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Case Report: Probable paroxysmal sympathetic hyperactivity during vascular and postoperative critical illness with bilateral white matter abnormalities
BackgroundRecognition of paroxysmal sympathetic hyperactivity (PSH) during vascular and postoperative critical illness is complicated by overlapping infection and seizure features.Case presentationA 37-year-old man developed encephalopathy and rigidity after extensive arterial thrombosis, thrombectomy, and suspected…
Single-cell dataset of juvenile mouse neurons from the thalamic reticular nucleus: whole-cell patch-clamp electrophysiology
This dataset provides single-cell whole-cell patch-clamp electrophysiology for 19 interneurons of the thalamic reticular nucleus (TRN) in juvenile mice. The recordings were obtained from male C57Bl/6J mice sampled within the developmental window of postnatal…
A systematic review and meta-analysis of quantitative pain outcomes in degenerative thoracic myelopathy
IntroductionDegenerative thoracic myelopathy (DTM) refers to symptomatic compression of the thoracic spinal cord secondary to degenerative pathology, including thoracic disc herniation (TDH), ossification of the ligamentum flavum (OLF) and ossification of the posterior longitudinal…
News
3067 results
Vagus nerve–driven microbiota homeostasis: a promising integrative add-on therapy for neurodevelopmental disorders
Over the past two decades, the conceptualization of neurodevelopmental disorders (NDDs) has undergone a profound transformation, shifting from a primarily brain-centric framework toward a systems-level perspective that integrates peripheral physiological processes. Among these, the gut microbiota has emerged as a…
Catastrophic consequences of prolonged immobilization after intracerebral hemorrhage: a case report of crush syndrome combined with capillary leak syndrome
BackgroundSpontaneous intracerebral hemorrhage is a neurological emergency with high mortality and disability rates. Prolonged immobilization after stroke can trigger severe systemic complications. The simultaneous occurrence of crush syndrome and capillary leak syndrome in the setting of acute intracerebral hemorrhage is…
Delayed multiple hemorrhagic brain metastases from atrial myxoma: a case report and literature review
ObjectiveBrain metastases from atrial myxoma are rare central nervous system manifestations and may mimic hemorrhagic malignant metastases or vascular lesions. We report a delayed case after prior cardiac myxoma resection and summarize the available patient-level literature.MethodsWe retrospectively reviewed the clinical…
Intraocular pressure spikes after intravitreal injection and their impact on OCT angiography
PurposeTo evaluate whether acute intraocular pressure (IOP) elevation after intravitreal anti-VEGF injection affects superficial capillary plexus (SCP) perfusion metrics on optical coherence tomography angiography (OCTA).MethodsIn this prospective single-center study, adults scheduled for unilateral intravitreal anti-VEGF treatment for macular edema were…
Sex-related molecular phenotypes in anxiety-depressive disorders: a machine learning analysis of routine blood biomarkers
BackgroundAnxiety disorders and depressive disorders are the most prevalent mental disorders worldwide. Their diagnosis has long relied on clinical symptom assessment, and objective blood−based biomarkers remain lacking. Sex is a critical risk factor for these disorders; however, sex−specific divergence in…
Art therapy for depression: a systematic review and meta-analysis
IntroductionDepression is among the leading causes of disability globally. Therefore, exploring the various non-medical treatment options for this condition is particularly important. The aim of the review was to assess the effect of art therapy on depressive symptoms.MethodsThe foundation of…
A comparison between seven scales of neuropsychological assessments for cognitive impairment screening in Chinese older population: a cross-sectional study in Chongqing, China
BackgroundThe Clinical Dementia Rating Scale (CDR), the Ascertain Dementia 8 (AD8), the Mini-Cog, the Verbal Fluency Test (VFT), the Community Screener for Dementia (CSI-D), the Rey Auditory Verbal Learning Test (RAVLT), and the Activities of Daily Living Scale (ADL) represent…
Changes in depression, anxiety, and post-traumatic stress symptoms among children and adolescents exposed to adverse childhood experiences following participation in the PROACT intervention in Nairobi, Kenya
IntroductionGlobally, children and adolescents exposed to Adverse Childhood Experiences (ACEs) face an increased risk of developing mental health disorders. The prevalence of these mental disorders is further amplified by the lack of access to specialised mental health treatment especially in…
Understanding cyber grooming in children and adolescents: a scoping review of risk factors and prevention strategies
The increasing digitalization of children’s daily lives has created new opportunities for communication, education, and social interaction while simultaneously increasing exposure to online exploitation risks. Among these risks, child grooming and cyber grooming have emerged as significant psychological, social, and…
Povorcitinib for hidradenitis suppurativa: the randomized, double-blind, placebo-controlled STOP-HS1 and STOP-HS2 phase 3 trials
Nature Medicine, Published online: 23 July 2026; doi:10.1038/s41591-026-04534-zIn a pair of pivotal phase 3, placebo-controlled, randomized clinical trials, the oral JAK1 inhibitor povorcitinib significantly reduced abscesses and inflammatory nodules in patients with moderate to severe hidradenitis suppurativa.
Focal astrocyte loss reveals nuclear translocation during lesion repopulation
Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02354-5Herwerth et al. demonstrate that, after focal astrocyte loss in the adult brain, perilesional astrocytes undergo extensive remodeling, proliferation and nuclear translocation to repopulate the depleted tissue without forming a glial scar.
Replay of procedural memory is independent of the hippocampus
Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02362-5Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error outcomes and predicted next-day…
How AI helps scientists design the next generation of medicines
Designing and developing a new medicine is an expensive, failure-prone scientific challenge. A new drug can take many years to develop, at the cost of a significant investment. And even then, most possible candidates never reach the patient. For biologic…
Expect a clash at today’s FDA peptide panel
The service members who refused the Covid vaccine, the fastest-growing Ebola outbreak in history, and other health news from Morning Rounds
STAT+: New data on Eli Lilly’s ‘triple-G’ drug leave open questions on heart benefit
On secondary endpoints that looked at major cardiovascular events, those taking retatrutide did not have a significant lower risk of death, heart attack, or stroke.
Filing of bipartisan Senate bill boosts momentum for office of men’s health
Mirroring the bipartisan bill introduced in the House, the measure would require a study from the GAO on the state of men’s health in the U.S. to be presented within…
The power line that could reshape New York’s grid is hitting snags
On July 3, as a heat wave swept the region, New York State’s grid imported 52 gigawatt-hours of electricity from Canada—enough to meet about 9% of its total electricity demand that day. Some of that power shuttled in on a…
Opinion: Good riddance to bundled ‘global’ maternal care billing
New maternal billing codes should create a transparent system where both patients and clinicians can thrive, ACOG writes.
STAT+: FDA staff and peptide enthusiasts set to clash at advisory panel
FDA advisers are set to consider whether allowing compounding pharmacies to offer largely unproven peptides is a safer bet than the gray-market versions now in use.
News Feed
Case Report: Probable paroxysmal sympathetic hyperactivity during vascular and postoperative critical illness with bilateral white matter abnormalities
BackgroundRecognition of paroxysmal sympathetic hyperactivity (PSH) during vascular and postoperative critical illness is complicated by overlapping infection and seizure features.Case presentationA 37-year-old man developed encephalopathy and rigidity after extensive arterial thrombosis, thrombectomy, and suspected…
Single-cell dataset of juvenile mouse neurons from the thalamic reticular nucleus: whole-cell patch-clamp electrophysiology
This dataset provides single-cell whole-cell patch-clamp electrophysiology for 19 interneurons of the thalamic reticular nucleus (TRN) in juvenile mice. The recordings were obtained from male C57Bl/6J mice sampled within the developmental window of postnatal…
A systematic review and meta-analysis of quantitative pain outcomes in degenerative thoracic myelopathy
IntroductionDegenerative thoracic myelopathy (DTM) refers to symptomatic compression of the thoracic spinal cord secondary to degenerative pathology, including thoracic disc herniation (TDH), ossification of the ligamentum flavum (OLF) and ossification of the posterior longitudinal…
News
3067 results
Vagus nerve–driven microbiota homeostasis: a promising integrative add-on therapy for neurodevelopmental disorders
Over the past two decades, the conceptualization of neurodevelopmental disorders (NDDs) has undergone a profound transformation, shifting from a primarily brain-centric framework toward a systems-level perspective that integrates peripheral physiological processes. Among these, the gut microbiota has emerged as a…
Catastrophic consequences of prolonged immobilization after intracerebral hemorrhage: a case report of crush syndrome combined with capillary leak syndrome
BackgroundSpontaneous intracerebral hemorrhage is a neurological emergency with high mortality and disability rates. Prolonged immobilization after stroke can trigger severe systemic complications. The simultaneous occurrence of crush syndrome and capillary leak syndrome in the setting of acute intracerebral hemorrhage is…
Delayed multiple hemorrhagic brain metastases from atrial myxoma: a case report and literature review
ObjectiveBrain metastases from atrial myxoma are rare central nervous system manifestations and may mimic hemorrhagic malignant metastases or vascular lesions. We report a delayed case after prior cardiac myxoma resection and summarize the available patient-level literature.MethodsWe retrospectively reviewed the clinical…
Intraocular pressure spikes after intravitreal injection and their impact on OCT angiography
PurposeTo evaluate whether acute intraocular pressure (IOP) elevation after intravitreal anti-VEGF injection affects superficial capillary plexus (SCP) perfusion metrics on optical coherence tomography angiography (OCTA).MethodsIn this prospective single-center study, adults scheduled for unilateral intravitreal anti-VEGF treatment for macular edema were…
Sex-related molecular phenotypes in anxiety-depressive disorders: a machine learning analysis of routine blood biomarkers
BackgroundAnxiety disorders and depressive disorders are the most prevalent mental disorders worldwide. Their diagnosis has long relied on clinical symptom assessment, and objective blood−based biomarkers remain lacking. Sex is a critical risk factor for these disorders; however, sex−specific divergence in…
Art therapy for depression: a systematic review and meta-analysis
IntroductionDepression is among the leading causes of disability globally. Therefore, exploring the various non-medical treatment options for this condition is particularly important. The aim of the review was to assess the effect of art therapy on depressive symptoms.MethodsThe foundation of…
A comparison between seven scales of neuropsychological assessments for cognitive impairment screening in Chinese older population: a cross-sectional study in Chongqing, China
BackgroundThe Clinical Dementia Rating Scale (CDR), the Ascertain Dementia 8 (AD8), the Mini-Cog, the Verbal Fluency Test (VFT), the Community Screener for Dementia (CSI-D), the Rey Auditory Verbal Learning Test (RAVLT), and the Activities of Daily Living Scale (ADL) represent…
Changes in depression, anxiety, and post-traumatic stress symptoms among children and adolescents exposed to adverse childhood experiences following participation in the PROACT intervention in Nairobi, Kenya
IntroductionGlobally, children and adolescents exposed to Adverse Childhood Experiences (ACEs) face an increased risk of developing mental health disorders. The prevalence of these mental disorders is further amplified by the lack of access to specialised mental health treatment especially in…
Understanding cyber grooming in children and adolescents: a scoping review of risk factors and prevention strategies
The increasing digitalization of children’s daily lives has created new opportunities for communication, education, and social interaction while simultaneously increasing exposure to online exploitation risks. Among these risks, child grooming and cyber grooming have emerged as significant psychological, social, and…
Povorcitinib for hidradenitis suppurativa: the randomized, double-blind, placebo-controlled STOP-HS1 and STOP-HS2 phase 3 trials
Nature Medicine, Published online: 23 July 2026; doi:10.1038/s41591-026-04534-zIn a pair of pivotal phase 3, placebo-controlled, randomized clinical trials, the oral JAK1 inhibitor povorcitinib significantly reduced abscesses and inflammatory nodules in patients with moderate to severe hidradenitis suppurativa.
Focal astrocyte loss reveals nuclear translocation during lesion repopulation
Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02354-5Herwerth et al. demonstrate that, after focal astrocyte loss in the adult brain, perilesional astrocytes undergo extensive remodeling, proliferation and nuclear translocation to repopulate the depleted tissue without forming a glial scar.
Replay of procedural memory is independent of the hippocampus
Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02362-5Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error outcomes and predicted next-day…
How AI helps scientists design the next generation of medicines
Designing and developing a new medicine is an expensive, failure-prone scientific challenge. A new drug can take many years to develop, at the cost of a significant investment. And even then, most possible candidates never reach the patient. For biologic…
Expect a clash at today’s FDA peptide panel
The service members who refused the Covid vaccine, the fastest-growing Ebola outbreak in history, and other health news from Morning Rounds
STAT+: New data on Eli Lilly’s ‘triple-G’ drug leave open questions on heart benefit
On secondary endpoints that looked at major cardiovascular events, those taking retatrutide did not have a significant lower risk of death, heart attack, or stroke.
Filing of bipartisan Senate bill boosts momentum for office of men’s health
Mirroring the bipartisan bill introduced in the House, the measure would require a study from the GAO on the state of men’s health in the U.S. to be presented within…
The power line that could reshape New York’s grid is hitting snags
On July 3, as a heat wave swept the region, New York State’s grid imported 52 gigawatt-hours of electricity from Canada—enough to meet about 9% of its total electricity demand that day. Some of that power shuttled in on a…
Opinion: Good riddance to bundled ‘global’ maternal care billing
New maternal billing codes should create a transparent system where both patients and clinicians can thrive, ACOG writes.
STAT+: FDA staff and peptide enthusiasts set to clash at advisory panel
FDA advisers are set to consider whether allowing compounding pharmacies to offer largely unproven peptides is a safer bet than the gray-market versions now in use.