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Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
A 20-Year Follow-up of First Episode Psychosis: Longitudinal Effects of Early Treatment Strategies and Relapse
Conditions: Schizophrenia Sponsors: The University of Hong Kong; Research Grants Council, Hong Kong Not yet recruiting
Group-based ACT for Psychological Distress of Young People
Conditions: Depression - Major Depressive Disorder; Depression Anxiety Disorder; Anxiety; Anxiety Depression Interventions: Other: Group-based Acceptance and Commitment Therapy; Other: TAU Sponsors: Sorlandet Hospital HF; University of Oslo; Helse Sor-Ost; Karolinska Institutet; Australian Catholic University Recruiting
Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD)
Conditions: Post Traumatic Stress Disorder Interventions: Procedure: Stellate ganglion block Sponsors: sara dichtwald Not yet recruiting
STAT+: For prostate cancer patients set on surgery, new hormone regimen may improve outcomes, study finds
By doing hormone therapy up front in prostate cancer cases, the hope was to shrink the relapse rate after surgery. Results were encouraging.
MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
Nature Medicine, Published online: 31 May 2026; doi:10.1038/s41591-026-04455-xAs presented at the 2026 ASCO Annual Meeting, in a prespecified interim analysis of a phase 1a trial of IMA401—a new bispecific TCR-based T cell engager that binds a MAGE-A4/MAGE-A8 peptide presented by…
STAT+: A standing ovation for RevMed, and caution for Akeso
ASCO Day 3: A huge advance for pancreatic cancer, a let down for Akeso and Summit, and a new approach to immunotherapy.
Ultra-low doses could bring costly cancer treatments to more patients in poorer countries
Low-dose, low-cost immunotherapies may help patients in poorer countries access high-tech cancer treatments.
STAT+: Practice-changing results reported for Revolution Medicines pancreatic cancer drug
Much-awaited results at ASCO show that scientists have indeed found a way to drug a "greasy ball" involved in pancreatic cancer.
STAT+: Akeso and Summit’s ivonescimab extends survival in squamous cell lung cancer
A lung cancer drug developed in China was a highlight of ASCO but doctors want to see follow-up in a more diverse population.
STAT+: BioNTech and Pfizer tout bispecifics data, and Pazdur sees silver lining at FDA
ASCO, Day 2: promising news around lung cancer, new immunotherapies, and bold words from Rick Pazdur.
STAT+: China competition, ‘destruction’ at FDA give agency chance to restructure, Rick Pazdur says
Rick Pazdur on the FDA: “We've had a lot of destruction here, and it doesn't mean that we have to just go back and say, well, let's rebuild it as…
STAT+: Revolution Medicines starts shipping experimental pancreatic cancer drug
CEO Mark Goldsmith says Revolution Medicines will submit pancreatic cancer drug daraxonrasib for FDA approval soon.
STAT+: As Ebola outbreak grows, Trump administration veers from previous government playbook
Trump officials are disregarding the Biden administration's detailed pandemic plans in favor of their own strategy.
Optically detected and radio wave-controlled spin chemistry in flavoproteins
Nature Biotechnology, Published online: 29 May 2026; doi:10.1038/s41587-026-03158-5Radio waves are shown to modulate fluorescence and associate spin chemistry in proteins.
STAT+: At ASCO, positive data for Bristol in multiple myeloma and Pfizer in lung cancer
You’re reading the web edition of ASCO in 30 Seconds, STAT’s guide to the American Society of Clinical Oncology annual meeting. Sign up for email editions here. We’re ASCOmaxxing. Rest…
STAT+: Trump administration seeks to overhaul federal grantmaking process, alarming researchers
The Trump administration has released a sweeping proposal to overhaul the bedrock regulation for all federal grants.
Co-Designing a Text Messaging Intervention for Youth Transitioning From Child to Adult Mental Health Services: Participatory Design Jam Study
Background: The transition from child to adult mental health services is a vulnerable period marked by service disengagement, care gaps, and worsening mental health outcomes. Although planned, developmentally appropriate transition processes can improve functioning, youths report insufficient preparation, limited continuity…
Kenya court suspends U.S. plan for Ebola quarantine facility for Americans
A court in Kenya on Friday suspended a U.S. plan to establish a quarantine facility for Americans exposed to a rare type of Ebola virus spreading in northeastern Congo.
News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
A 20-Year Follow-up of First Episode Psychosis: Longitudinal Effects of Early Treatment Strategies and Relapse
Conditions: Schizophrenia Sponsors: The University of Hong Kong; Research Grants Council, Hong Kong Not yet recruiting
Group-based ACT for Psychological Distress of Young People
Conditions: Depression - Major Depressive Disorder; Depression Anxiety Disorder; Anxiety; Anxiety Depression Interventions: Other: Group-based Acceptance and Commitment Therapy; Other: TAU Sponsors: Sorlandet Hospital HF; University of Oslo; Helse Sor-Ost; Karolinska Institutet; Australian Catholic University Recruiting
Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD)
Conditions: Post Traumatic Stress Disorder Interventions: Procedure: Stellate ganglion block Sponsors: sara dichtwald Not yet recruiting
STAT+: For prostate cancer patients set on surgery, new hormone regimen may improve outcomes, study finds
By doing hormone therapy up front in prostate cancer cases, the hope was to shrink the relapse rate after surgery. Results were encouraging.
MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
Nature Medicine, Published online: 31 May 2026; doi:10.1038/s41591-026-04455-xAs presented at the 2026 ASCO Annual Meeting, in a prespecified interim analysis of a phase 1a trial of IMA401—a new bispecific TCR-based T cell engager that binds a MAGE-A4/MAGE-A8 peptide presented by…
STAT+: A standing ovation for RevMed, and caution for Akeso
ASCO Day 3: A huge advance for pancreatic cancer, a let down for Akeso and Summit, and a new approach to immunotherapy.
Ultra-low doses could bring costly cancer treatments to more patients in poorer countries
Low-dose, low-cost immunotherapies may help patients in poorer countries access high-tech cancer treatments.
STAT+: Practice-changing results reported for Revolution Medicines pancreatic cancer drug
Much-awaited results at ASCO show that scientists have indeed found a way to drug a "greasy ball" involved in pancreatic cancer.
STAT+: Akeso and Summit’s ivonescimab extends survival in squamous cell lung cancer
A lung cancer drug developed in China was a highlight of ASCO but doctors want to see follow-up in a more diverse population.
STAT+: BioNTech and Pfizer tout bispecifics data, and Pazdur sees silver lining at FDA
ASCO, Day 2: promising news around lung cancer, new immunotherapies, and bold words from Rick Pazdur.
STAT+: China competition, ‘destruction’ at FDA give agency chance to restructure, Rick Pazdur says
Rick Pazdur on the FDA: “We've had a lot of destruction here, and it doesn't mean that we have to just go back and say, well, let's rebuild it as…
STAT+: Revolution Medicines starts shipping experimental pancreatic cancer drug
CEO Mark Goldsmith says Revolution Medicines will submit pancreatic cancer drug daraxonrasib for FDA approval soon.
STAT+: As Ebola outbreak grows, Trump administration veers from previous government playbook
Trump officials are disregarding the Biden administration's detailed pandemic plans in favor of their own strategy.
Optically detected and radio wave-controlled spin chemistry in flavoproteins
Nature Biotechnology, Published online: 29 May 2026; doi:10.1038/s41587-026-03158-5Radio waves are shown to modulate fluorescence and associate spin chemistry in proteins.
STAT+: At ASCO, positive data for Bristol in multiple myeloma and Pfizer in lung cancer
You’re reading the web edition of ASCO in 30 Seconds, STAT’s guide to the American Society of Clinical Oncology annual meeting. Sign up for email editions here. We’re ASCOmaxxing. Rest…
STAT+: Trump administration seeks to overhaul federal grantmaking process, alarming researchers
The Trump administration has released a sweeping proposal to overhaul the bedrock regulation for all federal grants.
Co-Designing a Text Messaging Intervention for Youth Transitioning From Child to Adult Mental Health Services: Participatory Design Jam Study
Background: The transition from child to adult mental health services is a vulnerable period marked by service disengagement, care gaps, and worsening mental health outcomes. Although planned, developmentally appropriate transition processes can improve functioning, youths report insufficient preparation, limited continuity…
Kenya court suspends U.S. plan for Ebola quarantine facility for Americans
A court in Kenya on Friday suspended a U.S. plan to establish a quarantine facility for Americans exposed to a rare type of Ebola virus spreading in northeastern Congo.