News Feed
Is the oxytocin system a keystone in human wellbeing?
It has also taken over a century for science to fully realize that oxytocin is far more than a “female reproductive hormone.” Both the measurement and interpretation of the biochemical and functional properties of…
Asymmetric encoder-decoder U-net with hybrid attention and residual dilated convolution for brain tumor segmentation
InroductionThe accurate and automatic segmentation of brain tumors from magnetic resonance imaging is regarded as essential for clinical diagnosis and surgical planning. Nevertheless, the concurrent extraction of both local fine details and global contextual…
News
3048 results
3D confocal imaging reveals quantitative bias in cerebral microhemorrhage counts from standard histology
Standard histological quantification of cerebral microhemorrhages (CMH), the pathologic substrate of cerebral microbleeds, may systematically undercount lesion burden due to sparse tissue sampling. CMH are visualized using Prussian blue-stained 2D tissue sections. This method provides a snapshot of CMH lesions…
Stress-induced dorsal striatal dopamine release is associated with changes in functional connectivity to the prefrontal cortex in nicotine-dependent individuals—a preliminary report
IntroductionThe neural mechanism linking stress to addiction pathophysiology remains unclear. A proposed pathway involves stress-induced dopamine (DA) transmission impairing inhibitory control, leading to relapse. Lipopolysaccharide (LPS), a biological stressor inducing systemic inflammation, amplifies DA release. Our prior study demonstrated this…
Case Report: Severe depression and suicidality in a young patient with RYR1-related congenital myopathy
BackgroundRYR1-related congenital myopathies (RYR1-CMYO) are rare inherited neuromuscular disorders characterized by considerable clinical and histopathological heterogeneity. Although chronic physical disability may be associated with substantial psychological burden, psychiatric manifestations in patients diagnosed with RYR1-related disorders remain insufficiently characterized.Case presentationWe report…
Family cohesion and adolescent self-esteem: mediating effects of interpersonal self-support and moderating role of school attachment
IntroductionAdolescent mental health is a pressing global concern, and in collectivist societies such as China, family and school contexts are particularly influential. This study examined whether interpersonal self-support mediates the association between family cohesion and self-esteem among Chinese adolescents and…
Developing and evaluating a customized evidence-based safety training program for healthcare staff: a quality improvement approach
The high risk of workplace violence (WPV) for workers in mental health care settings and the potentially serious impacts, both mental and physical, have prompted many hospitals to mandate behavioral safety skills training for their staff. There are, however, some…
When severe violence becomes a script: a vulnerability-script integration model of media exposure and the form of psychosis-associated maternal filicide
When a publicized act of severe violence is followed by one that resembles it, the resemblance is often read as contagion. This paper argues that resemblance is weak evidence of influence and asks a narrower question: under what conditions can…
Metabolic heterogeneity of obesity
Nature Medicine, Published online: 27 October 2026; doi:10.1038/s41591-026-04718-7This Review examines the cellular, organ-level and whole-body differences between metabolically healthy and metabolically unhealthy obesity, as well as variations in response to weight loss—with the goal of improving strategies for preventing and…
Persistent and compartmentalized T cell immunity in ALS
Nature Medicine, Published online: 27 October 2026; doi:10.1038/s41591-026-04728-5In ALS, persistent T cell responses relate to disease outcome differently in blood than in cerebrospinal fluid, with both intrathecal antigen presentation and cytomegalovirus-specific immunity linked to worse clinical outcomes.
Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success
Nature Neuroscience, Published online: 27 October 2026; doi:10.1038/s41593-026-02493-9The study shows that stimulus-specific neurons in the human amygdala determine which experiences become lasting memory, revealing a mechanism that predicts episodic memory formation and may guide future treatments for memory disorders.
Circuit mechanisms for disentangled representations and generalization in the hippocampus
Nature Neuroscience, Published online: 27 October 2026; doi:10.1038/s41593-026-02491-xThe hippocampus encodes different aspects of experience as disentangled variables, enabling flexible recombination and generalization to new situations. This code is supported by the geometry of population dynamics and cell–assembly interactions.
Industrial Intelligence: The next growth opportunity for manufacturing
Every manufacturer has its own industrial intelligence. Some is documented, and some resides in the knowledge of experienced workers. Consider an experienced operator preparing to restart a line after a changeover. The machine settings matter, but so does knowing how…
How solid-state transformers could help power the AI boom
Transformers are a crucial but nearly invisible part of our grid. The devices help efficiently move power across long distances, but they’re complicated and in short supply. And given that their basic design hasn’t changed much for about a century,…
STAT+: Pennsylvania Dutch country, tired of waiting for biopharma, builds drug company of its own
A small community tests if it can solve a crisis no one else could, for the simple reason that they have no other choice.
Opinion: Cancer vaccines are finally here. How do we get them to patients?
“If we want cancer vaccines to reach patients faster than BRCA testing did, there are several challenges to address now,” write Karen E. Knudsen and Othman Laraki.
Opinion: Emergency pediatric care is now in permanent crisis mode
“In 2026, the unprecedented pediatric patient crowding of 2022 has become a normal Tuesday,” write Jonathan Kohler and Mary King.
Microbiota Modulation for Psychiatry Patients
Conditions: Depression - Major Depressive Disorder; Generalized Anxiety Disorder (GAD); Anxiety Interventions: Other: Dietary Supplement: Acetate (Apple Cider Vinegar) Sponsors: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Not yet recruiting
e-Perinatal Butterfly: An Embedded Study for Parents Experiencing Perinatal Loss
Conditions: Depressive Symptoms; Perinatal Loss; Perinatal Grief; Anxiety Symptoms Interventions: Behavioral: e-Perinatal Butterfly; Other: Standard routine maternal care Sponsors: University of Seville; Andalusian Health Service Not yet recruiting
AI-Based CBT Chatbot for Adolescent Social Anxiety
Conditions: AI-CBT Intervention Group; Waitlist Control Group Interventions: Behavioral: AI-CBT intervention group Sponsors: Central China Normal University Not yet recruiting
Reducing Stigma – A Treatment for Early Psychosis to Prevent Suicide
Conditions: Suicide; Mental Health Stigma Interventions: Behavioral: RESTEPS Sponsors: Butler Hospital; American Foundation for Suicide Prevention Not yet recruiting
News Feed
Is the oxytocin system a keystone in human wellbeing?
It has also taken over a century for science to fully realize that oxytocin is far more than a “female reproductive hormone.” Both the measurement and interpretation of the biochemical and functional properties of…
Asymmetric encoder-decoder U-net with hybrid attention and residual dilated convolution for brain tumor segmentation
InroductionThe accurate and automatic segmentation of brain tumors from magnetic resonance imaging is regarded as essential for clinical diagnosis and surgical planning. Nevertheless, the concurrent extraction of both local fine details and global contextual…
News
3048 results
3D confocal imaging reveals quantitative bias in cerebral microhemorrhage counts from standard histology
Standard histological quantification of cerebral microhemorrhages (CMH), the pathologic substrate of cerebral microbleeds, may systematically undercount lesion burden due to sparse tissue sampling. CMH are visualized using Prussian blue-stained 2D tissue sections. This method provides a snapshot of CMH lesions…
Stress-induced dorsal striatal dopamine release is associated with changes in functional connectivity to the prefrontal cortex in nicotine-dependent individuals—a preliminary report
IntroductionThe neural mechanism linking stress to addiction pathophysiology remains unclear. A proposed pathway involves stress-induced dopamine (DA) transmission impairing inhibitory control, leading to relapse. Lipopolysaccharide (LPS), a biological stressor inducing systemic inflammation, amplifies DA release. Our prior study demonstrated this…
Case Report: Severe depression and suicidality in a young patient with RYR1-related congenital myopathy
BackgroundRYR1-related congenital myopathies (RYR1-CMYO) are rare inherited neuromuscular disorders characterized by considerable clinical and histopathological heterogeneity. Although chronic physical disability may be associated with substantial psychological burden, psychiatric manifestations in patients diagnosed with RYR1-related disorders remain insufficiently characterized.Case presentationWe report…
Family cohesion and adolescent self-esteem: mediating effects of interpersonal self-support and moderating role of school attachment
IntroductionAdolescent mental health is a pressing global concern, and in collectivist societies such as China, family and school contexts are particularly influential. This study examined whether interpersonal self-support mediates the association between family cohesion and self-esteem among Chinese adolescents and…
Developing and evaluating a customized evidence-based safety training program for healthcare staff: a quality improvement approach
The high risk of workplace violence (WPV) for workers in mental health care settings and the potentially serious impacts, both mental and physical, have prompted many hospitals to mandate behavioral safety skills training for their staff. There are, however, some…
When severe violence becomes a script: a vulnerability-script integration model of media exposure and the form of psychosis-associated maternal filicide
When a publicized act of severe violence is followed by one that resembles it, the resemblance is often read as contagion. This paper argues that resemblance is weak evidence of influence and asks a narrower question: under what conditions can…
Metabolic heterogeneity of obesity
Nature Medicine, Published online: 27 October 2026; doi:10.1038/s41591-026-04718-7This Review examines the cellular, organ-level and whole-body differences between metabolically healthy and metabolically unhealthy obesity, as well as variations in response to weight loss—with the goal of improving strategies for preventing and…
Persistent and compartmentalized T cell immunity in ALS
Nature Medicine, Published online: 27 October 2026; doi:10.1038/s41591-026-04728-5In ALS, persistent T cell responses relate to disease outcome differently in blood than in cerebrospinal fluid, with both intrathecal antigen presentation and cytomegalovirus-specific immunity linked to worse clinical outcomes.
Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success
Nature Neuroscience, Published online: 27 October 2026; doi:10.1038/s41593-026-02493-9The study shows that stimulus-specific neurons in the human amygdala determine which experiences become lasting memory, revealing a mechanism that predicts episodic memory formation and may guide future treatments for memory disorders.
Circuit mechanisms for disentangled representations and generalization in the hippocampus
Nature Neuroscience, Published online: 27 October 2026; doi:10.1038/s41593-026-02491-xThe hippocampus encodes different aspects of experience as disentangled variables, enabling flexible recombination and generalization to new situations. This code is supported by the geometry of population dynamics and cell–assembly interactions.
Industrial Intelligence: The next growth opportunity for manufacturing
Every manufacturer has its own industrial intelligence. Some is documented, and some resides in the knowledge of experienced workers. Consider an experienced operator preparing to restart a line after a changeover. The machine settings matter, but so does knowing how…
How solid-state transformers could help power the AI boom
Transformers are a crucial but nearly invisible part of our grid. The devices help efficiently move power across long distances, but they’re complicated and in short supply. And given that their basic design hasn’t changed much for about a century,…
STAT+: Pennsylvania Dutch country, tired of waiting for biopharma, builds drug company of its own
A small community tests if it can solve a crisis no one else could, for the simple reason that they have no other choice.
Opinion: Cancer vaccines are finally here. How do we get them to patients?
“If we want cancer vaccines to reach patients faster than BRCA testing did, there are several challenges to address now,” write Karen E. Knudsen and Othman Laraki.
Opinion: Emergency pediatric care is now in permanent crisis mode
“In 2026, the unprecedented pediatric patient crowding of 2022 has become a normal Tuesday,” write Jonathan Kohler and Mary King.
Microbiota Modulation for Psychiatry Patients
Conditions: Depression - Major Depressive Disorder; Generalized Anxiety Disorder (GAD); Anxiety Interventions: Other: Dietary Supplement: Acetate (Apple Cider Vinegar) Sponsors: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Not yet recruiting
e-Perinatal Butterfly: An Embedded Study for Parents Experiencing Perinatal Loss
Conditions: Depressive Symptoms; Perinatal Loss; Perinatal Grief; Anxiety Symptoms Interventions: Behavioral: e-Perinatal Butterfly; Other: Standard routine maternal care Sponsors: University of Seville; Andalusian Health Service Not yet recruiting
AI-Based CBT Chatbot for Adolescent Social Anxiety
Conditions: AI-CBT Intervention Group; Waitlist Control Group Interventions: Behavioral: AI-CBT intervention group Sponsors: Central China Normal University Not yet recruiting
Reducing Stigma – A Treatment for Early Psychosis to Prevent Suicide
Conditions: Suicide; Mental Health Stigma Interventions: Behavioral: RESTEPS Sponsors: Butler Hospital; American Foundation for Suicide Prevention Not yet recruiting