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Expression of Concern for: Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro
Expression of Concern for: “Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro,” by Ono et al. (Biol Psychiatry 2002; 52:880–886); https://doi.org/10.1016/S0006-3223(02)01417-8.
Opinion: The podcast bringing together MAHA and public health for hard conversations
“These sides aren't talking to each other. And there's a lot riding on it”: The hosts of “Why Should I Trust You?” on bringing together MAHA and public health.
Optimism for Trump’s CDC pick is tempered by questions about RFK Jr.’s role
As one CDC employee, who asked not to be named, put it on Friday, among staff “the general vibe is guarded but hopeful.”
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Mitochondrial dysfunction, neuroinflammation, and associated mechanisms in sepsis-associated encephalopathy: from pathogenesis to emerging therapeutics
Sepsis-associated encephalopathy (SAE) is a devastating neurological complication of sepsis, leading to diffuse brain dysfunction, long-term cognitive deficits, and increased mortality. Its pathogenesis is complex, with mitochondrial dysfunction and neuroinflammation emerging as central, interconnected drivers. This review systematically elucidates the…
Immersive virtual reality as a novel approach to improve social cognition in multiple sclerosis: an EEG-based pilot study
IntroductionMultiple sclerosis (MS) affects different cognitive domains, including social cognition. Immersive Virtual Reality (VR) may provide a novel rehabilitative approach to treat motor and cognitive symptoms of MS. This exploratory pilot study evaluated the effects of immersive VR rehabilitation on…
How stressful life events are associated with depression: the mediating pathway of security in a clinical adolescent sample
BackgroundStressful life events are well-established risk factors for adolescent depression; however, the psychological mechanisms underlying this association remain insufficiently understood, particularly regarding which types of stress and which dimensions of security are most closely linked to depression. This study aimed…
A longitudinal analysis of the prevalence of restrictive interventions involving women with mental health conditions, learning disabilities or autism in mental health services in England
IntroductionRestrictive interventions, including physical restraint, seclusion, chemical restraint, and segregation, continue to be used within mental health services, despite sustained policy efforts to promote least-restrictive and trauma-informed care. However, little is known about national trends affecting women, for whom restrictive…
Self images: an empirical enquiry into Rembrandt’s self-portraits
Many have speculated that events of personal and financial loss in the life of Rembrandt van Rijn (Rembrandt) caused depression and that this is revealed by examination of his work particularly self-portraits painted in old age. Some report detecting various…
Unmasking deep-rooted trauma: long-term effects of childhood adversities on posttraumatic stress disorder in healthcare workers facing acute multi-trauma
PurposeIn recent years, healthcare workers (HCWs) in Lebanon have encountered compounded traumatic exposures, including the Beirut Port blast, COVID-19, and an ongoing economic crisis, often preceded by early-life adversities such as adverse childhood experiences (ACEs). Understanding how these acute stressors…
Medical evaluation of first presentation of psychotic symptoms in children and adolescents
IntroductionPsychotic symptoms in children and adolescents may represent either normative developmental phenomena or severe psychiatric and medical conditions, requiring careful differential diagnosis.MethodsThis retrospective study aimed to evaluate the medical workup of children and adolescents admitted for a first presentation of…
Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2
Nature Biotechnology, Published online: 14 April 2026; doi:10.1038/s41587-026-03095-3FAMSA2 accurately aligns millions of protein sequences at high speed.
Editorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04390-xEditorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
The gut microbiome as a fingerprint of antibiotic use history
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04360-3Antibiotic use over the past 8 years was associated with alterations in the gut microbiome composition in 14,979 individuals. These analyses integrated data from the Swedish National Prescribed Drug Register and stool metagenomic…
Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04314-9Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus.
Elraglusib and chemotherapy in metastatic pancreatic ductal adenocarcinoma: a randomized controlled phase 2 trial
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04327-4In this phase 2 trial, combination treatment with elraglusib, a cell-permeable ATP-competitive inhibitor of glycogen synthase kinase-3β, and gemcitabine plus nab-paclitaxel (GnP), in patients with previously untreated metastatic pancreatic ductal adenocarcinoma led to…
Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04317-6A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness following treatment.
White matter pathways mediating dorsolateral prefrontal TMS therapy for depression
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02248-6Seguin et al. show that the efficacy of transcranial magnetic stimulation for depression depends on how stimulation spreads through the brain’s wiring. Patients with shorter communication pathways between stimulated sites and mood-related regions…
Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02250-yThis study shows that the brain’s smell center uses precise timing and inhibition to read out early odor signals, enabling reliable odor identity across concentrations while rapidly separating (decorrelating) similar smell patterns for…
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02254-8By assembling into ‘virion vesicles’, the H129 strain of herpes simplex virus-1 hijacks synaptic machinery for its anterograde spread, co-opting voltage-gated Ca2+ channels, Syt7 and SNAREs for presynaptic exit, then nectin-1/CME for postsynaptic…
A fluoride shortage for some U.S. water systems
An experimental Medicare program, how family dynamics affect brain recovery, and other health news from Morning Rounds
Coming soon: 10 Things That Matter in AI Right Now
Each year we compile our 10 Breakthrough Technologies list, featuring our educated predictions for which technologies will have the biggest impact on how we live and work. This year, however, we had a dilemma. While our final picks encompass all…
The problem with thinking you’re part Neanderthal
You’ve probably heard some version of this idea before: that many of us have an “inner Neanderthal.” That is to say, around 45,000 years ago, when Homo sapiens first arrived in Europe, they met members of a cousin species—the broad-browed,…