News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
Cross-subject EEG driving fatigue detection: early personal spectral reference and causal long-sequence residual encoding
BackgroundIn cross-subject electroencephalography (EEG)-based driving-fatigue detection, most existing decoders are designed around second-scale short windows, whereas fatigue is a slow drift; short-window spectral features provide little direct evidence of that slow drift, limiting fatigue…
Glial handling of alpha-synuclein seeds: uptake, degradation and redistribution in pathological propagation
α-synuclein (αS) aggregation and propagation are central features of Parkinson’s disease pathology. Preformed fibril (PFF) models have shown that extracellular αS aggregates can enter neurons and seed aggregation of endogenous αS. Within the brain,…
News
3107 results
Predictive value of antioxidant and thyroid function indicators for non-suicidal self-injury in adolescents with major depressive disorder
BackgroundNon-suicidal self-injury (NSSI) is highly prevalent in adolescents with major depressive disorder (MDD); however, its underlying pathophysiological mechanisms remain incompletely elucidated. Emerging evidence suggests a potential association between antioxidant markers, thyroid function parameters, and the occurrence of NSSI, although research…
Exercise interventions for depressive symptoms in adults with lung and digestive cancer: a meta-analysis of randomized controlled trials
BackgroundDepressive symptoms are common among patients with cancer and can substantially impair quality of life, treatment adherence and overall well-being. Although exercise has been increasingly recognised as a promising non-pharmacological strategy for alleviating depression in oncology settings, existing evidence has…
Two years of COVID-19: persistently reduced well-being and increases in global psychopathology during the pandemic in a representative Austrian population-sample within the COH-FIT study
IntroductionThe COVID-19 pandemic worsened well-being and mental health worldwide, but effects have diminished over time. However, prospective national data within representative samples remain scarce. We aimed to examine the change in well-being and psychopathology from pre-pandemic to intra-pandemic times in…
The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis
ObjectiveThe comorbidity of pain and depression is prevalent, adding difficulty to the treatment of depression. This systematic review with meta-analysis aims to determine the efficacy and safety of acupuncture in treating depression-associated chronic pain (DACP).MethodsA comprehensive search was conducted across…
Wearable low-level laser therapy (laser acupuncture) versus manual acupuncture for chronic insomnia: protocol for a randomized, assessor-blinded, superiority trial
BackgroundChronic insomnia is a prevalent and disabling condition associated with impaired daytime functioning, psychiatric comorbidity, and autonomic dysregulation. Although cognitive behavioral therapy for insomnia (CBT-I) is recommended as the first-line treatment, access is limited. Acupuncture has demonstrated therapeutic benefits for…
Decoding the origins of cellular self-organization for engineered biology
Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03161-wThis Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance biological engineering.
Selection of human hematopoietic stem cells bearing the intended functional edit by transient AND-gate reporters
Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03142-zSelection increases the purity of blood stem cells bearing targeted homologous recombination.
Downplaying toxicities in cancer drug trials is not acceptable
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04463-xAs a physician I want to treat the patient, not just the tumor.
Incretin therapies, nutrition and food insecurity in the UK
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04426-2Incretin therapies, nutrition and food insecurity in the UK
Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04419-1In an interim analysis of a phase 1/2 trial in 24 patients with newly diagnosed glioblastoma, a genetically engineered autologous stem cell transplant designed to deliver interferon-α to the tumor microenvironment was well tolerated,…
Manageable toxicity is not a label — it is an oxymoron
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04464-wFrom the patient’s perspective, toxicity is manageable only when it is met with empathy.
Towards a holistic understanding of pain in the biomarker age
Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02323-yPain biomarkers cannot prove or disprove another person’s pain, but they need not be rejected as futile or reductionist. When developed within a bio-psycho-social framework and guided by epistemic humility and ethical safeguards,…
Why pain biomarkers cannot replace the patient experience
Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02324-xUsing neuroimaging to understand the mechanisms of pain is an important task. But we must understand that the gold standard of measuring pain will always be the self-report.
Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks
Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02301-4In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this neuromodulation therapy may treat depression.
China has approved the world’s first invasive brain-computer chip—here’s what’s next
One day last October, sitting in the courtyard of his house in China’s Henan province, Dong Hui decided to see if he could hold a pen to write. Dong, 39, had sustained spinal cord injuries in a car accident six…
Opinion: Medical schools diversified. So where are all the diverse doctors?
Why are residency programs disciplining and dismissing trainees in a system funded to train them?
STAT+: Executives reveal tech initiatives at Summa Health, eight months after General Catalyst acquisition
Two years after General Catalyst said it was buying Ohio safety-net hospital Summa Health, executives shed light on how the “transformation” is going.
STAT+: Medicare still won’t say how much covering obesity drugs will cost
Older adults on Medicare can get Wegovy and Zepbound for $50 a month, starting in July. But the agency still is not sharing how much this will cost taxpayers.
The hidden history of BPC-157, a favorite MAHA peptide
A compound named “substance God help me” by its longtime champion could benefit from RFK Jr.'s favorable views on using peptides.
STAT+: No Surprises Act arbitration rule could worsen flood of provider disputes
The arbitration process has protected patients but generated financial windfalls for some clinicians.
News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
Cross-subject EEG driving fatigue detection: early personal spectral reference and causal long-sequence residual encoding
BackgroundIn cross-subject electroencephalography (EEG)-based driving-fatigue detection, most existing decoders are designed around second-scale short windows, whereas fatigue is a slow drift; short-window spectral features provide little direct evidence of that slow drift, limiting fatigue…
Glial handling of alpha-synuclein seeds: uptake, degradation and redistribution in pathological propagation
α-synuclein (αS) aggregation and propagation are central features of Parkinson’s disease pathology. Preformed fibril (PFF) models have shown that extracellular αS aggregates can enter neurons and seed aggregation of endogenous αS. Within the brain,…
News
3107 results
Predictive value of antioxidant and thyroid function indicators for non-suicidal self-injury in adolescents with major depressive disorder
BackgroundNon-suicidal self-injury (NSSI) is highly prevalent in adolescents with major depressive disorder (MDD); however, its underlying pathophysiological mechanisms remain incompletely elucidated. Emerging evidence suggests a potential association between antioxidant markers, thyroid function parameters, and the occurrence of NSSI, although research…
Exercise interventions for depressive symptoms in adults with lung and digestive cancer: a meta-analysis of randomized controlled trials
BackgroundDepressive symptoms are common among patients with cancer and can substantially impair quality of life, treatment adherence and overall well-being. Although exercise has been increasingly recognised as a promising non-pharmacological strategy for alleviating depression in oncology settings, existing evidence has…
Two years of COVID-19: persistently reduced well-being and increases in global psychopathology during the pandemic in a representative Austrian population-sample within the COH-FIT study
IntroductionThe COVID-19 pandemic worsened well-being and mental health worldwide, but effects have diminished over time. However, prospective national data within representative samples remain scarce. We aimed to examine the change in well-being and psychopathology from pre-pandemic to intra-pandemic times in…
The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis
ObjectiveThe comorbidity of pain and depression is prevalent, adding difficulty to the treatment of depression. This systematic review with meta-analysis aims to determine the efficacy and safety of acupuncture in treating depression-associated chronic pain (DACP).MethodsA comprehensive search was conducted across…
Wearable low-level laser therapy (laser acupuncture) versus manual acupuncture for chronic insomnia: protocol for a randomized, assessor-blinded, superiority trial
BackgroundChronic insomnia is a prevalent and disabling condition associated with impaired daytime functioning, psychiatric comorbidity, and autonomic dysregulation. Although cognitive behavioral therapy for insomnia (CBT-I) is recommended as the first-line treatment, access is limited. Acupuncture has demonstrated therapeutic benefits for…
Decoding the origins of cellular self-organization for engineered biology
Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03161-wThis Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance biological engineering.
Selection of human hematopoietic stem cells bearing the intended functional edit by transient AND-gate reporters
Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03142-zSelection increases the purity of blood stem cells bearing targeted homologous recombination.
Downplaying toxicities in cancer drug trials is not acceptable
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04463-xAs a physician I want to treat the patient, not just the tumor.
Incretin therapies, nutrition and food insecurity in the UK
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04426-2Incretin therapies, nutrition and food insecurity in the UK
Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04419-1In an interim analysis of a phase 1/2 trial in 24 patients with newly diagnosed glioblastoma, a genetically engineered autologous stem cell transplant designed to deliver interferon-α to the tumor microenvironment was well tolerated,…
Manageable toxicity is not a label — it is an oxymoron
Nature Medicine, Published online: 01 June 2026; doi:10.1038/s41591-026-04464-wFrom the patient’s perspective, toxicity is manageable only when it is met with empathy.
Towards a holistic understanding of pain in the biomarker age
Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02323-yPain biomarkers cannot prove or disprove another person’s pain, but they need not be rejected as futile or reductionist. When developed within a bio-psycho-social framework and guided by epistemic humility and ethical safeguards,…
Why pain biomarkers cannot replace the patient experience
Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02324-xUsing neuroimaging to understand the mechanisms of pain is an important task. But we must understand that the gold standard of measuring pain will always be the self-report.
Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks
Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02301-4In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this neuromodulation therapy may treat depression.
China has approved the world’s first invasive brain-computer chip—here’s what’s next
One day last October, sitting in the courtyard of his house in China’s Henan province, Dong Hui decided to see if he could hold a pen to write. Dong, 39, had sustained spinal cord injuries in a car accident six…
Opinion: Medical schools diversified. So where are all the diverse doctors?
Why are residency programs disciplining and dismissing trainees in a system funded to train them?
STAT+: Executives reveal tech initiatives at Summa Health, eight months after General Catalyst acquisition
Two years after General Catalyst said it was buying Ohio safety-net hospital Summa Health, executives shed light on how the “transformation” is going.
STAT+: Medicare still won’t say how much covering obesity drugs will cost
Older adults on Medicare can get Wegovy and Zepbound for $50 a month, starting in July. But the agency still is not sharing how much this will cost taxpayers.
The hidden history of BPC-157, a favorite MAHA peptide
A compound named “substance God help me” by its longtime champion could benefit from RFK Jr.'s favorable views on using peptides.
STAT+: No Surprises Act arbitration rule could worsen flood of provider disputes
The arbitration process has protected patients but generated financial windfalls for some clinicians.