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Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study
Background: University students experience elevated psychological distress, with limited access to mental health services. While cognitive behavioral therapy (CBT) demonstrates efficacy for anxiety and depression, treatment gaps persist due to access barriers and insufficient…
Using a Virtual Reality CAVE–Based Mindfulness Intervention to Promote Mental Well-Being in Adolescents With Anxiety Symptoms: Pre-Post Mixed Methods Pilot Study
Background: Adolescent anxiety is a growing public health concern associated with significant social and emotional impairment. Mindfulness-based interventions (MBIs) have shown promise in reducing anxiety and improving well-being; however, engagement remains challenging. Virtual reality…
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STAT+: Five biotech news updates to stay on top of today
Eli Lilly spends more of its GLP-1 cash, Humira's masterclass in monopoly, and more updates from The Readout
Progenitor diversity during formation of the mammalian neocortex
Mammalian neocortical development follows a precise spatiotemporal sequence to generate the organized structure responsible for higher-order cognition and behavior. Increasing evidence suggests that diversification of neural stem and progenitor cells during prenatal development is a key step in the emergence…
Autonomic imbalance and vascular injury in hypertensive chronic kidney disease: mechanisms and clinical potential of ultrasound-guided sympathetic blockade
Hypertensive Chronic Kidney Disease (CKD) constitutes a significant global health burden, characterized by a vicious cycle of hypertension and progressive renal decline. Autonomic imbalance, specifically sympathetic overactivity and parasympathetic withdrawal, is increasingly recognized as a central driver of this pathophysiology,…
Physiological determinants of cortical P100 responses in pattern visual evoked potentials: a scoping review
BackgroundPattern visual evoked potentials (pattern VEP) are widely used for functional assessment of the visual pathways. The P100 component represents the principal clinical parameter owing to its relative interindividual stability and diagnostic value. However, both latency and amplitude are modulated…
GGDA-net: geometry-guided deformable attention network for Alzheimer’s disease image classification
BackgroundConvolutional neural networks (CNNs) have achieved remarkable success in medical image analysis, including Alzheimer’s disease (AD) classification. However, conventional convolution operations rely on fixed sampling patterns, and most existing attention mechanisms primarily focus on feature responses while neglecting spatial sampling…
Disease-associated RNA and protein signatures in iPSC-derived microglia model of Alzheimer’s disease
IntroductionMicroglia, the resident immune cells of the central nervous system, play a critical role in maintaining neural homeostasis and regulating inflammatory responses in the brain. Increasing evidence suggests that microglial dysfunction contributes to the progression of neurodegenerative diseases, including Alzheimer’s…
Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study
BackgroundCognitive control deficits are a core feature of adolescent major depressive disorder (MDD), yet the associated task-state neurophysiological mechanisms remain poorly characterized. This study investigated electrophysiological alterations in MDD using a Stroop color-word task.MethodsTwenty-two adolescents with MDD and fifteen age-…
A bibliometric analysis of neuroimaging studies on cognitive control in autism spectrum disorder (2000–2025)
ObjectiveThis study aims to systematically analyze neuroimaging research on cognitive control in Autism spectrum disorder (ASD) from 2000 to 2025 using bibliometric methods, in order to reveal the evolutionary trajectory, core knowledge base, research hotspots, and future frontiers of the…
Aggression and emotional distress in adolescents: a cross-sectional chain mediation model of internet addiction and somatization
BackgroundAdolescent depression and anxiety are major public health concerns. Aggression is frequently associated with internalizing symptoms, but the behavioral and body related mechanisms underlying this association remain insufficiently clarified. This study examined a theoretically proposed chain mediation model linking aggression…
Author Correction: DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03180-7Author Correction: DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage
A framework for building a synthetic cell from the SynCell Asia Initiative
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03153-wBuilding a living cell from scratch requires overcoming a bottleneck that has remained unresolved despite decades of progress: orchestrating the spatiotemporal integration of core functional modules. To tackle this barrier, the SynCell Asia…
Improving multimodal wearable sensing for healthcare with artificial intelligence
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03134-zThis Comment explores artificial intelligence-driven strategies to accelerate the clinical translation of multimodal wearable sensors. We outline key data-science challenges and highlight disease contexts in which these systems could support therapeutic interventions.
Programming biology: next-gen AI firms raise billions to design better medicines
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03170-9Faster drug discovery, optimized drug design, even programmable therapeutics: AI is impacting R&D. Data and development bottlenecks remain.
Fetal monitoring for high-risk pregnancies using a wearable ultrasound patch
Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03140-1A wearable ultrasound device is optimized for continuous monitoring of pregnancies.
Enabling secure discovery in trusted research environments with improved tooling
Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04401-xBiobanks are introducing trusted research environments to enable secure data access, yet they can increase costs and complexity for biomedical researchers who use them. We discuss challenges and solutions and introduce the Python…
Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial
Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04376-9In a multicenter phase 2 trial, the fibroblast growth factor receptor inhibitor rogaratinib showed encouraging clinical efficacy in patients with succinate dehydrogenase-deficient gastrointestinal stromal tumors, suggesting a potential new treatment option for this…
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice
Nature Neuroscience, Published online: 26 May 2026; doi:10.1038/s41593-026-02317-wIn PS19 mice, microglia-derived glycoprotein nonmetastatic melanoma protein B promotes mitochondrial extracellular vesicle secretion, enabling mitochondrial transfer to astrocytes. This improves astrocytic function and reduces Alzheimer’s disease (AD) symptoms, while GPNMB deficiency impairs…
The Download: puncturing the AI jobs panic
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. A reality check on the AI jobs hysteria Despite the growing hysteria over AI’s threat to…