News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
Cross-subject EEG driving fatigue detection: early personal spectral reference and causal long-sequence residual encoding
BackgroundIn cross-subject electroencephalography (EEG)-based driving-fatigue detection, most existing decoders are designed around second-scale short windows, whereas fatigue is a slow drift; short-window spectral features provide little direct evidence of that slow drift, limiting fatigue…
Glial handling of alpha-synuclein seeds: uptake, degradation and redistribution in pathological propagation
α-synuclein (αS) aggregation and propagation are central features of Parkinson’s disease pathology. Preformed fibril (PFF) models have shown that extracellular αS aggregates can enter neurons and seed aggregation of endogenous αS. Within the brain,…
News
3107 results
Rehumanizing global health care with agentic AI
The global health care sector is under increasing strain. Decades of chronic underinvestment and constraints in recruitment have coincided with a surge in demand for services for aging populations. Gaps in provision are already taking a toll, with fragmented access…
How small businesses can leverage AI
This article is from Making AI Work, MIT Technology Review’s limited-run newsletter examining how to apply LLMs across industries. To receive it in your inbox,sign up here. From accounting to design to market research and product development, there’s a staggering…
Opinion: The virtual end of the doctor’s office waiting room
It’s time to rethink and redesign how patients enter the health care system altogether, writes emergency physician Iyesatta Massaquoi Emeli.
STAT+: Online care is caught in the crossfire as states crack down on corporate medicine
Growing legislative scrutiny across multiple states targets the corporate structure underlying most direct-to-consumer telehealth businesses.
Exploring the Feasibility of Transcranial Ultrasound Stimulation in the Treatment of Schizophrenia
Conditions: Schizo Affective Disorder Interventions: Device: Transcranial Ultrasound Stimulation; Device: Transcranial Ultrasound Stimulation Sponsors: Far Eastern Memorial Hospital Recruiting
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Conditions: Major Depressive Episode (MDE); Major Depressive Disorder (MDD); Depression Interventions: Drug: TNX-102 SL; Drug: Placebo sublingual tablet Sponsors: Tonix Pharmaceuticals, Inc. Recruiting
Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging
Conditions: Depression; Depression - Major Depressive Disorder; Depressive Episode; Major Depressive Disorder (MDD) Interventions: Device: repetitive Transcranial Magnetic Stimulation Sponsors: The Royal Ottawa Mental Health Centre Not yet recruiting
AI-Supported Therapy for Depression and Anxiety Compared With Standard CBT
Conditions: Generalized Anxiety Disorder (GAD); Major Depressive Disorder (MDD) Interventions: Device: AI-Digital CBT; Behavioral: Cognitive Behavioural Therapy Sponsors: PsyScale Not yet recruiting
STAT+: Trump administration releases rules for new Medicaid work requirements
States are racing to implement the new requirements by the start of next year.
STAT+: Eli Lilly warns hospitals to submit claims data in the next five days or lose their 340B drug discounts
Eli Lilly has told more than 1,000 hospitals participating in the 340B drug discount program to submit claims data over the next five days — or lose price breaks.
STAT+: Global coalition to fast-track three vaccines targeting Ebola outbreak with $62 million in funding
With no licensed vaccines available to protect against the Ebola virus currently spreading in the Congo, efforts are underway to fast-track development of at least three vaccines.
STAT+: Abivax ulcerative colitis drug shows strong efficacy, but cases of cancer raise concerns
Abivax said its experimental treatment for ulcerative colitis showed significant efficacy in a closely watched trial, but shares of the company tanked on safety concerns.
STAT+: At ASCO, talk of barriers to cancer care, new treatments, and other big takeaways
Here is some of what you may have missed from the world's largest cancer research meeting.
Neuropixels Opto Integrates Electrophysiology and Optogenetics to Probe Neuronal Function
Neuropixels Opto is a single brain probe combining electrophysiology and optogenetics that simultaneously records and controls neurons deep in the brain, enabling unprecedented insights into neural circuits and brain function. The post Neuropixels Opto Integrates Electrophysiology and Optogenetics to Probe…
The Download: China’s brain implant ambitions
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. China has approved the world’s first invasive brain-computer chip—here’s what’s next Sitting in the courtyard of…
Evaluating reliability of automated quantitative brain morphometry from fetal T2-weighted MRI
IntroductionThree-dimensional assessment of fetal cortical morphology from MRI is essential for understanding early brain neurodevelopment. However, measurement can be affected by fetal imaging quality, number and selection of available stacks, and reconstruction methods.MethodsWe evaluated the within-session reliability of an automated…
Domain-aware domain–class adaptation network for motor execution to motor imagery EEG classification
IntroductionMotor imagery (MI) is one of the most widely used paradigms in electroencephalogram (EEG)-based brain–computer interfaces (BCIs). In recent years, deep learning and transfer learning techniques have been increasingly adopted to further improve MI-EEG decoding performance, thereby facilitating the practical…
GLOBE: an explainable machine learning platform for preoperative prediction of thromboembolism and neurological deterioration in patients with glioma
BackgroundPatients with glioma are at high risk of postoperative venous thromboembolism (VTE) and postoperative neurological deterioration (PND). Conventional clinical scoring systems have limited accuracy in predicting these perioperative risks. This study aimed to develop and validate machine-learning models for individualized…
Efficacy of repetitive transcranial magnetic stimulation for insomnia disorder: a systematic review and meta-analysis of randomized controlled trials
ObjectiveInsomnia Disorder (ID) is associated with significant health burdens. First-line treatments are limited by accessibility or side effects, necessitating alternative approaches. rTMS, a noninvasive neuromodulation technique, has shown promise in treating various neuropsychiatric disorders by modulating cortical excitability. This comprehensive…
The effects of unilateral deprivation amblyopia on fixation stability
IntroductionDeprivation amblyopia is a neurodevelopmental disorder caused by obstruction of the visual pathway due to congenital cataracts, ptosis or corneal opacities that occur during early visual development. Visual deficits persist into adulthood even though the obstruction (e.g. cataracts) have been…
News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
Cross-subject EEG driving fatigue detection: early personal spectral reference and causal long-sequence residual encoding
BackgroundIn cross-subject electroencephalography (EEG)-based driving-fatigue detection, most existing decoders are designed around second-scale short windows, whereas fatigue is a slow drift; short-window spectral features provide little direct evidence of that slow drift, limiting fatigue…
Glial handling of alpha-synuclein seeds: uptake, degradation and redistribution in pathological propagation
α-synuclein (αS) aggregation and propagation are central features of Parkinson’s disease pathology. Preformed fibril (PFF) models have shown that extracellular αS aggregates can enter neurons and seed aggregation of endogenous αS. Within the brain,…
News
3107 results
Rehumanizing global health care with agentic AI
The global health care sector is under increasing strain. Decades of chronic underinvestment and constraints in recruitment have coincided with a surge in demand for services for aging populations. Gaps in provision are already taking a toll, with fragmented access…
How small businesses can leverage AI
This article is from Making AI Work, MIT Technology Review’s limited-run newsletter examining how to apply LLMs across industries. To receive it in your inbox,sign up here. From accounting to design to market research and product development, there’s a staggering…
Opinion: The virtual end of the doctor’s office waiting room
It’s time to rethink and redesign how patients enter the health care system altogether, writes emergency physician Iyesatta Massaquoi Emeli.
STAT+: Online care is caught in the crossfire as states crack down on corporate medicine
Growing legislative scrutiny across multiple states targets the corporate structure underlying most direct-to-consumer telehealth businesses.
Exploring the Feasibility of Transcranial Ultrasound Stimulation in the Treatment of Schizophrenia
Conditions: Schizo Affective Disorder Interventions: Device: Transcranial Ultrasound Stimulation; Device: Transcranial Ultrasound Stimulation Sponsors: Far Eastern Memorial Hospital Recruiting
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Conditions: Major Depressive Episode (MDE); Major Depressive Disorder (MDD); Depression Interventions: Drug: TNX-102 SL; Drug: Placebo sublingual tablet Sponsors: Tonix Pharmaceuticals, Inc. Recruiting
Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging
Conditions: Depression; Depression - Major Depressive Disorder; Depressive Episode; Major Depressive Disorder (MDD) Interventions: Device: repetitive Transcranial Magnetic Stimulation Sponsors: The Royal Ottawa Mental Health Centre Not yet recruiting
AI-Supported Therapy for Depression and Anxiety Compared With Standard CBT
Conditions: Generalized Anxiety Disorder (GAD); Major Depressive Disorder (MDD) Interventions: Device: AI-Digital CBT; Behavioral: Cognitive Behavioural Therapy Sponsors: PsyScale Not yet recruiting
STAT+: Trump administration releases rules for new Medicaid work requirements
States are racing to implement the new requirements by the start of next year.
STAT+: Eli Lilly warns hospitals to submit claims data in the next five days or lose their 340B drug discounts
Eli Lilly has told more than 1,000 hospitals participating in the 340B drug discount program to submit claims data over the next five days — or lose price breaks.
STAT+: Global coalition to fast-track three vaccines targeting Ebola outbreak with $62 million in funding
With no licensed vaccines available to protect against the Ebola virus currently spreading in the Congo, efforts are underway to fast-track development of at least three vaccines.
STAT+: Abivax ulcerative colitis drug shows strong efficacy, but cases of cancer raise concerns
Abivax said its experimental treatment for ulcerative colitis showed significant efficacy in a closely watched trial, but shares of the company tanked on safety concerns.
STAT+: At ASCO, talk of barriers to cancer care, new treatments, and other big takeaways
Here is some of what you may have missed from the world's largest cancer research meeting.
Neuropixels Opto Integrates Electrophysiology and Optogenetics to Probe Neuronal Function
Neuropixels Opto is a single brain probe combining electrophysiology and optogenetics that simultaneously records and controls neurons deep in the brain, enabling unprecedented insights into neural circuits and brain function. The post Neuropixels Opto Integrates Electrophysiology and Optogenetics to Probe…
The Download: China’s brain implant ambitions
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. China has approved the world’s first invasive brain-computer chip—here’s what’s next Sitting in the courtyard of…
Evaluating reliability of automated quantitative brain morphometry from fetal T2-weighted MRI
IntroductionThree-dimensional assessment of fetal cortical morphology from MRI is essential for understanding early brain neurodevelopment. However, measurement can be affected by fetal imaging quality, number and selection of available stacks, and reconstruction methods.MethodsWe evaluated the within-session reliability of an automated…
Domain-aware domain–class adaptation network for motor execution to motor imagery EEG classification
IntroductionMotor imagery (MI) is one of the most widely used paradigms in electroencephalogram (EEG)-based brain–computer interfaces (BCIs). In recent years, deep learning and transfer learning techniques have been increasingly adopted to further improve MI-EEG decoding performance, thereby facilitating the practical…
GLOBE: an explainable machine learning platform for preoperative prediction of thromboembolism and neurological deterioration in patients with glioma
BackgroundPatients with glioma are at high risk of postoperative venous thromboembolism (VTE) and postoperative neurological deterioration (PND). Conventional clinical scoring systems have limited accuracy in predicting these perioperative risks. This study aimed to develop and validate machine-learning models for individualized…
Efficacy of repetitive transcranial magnetic stimulation for insomnia disorder: a systematic review and meta-analysis of randomized controlled trials
ObjectiveInsomnia Disorder (ID) is associated with significant health burdens. First-line treatments are limited by accessibility or side effects, necessitating alternative approaches. rTMS, a noninvasive neuromodulation technique, has shown promise in treating various neuropsychiatric disorders by modulating cortical excitability. This comprehensive…
The effects of unilateral deprivation amblyopia on fixation stability
IntroductionDeprivation amblyopia is a neurodevelopmental disorder caused by obstruction of the visual pathway due to congenital cataracts, ptosis or corneal opacities that occur during early visual development. Visual deficits persist into adulthood even though the obstruction (e.g. cataracts) have been…