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Long-Read DNA Test Could Replace 15 Existing Tests for Rare Diseases
A DNA test for rare diseases using long-read sequencing can provide much more comprehensive results than standard diagnostics in a shorter amount of time. The post Long-Read DNA Test Could Replace 15 Existing Tests…
Opinion: ‘I’m pretty much all in’: An interview with a woman starting medical residency at almost 73
"There are some physicians that work to 100”: Dawn Zuidgeest-Craft on becoming a medical doctor in her 70s.
Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
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STAT+: Pharmalittle: We’re reading about Lilly and Pfizer obesity drug data, Roche and J&J deals, and more
Lilly disclosed new data that provide more details on the safety and tolerability of its next-generation obesity drug retatrutide
The Download: how the World Cup ball will fly and OpenAI’s “super app”
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Why this year’s World Cup ball may not fly as far Much is new about this…
Gut microbiome dynamics in autism: a prospective nested case–control study demonstrates microbial-clinical associations following rehabilitation interventions
BackgroundChildren with autism spectrum disorder (ASD) commonly exhibit gut microbiota dysbiosis and metabolic abnormalities, yet the mechanisms linking these changes to clinical symptoms remain unclear.ObjectiveThis study employed a nested case–control design and multi-omics approaches to evaluate the effects of rehabilitation…
Divergent dFC stability of DMN and SMN in narcolepsy
Narcolepsy type 1 (NT1) is characterized by profound sleep-wake state instability, pointing to a fundamental dysregulation of large-scale brain network dynamics. To elucidate this, we assessed whole-brain dynamic functional connectivity (dFC) stability using resting-state fMRI in 27 patients with NT1…
Integrative mechanisms and intervention targets of the microbiota–gut–brain axis in depressive disorders: advances across immune, endocrine, and central nervous system pathways
Depressive disorders are highly heterogeneous syndromes characterized not only by depressed mood but also by cognitive impairment, sleep–circadian rhythm disturbances, altered appetite, somatic discomfort, and metabolic or gastrointestinal comorbidities. In recent years, the microbiota–gut–brain axis (MGBA) has been increasingly recognized…
Comparative effects of structured exercise protocols on depression and anxiety symptoms: a network meta-analysis
ObjectiveTo systematically compare the intervention effects of eight common structured exercise modalities on depressive and anxiety symptoms in adults using a network meta-analysis approach, providing evidence-based insights for developing precision exercise prescriptions in mental health.MethodsA computer search was conducted across…
Disruption of a GalR2–mitochondrial axis in the ventral hippocampus contributes to depression-like phenotypes after prenatal stress
BackgroundPrenatal stress (PS) is a major risk factor for depression later in life, yet the cellular mechanisms linking early-life adversity to long-term affective vulnerability remain incompletely understood. Neuropeptide receptors have emerged as important modulators of stress-related psychopathology, but their roles…
Parkinson’s disease beyond motor symptoms: a review of the validity and limitations of current classification of non-motor symptoms
Non-motor symptoms (NMS) in Parkinson’s disease (PD) are highly prevalent and significantly impact quality of life. However, they are under-recognized and undertreated. Current classification systems of NMS inadequately reflect the phenomenological complexity and interrelationship of these symptoms. In this narrative…
Social connectedness in mobile gaming: how family dynamics shape children’s virtual interactions
BackgroundMobile gaming is important for children’s social interaction, but its impact on real-life social connectedness depends heavily on family dynamics. How family patterns shape children’s emotional and social experiences around gaming remains underexplored, particularly qualitatively. This study examined how family…
Single-cell spatial pharmacobiology for imaging antibody-based therapies in solid tumors
Nature Biotechnology, Published online: 08 June 2026; doi:10.1038/s41587-026-03171-8We have developed single-cell spatial pharmacobiology (SSP), which combines in situ imaging of a systemically infused fluorescent therapeutic antibody with high-plex spatial proteomics. Applied to head and neck and pancreatic tumors from patients…
Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04439-xIn a whole-exome sequencing analysis, the beneficial effects of the SGLT2 inhibitor dapagliflozin in reducing the risk of future heart failure hospitalization in individuals with type 2 diabetes were markedly greater in individuals…
Electronic cigarette use after smoking cessation and lung cancer risk
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04469-5A nationwide retrospective analysis of 4.5 million Korean adults found that electronic cigarette use after smoking cessation was associated with higher lung cancer incidence and mortality compared with complete smoking cessation.
Post-adjuvant chemotherapy in ctDNA-positive patients with resected colorectal cancer: a randomized phase 3 trial
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04428-0In the randomized, double-blind phase 3 ALTAIR trial, patients with resected colorectal cancer who became positive for circulating tumor DNA during post-adjuvant surveillance received trifluridine/tipiracil hydrochloride therapy, which did not significantly prolong disease-free…
Induction of cortical on/off periods in awake mice fulfills sleep functions
Nature Neuroscience, Published online: 08 June 2026; doi:10.1038/s41593-026-02318-9Driessen et al. show that core benefits of sleep—reduced local sleep pressure, renormalized synaptic strength and memory consolidation—can be reproduced in awake, behaving mice by inducing sleep-like on/off activity patterns in cortex.
STAT+: Combination of pancreatic cancer drugs from Tango, Revolution leads to high response rate
A combination of pancreatic cancer drugs from Tango Therapeutics and Revolution Medicines led to a strong response rate in an early-stage trial.
Why this year’s World Cup ball may not fly as far
Much is new about this month’s upcoming FIFA World Cup tournament, which will be held in the US, Canada, and Mexico. It hosts more teams than ever before. It’s the first to occur in three different host countries. And, like…
When it’s time to save a limb, novel clinic meets unhoused people where they are
Unmet vascular needs can lead to limb loss among unhoused patients. An unusual Massachusetts General Hospital program meets patients where they are.
Opinion: American horses are obese, too
“American horses are getting sick in ways that look remarkably familiar,” writes Joshua Moen.
Opinion: $2 million gene therapy cures require a financing model
“We do not lack cures. We lack the infrastructure to pay for and deliver them,” writes William Padula.
Fronto-Parietal Transcranial Alternating Current Stimulation for ADHD in Children and Adolescents
Conditions: Attention-Deficit/Hyperactivity Disorder Interventions: Device: Active transcranial alternating current stimulation; Device: Sham transcranial alternating current stimulation Sponsors: Central South University Recruiting