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Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
Cross-subject EEG driving fatigue detection: early personal spectral reference and causal long-sequence residual encoding
BackgroundIn cross-subject electroencephalography (EEG)-based driving-fatigue detection, most existing decoders are designed around second-scale short windows, whereas fatigue is a slow drift; short-window spectral features provide little direct evidence of that slow drift, limiting fatigue…
Glial handling of alpha-synuclein seeds: uptake, degradation and redistribution in pathological propagation
α-synuclein (αS) aggregation and propagation are central features of Parkinson’s disease pathology. Preformed fibril (PFF) models have shown that extracellular αS aggregates can enter neurons and seed aggregation of endogenous αS. Within the brain,…
News
3107 results
Recordanelles capture transient gene expression in single human cells
Nature Biotechnology, Published online: 22 October 2026; doi:10.1038/s41587-026-03350-7RNA sequencing can capture high-resolution snapshots of a cell’s transcriptome, but transient changes in individual cells cannot be captured over long periods at a transcriptome-wide scale. Now, a synthetic organelle termed the ‘recordanelle’…
Network geometry shapes the transformation of task representations across the human cortex
Nature Neuroscience, Published online: 22 October 2026; doi:10.1038/s41593-026-02486-8The dimensionality of intrinsic brain connectivity systematically shapes how task representations compress and expand across the cortex, and activity flow modeling shows the active role of network geometry in generating the transformation.
Human Argonaute 2 is a programmable targeting domain for RNA editing
Nature Biotechnology, Published online: 22 October 2026; doi:10.1038/s41587-026-03358-zALTER is a programmable RNA base editor built entirely from human proteins. By using human AGO2 instead of bacterial CRISPR–Cas proteins, ALTER mitigates a key risk factor for harmful immune responses in therapeutic…
Salience Network Informed rTMS for PTSD
Conditions: Stress Disorders, Post-Traumatic Interventions: Device: Active MRI-Guided intermittent theta burst stimulation (iTBS); Device: Sham MRI-Guided intermittent theta burst stimulation (iTBS) Sponsors: VA Office of Research and Development Not yet recruiting
SONATA Dose Duration LIFU for OCD
Conditions: Obsessive - Compulsive Disorder Interventions: Device: ATTN201 - Low Intensity Focused Ultrasound Sponsors: University of Pennsylvania Recruiting
Simultaneous measurement of Midbrain and Striatal Dopamine in Schizophrenia using an agonist radiotracer
Imaging studies showing greater amphetamine-induced dopamine release in patients with schizophrenia (SCZ) compared to matched healthy controls (HC) have been repeatedly replicated, but these studies all used radiotracers that were dopamine D2 receptor antagonists. A more recent study using an…
Thalamocortical dysconnectivity shapes cortical hierarchy disruption across illness durations in schizophrenia
Schizophrenia is increasingly conceptualized as a disorder of circuit-level dysfunction. However, how thalamocortical abnormalities differ across cohorts with varying illness durations and relate to large-scale cortical hierarchical organization remains unclear.
Recordanelles for transcriptome-wide single-cell RNA recording in human cells
Nature Biotechnology, Published online: 21 October 2026; doi:10.1038/s41587-026-03327-6Recordanelles continuously and unbiasedly record the transcriptome throughout time in living mammalian cells.
Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells
Nature Biotechnology, Published online: 21 October 2026; doi:10.1038/s41587-026-03348-1DynaVelo integrates single-cell omics data to infer cell state dynamics and regulatory interactions.
The BELONG Study: Black Equality in OCD NeuroGenomics
By Boris Litvin, MA, Matthew Riello, Andrew Marshall, PhD, Emily Rodriguez, MS, MSc, Martha Falkenstein, PhD, and Alexander Rosenberg One word appears more and more in the news surrounding mental... Read more » The post The BELONG Study: Black Equality…
Developing Virtual Reality Programs to Address Social Skills Deficits in Youth With ADHD
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD) Interventions: Device: VIP Suite Sponsors: Indiana University; National Institute of Mental Health (NIMH) Not yet recruiting
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
Conditions: Neurodevelopmental Disorders; Intellectual Disability; Autism Spectrum Disorder; Genetic Diseases, Inborn Sponsors: Istituto Giannina Gaslini; Ministry of Health, Italy Recruiting
Evaluating the Effectiveness of an Adapted-Dialectical Behavior Therapy (A-DBT)
Conditions: Treatment Interventions: Behavioral: Adapted Dialectical Behavioral Therapy (A-DBT) Sponsors: International Islamic University, Islamabad Completed
20 years of iPSCs: From cellular reprogramming to clinical translation
Induced pluripotent stem cells (iPSCs) were first generated in 2006 by Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University. Their landmark work demonstrated that mature somatic cells could be reprogrammed to a pluripotent state through the expression of four transcription…
What Is Guanfacine?
Guanfacine is a non-stimulant medication that is FDA-approved to treat ADHD in children and teens. It can also be used off label to treat tic disorders and symptoms of autism. Guanfacine is not as powerful in reducing ADHD symptoms as…
Deep TMS for PTSD With Suicidal Ideation
Conditions: Post Traumatic Stress Disorder PTSD; Suicidal Ideation Interventions: Device: Deep Transcranial Magnetic Stimulation (DTMS) Sponsors: D.R. Rut Zaks OHAYON; Ben-Gurion University of the Negev Not yet recruiting
Postpartum Care in the NICU Multi-Site Breastfeeding
Conditions: Postpartum Complication; Postpartum; PTSD; PTSD (Childbirth-Related); Infant Feeding Practices; Breastfeeding Education; Breastfeeding; Health Related Quality of Life; LACTATION IN MOTHERS WITH PREMATURE NEWBORNS Interventions: Other: NICU-informed postpartum doula support Sponsors: Children's Hospital of Philadelphia; University of Pennsylvania; Main Line…
“There is a Place for it”—Practitioners’ Perspectives on Situated Ethical Acceptability of AI Technologies for Mental Health Practice: Qualitative Study
Background: Design research on AI technologies for mental health has expanded rapidly, yet existing work has largely focused on practitioners’ perspectives within isolated therapeutic stages or specific services. As a result, there is limited understanding of how practitioners view the…
Incorporating Data From Text Messages and Email Into Psychotherapy: Randomized Controlled Trial
Background: As digital communication becomes central to daily life, psychotherapy increasingly has access to patients’ electronic media data. Although digital phenotyping has been widely studied, less is known about whether incorporating personal communication data, such as text messages, improves clinical…
Artificial Intelligence-Powered Virtual Reality Exposure Therapy for OCD in College Students: A Proof-of-Concept Study
Conditions: Obsessive Compulsive Disorder (OCD) Interventions: Other: Traditional Exposure and Response Prevention (ERP); Device: Artificial Intelligence-Powered Virtual Reality Exposure Therapy (AI-VRET) Sponsors: University of California, San Diego Not yet recruiting
News Feed
Case Report: A novel hemizygous nonsense variant in PPP1R3F gene associated with developmental delay, intellectual disability and autism spectrum disorder
BackgroundPPP1R3F deficiency syndrome is an extremely rare, recently identified X-linked recessive neurodevelopmental disorder. It is caused by hemizygous variants in the PPP1R3F gene, which encodes a glycogen-targeting subunit of the brain-specific protein phosphatase 1…
Cross-subject EEG driving fatigue detection: early personal spectral reference and causal long-sequence residual encoding
BackgroundIn cross-subject electroencephalography (EEG)-based driving-fatigue detection, most existing decoders are designed around second-scale short windows, whereas fatigue is a slow drift; short-window spectral features provide little direct evidence of that slow drift, limiting fatigue…
Glial handling of alpha-synuclein seeds: uptake, degradation and redistribution in pathological propagation
α-synuclein (αS) aggregation and propagation are central features of Parkinson’s disease pathology. Preformed fibril (PFF) models have shown that extracellular αS aggregates can enter neurons and seed aggregation of endogenous αS. Within the brain,…
News
3107 results
Recordanelles capture transient gene expression in single human cells
Nature Biotechnology, Published online: 22 October 2026; doi:10.1038/s41587-026-03350-7RNA sequencing can capture high-resolution snapshots of a cell’s transcriptome, but transient changes in individual cells cannot be captured over long periods at a transcriptome-wide scale. Now, a synthetic organelle termed the ‘recordanelle’…
Network geometry shapes the transformation of task representations across the human cortex
Nature Neuroscience, Published online: 22 October 2026; doi:10.1038/s41593-026-02486-8The dimensionality of intrinsic brain connectivity systematically shapes how task representations compress and expand across the cortex, and activity flow modeling shows the active role of network geometry in generating the transformation.
Human Argonaute 2 is a programmable targeting domain for RNA editing
Nature Biotechnology, Published online: 22 October 2026; doi:10.1038/s41587-026-03358-zALTER is a programmable RNA base editor built entirely from human proteins. By using human AGO2 instead of bacterial CRISPR–Cas proteins, ALTER mitigates a key risk factor for harmful immune responses in therapeutic…
Salience Network Informed rTMS for PTSD
Conditions: Stress Disorders, Post-Traumatic Interventions: Device: Active MRI-Guided intermittent theta burst stimulation (iTBS); Device: Sham MRI-Guided intermittent theta burst stimulation (iTBS) Sponsors: VA Office of Research and Development Not yet recruiting
SONATA Dose Duration LIFU for OCD
Conditions: Obsessive - Compulsive Disorder Interventions: Device: ATTN201 - Low Intensity Focused Ultrasound Sponsors: University of Pennsylvania Recruiting
Simultaneous measurement of Midbrain and Striatal Dopamine in Schizophrenia using an agonist radiotracer
Imaging studies showing greater amphetamine-induced dopamine release in patients with schizophrenia (SCZ) compared to matched healthy controls (HC) have been repeatedly replicated, but these studies all used radiotracers that were dopamine D2 receptor antagonists. A more recent study using an…
Thalamocortical dysconnectivity shapes cortical hierarchy disruption across illness durations in schizophrenia
Schizophrenia is increasingly conceptualized as a disorder of circuit-level dysfunction. However, how thalamocortical abnormalities differ across cohorts with varying illness durations and relate to large-scale cortical hierarchical organization remains unclear.
Recordanelles for transcriptome-wide single-cell RNA recording in human cells
Nature Biotechnology, Published online: 21 October 2026; doi:10.1038/s41587-026-03327-6Recordanelles continuously and unbiasedly record the transcriptome throughout time in living mammalian cells.
Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells
Nature Biotechnology, Published online: 21 October 2026; doi:10.1038/s41587-026-03348-1DynaVelo integrates single-cell omics data to infer cell state dynamics and regulatory interactions.
The BELONG Study: Black Equality in OCD NeuroGenomics
By Boris Litvin, MA, Matthew Riello, Andrew Marshall, PhD, Emily Rodriguez, MS, MSc, Martha Falkenstein, PhD, and Alexander Rosenberg One word appears more and more in the news surrounding mental... Read more » The post The BELONG Study: Black Equality…
Developing Virtual Reality Programs to Address Social Skills Deficits in Youth With ADHD
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD) Interventions: Device: VIP Suite Sponsors: Indiana University; National Institute of Mental Health (NIMH) Not yet recruiting
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
Conditions: Neurodevelopmental Disorders; Intellectual Disability; Autism Spectrum Disorder; Genetic Diseases, Inborn Sponsors: Istituto Giannina Gaslini; Ministry of Health, Italy Recruiting
Evaluating the Effectiveness of an Adapted-Dialectical Behavior Therapy (A-DBT)
Conditions: Treatment Interventions: Behavioral: Adapted Dialectical Behavioral Therapy (A-DBT) Sponsors: International Islamic University, Islamabad Completed
20 years of iPSCs: From cellular reprogramming to clinical translation
Induced pluripotent stem cells (iPSCs) were first generated in 2006 by Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University. Their landmark work demonstrated that mature somatic cells could be reprogrammed to a pluripotent state through the expression of four transcription…
What Is Guanfacine?
Guanfacine is a non-stimulant medication that is FDA-approved to treat ADHD in children and teens. It can also be used off label to treat tic disorders and symptoms of autism. Guanfacine is not as powerful in reducing ADHD symptoms as…
Deep TMS for PTSD With Suicidal Ideation
Conditions: Post Traumatic Stress Disorder PTSD; Suicidal Ideation Interventions: Device: Deep Transcranial Magnetic Stimulation (DTMS) Sponsors: D.R. Rut Zaks OHAYON; Ben-Gurion University of the Negev Not yet recruiting
Postpartum Care in the NICU Multi-Site Breastfeeding
Conditions: Postpartum Complication; Postpartum; PTSD; PTSD (Childbirth-Related); Infant Feeding Practices; Breastfeeding Education; Breastfeeding; Health Related Quality of Life; LACTATION IN MOTHERS WITH PREMATURE NEWBORNS Interventions: Other: NICU-informed postpartum doula support Sponsors: Children's Hospital of Philadelphia; University of Pennsylvania; Main Line…
“There is a Place for it”—Practitioners’ Perspectives on Situated Ethical Acceptability of AI Technologies for Mental Health Practice: Qualitative Study
Background: Design research on AI technologies for mental health has expanded rapidly, yet existing work has largely focused on practitioners’ perspectives within isolated therapeutic stages or specific services. As a result, there is limited understanding of how practitioners view the…
Incorporating Data From Text Messages and Email Into Psychotherapy: Randomized Controlled Trial
Background: As digital communication becomes central to daily life, psychotherapy increasingly has access to patients’ electronic media data. Although digital phenotyping has been widely studied, less is known about whether incorporating personal communication data, such as text messages, improves clinical…
Artificial Intelligence-Powered Virtual Reality Exposure Therapy for OCD in College Students: A Proof-of-Concept Study
Conditions: Obsessive Compulsive Disorder (OCD) Interventions: Other: Traditional Exposure and Response Prevention (ERP); Device: Artificial Intelligence-Powered Virtual Reality Exposure Therapy (AI-VRET) Sponsors: University of California, San Diego Not yet recruiting