News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
Mental Health Fitness Through a Youth Perspective
Insights on building and advancing mental health care solutions through collaboration — from the Global Youth Advisory Council at the SNF Global Center for Child and Adolescent Mental Health at the Child Mind Institute Mai El Shoush, Partnerships Campaign Manager,…
STAT+: Pharmalittle: We’re reading about Replimune drug getting third try at FDA approval, a Pfizer deal in China, and more
Pharma updates from the Pharmalot campus via the Pharmalittle newsletter
STAT+: Allogene CEO David Chang stepping down
Pfizer invests billions to buy Chinese drugs, WHO maps experimental response to Ebola outbreak, and other biotech news from The Readout
Derbyshire Healthcare to roll out Psyomics mental health platform
Derbyshire Healthcare NHS Foundation Trust will roll out Psyomics'digital platform to improve access to community mental health care.
Vascular endothelial growth factor receptor-1 (VEGFR-1) knock-down is protective against hypoxia, Aβ1-42 oligomer and Aβ1-42 fibril -induced neuronal cell death: implications in AD pathogenesis
IntroductionRecent transcriptome analysis has demonstrated increased expression of Vascular Endothelial Growth Factor receptor-1 (VEGFR-1/FLT1) and in AD brain. Increased expression of VEGFR1 and its ligand VEGFB were associated with a more rapid rate of cognitive decline, providing evidence of a…
Pain-side-specific alteration of structural networks in trigeminal neuralgia: a connectome analysis
ObjectivesTrigeminal neuralgia (TN) involves disruption in the integrity of the white matter, the side-specific pain topology of these alterations at the network has yet to be defined. In this study, we investigated the lateralization of structural network architecture and nodal…
Emotion recognition based on the temporal patterns of electroencephalogram signals and electrodermal response signals using the TRANSFORMER network
IntroductionEmotion recognition using physiological signals plays an important role in affective neuroscience and human-centered artificial intelligence. Current methods still face challenges in long-range temporal dependency modeling and explicit central–autonomic coupling representation, while generalization under subject-independent protocols needs further improvement.MethodsThis study…
Leveraging Synchrosqueezing Transform (SST)-based representations in a dual-stream attention framework to enhance sleep apnea detection and subtyping
IntroductionSleep apnea and hypopnea syndrome (SAHS) is a prevalent disorder with profound adverse effects on health and overall quality of life, thereby necessitating the development of accurate and accessible screening tools. Electrocardiogram (ECG)-based analysis, being non-invasive and readily deployable in…
The Sentinel Phenotype: a theoretical bioenergetic and neurobiological framework for high-fidelity predictive systems (HEPOE Theory)
The HEPOE Theory (High Entropy Predictive Organization Efficiency) proposes a novel conceptual framework for understanding Giftedness (HA/G), moving beyond academic performance-based models toward a biophysical and neuroscientific foundation. Through a theoretical synthesis grounded in the Free Energy Principle and Biological…
Perceptions of mental health services among informal caregivers in Sardinia, Italy, during the post-pandemic crisis of the national health system: a comparative study between 2024 and 2025
BackgroundItaly’s community-based mental health model, grounded in Law 180, has long been regarded as a global example of rights-oriented psychiatric reform. However, recent years have witnessed a crisis in the national health system, marked by chronic and progressively accumulating underfunding,…
Hyponatremia in patients with severe anorexia nervosa was associated with more severe and longer duration of disease
IntroductionSeveral mechanisms are thought to contribute to hyponatremia in patients with anorexia nervosa (AN). The aims of this descriptive, cross-sectional study among patients admitted to a specialized somatic unit for eating disorders (ED) were to determine the frequency of hyponatremia…
Metacognitive model of suicidality: a study of Iranian inpatients
BackgroundThe metacognitive model of suicidality proposes that positive metacognitions about suicide activate suicide-specific rumination, which in turn leads to the activation of negative metacognitions about suicide and an escalating aggravation of suicidal ideation/behavior. Initial studies support the model assumptions. However,…
Sleep-related problems among patients with rheumatoid arthritis in the World Health Organization Eastern Mediterranean region: a systematic review and meta-analysis
BackgroundSleep-related problems are common among patients with rheumatoid arthritis (RA) and contribute substantially to disease burden and reduced quality of life. Evidence from the World Health Organization Eastern Mediterranean Region (WHO EMRO) remains fragmented, with variability in reported prevalence, sleep…
Pathogenic germline variants identify elevated cancer risk in pediatric patients referred for genetic testing
Nature Medicine, Published online: 29 May 2026; doi:10.1038/s41591-026-04451-1Through large-scale genomic analysis, we show that pathogenic germline variants in pediatric cancer-predisposition genes are associated with increased subsequent tumor risk, highlighting their value for counseling and surveillance.
Mapping the genetic diversity of Indigenous Americans
Nature Medicine, Published online: 29 May 2026; doi:10.1038/d41591-026-00028-0A comprehensive analysis of Indigenous American genomes charts an evolutionary history shaped by unique geographic and cultural environments, climate shifts, and colonization, and reveals natural selection of genes involved in immunity, metabolism and…
An unexpected molecular explanation for how tau aggregation begins in Alzheimer’s disease
Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02298-wDisruption of a neuronal-specific protein degradation system, the plasma membrane-bound neuroproteasome, triggers the conversion of endogenous tau into aggregates that mirror those seen in patients with Alzheimer’s disease (AD). Aging and APOE4 —…
Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner
Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02297-xA cellular explanation for how tau aggregates into fibrils in Alzheimer’s disease has been elusive. This paper identifies the failure of ‘neuroproteasomes’ as sufficient to convert tau into paired helical filaments, a process…
The Download: unlocking lithium and controlling Ebola
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. How a new extraction process could unlock the world’s lithium A new method for extracting lithium…
The deadly Ebola outbreak is proving difficult to control
The alert was raised on May 5. Four health-care workers in the Ituri Province of the Democratic Republic of the Congo had died from an unknown illness within four days. Rapid response teams were sent to investigate, and tests at…
News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
News
3107 results
Mental Health Fitness Through a Youth Perspective
Insights on building and advancing mental health care solutions through collaboration — from the Global Youth Advisory Council at the SNF Global Center for Child and Adolescent Mental Health at the Child Mind Institute Mai El Shoush, Partnerships Campaign Manager,…
STAT+: Pharmalittle: We’re reading about Replimune drug getting third try at FDA approval, a Pfizer deal in China, and more
Pharma updates from the Pharmalot campus via the Pharmalittle newsletter
STAT+: Allogene CEO David Chang stepping down
Pfizer invests billions to buy Chinese drugs, WHO maps experimental response to Ebola outbreak, and other biotech news from The Readout
Derbyshire Healthcare to roll out Psyomics mental health platform
Derbyshire Healthcare NHS Foundation Trust will roll out Psyomics'digital platform to improve access to community mental health care.
Vascular endothelial growth factor receptor-1 (VEGFR-1) knock-down is protective against hypoxia, Aβ1-42 oligomer and Aβ1-42 fibril -induced neuronal cell death: implications in AD pathogenesis
IntroductionRecent transcriptome analysis has demonstrated increased expression of Vascular Endothelial Growth Factor receptor-1 (VEGFR-1/FLT1) and in AD brain. Increased expression of VEGFR1 and its ligand VEGFB were associated with a more rapid rate of cognitive decline, providing evidence of a…
Pain-side-specific alteration of structural networks in trigeminal neuralgia: a connectome analysis
ObjectivesTrigeminal neuralgia (TN) involves disruption in the integrity of the white matter, the side-specific pain topology of these alterations at the network has yet to be defined. In this study, we investigated the lateralization of structural network architecture and nodal…
Emotion recognition based on the temporal patterns of electroencephalogram signals and electrodermal response signals using the TRANSFORMER network
IntroductionEmotion recognition using physiological signals plays an important role in affective neuroscience and human-centered artificial intelligence. Current methods still face challenges in long-range temporal dependency modeling and explicit central–autonomic coupling representation, while generalization under subject-independent protocols needs further improvement.MethodsThis study…
Leveraging Synchrosqueezing Transform (SST)-based representations in a dual-stream attention framework to enhance sleep apnea detection and subtyping
IntroductionSleep apnea and hypopnea syndrome (SAHS) is a prevalent disorder with profound adverse effects on health and overall quality of life, thereby necessitating the development of accurate and accessible screening tools. Electrocardiogram (ECG)-based analysis, being non-invasive and readily deployable in…
The Sentinel Phenotype: a theoretical bioenergetic and neurobiological framework for high-fidelity predictive systems (HEPOE Theory)
The HEPOE Theory (High Entropy Predictive Organization Efficiency) proposes a novel conceptual framework for understanding Giftedness (HA/G), moving beyond academic performance-based models toward a biophysical and neuroscientific foundation. Through a theoretical synthesis grounded in the Free Energy Principle and Biological…
Perceptions of mental health services among informal caregivers in Sardinia, Italy, during the post-pandemic crisis of the national health system: a comparative study between 2024 and 2025
BackgroundItaly’s community-based mental health model, grounded in Law 180, has long been regarded as a global example of rights-oriented psychiatric reform. However, recent years have witnessed a crisis in the national health system, marked by chronic and progressively accumulating underfunding,…
Hyponatremia in patients with severe anorexia nervosa was associated with more severe and longer duration of disease
IntroductionSeveral mechanisms are thought to contribute to hyponatremia in patients with anorexia nervosa (AN). The aims of this descriptive, cross-sectional study among patients admitted to a specialized somatic unit for eating disorders (ED) were to determine the frequency of hyponatremia…
Metacognitive model of suicidality: a study of Iranian inpatients
BackgroundThe metacognitive model of suicidality proposes that positive metacognitions about suicide activate suicide-specific rumination, which in turn leads to the activation of negative metacognitions about suicide and an escalating aggravation of suicidal ideation/behavior. Initial studies support the model assumptions. However,…
Sleep-related problems among patients with rheumatoid arthritis in the World Health Organization Eastern Mediterranean region: a systematic review and meta-analysis
BackgroundSleep-related problems are common among patients with rheumatoid arthritis (RA) and contribute substantially to disease burden and reduced quality of life. Evidence from the World Health Organization Eastern Mediterranean Region (WHO EMRO) remains fragmented, with variability in reported prevalence, sleep…
Pathogenic germline variants identify elevated cancer risk in pediatric patients referred for genetic testing
Nature Medicine, Published online: 29 May 2026; doi:10.1038/s41591-026-04451-1Through large-scale genomic analysis, we show that pathogenic germline variants in pediatric cancer-predisposition genes are associated with increased subsequent tumor risk, highlighting their value for counseling and surveillance.
Mapping the genetic diversity of Indigenous Americans
Nature Medicine, Published online: 29 May 2026; doi:10.1038/d41591-026-00028-0A comprehensive analysis of Indigenous American genomes charts an evolutionary history shaped by unique geographic and cultural environments, climate shifts, and colonization, and reveals natural selection of genes involved in immunity, metabolism and…
An unexpected molecular explanation for how tau aggregation begins in Alzheimer’s disease
Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02298-wDisruption of a neuronal-specific protein degradation system, the plasma membrane-bound neuroproteasome, triggers the conversion of endogenous tau into aggregates that mirror those seen in patients with Alzheimer’s disease (AD). Aging and APOE4 —…
Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner
Nature Neuroscience, Published online: 29 May 2026; doi:10.1038/s41593-026-02297-xA cellular explanation for how tau aggregates into fibrils in Alzheimer’s disease has been elusive. This paper identifies the failure of ‘neuroproteasomes’ as sufficient to convert tau into paired helical filaments, a process…
The Download: unlocking lithium and controlling Ebola
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. How a new extraction process could unlock the world’s lithium A new method for extracting lithium…
The deadly Ebola outbreak is proving difficult to control
The alert was raised on May 5. Four health-care workers in the Ituri Province of the Democratic Republic of the Congo had died from an unknown illness within four days. Rapid response teams were sent to investigate, and tests at…