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A compressed sensing neuromorphic processor for sparse signal classification
This paper presents a neuromorphic processing system integrating a compressed sensing spiking neural network (CSSNN) designed for sparse signal classification. The proposed CSSNN combines data coding, data compression, and SNN classification, enabling end-to-end optimization of network performance and model compression.…
Structural connectome analysis using a graph-based deep model for prediction of non-imaging variables
We address the prediction of non-imaging variables based on structural brain connectivity derived from diffusion magnetic resonance images, using graph-based machine learning. We predict age and the mini-mental state examination (MMSE) score as examples of a demographic and a clinical…
ESMR: a process framework for calibration dynamics across psychosomatic and psychiatric phenomena
The brain can be modeled as a generative system that predicts bodily and environmental input and reduces mismatch through updating and action. From this perspective, stress is treated not as prediction error per se, but as a condition in which…
Precision diagnosis model for treatment-resistant depression integrating serum metabolomics and clinical risk factors
ObjectiveThis study aimed to construct a high-efficiency dual-modal diagnostic model for treatment-resistant depression (TRD) by integrating serum metabolomics and clinical risk factors, and explore its metabolic pathological mechanisms.MethodsA total of 93 major depressive disorder (MDD) patients (53 TRD, 40 non-TRD)…
Associations between serum tumor necrosis factor-alpha, hippocampal-prefrontal-ventricular volumes, and clinical profiles in schizophrenia: a biomarker and neuroimaging study in North Sumatera, Indonesia
IntroductionSchizophrenia is a neurodevelopmental disorder with systemic inflammation that is thought to play a role in its pathophysiology. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) has been reported to be dysregulated in individuals with schizophrenia, but its relationship with brain…
Baseline working memory was associated with improvement in psychological quality of life in patients with persistent depressive symptoms: a prospective observational study
BackgroundCognitive dysfunction is prevalent in patients with depressive symptoms and contributes to impaired quality of life (QOL) and functional outcomes. However, the prognostic significance of specific cognitive domains for long-term outcomes remains unclear in patients with persistent depressive symptoms.MethodsIn this…
Association between frailty and postoperative delirium after transcatheter aortic valve replacement: a meta-analysis
BackgroundPostoperative delirium (POD) is a common complication following transcatheter aortic valve replacement (TAVR) and is associated with adverse outcomes in older patients. Frailty, a multidimensional geriatric syndrome, has been increasingly recognized as a potential risk factor for POD. However, existing…
AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing
Nature Biotechnology, Published online: 21 May 2026; doi:10.1038/s41587-026-03149-6A computational redesign strategy improves evolved prime editors.
Integrating public health into house design
Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04413-7Housing is not just a backdrop to health, but a powerful intervention. A study now shows that redesigning the home environment can improve child health outcomes, but success requires community co-design and solutions…
Resetting autoimmune disease with CAR cell therapies
Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04430-6This Review surveys the fast-developing landscape of CAR T cells in autoimmune disease from both a technological and clinical standpoint, exploring the concept of deep B cell depletion and immune ‘reset’.
Foamy microglia link oxylipins to disease progression in multiple sclerosis
Nature Neuroscience, Published online: 21 May 2026; doi:10.1038/s41593-026-02302-3Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and disease severity, highlighting potential therapeutic targets.
STAT+: Lilly’s ‘triple-G’ drug leads to bariatric-surgery levels of weight loss in trial
A next-gen Eli Lilly obesity drug led to bariatric-surgery levels of weight loss in a study, but also saw patients dropping out because of side effects.
Climate tech companies are pivoting to critical minerals
We’re over a year into the second Trump administration here in the US, and support for climate causes is weak. But climate tech companies are finding ways to survive and even thrive in this new environment, including by focusing on…
Tech researchers are suing the Trump administration over the future of online safety
Since its earliest days back in office, the Trump administration has been going after researchers who study and try to counter hate speech, harassment, propaganda, and disinformation online. Now, some of those researchers are fighting back. Last week their lawsuit—which…
Opinion: Living with bullet fragments in the body can have long-term medical consequences
Living with bullet fragments in your body can lead to chronic pain, issues with mobility, depression, even lead poisoning.
STAT+: Are ‘AI co-scientist’ tools actually useful for scientists?
In this edition of AI Prognosis, Brittany Trang explains in detail why 'AI co-scientist' tools may not be as helpful for scientists, yet.
Opinion: STAT+: Dark times ahead at the FDA
It almost feels like the Trump administration is intentionally breaking the FDA, writes Lab Dish columnist Paul Knoepfler.
STAT+: After warning letter, Whoop and FDA in discussions about controversial blood pressure feature
Whoop is yet to resolve a dispute with the FDA over a blood pressure feature, a top executive said at STAT's Breakthrough Summit.
Exploring the life stories of young adult men in prison with a history of dual harm
People who engage in both self-harm and violence (‘dual harm’) in prison cause widespread disruption to prison services. Whilst the behavioural profile of such individuals is gaining attention, there is very little research which explores their life histories and how…
Factors associated with psychological distress among family caregivers of preschool children with autism: an analysis
ObjectiveTo identify factors associated with psychological distress among family caregivers of preschool-aged children with Autism Spectrum Disorder (ASD) using LASSO regression and random forest algorithms.MethodsA convenience sampling method was employed to recruit 213 caregivers of preschool-aged children with ASD from…