggest intestinal metaplasia as a single precancer pathway preceding the disease.
Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities
Nature Neuroscience, Published online: 16 April 2026; doi:10.1038/s41593-026-02265-5Integrating spatial and single-cell data from 100 patients, the authors define conserved cellular communities and communications in glioblastoma, revealing distinct mesenchymal-like tumor subtypes and predominant neurogliomal synapses that shape tumor progression.
Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe
Nature Neuroscience, Published online: 16 April 2026; doi:10.1038/s41593-026-02256-6The authors characterized the spatial origin of Drosophila medulla neurons, completing their previous characterization of the temporal and Notch origins of these neurons and allowing them to correlate patterning of progenitors and neuronal…
The mental health parity gap is gaping
RFK Jr.'s testimony to Congress, broader access to peptides, and more health news from Morning Rounds
STAT+: Roche to launch another Elevidys trial, with eyes on European approval
Roche is launching a Phase 3 trial of the controversial Duchenne gene therapy Elevidys, hoping it could lead to approval in Europe.
STAT+: Travere’s drug for a kidney disease doesn’t improve kidney function. The FDA approved it anyway
How a rare disease drugmaker won FDA approval after a clinical trial disappointed.