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Long-Read DNA Test Could Replace 15 Existing Tests for Rare Diseases
A DNA test for rare diseases using long-read sequencing can provide much more comprehensive results than standard diagnostics in a shorter amount of time. The post Long-Read DNA Test Could Replace 15 Existing Tests…
Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study
Background: University students experience elevated psychological distress, with limited access to mental health services. While cognitive behavioral therapy (CBT) demonstrates efficacy for anxiety and depression, treatment gaps persist due to access barriers and insufficient…
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The Download: soccer’s data renaissance and China’s big nuclear plans
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Inside soccer’s data renaissance Imagine tuning in to the opening kickoff of a World Cup match…
The exercise-microbiota-queuine-tRNA axis in Parkinson’s disease: evidence, uncertainties, and experimental priorities
Parkinson's disease (PD) is a multisystem neurodegenerative disorder characterized by progressive nigrostriatal dopaminergic degeneration, α-synuclein aggregation, mitochondrial dysfunction, oxidative stress, and neuroinflammatory remodeling. Although these mechanisms have been extensively investigated, how systemic metabolic and microbiota-derived signals intersect with neuronal translational…
Occipital and parietal non-invasive brain stimulation enhances perceptual learning and transfer: evidence from high-frequency tRNS
Perceptual training yields specific, long-lasting improvements, yet its transfer to untrained conditions is often limited. This tension has been proposed to involve interactions between early sensory plasticity and higher-order parietal processes, with the early visual cortex contributing to stimulus-specific learning…
Neural and autonomic regulation during brief mindfulness and relaxation interventions in clinical populations: a multimodal MEG study protocol
Mental disorders pose a major and growing challenge for health care systems worldwide, marked by persistent treatment gaps and limited access to psychotherapeutic care. Mind–body interventions such as mindfulness and relaxation practices are widely used in clinical contexts as low-threshold…
Do stretch sensors expressed by aortic baroreceptors interact with circulating estradiol to mediate baroreflex sensitivity in hypertension?
Hypertension, or high blood pressure, is a major risk factor for cardiovascular disease, the leading cause of mortality worldwide. The incidence and the severity of hypertension is higher in middle-aged men than women. The hallmark of hypertension is an increased…
Perceived organizational climate and turnover intention among young nurses from a humanistic care perspective: the mediating role of work engagement
BackgroundThe high turnover of young nurses poses a significant challenge to the stability of healthcare systems worldwide. While the relationships between perceived organizational climate, work engagement, and turnover intention are established, there is a lack of research integrating a humanistic…
Cultural adaptation and feasibility of action over inertia in Japan: a multi-site pilot intervention study
IntroductionAction Over Inertia (AOI) is a recovery-oriented intervention designed to promote occupational engagement and support personal recovery through changes in everyday activity patterns. While AOI has been examined in Western contexts, its applicability and clinical adaptation in East Asian settings…
Social anxiety but not callous-unemotional traits predicts shame coping in conduct disorder
IntroductionConduct disorders are characterized by emotional dysregulation. Both callous-unemotional traits and social anxiety are heightened in conduct disorder patients and are associated with different mechanisms of emotion regulation. Previous evidence has proposed that secondary emotions, such as shame, might also…
Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT
Nature Biotechnology, Published online: 11 June 2026; doi:10.1038/s41587-026-03127-yIn vivo CRISPR genetic perturbations are spatially mapped at scale.
Spatial CRISPR screens map total RNA in tissue
Nature Biotechnology, Published online: 11 June 2026; doi:10.1038/s41587-026-03126-zA method for spatial CRISPR perturbation screening reveals how genetic changes alter coding and non-coding RNA in a native tissue context, including the tumor microenvironment.
Clinical Profile and Genomic Characterization of the 2026 Bundibugyo Virus Index Case in Uganda
Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04510-7Clinical Profile and Genomic Characterization of the 2026 Bundibugyo Virus Index Case in Uganda
HHS responds coolly to paper on alcohol risk
Soda and liver cancer, scientists conflicted on a new NIH proposal, and more health news from Morning Rounds
Google DeepMind is worried about what happens when millions of agents start to interact
Google DeepMind is funding research into the potential dangers of situations where millions of different AI agents interact with each other online. According to Rohin Shah, who directs the company’s AGI safety and alignment research, the mass-market arrival of agents that…
Inside soccer’s data renaissance
Imagine tuning in to the opening kickoff of a World Cup match and seeing a player intentionally send the ball all the way down the pitch and right out of bounds on the opponent’s end. Casual fans might scratch their…
Job titles of the future: Nature’s drug designer
In 2018, after nearly two decades working in Big Pharma, chemist Tim Cernak was ready to put his skills to a new use. For Merck, he’d developed precision therapies for cancer, HIV, and diabetes that could target disease while minimizing…
Why China is betting on big nuclear reactors
It’s a tale of two nuclear industries. In China, large reactors are coming together at a stunning pace. The country has nearly doubled its nuclear fleet since 2016, reaching nearly 60 gigawatts of total power capacity. The new facilities are…