News Feed
News
1478 results
Systemic inflammation response index as an independent predictor of unfavorable prognosis and its application in risk stratification in patients with aneurysmal subarachnoid hemorrhage
BackgroundAneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular disease associated with high rates of mortality and long-term disability. Early risk stratification is essential to guide personalized management. Systemic inflammation plays a key role in secondary brain injury after aSAH. The…
CDKL5 deficiency results in atypical subregion-specific expression of perineuronal nets during mouse visual critical period
Perineuronal nets (PNNs) in the primary visual cortex (V1) are specialized extracellular matrix structures that form predominantly on parvalbumin+ GABAergic neurons, marking the closure of visual critical period plasticity. More recently, PNNs are used to characterize deficits in critical period…
Sleep quality and its associated factors among women of reproductive age in Ethiopia: a systematic review and meta-analysis
BackgroundQuality sleep is vital for women’s health during reproductive years, affecting both physical and mental well-being. In Ethiopia, socio-economic and cultural factors worsen sleep issues, but data on this demographic are scarce. This systematic review and meta-analysis assesses the prevalence…
Measuring the quality of life of students with autism in Chilean general education schools
IntroductionThe enrollment of students with autism in the Chilean general education system has increased exponentially, posing challenges for schools, which need useful approaches and strategies to enable them to respond to students and fulfill their aspirations and needs. The Quality…
Detecting bipolarity using the Lebanese Arabic hypomania checklist (HCL-32): validation of shortened HCL versions
IntroductionDue to the under diagnosis of bipolar disorder, screening instruments such as the hypomania checklist 32 items (HCL-32) is used to differentiate between Bipolar Disorder (BD) and Major Depressive Disorder (MDD). However due to its lengthy format, efforts were done…
The many manifestations of magical thinking: a systematic review
Magical thinking (MT) involves beliefs that thoughts or actions can influence events in unrealistic ways. While MT is integral to obsessive compulsive disorder, and reflected in the cognitive features of schizophrenia, it is observable across the general population in various…
Group-based psychosocial interventions reduce internalized stigma in psychiatric disorders: ISMI-focused systematic review
BackgroundInternalized stigma negatively impacts recovery outcomes, quality of life, and self-concept among individuals with psychiatric diagnoses. Group-based psychosocial interventions have been proposed as effective stigma-reduction strategies, but their impact across diverse populations remains under-evaluated.ObjectiveThis systematic review synthesizes global evidence on…
Novel antivenoms bite back
Nature Biotechnology, Published online: 20 May 2026; doi:10.1038/s41587-026-03157-6New approaches to antivenoms for snakebite lean on cutting-edge techniques, but can they successfully be brought to market?
Directed evolution of small RNA-stabilizing motifs that improve prime-editing efficiency
Nature Biotechnology, Published online: 20 May 2026; doi:10.1038/s41587-026-03123-2Prime editing is improved with engineered RNA-stabilizing motifs.
Unintended consequences of legacy oversight in digital medicine
Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04417-3Unintended consequences of legacy oversight in digital medicine
An AI framework for multi-disease detection via retinal imaging
Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04424-4Using large-scale retinal images from community and tertiary hospitals, we developed Reti-Pioneer, a quality-aware, multi-task framework for multi-disease detection. Diverse external validation confirmed its generalizability. Furthermore, a prospective silent trial and clinical pilot…
Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing
Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04423-5Analyses of sequencing data from 75,602 children referred for genetic testing from 2016 to 2025 provide insights on the association between pathogenic germline variants and childhood cancer.
Considering biological limitations of lesion network mapping
Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02319-8Lesion network mapping (LNM), or atrophy network mapping, has become a widely adopted tool for linking focal brain lesions or neurodegenerative brain clusters, respectively, to distributed functional networks associated with cognitive or clinical…
Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death
Nature Neuroscience, Published online: 20 May 2026; doi:10.1038/s41593-026-02299-9Tau aggregates disrupt heterochromatin by sequestering H3K9me3, reactivating transposable elements. This generates Z-RNAs, activating ZBP1 to drive neuronal death. ZBP1 haploinsufficiency reverses cognitive decline in aged tau mice, offering a therapeutic target for…
There’s a leadership vacuum at NIH, too
USAID cuts have painful outcomes for the Ebola outbreak, states sue over a new professional ed loan rule, and other health news
After Rubio’s critique, WHO defends work on Ebola response
The WHO defended its Ebola response, noting it's national authorities who detect outbreaks. Marco Rubio had said the WHO was 'a little late'
STAT+: Senate Democrats propose adding long-term care benefit to Medicare
It's part of Democrats' strategy to focus on health care affordability and access in drawing contrasts with Republicans ahead of the midterms.
STAT+: OpenEvidence makes its pitch to hospitals. ‘We’re not crazy monsters’
OpenEvidence CTO Zachary Ziegler said, at the STAT Breakthrough Summit West, that the company is looking beyond physician users.
NIH behind in filling top roles, with 15 of 27 institutes led by acting directors
An NIH leadership vacuum has persisted for months, with 15 of the 27 institutes being led by acting directors.
Sleep Architecture as a Digital Biomarker for Postpartum Depression in Hong Kong Mothers
Conditions: Postpartum Women Sponsors: The University of Hong Kong Not yet recruiting