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Expression of Concern for: Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro
Expression of Concern for: “Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro,” by Ono et al. (Biol Psychiatry 2002; 52:880–886); https://doi.org/10.1016/S0006-3223(02)01417-8.
Opinion: The podcast bringing together MAHA and public health for hard conversations
“These sides aren't talking to each other. And there's a lot riding on it”: The hosts of “Why Should I Trust You?” on bringing together MAHA and public health.
Optimism for Trump’s CDC pick is tempered by questions about RFK Jr.’s role
As one CDC employee, who asked not to be named, put it on Friday, among staff “the general vibe is guarded but hopeful.”
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Trial of Center-Based Early Start Denver Model vs. Pivotal Response Treatment in Children With Autism
Conditions: Autism Spectrum Disorder (ASD); Autism Interventions: Behavioral: Early Start Denver Model (ESDM); Behavioral: Pivotal Response Treatment (PRT); Behavioral: Developmental Reciprocity Treatment (DRT) Sponsors: Stanford University; John and Marcia Goldman Foundation Not yet recruiting
Trial Phase: Syndemic Adapted Medly Uganda
Conditions: Mental Health Interventions: Device: Syndemic-Adapted Medly Uganda (SAMU) Sponsors: Yale University; National Institute of Mental Health (NIMH) Not yet recruiting
Evaluation of an Online ACT and Compassion-based Intervention for Disorders of Gut-Brain Interaction
Conditions: DGBI; Depression/Anxiety Interventions: Behavioral: Acceptance and Commitment Therapy with explicit self-compassion training; Other: Education Sponsors: Örebro University, Sweden; Sahlgrenska University Hospital; Göteborg University; Uppsala University Not yet recruiting
Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD)
Conditions: Posttraumatic Stress Disorder (PTSD) Interventions: Device: Transcranial Magnetic Stimulation; Device: Transcranial Magnetic Stimulation Sham Sponsors: Massachusetts General Hospital; United States Air Force Research Laboratory Not yet recruiting
Opinion: Sports betting is creating a twofold public health crisis for some young men
“Even if not everybody is losing a ton of money right now, you're creating this culture of large numbers of gamblers,” Isaac Rose-Berman says on the First Opinion Podcast.
Opinion: What STAT readers think about nutrition education in med school
“Is ‘lack of education’ really what we think the problem is in prevention care?” a STAT reader asks.
Epigenetics at Birth Links Microbiome to Neurodevelopment, Potentially ASD and ADHD
Researchers have found that the human gut microbiome and epigenetics are intertwined, and that both contribute to early life neurodevelopment, and potentially to the development of ASD and ADHD. The post Epigenetics at Birth Links Microbiome to Neurodevelopment, Potentially ASD…
GAO report shows gap between scale of illegal vapes and enforcement
The Justice Department's actions on illegal vapes pales next to the scale of the problem, anti-smoking advocates say.
STAT+: Replimune skin cancer drug that became FDA flashpoint is rejected again
A cancer drug candidate that, rightly or wrongly, became a flashpoint at FDA, fails on a second try at approval.
What’s in a name? Moderna’s “vaccine” vs. “therapy” dilemma
Is it the Department of Defense or the Department of War? The Gulf of Mexico or the Gulf of America? A vaccine—or an “individualized neoantigen treatment”? That’s the Trump-era vocabulary paradox facing Moderna, the covid-19 shot maker whose plans for…
The Download: an exclusive Jeff VanderMeer story and AI models too scary to release
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Constellations —Constellations is a short story by Jeff VanderMeer, the author of the critically acclaimed, bestselling…
How blindness shapes personality: a neuro-ecological account
IntroductionThe established link between personality and psychological well-being underscores the need to understand how major life changes, such as vision loss, reshape an individual’s disposition. While previous research has produced inconsistent findings, the roles of concurrent environmental factors and underlying…
Zingerone alleviates acute seizures by reducing intrinsic hippocampal neuronal excitability in a rat model of temporal lobe epilepsy
BackgroundEpilepsy is a complex neurological disorder characterized by recurrent seizures. Neuroinflammation and excessive neuronal excitation are key pathogenic factors, but current therapies fail to target these mechanisms effectively, highlighting the need for novel therapeutic agents. Zingerone, a bioactive compound derived…
Exploratory assessment of cerebrospinal fluid-related microdynamics after mild traumatic brain injury using intravoxel incoherent motion magnetic resonance imaging
AimThis study aimed to characterize regional alterations in cerebrospinal fluid (CSF) microdynamics following mild traumatic brain injury (TBI) using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and compare f-value–based CSF motion between patients with TBI and healthy controls.MethodsIn this…
A novel phase-difference transcranial alternating current stimulation system enables precise dual-site neuromodulation
Precise modulation of large-scale brain networks requires neuromodulation technologies capable of delivering frequency-locked stimulation with accurate and stable inter-regional phase control. However, conventional transcranial alternating current stimulation (tACS) systems generally lack robust dual-channel phase regulation and are rarely validated under…
A survey on data augmentation for EEG-based emotion recognition and cognitive workload decoding
Electroencephalography (EEG) is extensively employed in emotion recognition and cognitive workload decoding. However, signal characteristics and inter-subject variability pose significant challenges for deep learning models, particularly due to data scarcity and limited generalization. Although data augmentation (DA) is a critical…
Effect of transcranial magnetic stimulation on prognosis in patients with postherpetic neuralgia and comorbid depression undergoing interventional neuromodulation therapy: protocol for a randomized double-blind placebo-controlled trial
BackgroundPostherpetic neuralgia (PHN) is often accompanied by depression, creating a vicious cycle that exacerbates symptoms and contributes to suboptimal treatment outcomes, even with interventional therapies. Repetitive transcranial magnetic stimulation (rTMS) has demonstrated potential in alleviating both pain and mood disturbances.…
From work-related trauma to suicidal ideation: a serial mediation model of posttraumatic stress and depression in rescue workers
ObjectivesRescue workers face frequent occupational trauma, increasing their risk for posttraumatic stress symptoms (PTSS), depression, and suicidal ideation. However, pathways linking trauma to suicidality remain poorly understood. This study investigated these mechanisms by testing a serial mediation model.MethodsFrom a larger…
The efficacy and safety of transcranial direct current stimulation in patients with ADHD: a systematic review and meta-analysis
ObjectiveThis meta-analysis evaluated the efficacy and safety of transcranial direct current stimulation (tDCS) for treating Attention-Deficit/Hyperactivity Disorder (ADHD).MethodsFollowing PRISMA guidelines, we analyzed 28 randomized controlled trials (RCTs) involving 1,864 participants. Outcomes encompassed core ADHD symptoms, hot and cold executive functions…
The mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest in students with learning disabilities
IntroductionThe present work is investigating the mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest among students with learning disabilities.MethodsThis descriptive-analytical study employed a correlational design within a structural equation modelling framework. The…