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1H-MRS brain metabolites as biomarkers of high-altitude hypobaric hypoxia following mild traumatic brain injury in mice
Introduction and objectivePopulations at high altitude (HA) face a higher incidence and severity of traumatic brain injury (TBI). This pilot study utilized longitudinal 1H-MRS to identify neurochemical biomarkers of HA adaptation and the subsequent metabolic response to mild TBI (mTBI).MethodsMale…
Natural head orientation and spatial hearing with symmetric frontal maskers
The purpose of this study was to evaluate the effect of natural, undirected head orientation on speech perception in the presence of interfering speech maskers that were symmetrically arranged to minimize the better-ear advantage. We also examined the characteristics of…
Disrupted sleep-wake cycles and circadian rhythms in a Drosophila model of C9orf72-FTD
Frontotemporal dementia (FTD) is a neurodegenerative disorder that affects behavior, personality, motor activity, speech, cognition, and sleeping patterns. Previous findings support the idea that disruption of sleep and circadian systems may not only be affected by this disease but also…
Can the treatment effects of human-animal interaction be maintained? A randomized controlled trial including follow-up in people with severe mental illness
IntroductionThere are persistent demands for well-designed randomized controlled trials (RCTs), including follow-up measurements, in studies on animal-assisted treatment (AAT). In addition, a possible dose-response relationship is under discussion. The aim of the present study was to investigate the efficacy of…
Large-scale meta- and cross-trait analyses uncover shared genetic risk factors for IBS and psychiatric disorders
IntroductionIrritable bowel syndrome (IBS) is a common gut-brain axis disorder characterized by abdominal pain and altered bowel habits, and it shows high comorbidity with psychiatric disorders. However, the shared genetic mechanisms underlying these associations remain incompletely understood.MethodsWe performed a large-scale…
Getting the timing right. Autistic adolescents reflect on the value of an early diagnosis
IntroductionIn Western countries, autism diagnoses are increasingly assigned in the first years of life. But is earlier necessarily better? Despite potential benefits, autistic infants and toddlers cannot participate in these discussions. In the ethical debate on early autism diagnosis, this…
Recognizing anxiety and depression in cancer patients based on speech and facial expressions
PurposeTo address the anxiety and depression experienced by cancer patients due to the stress of diagnosis and treatment, as well as the limitations of traditional assessment methods characterized by high subjectivity and low efficiency, this study aims to develop a…
Cortical high-threshold and low-activation characteristics in adolescent depression: a cross-age differential analysis
BackgroundAdolescent depression exhibits distinct neurophysiological features, with marked age heterogeneity particularly in the resting motor threshold (RMT) measured during repetitive transcranial magnetic stimulation (rTMS), and substantial variability in clinical therapeutic efficacy. Functional near-infrared spectroscopy (fNIRS) enables the assessment of cortical…
Performance of traumatic encephalopathy syndrome criteria in identifying individuals with chronic traumatic encephalopathy
Nature Medicine, Published online: 14 May 2026; doi:10.1038/s41591-026-04392-9The proposed clinical features of traumatic encephalopathy syndrome have low predictive value for chronic traumatic encephalopathy pathology, raising significant concern for incorrect diagnoses of neurodegeneration in former athletes.
Advancing conversational diagnostic AI with multimodal reasoning
Nature Medicine, Published online: 14 May 2026; doi:10.1038/s41591-026-04371-0Improvements in the Articulate Medical Intelligence Explorer, a large language model designed for diagnostic dialogue, enable the model to request, interpret and reason about multimodal medical data.
Abatacept versus hydroxychloroquine for prevention of rheumatoid arthritis in individuals with palindromic rheumatism: a randomized open-label trial
Nature Medicine, Published online: 14 May 2026; doi:10.1038/s41591-026-04395-6Subcutaneous injections of abatacept were superior to oral hydroxychloroquine in preventing progression to persistent arthritis in individuals with palindromic rheumatism.
Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming
Nature Neuroscience, Published online: 14 May 2026; doi:10.1038/s41593-026-02300-5This study reveals that the immune system has a role in driving ALS. These findings link blood immune changes to spinal cord damage and suggest personalized treatments targeting specific immune pathways.
Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits
Nature Neuroscience, Published online: 14 May 2026; doi:10.1038/s41593-026-02268-2Combining connectomics, physiology and behavior, this study shows how the cerebellum decides when to learn. Synchronized climbing-fiber error signals lift an inhibitory signal gate on Purkinje cells, enabling synaptic plasticity and motor adaptation.
The Download: deepfake porn’s stolen bodies and AI sharing private numbers
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The shock of seeing your body used in deepfake porn When Jennifer got a research job…
STAT+: Three years of declining overdose deaths begets cautious optimism and some concerns
The next FDA leader, how the CDC is responding to hantavirus, and more health news from Morning Rounds
STAT+: Biogen’s tau-targeting Alzheimer’s drug posts mixed results in mid-stage study
Biogen is moving its tau-targeting Alzheimer's drug into Phase 3 studies, despite mixed data from a Phase 2 trial.
STAT+: Regenxbio says Duchenne gene therapy succeeded in clinical trial, paving way for FDA submission
Regenxbio said its experimental gene therapy for Duchenne muscular dystrophy succeeded in a trial, paving the way for a submission to the FDA.
STAT+: CREATE Medicines, a biotech company developing CAR-T therapies, raises $122 million
CREATE Medicines has a new name, an expanded pipeline, and now fresh funding to propel the company’s first CAR-T candidates through human trials.
STAT+: ‘No drama’ Diamantas should serve biotech well as acting FDA chief
Kyle Diamantas, the acting commissioner of the FDA, is expected to be a drama-free, stabilizing caretaker at the top of the agency.
The Tesla Semi could be a big deal for electric trucking
The Tesla Semi has officially arrived. The company recently released a photo of the first vehicle rolling off its new full-scale production line. This moment has been nearly a decade in the making: The company first announced the Tesla Semi…