News Feed
5-year outcomes of chemotherapy de-escalation in HER2-positive early breast cancer and exploratory circulating tumor DNA analyses from the randomized phase 2 PHERGain trial
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04723-wA 5-year secondary analysis of the phase 2 PHERGain trial supports the clinical utility of a PET-guided adaptive strategy for treatment de-escalation in HER2-positive early breast cancer…
A clinical multimodal vision language foundation model with fine-grain explainability
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04655-5A multimodal vision language foundation model, EVLF-FM, integrates extensive clinical data and advanced training techniques, achieving superior diagnostic accuracy and explainability across diverse imaging modalities, enhancing clinical…
Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04721-yA high-resolution snRNA-seq atlas of 189 colorectal tumors from patients aged 20–90+ years uncovers age-associated features of colorectal cancer.
News
3052 results
STAT+: As some medical schools embrace RFK Jr.’s nutrition push, they deftly sidestep MAHA priorities
Even as some medical schools heed health secretary Robert F. Kennedy Jr.’s call for more nutrition education, several told STAT that they plan to steer clear of topics that aren’t…
Opinion: E-bikes, e-scooters are a burgeoning pediatric public health emergency
“Emergency departments across America report dramatic increases in serious injuries from e-bikes and e-scooters,” write CHOP’s J. Todd R. Lawrence and Madison A. Kesler.
Clinical Trial of “Exploradores de Sabores” to Improve Food Selectivity in ASD Kids
Conditions: Autism Spectrum Disorder; Food Selectivity Interventions: Behavioral: Exploradores de Sabores Parent-Mediated Nutrition Intervention; Other: Education as Usual (EAU) Sponsors: Universidad Autonoma de Baja California Recruiting
SONATA LIFU for OCD
Conditions: Obsessive Compulsive Disorder Interventions: Device: Low Intensity Focused Ultrasound; Device: Sham (No Treatment) Sponsors: University of Pennsylvania; Attune Neurosciences Inc Recruiting
Probiotic IBNI617 for Moderate to Severe Depression: A Randomized Controlled Trial
Conditions: Major Depressive Disorder (MDD); IBNI617 Interventions: Other: Live biotherapeutic product; Other: Placebo Sponsors: IBIOME BIOTECHNOLOGY CO., LTD Not yet recruiting
Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive Syndrome
Conditions: Major Depressive Disorder (MDD); Depressive Episodes; Depressive Syndrome Interventions: Device: Repetitive Transcranial Magnetic Stimulation (rTMS), Theta Burst Stimulation Sponsors: Technical University of Munich; Medizinische Universitätsklinik Tübingen Not yet recruiting
Randomized Trial Evaluating the Effect of Light Therapy Using Glasses Versus a Sham Device on the Evolution of Self-reported Depressive Disorders in Chronic Hemodialysis Patients
Conditions: End-stage Chronic Kidney Disease Treated With Hemodialysis; Depressive Disorders Interventions: Other: Light therapy using active glasses; Other: Light therapy using inactive glasses Sponsors: Centre Hospitalier Annecy Genevois; Direction Générale de la Santé, France; Association France REIN; LUCIMED Not yet…
Opinion: I led the FDA’s food safety and nutrition center. Here’s what people are missing about the cyclospora outbreak
“Consumers should not be faced with a trade-off between nutrition and food safety,” writes Susan Mayne, former director of the FDA Center for Food Safety and Applied Nutrition.
Clinical Outcomes and Predictors of Improvement With Virtual Behavioral Health Care for Gambling Disorder: Retrospective Cohort Study
Background: Gambling disorder is associated with substantial psychiatric and functional burden, yet few individuals receive treatment. Limited real-world evidence exists evaluating outcomes of virtually delivered behavioral health care for gambling disorder, particularly among clinically complex patients. Objective: The purpose of…
FDA advisory panel narrowly rejects compounding of one peptide, backs two others
Robert F. Kennedy Jr. has lauded peptides and said he takes them himself.
The quest to keep organs alive outside the body
This week, I covered a fascinating effort to preserve organs outside the body. There’s a huge shortage of donor organs, and one of the main reasons is time—they survive only a matter of hours outside the body, even when they’re…
There are already more U.S. measles cases this year than in all of 2025
The number of measles cases in the U.S. has surpassed the record-breaking tally for all of 2025, with five more months of 2026 still to come.
International OCD Foundation Responds to OCD Representation in TLC’s “90 Day Fiancé”
Recent conversations about the portrayal of OCD on TLC’s 90 Day Fiancé underscore an important truth: how OCD is portrayed in television, film, and other media matters. OCD is a... Read more » The post International OCD Foundation Responds to…
The Download: an organ transplant breakthrough, and homegrown Chinese chips
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Supercooled kidneys have been transplanted into pigs in a “landmark achievement” When it comes to organ…
Machine learning methods evaluation for identification of cognitive phenotypes in multiple sclerosis and their MRI correlates
BackgroundCognitive impairment (CI) is common in multiple sclerosis (MS) yet poorly captured by conventional disability scales. Although neuropsychological assessment and magnetic resonance imaging (MRI) are routinely used separately, there is no simple clinically applicable framework integrating cognitive performance with structural…
Identification and validation of mitophagy and astrocyte-related molecular signature in the pathogenesis of Alzheimer’s disease: evidence from ensemble learning-driven multi-omics and clinical validation
BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder with limited diagnostic tools and therapeutic options. Dysregulated mitophagy in astrocytes plays a pivotal role in AD pathogenesis. This study aims to identify a mitophagy and astrocyte (MA)-associated molecular signature for AD…
Identifying and investigating emergent behaviour in neural systems
The concept of emergence is key to understanding much of neurophysiology, neurodevelopment, and neurodegeneration. Many brain functions are underpinned by behaviour that emerges from interactions of components such as neurons, synapses, and glia. Perturbations such as ion channel mutations or…
Effects of music interventions on disorders of consciousness: a systematic review and meta-analysis
ObjectiveThe study aimed to systematically evaluate the effects of music intervention on outcomes related to the recovery of consciousness in patients with disorders of consciousness (DOC).MethodsDatabases including PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI),…
The associations between emotional neglect and positive mental health: the mediating role of stress-is-enhancing mindset and the moderating role of stress-is-debilitating mindset
ObjectiveThis study aimed to investigate the associations among emotional neglect (EN), stress-is-enhancing mindset (SIEM), stress-is-debilitating mindset (SIDM), and positive mental health (PMH).MethodsThe cross-sectional survey was employed in this study. A sample of 2150 college students (826 males) completed the emotional…
News Feed
5-year outcomes of chemotherapy de-escalation in HER2-positive early breast cancer and exploratory circulating tumor DNA analyses from the randomized phase 2 PHERGain trial
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04723-wA 5-year secondary analysis of the phase 2 PHERGain trial supports the clinical utility of a PET-guided adaptive strategy for treatment de-escalation in HER2-positive early breast cancer…
A clinical multimodal vision language foundation model with fine-grain explainability
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04655-5A multimodal vision language foundation model, EVLF-FM, integrates extensive clinical data and advanced training techniques, achieving superior diagnostic accuracy and explainability across diverse imaging modalities, enhancing clinical…
Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum
Nature Medicine, Published online: 29 October 2026; doi:10.1038/s41591-026-04721-yA high-resolution snRNA-seq atlas of 189 colorectal tumors from patients aged 20–90+ years uncovers age-associated features of colorectal cancer.
News
3052 results
STAT+: As some medical schools embrace RFK Jr.’s nutrition push, they deftly sidestep MAHA priorities
Even as some medical schools heed health secretary Robert F. Kennedy Jr.’s call for more nutrition education, several told STAT that they plan to steer clear of topics that aren’t…
Opinion: E-bikes, e-scooters are a burgeoning pediatric public health emergency
“Emergency departments across America report dramatic increases in serious injuries from e-bikes and e-scooters,” write CHOP’s J. Todd R. Lawrence and Madison A. Kesler.
Clinical Trial of “Exploradores de Sabores” to Improve Food Selectivity in ASD Kids
Conditions: Autism Spectrum Disorder; Food Selectivity Interventions: Behavioral: Exploradores de Sabores Parent-Mediated Nutrition Intervention; Other: Education as Usual (EAU) Sponsors: Universidad Autonoma de Baja California Recruiting
SONATA LIFU for OCD
Conditions: Obsessive Compulsive Disorder Interventions: Device: Low Intensity Focused Ultrasound; Device: Sham (No Treatment) Sponsors: University of Pennsylvania; Attune Neurosciences Inc Recruiting
Probiotic IBNI617 for Moderate to Severe Depression: A Randomized Controlled Trial
Conditions: Major Depressive Disorder (MDD); IBNI617 Interventions: Other: Live biotherapeutic product; Other: Placebo Sponsors: IBIOME BIOTECHNOLOGY CO., LTD Not yet recruiting
Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive Syndrome
Conditions: Major Depressive Disorder (MDD); Depressive Episodes; Depressive Syndrome Interventions: Device: Repetitive Transcranial Magnetic Stimulation (rTMS), Theta Burst Stimulation Sponsors: Technical University of Munich; Medizinische Universitätsklinik Tübingen Not yet recruiting
Randomized Trial Evaluating the Effect of Light Therapy Using Glasses Versus a Sham Device on the Evolution of Self-reported Depressive Disorders in Chronic Hemodialysis Patients
Conditions: End-stage Chronic Kidney Disease Treated With Hemodialysis; Depressive Disorders Interventions: Other: Light therapy using active glasses; Other: Light therapy using inactive glasses Sponsors: Centre Hospitalier Annecy Genevois; Direction Générale de la Santé, France; Association France REIN; LUCIMED Not yet…
Opinion: I led the FDA’s food safety and nutrition center. Here’s what people are missing about the cyclospora outbreak
“Consumers should not be faced with a trade-off between nutrition and food safety,” writes Susan Mayne, former director of the FDA Center for Food Safety and Applied Nutrition.
Clinical Outcomes and Predictors of Improvement With Virtual Behavioral Health Care for Gambling Disorder: Retrospective Cohort Study
Background: Gambling disorder is associated with substantial psychiatric and functional burden, yet few individuals receive treatment. Limited real-world evidence exists evaluating outcomes of virtually delivered behavioral health care for gambling disorder, particularly among clinically complex patients. Objective: The purpose of…
FDA advisory panel narrowly rejects compounding of one peptide, backs two others
Robert F. Kennedy Jr. has lauded peptides and said he takes them himself.
The quest to keep organs alive outside the body
This week, I covered a fascinating effort to preserve organs outside the body. There’s a huge shortage of donor organs, and one of the main reasons is time—they survive only a matter of hours outside the body, even when they’re…
There are already more U.S. measles cases this year than in all of 2025
The number of measles cases in the U.S. has surpassed the record-breaking tally for all of 2025, with five more months of 2026 still to come.
International OCD Foundation Responds to OCD Representation in TLC’s “90 Day Fiancé”
Recent conversations about the portrayal of OCD on TLC’s 90 Day Fiancé underscore an important truth: how OCD is portrayed in television, film, and other media matters. OCD is a... Read more » The post International OCD Foundation Responds to…
The Download: an organ transplant breakthrough, and homegrown Chinese chips
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Supercooled kidneys have been transplanted into pigs in a “landmark achievement” When it comes to organ…
Machine learning methods evaluation for identification of cognitive phenotypes in multiple sclerosis and their MRI correlates
BackgroundCognitive impairment (CI) is common in multiple sclerosis (MS) yet poorly captured by conventional disability scales. Although neuropsychological assessment and magnetic resonance imaging (MRI) are routinely used separately, there is no simple clinically applicable framework integrating cognitive performance with structural…
Identification and validation of mitophagy and astrocyte-related molecular signature in the pathogenesis of Alzheimer’s disease: evidence from ensemble learning-driven multi-omics and clinical validation
BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder with limited diagnostic tools and therapeutic options. Dysregulated mitophagy in astrocytes plays a pivotal role in AD pathogenesis. This study aims to identify a mitophagy and astrocyte (MA)-associated molecular signature for AD…
Identifying and investigating emergent behaviour in neural systems
The concept of emergence is key to understanding much of neurophysiology, neurodevelopment, and neurodegeneration. Many brain functions are underpinned by behaviour that emerges from interactions of components such as neurons, synapses, and glia. Perturbations such as ion channel mutations or…
Effects of music interventions on disorders of consciousness: a systematic review and meta-analysis
ObjectiveThe study aimed to systematically evaluate the effects of music intervention on outcomes related to the recovery of consciousness in patients with disorders of consciousness (DOC).MethodsDatabases including PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI),…
The associations between emotional neglect and positive mental health: the mediating role of stress-is-enhancing mindset and the moderating role of stress-is-debilitating mindset
ObjectiveThis study aimed to investigate the associations among emotional neglect (EN), stress-is-enhancing mindset (SIEM), stress-is-debilitating mindset (SIDM), and positive mental health (PMH).MethodsThe cross-sectional survey was employed in this study. A sample of 2150 college students (826 males) completed the emotional…