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Disease Detection Gets Boost from Keck’s New Brain Reference Map
A research team used diffusion magnetic resonance imaging (MRI) scans from more than 54,000 people to chart how the brain’s communication pathways develop, mature, and decline across the lifespan. The post Disease Detection Gets…
Mature Intestinal Cells Revert to Stem-Like State to Sustain Colorectal Cancer
The research shows that mature intestinal cells that revert to a stem cell-like state can sustain tumor growth more effectively than mutated intestinal stem cells. The post Mature Intestinal Cells Revert to Stem-Like State…
Use of the Dynamic Systems Development Method to Inform Technology-Assisted Motivational Interviewing (TAMI) for Tobacco Cessation: Qualitative Study
Background: Smoking continues to be a leading cause of preventable morbidity and mortality, and more than 480,000 Americans die annually due to smoking-related illness attributable to smoking and secondhand smoke. More advanced, responsive, and…
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STAT+: Eli Lilly says Verve’s gene editor lowers cholesterol levels in early study
Eli Lilly said Monday that a high dose of its gene-editing therapy reduced cholesterol levels by 62% in participants in a clinical trial.
Machine learning for Alzheimer’s disease progression under extreme class imbalance
BackgroundTimely identification of individuals at risk for Alzheimer’s disease (AD) progression remains a major clinical challenge. Traditional cognitive assessments provide limited prognostic insight, while many machine learning (ML) models rely on costly biomarkers or poorly interpretable algorithms that limit clinical…
Workload analysis of pilot steep turn maneuvers using SR20 aircraft and EEG data
ObjectiveTo compare left vs. right steep turns in terms of workload-related neurophysiological signatures using electroencephalogram (EEG) and machine learning.MethodsThirty-seven flight cadets performed one left and one right steep turn in an SR20 desktop flight simulator while a 32-channel EEG (Emotiv…
The impact of face-to-face social exclusion on university students’ interpersonal cooperation behavior: a hyperscanning study based on fNIRS
BackgroundMost studies on social exclusion adopt virtual paradigms focusing on unilateral responses, while neglecting real-world face-to-face interaction and its neural basis. Functional near-infrared spectroscopy (fNIRS) hyperscanning allows recording of interpersonal neural synchronization (INS) during dyadic interaction, providing a novel approach…
Long-term psychological and functional outcomes after hepatitis C eradication with direct-acting antivirals: an 80-month follow-up study
IntroductionDirect-acting antivirals (DAAs) have dramatically changed hepatitis C virus (HCV) treatment, by achieving high virological cure rates and a reduced percentage of adverse events compared with previous treatments. Despite this, long-term psychiatric and quality-of-life (QoL) outcomes after viral eradication remain…
Role of psychological resilience and psychological distress in linking fear of disease progression to quality of life in chronic heart failure: a cross-sectional serial mediation analysis
ObjectiveTo examine whether psychological resilience and psychological distress serially mediate the association between fear of disease progression and quality of life (QoL) in patients with chronic heart failure (CHF).MethodsThis cross-sectional study enrolled 212 patients with CHF admitted between June 2023…
Craving fullness: a fullness-seeking phenotype that blurs the line between binge eating disorder and food addiction
Food addiction and binge eating disorder show striking clinical overlap that current diagnostic frameworks do not fully capture. In binge eating disorder samples, Yale Food Addiction Scale-defined food addiction has been reported in roughly half of participants. Higher symptom severity…
Beyond surface acting: a mixed-methods investigation of an ACT-based intervention for promoting psychological flexibility and regulatory shift in hotel frontline emotional labor
BackgroundFrontline hotel employees in Thailand’s Eastern Economic Corridor (EEC) routinely suppress authentic emotions to meet organizational display rules—a process known as surface acting—associated with burnout, emotional exhaustion, and diminished well-being. Acceptance and Commitment Therapy (ACT), adapted within a collectivist, Buddhist-informed…
Factors influencing the sensory profile in patients with autism spectrum disorder from 16 months to 14 years: results of an observational study
IntroductionSensory processing abnormalities represent a high-impact clinical feature in individuals with Autism Spectrum Disorder (ASD). Sensory alterations can be classified by modality and behavioral responses to stimuli. The literature presents conflicting results regarding the association between the sensory profile and…
Low-dimensional population dynamics in the brainstem gate REM sleep
Nature Neuroscience, Published online: 25 May 2026; doi:10.1038/s41593-026-02314-zLozano et al. show that REM sleep is gated by low-dimensional brainstem network dynamics, in which opposing neuron populations across the midbrain and pons determine when transitions into REM sleep can occur.
Fixation duration on natural scenes is explained by memory encoding not processing demand
Nature Neuroscience, Published online: 25 May 2026; doi:10.1038/s41593-026-02285-1By combining magnetoencephalography and eye tracking, this study sheds light on why people fixate on some parts of natural scenes longer than others. Rather than visual complexity, fixation durations are affected by memory…
Opinion: How the perimenopause movement is hurting women
“There's a whole industry that seems to have sprung up”: Two experts on the people profiting from the rise of the perimenopause movement.
NIH researchers identify avenue for enhanced GLP-1-induced weight loss
Modulating intracellular signaling may extend drug effects.
STAT+: Congress slashed Medicaid funding to providers. The Trump administration wants to cut even further
The Trump administration disclosed plans to reduce state directed payments even more, setting up a probable showdown with provider groups.
STAT+: EU and US advisers split over AstraZeneca breast cancer drug
Merck-Kelun ADC outperforms Keytruda in trial, a closely watched Parkinson’s drug fails, and more biotech news from The Readout
STAT+: Pharmalittle: We’re reading about a Parkinson’s drug setback, a Merck lung cancer therapy, and more
Biogen and Denali said their experimental Parkinson’s therapy failed to slow the degenerative brain disorder in a randomized trial
A CDC page on mpox caught in political crosshairs
Seed oil panic, how STIs spread, and more health news from Morning Rounds
The Download: coding’s future, the ‘Steroid Olympics,’ and AI-driven science
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Anthropic’s Code with Claude showed off coding’s future—whether you like it or not At Anthropic’s developer…
The triple-hit hypothesis of Alzheimer’s disease: blood–brain barrier breakdown, infection, and neuroimmune activation as a unified etiological framework
Studies of Alzheimer’s disease (AD) have long been dominated by the amyloid cascade hypothesis, although mounting evidence suggests that amyloid-β (Aβ) deposition might be a late downstream event, rather than the initiating trigger of AD. Here, I propose a unifying…