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Binge Eating, Depression and Anxiety Outcomes After Sleeve Gastrectomy Versus Gastric Bypass: A Cohort Study
Conditions: Obesity Interventions: Procedure: Laparoscopic Sleeve Gastrectomy; Procedure: Gastric Bypass Sponsors: Cairo University Recruiting
Colossal Biosciences is growing chickens in a 3D-printed artificial eggshell
The baby chicks were shifting and starting to pip—or trying to hatch. But not from an egg. Instead, these chickens were growing inside transparent 3D-printed plastic cups at the Dallas headquarters of Colossal Biosciences. The biotech company today claimed it…
Machine learning-based predictive factor analysis of depression among Chinese adolescents
IntroductionAdolescent depression has emerged as a critical global public health concern, with rising prevalence in China posing severe threats to psychological development and social adaptation. Traditional statistical methods face limitations in capturing complex non-linear relationships and interactions among influencing factors,…
Understanding the workplace needs of autistic adults in Singapore: insights to inform inclusive AI support
IntroductionAutistic adults face persistent challenges in obtaining and sustaining meaningful employment. Despite growing attention to workplace inclusion, research on autistic adults’ employment experiences in non-Western contexts remains scarce. The potential of emerging technologies, such as large language models (LLMs), to…
A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy
Petrova et al. develop a high-throughput human iPSC-derived sensory neuron platform for drug discovery in chemotherapy-induced peripheral neuropathy. They uncover that inhibition of three members of the STE20 kinase family (MAP4K4/MINK1/TNIK) is neuroprotective against paclitaxel-induced axon damage, with validation in…
T cell-engaging bispecific antibodies for myeloid malignancies: Targets, formats, and clinical challenges
Paczesny et al. review why bispecific antibodies, successful in other blood cancers, have lagged in acute myeloid leukemia. They highlight how limited tumor specificity and toxicity hinder progress and outline emerging targets and engineering strategies that could enable safer, more…
Antibody-drug conjugates in breast cancer: Progress and future directions
Newman et al. review the evolving landscape of antibody-drug conjugates (ADCs) in breast cancer, including approved agents, resistance mechanisms, and combinatorial strategies. The authors highlight novel agents, antigen targets, and next-generation platforms, underscoring the need for predictive biomarkers and optimized…
Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis
Wong et al. review gut microbiota biomarkers for ASD, detailing gut-brain axis mechanisms, biomarker evolution from taxonomic profiling to multi-omics and multi-kingdom integration, key translational challenges, and actionable research guidelines to boost clinical utility for ASD diagnosis and prognosis.
BDNF insufficiency exacerbates ALS progression
Xu and He et al. provide in vivo evidence that BDNF insufficiency exacerbates the symptoms and pathologies in amyotrophic lateral sclerosis (ALS) patients and mouse models, leading to accelerated demise. They develop an agonistic antibody that boosts BDNF signaling and…
Bridging the gap in TB case detection
Nature Medicine, Published online: 19 May 2026; doi:10.1038/d41591-026-00026-2The portable, low-resource MiniDock MTB test, evaluated across multiple countries, shows promise for detecting pulmonary tuberculosis using sputum and tongue swabs.
STAT+: Marc Tessier-Lavigne addresses new book’s allegations about his conduct in Stanford misconduct case
Former Stanford President Marc Tessier-Lavigne responded publicly for the first time, at a STAT event Tuesday, to allegations in a new book about why he was forced to resign.
Trump’s cuts to foreign aid are undermining the Ebola response, insiders say
President Trump's cuts to foreign aid probably hampered the detection of the Ebola outbreak and the response to it.
Effects of an Eye-Tracking Digital Serious Game on Cognitive Function in Mild Cognitive Impairment: Pilot Intervention Study
Background: Cognitive decline in aging populations underscores the need for early interventions in mild cognitive impairment (MCI), where pharmacological treatments show limited benefit. Eye-movement metrics serve as sensitive markers of cognitive deficits in MCI, and digital programs integrating these tasks…
Automated Safety Testing and Reporting Application for Conversational Safety Monitoring of Generative AI Tools for Mental Health: Development and Validation Study
Background: Artificial intelligence (AI)–based conversational tools are rapidly expanding within mental health care as a means of increasing access and scalability. At the same time, these systems introduce distinct safety risks arising from both user disclosures (eg, self-harm ideation) and…
COVID-19 Knowledge, Attitudes, and Practices and Perceived Risk: Cross-Sectional Mixed Methods Study
Background: The COVID-19 pandemic was marked by rapidly evolving and inconsistent public health messaging, contributing to confusion regarding recommended preventive behaviors. Knowledge, attitudes, and practices (KAP) and perceived risk frameworks offer a structured approach to examine how education, personal beliefs,…
Detection of Posttraumatic Stress Disorder With Rest-Activity Data: Machine Learning Approach Using Wearable and Self-Report Data
Background: Growing evidence suggests that disruptions in rest-activity rhythms may serve as relevant markers of posttraumatic stress disorder (PTSD). Despite the emergence of machine learning methods applied to actigraphy and self-report data, few studies have used these approaches to identify…
STAT+: Virginia governor vetoes legislation to create an advisory panel to lower the cost of prescription drugs
Virginia's governor vetoed a closely watched effort to create an advisory panel to lower prescription drug costs.
STAT+: This spine surgery usually costs $1,400. Under No Surprises Act arbitration? $34,000
A new analysis shows how some clinicians are cashing in on a new process designed to protect patients from surprise bills.
How AI helped treat a newborn’s ultra rare disease. ‘It was almost like a light switch.’
The parents of Jorie Krause told the audience at STAT's Breakthrough Summit West about how AI helped their daughter who was born with a rare disease.
Roundtables: Inside the Musk v. Altman Trial
Listen to the session or watch below Elon Musk lost his suit against OpenAI, in which he alleged CEO Sam Altman and President Greg Brockman had deceived him over the company’s non-profit status. Watch as AI reporter and attorney Michelle…