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Romanian male patients with the dual diagnosis of schizophrenia and alcohol use disorder: a prospective study of clinical, social, and treatment-related factors affecting quality of life
BackgroundSchizophrenia frequently co-occurs with alcohol use disorder (AUD), resulting in a complex clinical profile associated with poor functional outcomes and reduced quality of life (QoL). Although both conditions independently impair psychosocial functioning, few studies have examined the combined effects of…
Perception of social support and psychological well-being among mothers of individuals with intellectual disabilities: the mediating role of self-efficacy
BackgroundThe aim of this study is to examine the mediating role of self-efficacy in the relationship between social support perception and psychological well-being among mothers of individuals with intellectual disabilities.MethodsA correlational survey model was used in this study in line…
Assessing directional connections between symptoms, cognition, insight, and real-life functioning in schizophrenia: a partial ancestor graphs analysis
IntroductionSchizophrenia is a severe chronic mental disorder causing significant global disability. Understanding the intricate relationships between symptoms, cognitive functions, and real-life outcomes is essential for developing effective interventions. Prior research, while informative, could not often determine the direction of the…
From cats to cortex: T. gondii and psychosis, depression, and anxiety
This review examines whether cat ownership, via exposure to the neurotropic parasite T. gondii, contributes to vulnerability for psychotic, depressive, and anxiety symptoms. T. gondii establishes lifelong latent infection in the brain and muscle, where it can modulate dopaminergic signaling,…
Internalizing and externalizing pathways to internet gaming disorder: the roles of anger and social anxiety
BackgroundInternet Gaming Disorder (IGD) represents a significant behavioral health concern, yet the roles of internalizing and externalizing psychological vulnerabilities in its development remain underexplored, particularly in Arabic-speaking populations.ObjectiveThis study examined anger and social anxiety as distinct externalizing and internalizing predictors…
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models
Nature Biotechnology, Published online: 13 May 2026; doi:10.1038/s41587-026-03115-2Immune-remodeling mRNAs delivered in lipid nanoparticles boost antitumor immunity.
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
Nature Biotechnology, Published online: 13 May 2026; doi:10.1038/s41587-026-03128-xA deep-learning method predicts T cell receptor specificity and disease-associated antigens.
Fluctuating internal states mediate neural–behavioral covariations in V1
Nature Neuroscience, Published online: 13 May 2026; doi:10.1038/s41593-026-02296-yThe authors report surprising covariations between subthreshold activity of single V1 neurons and behavior, demonstrating that interactions between external sensory inputs and internal states are implemented by a nonlinear modulatory signal in V1.
Closed-loop stimulation modulates attention shifting in children
Nature Neuroscience, Published online: 13 May 2026; doi:10.1038/s41593-026-02294-0Intracranial recordings in children revealed neural signals predicting attentional lapses. Closed-loop stimulation rescued performance and scalp EEG enabled noninvasive modulation, identifying a reproducible marker of attentional control.
Extreme heat is worsening faster for Black Americans
Bill Cassidy's can't-win conundrum, what RFK Jr. gets right and wrong about antidepressants, and more health news
STAT+: Scientists link boy’s tumor to gene therapy viruses, in rare finding
Doctors have linked a boy's tumor to a gene therapy, but say the rare risks need to be weighed against the profound benefits such medicines can offer.
A plan to make drugs in orbit is going commercial
Varda Space Industries, a startup that’s been pitching its ability to perform drug experiments in space, says it has signed up the pharmaceutical company United Therapeutics in what may be remembered as a notable step toward in-orbit manufacturing. The idea…
STAT+: Drug meant to make gene therapy safer may also make it less effective
Encoded Therapeutics gives a heads-up to other gene therapy company about the trade-offs with a drug meant to improve safety.
Opinion: What can ‘blue zones’ really teach us about aging?
Have you heard about blue zones where people tend to live much longer? They’re more complicated than they might sound.
Opinion: RFK Jr.’s antidepressant deprescribing push gets one thing right — and others dangerously wrong
“Deprescribing requires gradual tapering, psychological support, careful risk stratification, and accessible alternatives — none of which Kennedy’s initiative provides at scale.”
A Randomized, Double-blind, Placebo-controlled, Dose-escalating Phase I Clinical Trial
Conditions: Schizophrenia Interventions: Drug: KR23248; Drug: Matching Placebo Sponsors: Jiangxi Kvvit Pharmaceutical Co., Ltd. Not yet recruiting
NIH-funded study maps human pancreatic islet cells, offering new clues to diabetes risk
Comprehensive characterization of islet cells facilitated by national organ donation program.
Revolution’s aftermath: population based cross-sectional study to understand the intergeneration mental health and wellbeing following the 2024 student-led uprising
BackgroundBangladesh was confronted with a nationwide student uprising in July 2024, that exposed both participants and observers to widespread unrest and traumatic events. To better understand the kind of support the population will need, it is important to understand its…
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
Nature Medicine, Published online: 13 May 2026; doi:10.1038/s41591-026-04386-7As presented at the European Congress on Obesity, this randomized, placebo-controlled trial demonstrates that oral orforglipron, a nonpeptide GLP-1 receptor agonist, preserves weight loss and cardiometabolic benefits achieved with injectable GLP-1 receptor agonist…
Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial
Nature Medicine, Published online: 13 May 2026; doi:10.1038/s41591-026-04394-7In a randomized trial, pasteurized Akkermansia muciniphila improved weight loss maintenance and metabolic health after a low-energy diet, especially in individuals with initially lower Akkermansia levels. The work suggests leveraging gut A. muciniphila…